Amino acid dipepetide frequency for Kingella potus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.12AlaAla: 22.12 ± 0.377
1.499AlaCys: 1.499 ± 0.051
7.563AlaAsp: 7.563 ± 0.136
8.165AlaGlu: 8.165 ± 0.154
4.387AlaPhe: 4.387 ± 0.098
9.85AlaGly: 9.85 ± 0.168
2.253AlaHis: 2.253 ± 0.066
3.79AlaIle: 3.79 ± 0.097
5.146AlaLys: 5.146 ± 0.103
12.061AlaLeu: 12.061 ± 0.211
2.518AlaMet: 2.518 ± 0.067
3.252AlaAsn: 3.252 ± 0.095
4.354AlaPro: 4.354 ± 0.105
5.542AlaGln: 5.542 ± 0.1
6.294AlaArg: 6.294 ± 0.126
4.529AlaSer: 4.529 ± 0.102
3.723AlaThr: 3.723 ± 0.092
10.009AlaVal: 10.009 ± 0.15
1.414AlaTrp: 1.414 ± 0.053
3.139AlaTyr: 3.139 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
1.347CysAla: 1.347 ± 0.052
0.201CysCys: 0.201 ± 0.016
0.484CysAsp: 0.484 ± 0.027
0.503CysGlu: 0.503 ± 0.029
0.401CysPhe: 0.401 ± 0.022
1.398CysGly: 1.398 ± 0.053
0.241CysHis: 0.241 ± 0.02
0.503CysIle: 0.503 ± 0.03
0.356CysLys: 0.356 ± 0.021
1.018CysLeu: 1.018 ± 0.04
0.172CysMet: 0.172 ± 0.015
0.326CysAsn: 0.326 ± 0.023
0.562CysPro: 0.562 ± 0.03
0.314CysGln: 0.314 ± 0.024
0.887CysArg: 0.887 ± 0.039
0.506CysSer: 0.506 ± 0.025
0.568CysThr: 0.568 ± 0.031
0.652CysVal: 0.652 ± 0.033
0.111CysTrp: 0.111 ± 0.012
0.323CysTyr: 0.323 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
5.363AspAla: 5.363 ± 0.101
0.529AspCys: 0.529 ± 0.028
2.465AspAsp: 2.465 ± 0.079
3.377AspGlu: 3.377 ± 0.077
2.384AspPhe: 2.384 ± 0.061
5.08AspGly: 5.08 ± 0.129
0.827AspHis: 0.827 ± 0.039
3.398AspIle: 3.398 ± 0.073
2.896AspLys: 2.896 ± 0.078
4.937AspLeu: 4.937 ± 0.097
1.159AspMet: 1.159 ± 0.04
1.918AspAsn: 1.918 ± 0.06
2.244AspPro: 2.244 ± 0.064
1.141AspGln: 1.141 ± 0.043
2.413AspArg: 2.413 ± 0.067
2.856AspSer: 2.856 ± 0.079
3.552AspThr: 3.552 ± 0.075
2.89AspVal: 2.89 ± 0.069
0.848AspTrp: 0.848 ± 0.043
1.915AspTyr: 1.915 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
6.913GluAla: 6.913 ± 0.141
0.512GluCys: 0.512 ± 0.031
2.445GluAsp: 2.445 ± 0.066
3.505GluGlu: 3.505 ± 0.089
1.904GluPhe: 1.904 ± 0.062
3.525GluGly: 3.525 ± 0.101
1.513GluHis: 1.513 ± 0.054
3.877GluIle: 3.877 ± 0.093
3.619GluLys: 3.619 ± 0.093
5.348GluLeu: 5.348 ± 0.103
1.555GluMet: 1.555 ± 0.049
2.996GluAsn: 2.996 ± 0.075
1.956GluPro: 1.956 ± 0.062
2.839GluGln: 2.839 ± 0.078
3.842GluArg: 3.842 ± 0.083
2.911GluSer: 2.911 ± 0.073
3.482GluThr: 3.482 ± 0.073
2.989GluVal: 2.989 ± 0.078
0.821GluTrp: 0.821 ± 0.038
1.624GluTyr: 1.624 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
5.309PheAla: 5.309 ± 0.097
0.539PheCys: 0.539 ± 0.03
2.634PheAsp: 2.634 ± 0.063
1.919PheGlu: 1.919 ± 0.059
1.758PhePhe: 1.758 ± 0.065
3.59PheGly: 3.59 ± 0.091
0.827PheHis: 0.827 ± 0.043
1.758PheIle: 1.758 ± 0.058
1.651PheLys: 1.651 ± 0.059
3.502PheLeu: 3.502 ± 0.096
0.806PheMet: 0.806 ± 0.039
1.417PheAsn: 1.417 ± 0.044
1.622PhePro: 1.622 ± 0.055
1.325PheGln: 1.325 ± 0.047
1.924PheArg: 1.924 ± 0.061
2.594PheSer: 2.594 ± 0.071
2.014PheThr: 2.014 ± 0.06
2.67PheVal: 2.67 ± 0.073
0.539PheTrp: 0.539 ± 0.033
1.263PheTyr: 1.263 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
7.007GlyAla: 7.007 ± 0.13
0.979GlyCys: 0.979 ± 0.04
3.462GlyAsp: 3.462 ± 0.094
4.571GlyGlu: 4.571 ± 0.102
3.609GlyPhe: 3.609 ± 0.089
7.388GlyGly: 7.388 ± 0.133
1.648GlyHis: 1.648 ± 0.054
5.016GlyIle: 5.016 ± 0.084
4.874GlyLys: 4.874 ± 0.106
8.066GlyLeu: 8.066 ± 0.133
2.079GlyMet: 2.079 ± 0.072
2.721GlyAsn: 2.721 ± 0.12
1.155GlyPro: 1.155 ± 0.04
2.975GlyGln: 2.975 ± 0.088
5.854GlyArg: 5.854 ± 0.128
5.068GlySer: 5.068 ± 0.14
3.913GlyThr: 3.913 ± 0.114
4.74GlyVal: 4.74 ± 0.106
1.24GlyTrp: 1.24 ± 0.043
2.449GlyTyr: 2.449 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
2.143HisAla: 2.143 ± 0.055
0.233HisCys: 0.233 ± 0.02
1.074HisAsp: 1.074 ± 0.04
1.167HisGlu: 1.167 ± 0.041
0.922HisPhe: 0.922 ± 0.039
2.017HisGly: 2.017 ± 0.063
0.618HisHis: 0.618 ± 0.038
1.499HisIle: 1.499 ± 0.052
0.873HisLys: 0.873 ± 0.038
2.126HisLeu: 2.126 ± 0.059
0.382HisMet: 0.382 ± 0.019
0.781HisAsn: 0.781 ± 0.038
1.481HisPro: 1.481 ± 0.054
0.743HisGln: 0.743 ± 0.034
1.296HisArg: 1.296 ± 0.047
1.171HisSer: 1.171 ± 0.046
1.543HisThr: 1.543 ± 0.047
0.917HisVal: 0.917 ± 0.037
0.341HisTrp: 0.341 ± 0.026
0.798HisTyr: 0.798 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.005IleAla: 6.005 ± 0.101
0.556IleCys: 0.556 ± 0.028
3.001IleAsp: 3.001 ± 0.073
3.248IleGlu: 3.248 ± 0.086
1.685IlePhe: 1.685 ± 0.057
4.695IleGly: 4.695 ± 0.097
1.034IleHis: 1.034 ± 0.041
2.55IleIle: 2.55 ± 0.075
2.09IleLys: 2.09 ± 0.065
4.937IleLeu: 4.937 ± 0.099
1.072IleMet: 1.072 ± 0.041
1.746IleAsn: 1.746 ± 0.058
2.442IlePro: 2.442 ± 0.06
1.59IleGln: 1.59 ± 0.051
3.628IleArg: 3.628 ± 0.088
2.853IleSer: 2.853 ± 0.073
2.859IleThr: 2.859 ± 0.061
3.443IleVal: 3.443 ± 0.082
0.541IleTrp: 0.541 ± 0.024
1.293IleTyr: 1.293 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.932LysAla: 4.932 ± 0.107
0.25LysCys: 0.25 ± 0.019
2.276LysAsp: 2.276 ± 0.074
2.561LysGlu: 2.561 ± 0.065
1.324LysPhe: 1.324 ± 0.048
3.04LysGly: 3.04 ± 0.079
1.106LysHis: 1.106 ± 0.039
2.943LysIle: 2.943 ± 0.06
2.62LysLys: 2.62 ± 0.077
4.291LysLeu: 4.291 ± 0.094
1.307LysMet: 1.307 ± 0.056
2.334LysAsn: 2.334 ± 0.07
2.433LysPro: 2.433 ± 0.074
2.338LysGln: 2.338 ± 0.064
2.696LysArg: 2.696 ± 0.063
2.384LysSer: 2.384 ± 0.063
3.386LysThr: 3.386 ± 0.075
2.495LysVal: 2.495 ± 0.067
0.516LysTrp: 0.516 ± 0.028
1.187LysTyr: 1.187 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
13.243LeuAla: 13.243 ± 0.198
1.161LeuCys: 1.161 ± 0.043
5.549LeuAsp: 5.549 ± 0.095
5.082LeuGlu: 5.082 ± 0.098
4.171LeuPhe: 4.171 ± 0.106
6.748LeuGly: 6.748 ± 0.115
2.41LeuHis: 2.41 ± 0.065
4.841LeuIle: 4.841 ± 0.096
4.806LeuLys: 4.806 ± 0.097
10.975LeuLeu: 10.975 ± 0.211
2.321LeuMet: 2.321 ± 0.059
3.735LeuAsn: 3.735 ± 0.093
6.488LeuPro: 6.488 ± 0.125
3.724LeuGln: 3.724 ± 0.074
5.973LeuArg: 5.973 ± 0.123
6.267LeuSer: 6.267 ± 0.109
4.942LeuThr: 4.942 ± 0.091
5.664LeuVal: 5.664 ± 0.111
1.333LeuTrp: 1.333 ± 0.058
2.707LeuTyr: 2.707 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.436MetAla: 2.436 ± 0.061
0.172MetCys: 0.172 ± 0.017
1.051MetAsp: 1.051 ± 0.041
1.002MetGlu: 1.002 ± 0.046
0.722MetPhe: 0.722 ± 0.04
1.546MetGly: 1.546 ± 0.054
0.498MetHis: 0.498 ± 0.031
1.065MetIle: 1.065 ± 0.043
1.42MetLys: 1.42 ± 0.05
2.408MetLeu: 2.408 ± 0.068
0.669MetMet: 0.669 ± 0.035
1.147MetAsn: 1.147 ± 0.044
1.33MetPro: 1.33 ± 0.047
1.158MetGln: 1.158 ± 0.045
1.415MetArg: 1.415 ± 0.053
1.357MetSer: 1.357 ± 0.044
1.269MetThr: 1.269 ± 0.051
1.385MetVal: 1.385 ± 0.056
0.212MetTrp: 0.212 ± 0.02
0.481MetTyr: 0.481 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.878AsnAla: 3.878 ± 0.088
0.352AsnCys: 0.352 ± 0.024
1.642AsnAsp: 1.642 ± 0.072
1.721AsnGlu: 1.721 ± 0.058
1.161AsnPhe: 1.161 ± 0.047
3.514AsnGly: 3.514 ± 0.111
0.716AsnHis: 0.716 ± 0.031
2.457AsnIle: 2.457 ± 0.067
1.551AsnLys: 1.551 ± 0.057
3.289AsnLeu: 3.289 ± 0.078
0.756AsnMet: 0.756 ± 0.035
1.277AsnAsn: 1.277 ± 0.082
2.361AsnPro: 2.361 ± 0.064
1.126AsnGln: 1.126 ± 0.05
2.329AsnArg: 2.329 ± 0.069
1.665AsnSer: 1.665 ± 0.054
2.116AsnThr: 2.116 ± 0.057
2.114AsnVal: 2.114 ± 0.089
0.503AsnTrp: 0.503 ± 0.029
0.973AsnTyr: 0.973 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
6.372ProAla: 6.372 ± 0.137
0.448ProCys: 0.448 ± 0.027
3.127ProAsp: 3.127 ± 0.069
3.877ProGlu: 3.877 ± 0.104
1.999ProPhe: 1.999 ± 0.06
2.125ProGly: 2.125 ± 0.065
1.249ProHis: 1.249 ± 0.043
1.496ProIle: 1.496 ± 0.056
1.851ProLys: 1.851 ± 0.069
4.612ProLeu: 4.612 ± 0.1
0.941ProMet: 0.941 ± 0.042
1.485ProAsn: 1.485 ± 0.046
2.404ProPro: 2.404 ± 0.086
2.625ProGln: 2.625 ± 0.067
2.067ProArg: 2.067 ± 0.065
2.375ProSer: 2.375 ± 0.07
1.682ProThr: 1.682 ± 0.053
3.732ProVal: 3.732 ± 0.083
0.42ProTrp: 0.42 ± 0.028
1.33ProTyr: 1.33 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
5.109GlnAla: 5.109 ± 0.107
0.317GlnCys: 0.317 ± 0.02
1.782GlnAsp: 1.782 ± 0.057
2.23GlnGlu: 2.23 ± 0.071
1.258GlnPhe: 1.258 ± 0.041
2.698GlnGly: 2.698 ± 0.075
0.973GlnHis: 0.973 ± 0.034
2.451GlnIle: 2.451 ± 0.067
2.026GlnLys: 2.026 ± 0.058
3.149GlnLeu: 3.149 ± 0.082
1.05GlnMet: 1.05 ± 0.039
1.977GlnAsn: 1.977 ± 0.052
1.84GlnPro: 1.84 ± 0.06
2.029GlnGln: 2.029 ± 0.064
2.358GlnArg: 2.358 ± 0.062
2.504GlnSer: 2.504 ± 0.06
3.188GlnThr: 3.188 ± 0.085
1.982GlnVal: 1.982 ± 0.063
0.599GlnTrp: 0.599 ± 0.034
1.225GlnTyr: 1.225 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
5.67ArgAla: 5.67 ± 0.101
0.564ArgCys: 0.564 ± 0.029
2.859ArgAsp: 2.859 ± 0.073
3.823ArgGlu: 3.823 ± 0.093
3.1ArgPhe: 3.1 ± 0.074
3.695ArgGly: 3.695 ± 0.086
1.733ArgHis: 1.733 ± 0.054
3.686ArgIle: 3.686 ± 0.082
2.478ArgLys: 2.478 ± 0.06
7.501ArgLeu: 7.501 ± 0.149
1.426ArgMet: 1.426 ± 0.052
2.059ArgAsn: 2.059 ± 0.067
3.132ArgPro: 3.132 ± 0.093
3.072ArgGln: 3.072 ± 0.075
4.925ArgArg: 4.925 ± 0.129
3.26ArgSer: 3.26 ± 0.078
2.867ArgThr: 2.867 ± 0.066
3.315ArgVal: 3.315 ± 0.081
0.685ArgTrp: 0.685 ± 0.031
2.262ArgTyr: 2.262 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
6.04SerAla: 6.04 ± 0.115
0.583SerCys: 0.583 ± 0.033
3.269SerAsp: 3.269 ± 0.094
3.287SerGlu: 3.287 ± 0.08
2.095SerPhe: 2.095 ± 0.062
5.843SerGly: 5.843 ± 0.131
1.124SerHis: 1.124 ± 0.041
2.436SerIle: 2.436 ± 0.067
2.05SerLys: 2.05 ± 0.053
5.485SerLeu: 5.485 ± 0.093
1.085SerMet: 1.085 ± 0.039
1.583SerAsn: 1.583 ± 0.063
2.539SerPro: 2.539 ± 0.067
1.721SerGln: 1.721 ± 0.05
3.568SerArg: 3.568 ± 0.083
2.833SerSer: 2.833 ± 0.076
2.172SerThr: 2.172 ± 0.066
3.869SerVal: 3.869 ± 0.082
0.661SerTrp: 0.661 ± 0.034
1.508SerTyr: 1.508 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
7.306ThrAla: 7.306 ± 0.121
0.416ThrCys: 0.416 ± 0.023
2.931ThrAsp: 2.931 ± 0.08
2.661ThrGlu: 2.661 ± 0.054
1.781ThrPhe: 1.781 ± 0.057
4.422ThrGly: 4.422 ± 0.118
1.06ThrHis: 1.06 ± 0.039
2.152ThrIle: 2.152 ± 0.067
1.535ThrLys: 1.535 ± 0.063
5.827ThrLeu: 5.827 ± 0.106
0.879ThrMet: 0.879 ± 0.036
1.368ThrAsn: 1.368 ± 0.065
3.124ThrPro: 3.124 ± 0.072
1.765ThrGln: 1.765 ± 0.058
2.832ThrArg: 2.832 ± 0.068
2.021ThrSer: 2.021 ± 0.07
2.032ThrThr: 2.032 ± 0.071
4.468ThrVal: 4.468 ± 0.112
0.465ThrTrp: 0.465 ± 0.031
1.161ThrTyr: 1.161 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
6.247ValAla: 6.247 ± 0.125
1.037ValCys: 1.037 ± 0.044
2.501ValAsp: 2.501 ± 0.064
3.398ValGlu: 3.398 ± 0.087
3.022ValPhe: 3.022 ± 0.069
4.314ValGly: 4.314 ± 0.1
1.231ValHis: 1.231 ± 0.046
3.328ValIle: 3.328 ± 0.085
3.019ValLys: 3.019 ± 0.082
7.473ValLeu: 7.473 ± 0.124
1.81ValMet: 1.81 ± 0.062
2.002ValAsn: 2.002 ± 0.074
2.859ValPro: 2.859 ± 0.065
2.48ValGln: 2.48 ± 0.068
4.53ValArg: 4.53 ± 0.111
4.573ValSer: 4.573 ± 0.107
2.625ValThr: 2.625 ± 0.085
4.178ValVal: 4.178 ± 0.097
0.998ValTrp: 0.998 ± 0.04
2.006ValTyr: 2.006 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.034TrpAla: 1.034 ± 0.045
0.149TrpCys: 0.149 ± 0.016
0.554TrpAsp: 0.554 ± 0.03
0.573TrpGlu: 0.573 ± 0.029
0.64TrpPhe: 0.64 ± 0.034
0.765TrpGly: 0.765 ± 0.04
0.439TrpHis: 0.439 ± 0.027
0.602TrpIle: 0.602 ± 0.03
0.469TrpLys: 0.469 ± 0.022
2.037TrpLeu: 2.037 ± 0.068
0.28TrpMet: 0.28 ± 0.021
0.384TrpAsn: 0.384 ± 0.022
0.451TrpPro: 0.451 ± 0.03
1.104TrpGln: 1.104 ± 0.044
1.068TrpArg: 1.068 ± 0.05
0.512TrpSer: 0.512 ± 0.03
0.541TrpThr: 0.541 ± 0.037
0.669TrpVal: 0.669 ± 0.03
0.197TrpTrp: 0.197 ± 0.02
0.385TrpTyr: 0.385 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.133TyrAla: 3.133 ± 0.079
0.375TyrCys: 0.375 ± 0.024
1.522TyrAsp: 1.522 ± 0.057
1.505TyrGlu: 1.505 ± 0.045
1.342TyrPhe: 1.342 ± 0.046
2.562TyrGly: 2.562 ± 0.071
0.626TyrHis: 0.626 ± 0.03
1.42TyrIle: 1.42 ± 0.048
1.088TyrLys: 1.088 ± 0.046
3.097TyrLeu: 3.097 ± 0.082
0.474TyrMet: 0.474 ± 0.027
0.993TyrAsn: 0.993 ± 0.043
1.441TyrPro: 1.441 ± 0.048
1.133TyrGln: 1.133 ± 0.046
2.215TyrArg: 2.215 ± 0.075
1.513TyrSer: 1.513 ± 0.052
1.732TyrThr: 1.732 ± 0.066
1.452TyrVal: 1.452 ± 0.045
0.408TyrTrp: 0.408 ± 0.025
0.937TyrTyr: 0.937 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2195 proteins (656480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski