Amino acid dipepetide frequency for Bifidobacterium choloepi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.317AlaAla: 15.317 ± 0.228
1.033AlaCys: 1.033 ± 0.043
8.803AlaAsp: 8.803 ± 0.146
6.542AlaGlu: 6.542 ± 0.118
3.272AlaPhe: 3.272 ± 0.078
10.161AlaGly: 10.161 ± 0.165
1.978AlaHis: 1.978 ± 0.064
5.702AlaIle: 5.702 ± 0.094
4.273AlaLys: 4.273 ± 0.098
9.714AlaLeu: 9.714 ± 0.14
3.239AlaMet: 3.239 ± 0.083
3.489AlaAsn: 3.489 ± 0.089
4.004AlaPro: 4.004 ± 0.101
3.397AlaGln: 3.397 ± 0.083
6.128AlaArg: 6.128 ± 0.117
6.251AlaSer: 6.251 ± 0.13
7.144AlaThr: 7.144 ± 0.138
9.143AlaVal: 9.143 ± 0.131
1.268AlaTrp: 1.268 ± 0.047
2.52AlaTyr: 2.52 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
1.015CysAla: 1.015 ± 0.042
0.154CysCys: 0.154 ± 0.015
0.482CysAsp: 0.482 ± 0.029
0.518CysGlu: 0.518 ± 0.024
0.344CysPhe: 0.344 ± 0.029
1.0CysGly: 1.0 ± 0.045
0.192CysHis: 0.192 ± 0.017
0.391CysIle: 0.391 ± 0.027
0.226CysLys: 0.226 ± 0.019
0.765CysLeu: 0.765 ± 0.04
0.237CysMet: 0.237 ± 0.021
0.222CysAsn: 0.222 ± 0.02
0.451CysPro: 0.451 ± 0.03
0.234CysGln: 0.234 ± 0.021
0.591CysArg: 0.591 ± 0.029
0.58CysSer: 0.58 ± 0.032
0.549CysThr: 0.549 ± 0.032
0.737CysVal: 0.737 ± 0.037
0.161CysTrp: 0.161 ± 0.02
0.27CysTyr: 0.27 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
7.522AspAla: 7.522 ± 0.12
0.539AspCys: 0.539 ± 0.027
6.186AspAsp: 6.186 ± 0.146
5.507AspGlu: 5.507 ± 0.115
2.455AspPhe: 2.455 ± 0.068
7.399AspGly: 7.399 ± 0.151
1.385AspHis: 1.385 ± 0.047
3.525AspIle: 3.525 ± 0.087
2.138AspLys: 2.138 ± 0.061
5.585AspLeu: 5.585 ± 0.095
1.705AspMet: 1.705 ± 0.053
2.14AspAsn: 2.14 ± 0.066
3.648AspPro: 3.648 ± 0.074
1.677AspGln: 1.677 ± 0.054
3.919AspArg: 3.919 ± 0.102
4.277AspSer: 4.277 ± 0.113
3.088AspThr: 3.088 ± 0.082
5.834AspVal: 5.834 ± 0.106
1.088AspTrp: 1.088 ± 0.054
2.192AspTyr: 2.192 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
6.327GluAla: 6.327 ± 0.11
0.416GluCys: 0.416 ± 0.023
3.436GluAsp: 3.436 ± 0.093
3.775GluGlu: 3.775 ± 0.106
1.927GluPhe: 1.927 ± 0.064
3.713GluGly: 3.713 ± 0.087
1.62GluHis: 1.62 ± 0.055
2.888GluIle: 2.888 ± 0.075
2.194GluLys: 2.194 ± 0.069
5.715GluLeu: 5.715 ± 0.117
1.499GluMet: 1.499 ± 0.059
1.849GluAsn: 1.849 ± 0.062
2.828GluPro: 2.828 ± 0.072
2.562GluGln: 2.562 ± 0.063
4.161GluArg: 4.161 ± 0.092
3.52GluSer: 3.52 ± 0.067
3.585GluThr: 3.585 ± 0.086
3.497GluVal: 3.497 ± 0.08
0.745GluTrp: 0.745 ± 0.036
1.674GluTyr: 1.674 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
4.069PheAla: 4.069 ± 0.087
0.386PheCys: 0.386 ± 0.027
2.801PheAsp: 2.801 ± 0.074
1.856PheGlu: 1.856 ± 0.062
1.33PhePhe: 1.33 ± 0.059
3.312PheGly: 3.312 ± 0.087
0.711PheHis: 0.711 ± 0.034
1.617PheIle: 1.617 ± 0.063
0.994PheLys: 0.994 ± 0.043
2.908PheLeu: 2.908 ± 0.081
0.739PheMet: 0.739 ± 0.038
1.145PheAsn: 1.145 ± 0.049
1.398PhePro: 1.398 ± 0.046
0.982PheGln: 0.982 ± 0.041
1.903PheArg: 1.903 ± 0.053
2.099PheSer: 2.099 ± 0.068
2.273PheThr: 2.273 ± 0.069
2.932PheVal: 2.932 ± 0.073
0.471PheTrp: 0.471 ± 0.03
0.903PheTyr: 0.903 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
8.027GlyAla: 8.027 ± 0.134
0.812GlyCys: 0.812 ± 0.04
5.66GlyAsp: 5.66 ± 0.121
5.007GlyGlu: 5.007 ± 0.097
3.075GlyPhe: 3.075 ± 0.064
6.241GlyGly: 6.241 ± 0.121
1.971GlyHis: 1.971 ± 0.064
4.686GlyIle: 4.686 ± 0.104
3.423GlyLys: 3.423 ± 0.069
7.034GlyLeu: 7.034 ± 0.115
2.189GlyMet: 2.189 ± 0.068
2.987GlyAsn: 2.987 ± 0.085
2.711GlyPro: 2.711 ± 0.079
2.629GlyGln: 2.629 ± 0.075
4.939GlyArg: 4.939 ± 0.104
5.226GlySer: 5.226 ± 0.124
5.722GlyThr: 5.722 ± 0.136
6.345GlyVal: 6.345 ± 0.102
1.21GlyTrp: 1.21 ± 0.047
2.663GlyTyr: 2.663 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
2.21HisAla: 2.21 ± 0.065
0.211HisCys: 0.211 ± 0.018
1.737HisAsp: 1.737 ± 0.051
1.166HisGlu: 1.166 ± 0.05
0.602HisPhe: 0.602 ± 0.03
1.981HisGly: 1.981 ± 0.069
0.508HisHis: 0.508 ± 0.033
0.851HisIle: 0.851 ± 0.042
0.552HisLys: 0.552 ± 0.032
1.435HisLeu: 1.435 ± 0.048
0.529HisMet: 0.529 ± 0.029
0.596HisAsn: 0.596 ± 0.031
1.255HisPro: 1.255 ± 0.048
0.524HisGln: 0.524 ± 0.03
1.507HisArg: 1.507 ± 0.049
0.956HisSer: 0.956 ± 0.039
1.023HisThr: 1.023 ± 0.043
2.0HisVal: 2.0 ± 0.065
0.296HisTrp: 0.296 ± 0.024
0.614HisTyr: 0.614 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.238IleAla: 6.238 ± 0.106
0.619IleCys: 0.619 ± 0.035
3.921IleAsp: 3.921 ± 0.076
3.048IleGlu: 3.048 ± 0.081
1.646IlePhe: 1.646 ± 0.066
4.454IleGly: 4.454 ± 0.087
0.948IleHis: 0.948 ± 0.041
2.348IleIle: 2.348 ± 0.078
1.435IleLys: 1.435 ± 0.057
3.858IleLeu: 3.858 ± 0.1
1.159IleMet: 1.159 ± 0.045
1.583IleAsn: 1.583 ± 0.049
2.491IlePro: 2.491 ± 0.069
1.281IleGln: 1.281 ± 0.053
2.749IleArg: 2.749 ± 0.072
2.604IleSer: 2.604 ± 0.074
2.635IleThr: 2.635 ± 0.079
5.413IleVal: 5.413 ± 0.096
0.521IleTrp: 0.521 ± 0.032
1.13IleTyr: 1.13 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.014LysAla: 4.014 ± 0.088
0.179LysCys: 0.179 ± 0.016
2.174LysAsp: 2.174 ± 0.064
1.887LysGlu: 1.887 ± 0.068
1.085LysPhe: 1.085 ± 0.038
2.19LysGly: 2.19 ± 0.079
0.7LysHis: 0.7 ± 0.037
1.786LysIle: 1.786 ± 0.063
1.942LysLys: 1.942 ± 0.07
3.121LysLeu: 3.121 ± 0.079
0.951LysMet: 0.951 ± 0.039
1.352LysAsn: 1.352 ± 0.05
1.934LysPro: 1.934 ± 0.06
1.224LysGln: 1.224 ± 0.048
2.106LysArg: 2.106 ± 0.07
2.116LysSer: 2.116 ± 0.071
2.554LysThr: 2.554 ± 0.074
2.5LysVal: 2.5 ± 0.066
0.435LysTrp: 0.435 ± 0.029
1.012LysTyr: 1.012 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
10.737LeuAla: 10.737 ± 0.145
0.981LeuCys: 0.981 ± 0.045
6.633LeuAsp: 6.633 ± 0.116
4.803LeuGlu: 4.803 ± 0.095
3.142LeuPhe: 3.142 ± 0.085
7.102LeuGly: 7.102 ± 0.125
1.651LeuHis: 1.651 ± 0.053
3.997LeuIle: 3.997 ± 0.1
3.181LeuLys: 3.181 ± 0.085
7.745LeuLeu: 7.745 ± 0.153
2.155LeuMet: 2.155 ± 0.067
2.567LeuAsn: 2.567 ± 0.073
4.515LeuPro: 4.515 ± 0.092
2.354LeuGln: 2.354 ± 0.069
4.955LeuArg: 4.955 ± 0.092
5.004LeuSer: 5.004 ± 0.086
5.436LeuThr: 5.436 ± 0.1
7.113LeuVal: 7.113 ± 0.124
1.008LeuTrp: 1.008 ± 0.046
2.094LeuTyr: 2.094 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.984MetAla: 2.984 ± 0.072
0.247MetCys: 0.247 ± 0.019
1.404MetAsp: 1.404 ± 0.05
1.177MetGlu: 1.177 ± 0.047
0.903MetPhe: 0.903 ± 0.035
1.734MetGly: 1.734 ± 0.061
0.524MetHis: 0.524 ± 0.028
1.335MetIle: 1.335 ± 0.051
1.042MetLys: 1.042 ± 0.043
2.575MetLeu: 2.575 ± 0.073
0.765MetMet: 0.765 ± 0.04
0.916MetAsn: 0.916 ± 0.04
1.507MetPro: 1.507 ± 0.052
0.739MetGln: 0.739 ± 0.04
1.481MetArg: 1.481 ± 0.049
1.672MetSer: 1.672 ± 0.063
2.25MetThr: 2.25 ± 0.058
1.669MetVal: 1.669 ± 0.055
0.281MetTrp: 0.281 ± 0.02
0.503MetTyr: 0.503 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.478AsnAla: 3.478 ± 0.081
0.245AsnCys: 0.245 ± 0.019
2.359AsnAsp: 2.359 ± 0.073
1.713AsnGlu: 1.713 ± 0.051
1.023AsnPhe: 1.023 ± 0.042
3.338AsnGly: 3.338 ± 0.113
0.57AsnHis: 0.57 ± 0.031
1.562AsnIle: 1.562 ± 0.046
0.942AsnLys: 0.942 ± 0.043
2.5AsnLeu: 2.5 ± 0.067
0.771AsnMet: 0.771 ± 0.031
1.042AsnAsn: 1.042 ± 0.047
2.073AsnPro: 2.073 ± 0.055
0.861AsnGln: 0.861 ± 0.039
1.952AsnArg: 1.952 ± 0.063
1.749AsnSer: 1.749 ± 0.058
1.934AsnThr: 1.934 ± 0.071
2.333AsnVal: 2.333 ± 0.059
0.477AsnTrp: 0.477 ± 0.028
0.974AsnTyr: 0.974 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
5.442ProAla: 5.442 ± 0.095
0.312ProCys: 0.312 ± 0.025
3.919ProAsp: 3.919 ± 0.1
3.164ProGlu: 3.164 ± 0.075
1.648ProPhe: 1.648 ± 0.047
3.639ProGly: 3.639 ± 0.084
0.87ProHis: 0.87 ± 0.038
2.085ProIle: 2.085 ± 0.066
1.641ProLys: 1.641 ± 0.054
3.707ProLeu: 3.707 ± 0.087
1.052ProMet: 1.052 ± 0.044
1.523ProAsn: 1.523 ± 0.054
1.245ProPro: 1.245 ± 0.045
1.37ProGln: 1.37 ± 0.052
2.307ProArg: 2.307 ± 0.07
2.947ProSer: 2.947 ± 0.076
2.953ProThr: 2.953 ± 0.075
4.182ProVal: 4.182 ± 0.081
0.643ProTrp: 0.643 ± 0.031
1.439ProTyr: 1.439 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
3.509GlnAla: 3.509 ± 0.075
0.268GlnCys: 0.268 ± 0.019
1.531GlnAsp: 1.531 ± 0.05
1.49GlnGlu: 1.49 ± 0.055
1.169GlnPhe: 1.169 ± 0.044
1.849GlnGly: 1.849 ± 0.059
0.661GlnHis: 0.661 ± 0.037
1.638GlnIle: 1.638 ± 0.058
1.038GlnLys: 1.038 ± 0.044
3.247GlnLeu: 3.247 ± 0.083
0.929GlnMet: 0.929 ± 0.042
0.807GlnAsn: 0.807 ± 0.042
1.603GlnPro: 1.603 ± 0.062
1.52GlnGln: 1.52 ± 0.069
2.08GlnArg: 2.08 ± 0.078
1.646GlnSer: 1.646 ± 0.056
1.654GlnThr: 1.654 ± 0.055
2.187GlnVal: 2.187 ± 0.054
0.588GlnTrp: 0.588 ± 0.033
1.133GlnTyr: 1.133 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
5.397ArgAla: 5.397 ± 0.105
0.487ArgCys: 0.487 ± 0.03
3.882ArgAsp: 3.882 ± 0.087
3.924ArgGlu: 3.924 ± 0.089
2.262ArgPhe: 2.262 ± 0.065
3.988ArgGly: 3.988 ± 0.099
1.679ArgHis: 1.679 ± 0.056
3.241ArgIle: 3.241 ± 0.083
2.421ArgLys: 2.421 ± 0.072
5.615ArgLeu: 5.615 ± 0.12
1.637ArgMet: 1.637 ± 0.056
1.934ArgAsn: 1.934 ± 0.067
2.739ArgPro: 2.739 ± 0.076
2.427ArgGln: 2.427 ± 0.079
5.364ArgArg: 5.364 ± 0.15
2.874ArgSer: 2.874 ± 0.07
3.354ArgThr: 3.354 ± 0.067
3.915ArgVal: 3.915 ± 0.084
0.864ArgTrp: 0.864 ± 0.043
1.677ArgTyr: 1.677 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.396SerAla: 6.396 ± 0.138
0.479SerCys: 0.479 ± 0.031
3.866SerAsp: 3.866 ± 0.101
2.658SerGlu: 2.658 ± 0.068
2.281SerPhe: 2.281 ± 0.066
5.574SerGly: 5.574 ± 0.108
1.158SerHis: 1.158 ± 0.053
2.726SerIle: 2.726 ± 0.07
1.77SerLys: 1.77 ± 0.053
5.205SerLeu: 5.205 ± 0.103
1.614SerMet: 1.614 ± 0.052
1.762SerAsn: 1.762 ± 0.06
2.689SerPro: 2.689 ± 0.062
1.786SerGln: 1.786 ± 0.062
3.473SerArg: 3.473 ± 0.088
5.382SerSer: 5.382 ± 0.203
3.915SerThr: 3.915 ± 0.113
4.45SerVal: 4.45 ± 0.091
0.88SerTrp: 0.88 ± 0.037
1.633SerTyr: 1.633 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
7.155ThrAla: 7.155 ± 0.132
0.476ThrCys: 0.476 ± 0.032
4.077ThrAsp: 4.077 ± 0.1
2.934ThrGlu: 2.934 ± 0.066
2.185ThrPhe: 2.185 ± 0.069
5.688ThrGly: 5.688 ± 0.132
1.063ThrHis: 1.063 ± 0.042
3.559ThrIle: 3.559 ± 0.082
2.189ThrLys: 2.189 ± 0.07
5.545ThrLeu: 5.545 ± 0.108
1.672ThrMet: 1.672 ± 0.051
1.895ThrAsn: 1.895 ± 0.051
3.215ThrPro: 3.215 ± 0.082
1.643ThrGln: 1.643 ± 0.054
2.645ThrArg: 2.645 ± 0.081
3.704ThrSer: 3.704 ± 0.112
4.468ThrThr: 4.468 ± 0.129
5.99ThrVal: 5.99 ± 0.138
0.744ThrTrp: 0.744 ± 0.039
1.59ThrTyr: 1.59 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
9.545ValAla: 9.545 ± 0.145
0.805ValCys: 0.805 ± 0.034
6.142ValAsp: 6.142 ± 0.114
4.619ValGlu: 4.619 ± 0.096
2.838ValPhe: 2.838 ± 0.072
5.671ValGly: 5.671 ± 0.106
1.526ValHis: 1.526 ± 0.051
4.249ValIle: 4.249 ± 0.104
2.611ValLys: 2.611 ± 0.065
7.152ValLeu: 7.152 ± 0.13
1.879ValMet: 1.879 ± 0.053
2.562ValAsn: 2.562 ± 0.067
4.007ValPro: 4.007 ± 0.076
1.937ValGln: 1.937 ± 0.058
4.709ValArg: 4.709 ± 0.098
4.663ValSer: 4.663 ± 0.1
5.499ValThr: 5.499 ± 0.131
7.526ValVal: 7.526 ± 0.13
0.963ValTrp: 0.963 ± 0.042
1.846ValTyr: 1.846 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
1.068TrpAla: 1.068 ± 0.042
0.151TrpCys: 0.151 ± 0.015
0.8TrpAsp: 0.8 ± 0.038
0.576TrpGlu: 0.576 ± 0.033
0.56TrpPhe: 0.56 ± 0.032
0.865TrpGly: 0.865 ± 0.037
0.32TrpHis: 0.32 ± 0.021
0.784TrpIle: 0.784 ± 0.035
0.555TrpLys: 0.555 ± 0.033
1.396TrpLeu: 1.396 ± 0.056
0.382TrpMet: 0.382 ± 0.029
0.659TrpAsn: 0.659 ± 0.038
0.542TrpPro: 0.542 ± 0.026
0.58TrpGln: 0.58 ± 0.031
0.859TrpArg: 0.859 ± 0.045
0.841TrpSer: 0.841 ± 0.041
0.929TrpThr: 0.929 ± 0.048
0.771TrpVal: 0.771 ± 0.028
0.281TrpTrp: 0.281 ± 0.022
0.434TrpTyr: 0.434 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.926TyrAla: 2.926 ± 0.071
0.32TyrCys: 0.32 ± 0.023
1.995TyrAsp: 1.995 ± 0.061
1.568TyrGlu: 1.568 ± 0.054
1.081TyrPhe: 1.081 ± 0.043
2.658TyrGly: 2.658 ± 0.07
0.518TyrHis: 0.518 ± 0.031
1.111TyrIle: 1.111 ± 0.041
0.695TyrLys: 0.695 ± 0.038
2.353TyrLeu: 2.353 ± 0.059
0.606TyrMet: 0.606 ± 0.033
0.865TyrAsn: 0.865 ± 0.044
1.234TyrPro: 1.234 ± 0.044
0.82TyrGln: 0.82 ± 0.039
1.853TyrArg: 1.853 ± 0.054
1.585TyrSer: 1.585 ± 0.057
1.469TyrThr: 1.469 ± 0.055
2.211TyrVal: 2.211 ± 0.065
0.432TyrTrp: 0.432 ± 0.028
0.849TyrTyr: 0.849 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1599 proteins (615902 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski