Amino acid dipepetide frequency for Pichia kudriavzevii (Yeast) (Issatchenkia orientalis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.565AlaAla: 3.565 ± 0.06	0.695AlaCys: 0.695 ± 0.016	2.645AlaAsp: 2.645 ± 0.036	3.214AlaGlu: 3.214 ± 0.048	2.273AlaPhe: 2.273 ± 0.034	2.81AlaGly: 2.81 ± 0.044	1.011AlaHis: 1.011 ± 0.018	3.682AlaIle: 3.682 ± 0.046	3.797AlaLys: 3.797 ± 0.048	4.979AlaLeu: 4.979 ± 0.053	1.175AlaMet: 1.175 ± 0.022	3.002AlaAsn: 3.002 ± 0.034	2.095AlaPro: 2.095 ± 0.04	1.918AlaGln: 1.918 ± 0.03	2.308AlaArg: 2.308 ± 0.033	4.618AlaSer: 4.618 ± 0.058	3.266AlaThr: 3.266 ± 0.05	3.109AlaVal: 3.109 ± 0.041	0.484AlaTrp: 0.484 ± 0.016	1.681AlaTyr: 1.681 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.638CysAla: 0.638 ± 0.016	0.267CysCys: 0.267 ± 0.011	0.707CysAsp: 0.707 ± 0.017	0.688CysGlu: 0.688 ± 0.017	0.697CysPhe: 0.697 ± 0.017	0.849CysGly: 0.849 ± 0.022	0.314CysHis: 0.314 ± 0.012	0.946CysIle: 0.946 ± 0.018	0.776CysLys: 0.776 ± 0.02	1.277CysLeu: 1.277 ± 0.024	0.28CysMet: 0.28 ± 0.01	0.581CysAsn: 0.581 ± 0.014	0.478CysPro: 0.478 ± 0.015	0.367CysGln: 0.367 ± 0.013	0.495CysArg: 0.495 ± 0.014	1.015CysSer: 1.015 ± 0.023	0.641CysThr: 0.641 ± 0.018	0.782CysVal: 0.782 ± 0.019	0.152CysTrp: 0.152 ± 0.008	0.491CysTyr: 0.491 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.115AspAla: 3.115 ± 0.044	0.658AspCys: 0.658 ± 0.017	4.973AspAsp: 4.973 ± 0.079	5.23AspGlu: 5.23 ± 0.057	2.721AspPhe: 2.721 ± 0.034	3.169AspGly: 3.169 ± 0.044	1.139AspHis: 1.139 ± 0.023	4.391AspIle: 4.391 ± 0.046	3.671AspLys: 3.671 ± 0.042	5.515AspLeu: 5.515 ± 0.053	1.216AspMet: 1.216 ± 0.023	3.24AspAsn: 3.24 ± 0.039	2.444AspPro: 2.444 ± 0.031	1.776AspGln: 1.776 ± 0.025	2.084AspArg: 2.084 ± 0.025	5.0AspSer: 5.0 ± 0.052	3.04AspThr: 3.04 ± 0.034	3.632AspVal: 3.632 ± 0.037	0.615AspTrp: 0.615 ± 0.017	2.299AspTyr: 2.299 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	3.333GluAla: 3.333 ± 0.053	0.719GluCys: 0.719 ± 0.016	4.374GluAsp: 4.374 ± 0.05	6.427GluGlu: 6.427 ± 0.095	2.899GluPhe: 2.899 ± 0.034	2.952GluGly: 2.952 ± 0.036	1.305GluHis: 1.305 ± 0.022	4.797GluIle: 4.797 ± 0.041	5.913GluLys: 5.913 ± 0.063	6.605GluLeu: 6.605 ± 0.063	1.566GluMet: 1.566 ± 0.024	4.623GluAsn: 4.623 ± 0.048	1.932GluPro: 1.932 ± 0.029	2.369GluGln: 2.369 ± 0.033	3.159GluArg: 3.159 ± 0.041	5.068GluSer: 5.068 ± 0.047	3.764GluThr: 3.764 ± 0.043	3.553GluVal: 3.553 ± 0.043	0.661GluTrp: 0.661 ± 0.015	2.463GluTyr: 2.463 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	2.319PheAla: 2.319 ± 0.034	0.561PheCys: 0.561 ± 0.014	2.908PheAsp: 2.908 ± 0.034	2.924PheGlu: 2.924 ± 0.038	2.103PhePhe: 2.103 ± 0.04	2.663PheGly: 2.663 ± 0.045	0.941PheHis: 0.941 ± 0.02	2.938PheIle: 2.938 ± 0.041	3.257PheLys: 3.257 ± 0.042	4.007PheLeu: 4.007 ± 0.047	0.946PheMet: 0.946 ± 0.022	2.741PheAsn: 2.741 ± 0.038	1.722PhePro: 1.722 ± 0.03	1.785PheGln: 1.785 ± 0.023	1.67PheArg: 1.67 ± 0.025	3.737PheSer: 3.737 ± 0.046	2.483PheThr: 2.483 ± 0.032	2.664PheVal: 2.664 ± 0.035	0.507PheTrp: 0.507 ± 0.016	1.541PheTyr: 1.541 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	2.815GlyAla: 2.815 ± 0.051	0.754GlyCys: 0.754 ± 0.017	3.136GlyAsp: 3.136 ± 0.042	3.288GlyGlu: 3.288 ± 0.042	2.552GlyPhe: 2.552 ± 0.037	3.401GlyGly: 3.401 ± 0.064	1.109GlyHis: 1.109 ± 0.022	3.596GlyIle: 3.596 ± 0.034	3.854GlyLys: 3.854 ± 0.045	4.773GlyLeu: 4.773 ± 0.048	1.136GlyMet: 1.136 ± 0.024	3.022GlyAsn: 3.022 ± 0.047	1.522GlyPro: 1.522 ± 0.028	1.443GlyGln: 1.443 ± 0.026	2.135GlyArg: 2.135 ± 0.027	4.591GlySer: 4.591 ± 0.089	2.857GlyThr: 2.857 ± 0.045	3.301GlyVal: 3.301 ± 0.045	0.615GlyTrp: 0.615 ± 0.016	2.048GlyTyr: 2.048 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.045HisAla: 1.045 ± 0.018	0.293HisCys: 0.293 ± 0.011	1.182HisAsp: 1.182 ± 0.024	1.305HisGlu: 1.305 ± 0.022	0.922HisPhe: 0.922 ± 0.019	1.199HisGly: 1.199 ± 0.023	0.722HisHis: 0.722 ± 0.02	1.372HisIle: 1.372 ± 0.022	1.262HisLys: 1.262 ± 0.023	2.094HisLeu: 2.094 ± 0.029	0.437HisMet: 0.437 ± 0.013	1.149HisAsn: 1.149 ± 0.024	1.131HisPro: 1.131 ± 0.02	0.972HisGln: 0.972 ± 0.022	0.999HisArg: 0.999 ± 0.02	1.921HisSer: 1.921 ± 0.03	1.096HisThr: 1.096 ± 0.021	1.245HisVal: 1.245 ± 0.024	0.206HisTrp: 0.206 ± 0.009	0.808HisTyr: 0.808 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.553IleAla: 3.553 ± 0.04	0.895IleCys: 0.895 ± 0.019	4.571IleAsp: 4.571 ± 0.044	4.608IleGlu: 4.608 ± 0.043	2.859IlePhe: 2.859 ± 0.044	3.395IleGly: 3.395 ± 0.045	1.478IleHis: 1.478 ± 0.029	4.27IleIle: 4.27 ± 0.052	4.746IleLys: 4.746 ± 0.047	6.227IleLeu: 6.227 ± 0.073	1.365IleMet: 1.365 ± 0.023	4.087IleAsn: 4.087 ± 0.041	3.411IlePro: 3.411 ± 0.039	2.509IleGln: 2.509 ± 0.03	2.748IleArg: 2.748 ± 0.037	5.69IleSer: 5.69 ± 0.057	3.652IleThr: 3.652 ± 0.039	3.995IleVal: 3.995 ± 0.043	0.655IleTrp: 0.655 ± 0.017	2.303IleTyr: 2.303 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.558LysAla: 3.558 ± 0.041	0.835LysCys: 0.835 ± 0.019	4.116LysAsp: 4.116 ± 0.043	5.403LysGlu: 5.403 ± 0.067	3.181LysPhe: 3.181 ± 0.039	3.126LysGly: 3.126 ± 0.04	1.579LysHis: 1.579 ± 0.027	4.903LysIle: 4.903 ± 0.049	6.187LysLys: 6.187 ± 0.073	7.556LysLeu: 7.556 ± 0.065	1.673LysMet: 1.673 ± 0.025	4.303LysAsn: 4.303 ± 0.045	2.91LysPro: 2.91 ± 0.036	2.727LysGln: 2.727 ± 0.037	3.751LysArg: 3.751 ± 0.048	5.906LysSer: 5.906 ± 0.062	3.987LysThr: 3.987 ± 0.043	4.237LysVal: 4.237 ± 0.044	0.742LysTrp: 0.742 ± 0.016	2.804LysTyr: 2.804 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	5.091LeuAla: 5.091 ± 0.052	1.19LeuCys: 1.19 ± 0.022	5.533LeuAsp: 5.533 ± 0.048	6.299LeuGlu: 6.299 ± 0.062	4.107LeuPhe: 4.107 ± 0.05	4.683LeuGly: 4.683 ± 0.041	2.053LeuHis: 2.053 ± 0.03	5.973LeuIle: 5.973 ± 0.063	7.612LeuLys: 7.612 ± 0.079	9.211LeuLeu: 9.211 ± 0.083	2.053LeuMet: 2.053 ± 0.027	6.055LeuAsn: 6.055 ± 0.049	4.235LeuPro: 4.235 ± 0.049	3.924LeuGln: 3.924 ± 0.042	4.321LeuArg: 4.321 ± 0.041	8.389LeuSer: 8.389 ± 0.06	5.064LeuThr: 5.064 ± 0.046	5.489LeuVal: 5.489 ± 0.056	0.824LeuTrp: 0.824 ± 0.02	3.051LeuTyr: 3.051 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	1.297MetAla: 1.297 ± 0.022	0.258MetCys: 0.258 ± 0.011	1.327MetAsp: 1.327 ± 0.024	1.375MetGlu: 1.375 ± 0.021	0.987MetPhe: 0.987 ± 0.02	1.163MetGly: 1.163 ± 0.023	0.373MetHis: 0.373 ± 0.012	1.354MetIle: 1.354 ± 0.022	1.666MetLys: 1.666 ± 0.026	1.944MetLeu: 1.944 ± 0.03	0.585MetMet: 0.585 ± 0.02	1.416MetAsn: 1.416 ± 0.028	0.8MetPro: 0.8 ± 0.02	0.725MetGln: 0.725 ± 0.021	0.907MetArg: 0.907 ± 0.018	2.052MetSer: 2.052 ± 0.029	1.12MetThr: 1.12 ± 0.021	1.273MetVal: 1.273 ± 0.023	0.179MetTrp: 0.179 ± 0.009	0.699MetTyr: 0.699 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.1AsnAla: 3.1 ± 0.038	0.665AsnCys: 0.665 ± 0.017	3.961AsnAsp: 3.961 ± 0.051	4.282AsnGlu: 4.282 ± 0.047	2.501AsnPhe: 2.501 ± 0.035	3.473AsnGly: 3.473 ± 0.038	1.303AsnHis: 1.303 ± 0.025	4.146AsnIle: 4.146 ± 0.045	4.187AsnLys: 4.187 ± 0.042	5.258AsnLeu: 5.258 ± 0.053	1.356AsnMet: 1.356 ± 0.026	4.397AsnAsn: 4.397 ± 0.086	2.606AsnPro: 2.606 ± 0.033	2.149AsnGln: 2.149 ± 0.031	2.327AsnArg: 2.327 ± 0.028	5.552AsnSer: 5.552 ± 0.066	3.543AsnThr: 3.543 ± 0.083	3.51AsnVal: 3.51 ± 0.037	0.578AsnTrp: 0.578 ± 0.017	2.216AsnTyr: 2.216 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	2.123ProAla: 2.123 ± 0.037	0.389ProCys: 0.389 ± 0.016	2.106ProAsp: 2.106 ± 0.027	2.818ProGlu: 2.818 ± 0.037	1.85ProPhe: 1.85 ± 0.023	1.856ProGly: 1.856 ± 0.031	0.905ProHis: 0.905 ± 0.02	2.845ProIle: 2.845 ± 0.033	2.854ProLys: 2.854 ± 0.041	4.091ProLeu: 4.091 ± 0.044	0.781ProMet: 0.781 ± 0.018	2.473ProAsn: 2.473 ± 0.034	2.323ProPro: 2.323 ± 0.055	1.807ProGln: 1.807 ± 0.034	1.609ProArg: 1.609 ± 0.024	4.018ProSer: 4.018 ± 0.056	2.718ProThr: 2.718 ± 0.039	2.623ProVal: 2.623 ± 0.041	0.368ProTrp: 0.368 ± 0.013	1.4ProTyr: 1.4 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	1.85GlnAla: 1.85 ± 0.036	0.419GlnCys: 0.419 ± 0.013	1.752GlnAsp: 1.752 ± 0.025	2.338GlnGlu: 2.338 ± 0.036	1.675GlnPhe: 1.675 ± 0.027	1.61GlnGly: 1.61 ± 0.03	0.966GlnHis: 0.966 ± 0.023	2.511GlnIle: 2.511 ± 0.037	2.423GlnLys: 2.423 ± 0.036	4.043GlnLeu: 4.043 ± 0.044	0.871GlnMet: 0.871 ± 0.019	2.126GlnAsn: 2.126 ± 0.031	1.576GlnPro: 1.576 ± 0.033	3.17GlnGln: 3.17 ± 0.135	1.87GlnArg: 1.87 ± 0.026	2.903GlnSer: 2.903 ± 0.04	2.001GlnThr: 2.001 ± 0.03	2.061GlnVal: 2.061 ± 0.031	0.363GlnTrp: 0.363 ± 0.013	1.395GlnTyr: 1.395 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	2.188ArgAla: 2.188 ± 0.025	0.541ArgCys: 0.541 ± 0.015	2.354ArgAsp: 2.354 ± 0.03	3.14ArgGlu: 3.14 ± 0.04	1.932ArgPhe: 1.932 ± 0.03	2.286ArgGly: 2.286 ± 0.037	0.996ArgHis: 0.996 ± 0.019	2.802ArgIle: 2.802 ± 0.033	3.695ArgLys: 3.695 ± 0.049	4.19ArgLeu: 4.19 ± 0.045	0.964ArgMet: 0.964 ± 0.022	2.566ArgAsn: 2.566 ± 0.03	1.512ArgPro: 1.512 ± 0.03	1.616ArgGln: 1.616 ± 0.03	2.73ArgArg: 2.73 ± 0.04	3.384ArgSer: 3.384 ± 0.037	2.106ArgThr: 2.106 ± 0.028	2.411ArgVal: 2.411 ± 0.03	0.433ArgTrp: 0.433 ± 0.013	1.551ArgTyr: 1.551 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	4.253SerAla: 4.253 ± 0.054	0.975SerCys: 0.975 ± 0.021	4.747SerAsp: 4.747 ± 0.054	4.848SerGlu: 4.848 ± 0.049	3.908SerPhe: 3.908 ± 0.042	4.449SerGly: 4.449 ± 0.062	1.811SerHis: 1.811 ± 0.029	6.049SerIle: 6.049 ± 0.058	6.471SerLys: 6.471 ± 0.061	8.351SerLeu: 8.351 ± 0.077	1.811SerMet: 1.811 ± 0.03	5.794SerAsn: 5.794 ± 0.079	3.667SerPro: 3.667 ± 0.051	3.088SerGln: 3.088 ± 0.046	3.579SerArg: 3.579 ± 0.05	9.649SerSer: 9.649 ± 0.176	5.867SerThr: 5.867 ± 0.091	4.857SerVal: 4.857 ± 0.046	0.765SerTrp: 0.765 ± 0.021	2.757SerTyr: 2.757 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	3.029ThrAla: 3.029 ± 0.04	0.737ThrCys: 0.737 ± 0.016	2.872ThrAsp: 2.872 ± 0.035	3.227ThrGlu: 3.227 ± 0.041	2.468ThrPhe: 2.468 ± 0.032	3.128ThrGly: 3.128 ± 0.073	1.158ThrHis: 1.158 ± 0.025	3.882ThrIle: 3.882 ± 0.043	3.837ThrLys: 3.837 ± 0.043	5.362ThrLeu: 5.362 ± 0.047	1.128ThrMet: 1.128 ± 0.022	3.419ThrAsn: 3.419 ± 0.06	3.137ThrPro: 3.137 ± 0.059	1.896ThrGln: 1.896 ± 0.027	2.344ThrArg: 2.344 ± 0.03	5.476ThrSer: 5.476 ± 0.068	3.822ThrThr: 3.822 ± 0.089	3.286ThrVal: 3.286 ± 0.045	0.517ThrTrp: 0.517 ± 0.013	1.774ThrTyr: 1.774 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	3.24ValAla: 3.24 ± 0.045	0.87ValCys: 0.87 ± 0.019	3.855ValAsp: 3.855 ± 0.044	4.216ValGlu: 4.216 ± 0.04	2.579ValPhe: 2.579 ± 0.035	3.226ValGly: 3.226 ± 0.057	1.238ValHis: 1.238 ± 0.022	3.556ValIle: 3.556 ± 0.044	4.1ValLys: 4.1 ± 0.048	5.329ValLeu: 5.329 ± 0.053	1.145ValMet: 1.145 ± 0.021	3.249ValAsn: 3.249 ± 0.037	2.72ValPro: 2.72 ± 0.032	2.027ValGln: 2.027 ± 0.028	2.327ValArg: 2.327 ± 0.033	5.138ValSer: 5.138 ± 0.056	3.06ValThr: 3.06 ± 0.043	3.749ValVal: 3.749 ± 0.055	0.582ValTrp: 0.582 ± 0.017	2.097ValTyr: 2.097 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	0.467TrpAla: 0.467 ± 0.015	0.214TrpCys: 0.214 ± 0.008	0.628TrpAsp: 0.628 ± 0.018	0.629TrpGlu: 0.629 ± 0.016	0.485TrpPhe: 0.485 ± 0.015	0.54TrpGly: 0.54 ± 0.019	0.162TrpHis: 0.162 ± 0.009	0.697TrpIle: 0.697 ± 0.02	0.824TrpLys: 0.824 ± 0.019	0.88TrpLeu: 0.88 ± 0.018	0.248TrpMet: 0.248 ± 0.011	0.668TrpAsn: 0.668 ± 0.017	0.273TrpPro: 0.273 ± 0.011	0.257TrpGln: 0.257 ± 0.01	0.517TrpArg: 0.517 ± 0.017	0.748TrpSer: 0.748 ± 0.019	0.511TrpThr: 0.511 ± 0.015	0.554TrpVal: 0.554 ± 0.016	0.142TrpTrp: 0.142 ± 0.008	0.361TrpTyr: 0.361 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.748TyrAla: 1.748 ± 0.028	0.506TyrCys: 0.506 ± 0.014	2.18TyrAsp: 2.18 ± 0.025	2.225TyrGlu: 2.225 ± 0.035	1.714TyrPhe: 1.714 ± 0.029	1.971TyrGly: 1.971 ± 0.029	0.799TyrHis: 0.799 ± 0.017	2.308TyrIle: 2.308 ± 0.028	2.35TyrLys: 2.35 ± 0.031	3.466TyrLeu: 3.466 ± 0.041	0.765TyrMet: 0.765 ± 0.019	2.196TyrAsn: 2.196 ± 0.036	1.46TyrPro: 1.46 ± 0.024	1.394TyrGln: 1.394 ± 0.023	1.518TyrArg: 1.518 ± 0.03	2.845TyrSer: 2.845 ± 0.034	1.902TyrThr: 1.902 ± 0.032	1.972TyrVal: 1.972 ± 0.033	0.419TyrTrp: 0.419 ± 0.014	1.507TyrTyr: 1.507 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5146 proteins (2636562 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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