Amino acid dipepetide frequency for Streptococcus satellite phage Javan571

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.779AlaAla: 0.779 ± 0.473
0.39AlaCys: 0.39 ± 0.42
5.064AlaAsp: 5.064 ± 1.524
7.012AlaGlu: 7.012 ± 2.132
1.948AlaPhe: 1.948 ± 1.005
3.116AlaGly: 3.116 ± 0.814
0.39AlaHis: 0.39 ± 0.446
3.896AlaIle: 3.896 ± 1.466
6.623AlaLys: 6.623 ± 1.444
7.012AlaLeu: 7.012 ± 1.146
1.169AlaMet: 1.169 ± 0.823
4.675AlaAsn: 4.675 ± 1.661
1.948AlaPro: 1.948 ± 0.725
3.506AlaGln: 3.506 ± 1.011
3.116AlaArg: 3.116 ± 0.933
3.506AlaSer: 3.506 ± 1.228
4.285AlaThr: 4.285 ± 1.101
1.169AlaVal: 1.169 ± 0.481
0.39AlaTrp: 0.39 ± 0.326
2.727AlaTyr: 2.727 ± 0.927
0.0AlaXaa: 0.0 ± 0.0
Cys
0.779CysAla: 0.779 ± 0.521
0.0CysCys: 0.0 ± 0.0
0.779CysAsp: 0.779 ± 0.483
0.39CysGlu: 0.39 ± 0.317
0.0CysPhe: 0.0 ± 0.0
0.39CysGly: 0.39 ± 0.362
0.0CysHis: 0.0 ± 0.0
0.39CysIle: 0.39 ± 0.359
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.39CysGln: 0.39 ± 0.326
0.0CysArg: 0.0 ± 0.0
0.39CysSer: 0.39 ± 0.42
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.169CysTyr: 1.169 ± 1.084
0.0CysXaa: 0.0 ± 0.0
Asp
1.169AspAla: 1.169 ± 0.683
0.39AspCys: 0.39 ± 0.359
2.727AspAsp: 2.727 ± 0.84
4.675AspGlu: 4.675 ± 1.354
4.285AspPhe: 4.285 ± 1.19
1.948AspGly: 1.948 ± 0.583
1.169AspHis: 1.169 ± 0.785
4.675AspIle: 4.675 ± 1.383
6.623AspLys: 6.623 ± 1.39
5.454AspLeu: 5.454 ± 1.678
2.337AspMet: 2.337 ± 0.772
2.727AspAsn: 2.727 ± 0.85
1.558AspPro: 1.558 ± 0.838
2.727AspGln: 2.727 ± 0.58
2.337AspArg: 2.337 ± 0.626
1.948AspSer: 1.948 ± 0.874
2.727AspThr: 2.727 ± 0.709
2.727AspVal: 2.727 ± 1.249
0.779AspTrp: 0.779 ± 0.556
4.675AspTyr: 4.675 ± 1.165
0.0AspXaa: 0.0 ± 0.0
Glu
8.96GluAla: 8.96 ± 2.181
0.0GluCys: 0.0 ± 0.0
5.064GluAsp: 5.064 ± 1.646
4.285GluGlu: 4.285 ± 1.632
1.948GluPhe: 1.948 ± 0.814
2.337GluGly: 2.337 ± 0.879
4.285GluHis: 4.285 ± 1.767
5.454GluIle: 5.454 ± 0.846
8.181GluLys: 8.181 ± 2.344
10.129GluLeu: 10.129 ± 2.736
1.948GluMet: 1.948 ± 0.995
4.675GluAsn: 4.675 ± 2.235
1.169GluPro: 1.169 ± 0.69
3.506GluGln: 3.506 ± 1.361
5.454GluArg: 5.454 ± 1.006
1.558GluSer: 1.558 ± 0.644
5.064GluThr: 5.064 ± 1.258
3.896GluVal: 3.896 ± 1.139
0.39GluTrp: 0.39 ± 0.317
3.506GluTyr: 3.506 ± 1.501
0.0GluXaa: 0.0 ± 0.0
Phe
1.169PheAla: 1.169 ± 0.544
0.39PheCys: 0.39 ± 0.317
2.337PheAsp: 2.337 ± 0.818
5.064PheGlu: 5.064 ± 1.073
1.948PhePhe: 1.948 ± 1.326
2.727PheGly: 2.727 ± 0.831
0.39PheHis: 0.39 ± 0.326
1.948PheIle: 1.948 ± 0.931
3.506PheLys: 3.506 ± 1.024
2.727PheLeu: 2.727 ± 0.762
0.779PheMet: 0.779 ± 0.658
2.337PheAsn: 2.337 ± 0.977
0.39PhePro: 0.39 ± 0.341
2.727PheGln: 2.727 ± 0.81
2.727PheArg: 2.727 ± 1.056
2.727PheSer: 2.727 ± 0.887
2.337PheThr: 2.337 ± 0.851
1.558PheVal: 1.558 ± 0.93
0.39PheTrp: 0.39 ± 0.326
1.948PheTyr: 1.948 ± 0.964
0.0PheXaa: 0.0 ± 0.0
Gly
2.337GlyAla: 2.337 ± 0.732
0.0GlyCys: 0.0 ± 0.0
3.506GlyAsp: 3.506 ± 1.502
2.337GlyGlu: 2.337 ± 1.242
3.116GlyPhe: 3.116 ± 1.007
1.948GlyGly: 1.948 ± 0.751
0.39GlyHis: 0.39 ± 0.317
2.727GlyIle: 2.727 ± 0.931
3.506GlyLys: 3.506 ± 0.916
6.623GlyLeu: 6.623 ± 2.155
1.558GlyMet: 1.558 ± 0.493
1.169GlyAsn: 1.169 ± 0.558
0.0GlyPro: 0.0 ± 0.0
3.896GlyGln: 3.896 ± 1.728
3.896GlyArg: 3.896 ± 0.851
1.558GlySer: 1.558 ± 0.752
1.948GlyThr: 1.948 ± 0.704
3.506GlyVal: 3.506 ± 0.953
0.39GlyTrp: 0.39 ± 0.326
3.506GlyTyr: 3.506 ± 0.932
0.0GlyXaa: 0.0 ± 0.0
His
1.169HisAla: 1.169 ± 0.651
0.39HisCys: 0.39 ± 0.317
1.169HisAsp: 1.169 ± 0.769
0.779HisGlu: 0.779 ± 0.444
1.169HisPhe: 1.169 ± 0.524
0.39HisGly: 0.39 ± 0.58
0.39HisHis: 0.39 ± 0.326
3.116HisIle: 3.116 ± 1.405
1.558HisLys: 1.558 ± 0.911
1.558HisLeu: 1.558 ± 0.667
0.0HisMet: 0.0 ± 0.0
0.39HisAsn: 0.39 ± 0.393
0.0HisPro: 0.0 ± 0.0
0.39HisGln: 0.39 ± 0.341
1.169HisArg: 1.169 ± 0.659
0.779HisSer: 0.779 ± 0.633
1.948HisThr: 1.948 ± 0.784
1.558HisVal: 1.558 ± 0.94
0.0HisTrp: 0.0 ± 0.0
1.169HisTyr: 1.169 ± 0.973
0.0HisXaa: 0.0 ± 0.0
Ile
5.064IleAla: 5.064 ± 1.337
0.39IleCys: 0.39 ± 0.389
4.285IleAsp: 4.285 ± 0.891
4.285IleGlu: 4.285 ± 1.105
2.337IlePhe: 2.337 ± 1.124
2.727IleGly: 2.727 ± 0.682
0.779IleHis: 0.779 ± 0.556
2.727IleIle: 2.727 ± 0.945
8.181IleLys: 8.181 ± 1.625
4.285IleLeu: 4.285 ± 1.272
0.39IleMet: 0.39 ± 0.326
4.285IleAsn: 4.285 ± 1.285
2.727IlePro: 2.727 ± 0.83
2.337IleGln: 2.337 ± 0.801
3.116IleArg: 3.116 ± 1.239
3.116IleSer: 3.116 ± 0.793
4.285IleThr: 4.285 ± 1.008
2.337IleVal: 2.337 ± 0.904
0.779IleTrp: 0.779 ± 0.538
2.727IleTyr: 2.727 ± 0.808
0.0IleXaa: 0.0 ± 0.0
Lys
7.012LysAla: 7.012 ± 1.568
0.0LysCys: 0.0 ± 0.0
7.012LysAsp: 7.012 ± 1.454
8.181LysGlu: 8.181 ± 1.783
1.558LysPhe: 1.558 ± 0.725
3.506LysGly: 3.506 ± 1.504
0.779LysHis: 0.779 ± 0.443
7.402LysIle: 7.402 ± 1.284
6.623LysLys: 6.623 ± 2.082
9.739LysLeu: 9.739 ± 2.961
2.727LysMet: 2.727 ± 1.053
5.064LysAsn: 5.064 ± 1.281
5.064LysPro: 5.064 ± 1.332
5.454LysGln: 5.454 ± 1.317
6.233LysArg: 6.233 ± 1.479
4.675LysSer: 4.675 ± 1.387
5.454LysThr: 5.454 ± 1.164
5.454LysVal: 5.454 ± 1.256
0.39LysTrp: 0.39 ± 0.393
2.727LysTyr: 2.727 ± 1.152
0.0LysXaa: 0.0 ± 0.0
Leu
7.791LeuAla: 7.791 ± 1.58
0.39LeuCys: 0.39 ± 0.456
7.012LeuAsp: 7.012 ± 1.597
10.129LeuGlu: 10.129 ± 2.021
3.506LeuPhe: 3.506 ± 0.968
6.233LeuGly: 6.233 ± 2.038
2.727LeuHis: 2.727 ± 0.802
5.454LeuIle: 5.454 ± 1.278
9.349LeuLys: 9.349 ± 2.896
10.518LeuLeu: 10.518 ± 1.995
1.558LeuMet: 1.558 ± 0.718
1.948LeuAsn: 1.948 ± 0.713
6.233LeuPro: 6.233 ± 1.998
6.233LeuGln: 6.233 ± 1.317
2.727LeuArg: 2.727 ± 1.313
6.233LeuSer: 6.233 ± 2.048
7.012LeuThr: 7.012 ± 1.422
5.454LeuVal: 5.454 ± 1.16
1.169LeuTrp: 1.169 ± 0.721
2.727LeuTyr: 2.727 ± 1.151
0.0LeuXaa: 0.0 ± 0.0
Met
2.337MetAla: 2.337 ± 1.105
0.0MetCys: 0.0 ± 0.0
1.169MetAsp: 1.169 ± 0.725
1.558MetGlu: 1.558 ± 0.738
1.948MetPhe: 1.948 ± 0.734
0.39MetGly: 0.39 ± 0.389
0.39MetHis: 0.39 ± 0.393
0.39MetIle: 0.39 ± 0.436
2.727MetLys: 2.727 ± 1.111
1.558MetLeu: 1.558 ± 0.64
0.39MetMet: 0.39 ± 0.341
1.558MetAsn: 1.558 ± 0.732
0.0MetPro: 0.0 ± 0.0
0.779MetGln: 0.779 ± 0.724
1.948MetArg: 1.948 ± 0.736
0.0MetSer: 0.0 ± 0.0
3.506MetThr: 3.506 ± 1.041
1.169MetVal: 1.169 ± 0.512
0.39MetTrp: 0.39 ± 0.417
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.727AsnAla: 2.727 ± 0.724
0.0AsnCys: 0.0 ± 0.0
1.169AsnAsp: 1.169 ± 0.674
4.285AsnGlu: 4.285 ± 1.733
3.116AsnPhe: 3.116 ± 1.219
3.506AsnGly: 3.506 ± 1.221
0.779AsnHis: 0.779 ± 0.402
1.948AsnIle: 1.948 ± 1.118
3.896AsnLys: 3.896 ± 1.651
3.116AsnLeu: 3.116 ± 1.463
2.727AsnMet: 2.727 ± 0.801
3.116AsnAsn: 3.116 ± 0.886
3.506AsnPro: 3.506 ± 0.884
2.727AsnGln: 2.727 ± 0.88
3.116AsnArg: 3.116 ± 0.895
2.727AsnSer: 2.727 ± 1.068
1.948AsnThr: 1.948 ± 1.084
1.948AsnVal: 1.948 ± 0.572
0.39AsnTrp: 0.39 ± 0.441
1.948AsnTyr: 1.948 ± 1.126
0.0AsnXaa: 0.0 ± 0.0
Pro
1.169ProAla: 1.169 ± 0.53
0.0ProCys: 0.0 ± 0.0
1.948ProAsp: 1.948 ± 0.804
3.506ProGlu: 3.506 ± 0.99
1.948ProPhe: 1.948 ± 1.164
0.779ProGly: 0.779 ± 0.412
0.39ProHis: 0.39 ± 0.362
1.558ProIle: 1.558 ± 0.597
1.558ProLys: 1.558 ± 0.825
3.116ProLeu: 3.116 ± 1.018
0.779ProMet: 0.779 ± 0.6
1.558ProAsn: 1.558 ± 0.945
1.558ProPro: 1.558 ± 0.58
1.948ProGln: 1.948 ± 0.532
3.896ProArg: 3.896 ± 1.102
0.779ProSer: 0.779 ± 0.719
2.727ProThr: 2.727 ± 0.983
3.116ProVal: 3.116 ± 1.063
0.0ProTrp: 0.0 ± 0.0
1.558ProTyr: 1.558 ± 0.71
0.0ProXaa: 0.0 ± 0.0
Gln
3.506GlnAla: 3.506 ± 0.835
0.779GlnCys: 0.779 ± 0.724
2.727GlnAsp: 2.727 ± 0.931
4.285GlnGlu: 4.285 ± 1.042
1.558GlnPhe: 1.558 ± 0.675
1.169GlnGly: 1.169 ± 0.69
1.558GlnHis: 1.558 ± 0.804
1.169GlnIle: 1.169 ± 0.592
6.623GlnLys: 6.623 ± 1.806
6.233GlnLeu: 6.233 ± 1.813
1.558GlnMet: 1.558 ± 0.677
1.558GlnAsn: 1.558 ± 0.564
1.169GlnPro: 1.169 ± 0.788
1.558GlnGln: 1.558 ± 0.88
2.337GlnArg: 2.337 ± 1.009
3.506GlnSer: 3.506 ± 1.121
2.337GlnThr: 2.337 ± 0.748
3.116GlnVal: 3.116 ± 0.806
0.0GlnTrp: 0.0 ± 0.0
3.116GlnTyr: 3.116 ± 1.242
0.0GlnXaa: 0.0 ± 0.0
Arg
2.337ArgAla: 2.337 ± 0.674
0.39ArgCys: 0.39 ± 0.42
1.948ArgAsp: 1.948 ± 0.813
3.506ArgGlu: 3.506 ± 1.452
1.558ArgPhe: 1.558 ± 0.675
3.116ArgGly: 3.116 ± 1.046
0.779ArgHis: 0.779 ± 0.633
2.727ArgIle: 2.727 ± 0.773
5.843ArgLys: 5.843 ± 1.469
7.402ArgLeu: 7.402 ± 1.364
1.948ArgMet: 1.948 ± 0.642
3.506ArgAsn: 3.506 ± 1.192
1.558ArgPro: 1.558 ± 0.765
3.896ArgGln: 3.896 ± 1.109
2.727ArgArg: 2.727 ± 1.358
2.727ArgSer: 2.727 ± 0.612
5.064ArgThr: 5.064 ± 1.524
3.896ArgVal: 3.896 ± 1.561
0.779ArgTrp: 0.779 ± 0.627
1.948ArgTyr: 1.948 ± 0.939
0.0ArgXaa: 0.0 ± 0.0
Ser
1.558SerAla: 1.558 ± 0.555
0.0SerCys: 0.0 ± 0.0
3.896SerAsp: 3.896 ± 0.878
4.285SerGlu: 4.285 ± 1.151
1.169SerPhe: 1.169 ± 1.084
2.727SerGly: 2.727 ± 1.147
1.948SerHis: 1.948 ± 0.859
5.064SerIle: 5.064 ± 1.857
3.896SerLys: 3.896 ± 0.63
7.012SerLeu: 7.012 ± 1.191
0.0SerMet: 0.0 ± 0.0
2.337SerAsn: 2.337 ± 0.657
0.779SerPro: 0.779 ± 0.445
2.337SerGln: 2.337 ± 0.878
1.558SerArg: 1.558 ± 0.671
1.948SerSer: 1.948 ± 0.713
1.948SerThr: 1.948 ± 0.578
1.558SerVal: 1.558 ± 0.621
0.39SerTrp: 0.39 ± 0.317
3.896SerTyr: 3.896 ± 1.207
0.0SerXaa: 0.0 ± 0.0
Thr
4.675ThrAla: 4.675 ± 1.585
0.0ThrCys: 0.0 ± 0.0
2.337ThrAsp: 2.337 ± 0.633
3.896ThrGlu: 3.896 ± 1.693
3.116ThrPhe: 3.116 ± 1.609
6.233ThrGly: 6.233 ± 1.997
0.779ThrHis: 0.779 ± 0.602
3.896ThrIle: 3.896 ± 0.805
6.233ThrLys: 6.233 ± 1.336
6.623ThrLeu: 6.623 ± 1.867
0.39ThrMet: 0.39 ± 0.359
1.558ThrAsn: 1.558 ± 0.862
3.116ThrPro: 3.116 ± 0.857
1.169ThrGln: 1.169 ± 0.589
4.675ThrArg: 4.675 ± 1.388
2.727ThrSer: 2.727 ± 1.408
1.169ThrThr: 1.169 ± 0.844
3.506ThrVal: 3.506 ± 0.802
0.39ThrTrp: 0.39 ± 0.359
2.727ThrTyr: 2.727 ± 1.068
0.0ThrXaa: 0.0 ± 0.0
Val
5.454ValAla: 5.454 ± 0.9
0.779ValCys: 0.779 ± 0.456
1.558ValAsp: 1.558 ± 0.54
4.285ValGlu: 4.285 ± 1.94
2.727ValPhe: 2.727 ± 0.985
3.116ValGly: 3.116 ± 0.775
0.779ValHis: 0.779 ± 0.551
3.506ValIle: 3.506 ± 1.746
4.675ValLys: 4.675 ± 1.424
5.064ValLeu: 5.064 ± 1.42
0.779ValMet: 0.779 ± 0.452
2.337ValAsn: 2.337 ± 1.012
1.169ValPro: 1.169 ± 0.744
1.948ValGln: 1.948 ± 0.743
1.558ValArg: 1.558 ± 0.642
3.506ValSer: 3.506 ± 1.309
3.506ValThr: 3.506 ± 1.527
3.116ValVal: 3.116 ± 1.063
0.39ValTrp: 0.39 ± 0.326
0.779ValTyr: 0.779 ± 0.719
0.0ValXaa: 0.0 ± 0.0
Trp
0.39TrpAla: 0.39 ± 0.441
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.779TrpGlu: 0.779 ± 0.733
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.39TrpIle: 0.39 ± 0.476
1.169TrpLys: 1.169 ± 0.582
1.558TrpLeu: 1.558 ± 0.959
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.39TrpGln: 0.39 ± 0.389
0.779TrpArg: 0.779 ± 0.456
0.779TrpSer: 0.779 ± 0.445
0.39TrpThr: 0.39 ± 0.341
0.39TrpVal: 0.39 ± 0.359
0.0TrpTrp: 0.0 ± 0.0
0.779TrpTyr: 0.779 ± 0.601
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.337TyrAla: 2.337 ± 1.213
0.39TyrCys: 0.39 ± 0.359
1.948TyrAsp: 1.948 ± 0.628
4.285TyrGlu: 4.285 ± 1.617
1.169TyrPhe: 1.169 ± 0.721
1.558TyrGly: 1.558 ± 0.614
0.39TyrHis: 0.39 ± 0.389
2.727TyrIle: 2.727 ± 0.589
4.675TyrLys: 4.675 ± 1.332
4.675TyrLeu: 4.675 ± 1.628
0.779TyrMet: 0.779 ± 0.457
3.896TyrAsn: 3.896 ± 1.421
1.948TyrPro: 1.948 ± 1.164
1.948TyrGln: 1.948 ± 0.913
4.285TyrArg: 4.285 ± 1.197
3.116TyrSer: 3.116 ± 0.723
1.558TyrThr: 1.558 ± 0.589
1.558TyrVal: 1.558 ± 0.586
0.39TyrTrp: 0.39 ± 0.446
3.116TyrTyr: 3.116 ± 0.865
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (2568 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski