Amino acid dipepetide frequency for Aliidiomarina minuta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.234AlaAla: 9.234 ± 0.133	0.962AlaCys: 0.962 ± 0.033	5.622AlaAsp: 5.622 ± 0.085	7.087AlaGlu: 7.087 ± 0.091	3.466AlaPhe: 3.466 ± 0.062	7.085AlaGly: 7.085 ± 0.114	1.787AlaHis: 1.787 ± 0.047	5.464AlaIle: 5.464 ± 0.09	3.371AlaLys: 3.371 ± 0.079	10.605AlaLeu: 10.605 ± 0.137	2.683AlaMet: 2.683 ± 0.062	3.078AlaAsn: 3.078 ± 0.053	3.197AlaPro: 3.197 ± 0.067	4.442AlaGln: 4.442 ± 0.073	5.218AlaArg: 5.218 ± 0.075	5.655AlaSer: 5.655 ± 0.073	4.542AlaThr: 4.542 ± 0.067	6.477AlaVal: 6.477 ± 0.085	1.057AlaTrp: 1.057 ± 0.039	2.513AlaTyr: 2.513 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.807CysAla: 0.807 ± 0.032	0.104CysCys: 0.104 ± 0.01	0.469CysAsp: 0.469 ± 0.024	0.503CysGlu: 0.503 ± 0.025	0.326CysPhe: 0.326 ± 0.017	0.722CysGly: 0.722 ± 0.032	0.247CysHis: 0.247 ± 0.017	0.461CysIle: 0.461 ± 0.022	0.325CysLys: 0.325 ± 0.02	0.853CysLeu: 0.853 ± 0.032	0.194CysMet: 0.194 ± 0.016	0.287CysAsn: 0.287 ± 0.02	0.416CysPro: 0.416 ± 0.025	0.391CysGln: 0.391 ± 0.02	0.457CysArg: 0.457 ± 0.024	0.617CysSer: 0.617 ± 0.026	0.408CysThr: 0.408 ± 0.022	0.541CysVal: 0.541 ± 0.023	0.117CysTrp: 0.117 ± 0.012	0.276CysTyr: 0.276 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.854AspAla: 4.854 ± 0.076	0.49AspCys: 0.49 ± 0.022	3.612AspAsp: 3.612 ± 0.083	4.228AspGlu: 4.228 ± 0.074	2.715AspPhe: 2.715 ± 0.061	3.895AspGly: 3.895 ± 0.087	1.155AspHis: 1.155 ± 0.039	3.934AspIle: 3.934 ± 0.07	2.57AspLys: 2.57 ± 0.062	5.366AspLeu: 5.366 ± 0.08	1.593AspMet: 1.593 ± 0.046	2.372AspAsn: 2.372 ± 0.059	2.267AspPro: 2.267 ± 0.057	2.163AspGln: 2.163 ± 0.045	2.642AspArg: 2.642 ± 0.059	3.447AspSer: 3.447 ± 0.065	2.694AspThr: 2.694 ± 0.059	3.838AspVal: 3.838 ± 0.073	1.028AspTrp: 1.028 ± 0.039	2.245AspTyr: 2.245 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.971GluAla: 5.971 ± 0.094	0.404GluCys: 0.404 ± 0.022	3.447GluAsp: 3.447 ± 0.068	4.281GluGlu: 4.281 ± 0.088	2.374GluPhe: 2.374 ± 0.061	4.057GluGly: 4.057 ± 0.076	1.887GluHis: 1.887 ± 0.05	3.423GluIle: 3.423 ± 0.061	2.82GluLys: 2.82 ± 0.07	7.835GluLeu: 7.835 ± 0.102	1.608GluMet: 1.608 ± 0.04	2.469GluAsn: 2.469 ± 0.057	2.419GluPro: 2.419 ± 0.052	5.031GluGln: 5.031 ± 0.102	4.601GluArg: 4.601 ± 0.076	3.71GluSer: 3.71 ± 0.067	2.931GluThr: 2.931 ± 0.052	4.624GluVal: 4.624 ± 0.08	0.83GluTrp: 0.83 ± 0.028	1.8GluTyr: 1.8 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.968PheAla: 3.968 ± 0.066	0.422PheCys: 0.422 ± 0.026	2.447PheAsp: 2.447 ± 0.057	2.296PheGlu: 2.296 ± 0.049	1.7PhePhe: 1.7 ± 0.05	2.838PheGly: 2.838 ± 0.056	0.811PheHis: 0.811 ± 0.034	2.518PheIle: 2.518 ± 0.058	1.493PheLys: 1.493 ± 0.039	3.273PheLeu: 3.273 ± 0.066	1.063PheMet: 1.063 ± 0.035	1.754PheAsn: 1.754 ± 0.048	1.405PhePro: 1.405 ± 0.035	1.311PheGln: 1.311 ± 0.037	1.931PheArg: 1.931 ± 0.048	3.216PheSer: 3.216 ± 0.074	2.213PheThr: 2.213 ± 0.053	2.523PheVal: 2.523 ± 0.052	0.607PheTrp: 0.607 ± 0.03	1.374PheTyr: 1.374 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.826GlyAla: 5.826 ± 0.094	0.744GlyCys: 0.744 ± 0.032	4.028GlyAsp: 4.028 ± 0.085	4.656GlyGlu: 4.656 ± 0.081	3.196GlyPhe: 3.196 ± 0.059	4.992GlyGly: 4.992 ± 0.085	1.724GlyHis: 1.724 ± 0.038	4.318GlyIle: 4.318 ± 0.066	3.034GlyLys: 3.034 ± 0.067	7.204GlyLeu: 7.204 ± 0.115	2.03GlyMet: 2.03 ± 0.049	2.496GlyAsn: 2.496 ± 0.057	2.171GlyPro: 2.171 ± 0.054	3.264GlyGln: 3.264 ± 0.063	3.864GlyArg: 3.864 ± 0.075	4.354GlySer: 4.354 ± 0.076	3.346GlyThr: 3.346 ± 0.066	5.16GlyVal: 5.16 ± 0.083	1.043GlyTrp: 1.043 ± 0.038	2.502GlyTyr: 2.502 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.909HisAla: 1.909 ± 0.052	0.317HisCys: 0.317 ± 0.021	1.252HisAsp: 1.252 ± 0.041	1.469HisGlu: 1.469 ± 0.043	1.096HisPhe: 1.096 ± 0.037	1.699HisGly: 1.699 ± 0.049	0.624HisHis: 0.624 ± 0.027	1.38HisIle: 1.38 ± 0.036	0.94HisLys: 0.94 ± 0.036	2.295HisLeu: 2.295 ± 0.059	0.493HisMet: 0.493 ± 0.024	0.843HisAsn: 0.843 ± 0.026	1.222HisPro: 1.222 ± 0.041	1.28HisGln: 1.28 ± 0.04	1.275HisArg: 1.275 ± 0.042	1.484HisSer: 1.484 ± 0.047	0.985HisThr: 0.985 ± 0.032	1.326HisVal: 1.326 ± 0.037	0.424HisTrp: 0.424 ± 0.02	0.869HisTyr: 0.869 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.97IleAla: 5.97 ± 0.093	0.521IleCys: 0.521 ± 0.025	3.605IleAsp: 3.605 ± 0.066	4.327IleGlu: 4.327 ± 0.069	2.03IlePhe: 2.03 ± 0.046	4.176IleGly: 4.176 ± 0.08	1.199IleHis: 1.199 ± 0.039	3.138IleIle: 3.138 ± 0.069	2.317IleLys: 2.317 ± 0.059	4.859IleLeu: 4.859 ± 0.079	1.32IleMet: 1.32 ± 0.034	2.443IleAsn: 2.443 ± 0.063	2.393IlePro: 2.393 ± 0.052	2.342IleGln: 2.342 ± 0.048	3.068IleArg: 3.068 ± 0.056	3.847IleSer: 3.847 ± 0.069	3.158IleThr: 3.158 ± 0.063	3.598IleVal: 3.598 ± 0.068	0.658IleTrp: 0.658 ± 0.03	1.484IleTyr: 1.484 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.039LysAla: 4.039 ± 0.095	0.204LysCys: 0.204 ± 0.014	1.993LysAsp: 1.993 ± 0.06	2.601LysGlu: 2.601 ± 0.058	1.125LysPhe: 1.125 ± 0.04	2.528LysGly: 2.528 ± 0.066	0.906LysHis: 0.906 ± 0.035	1.961LysIle: 1.961 ± 0.053	2.059LysLys: 2.059 ± 0.059	3.976LysLeu: 3.976 ± 0.073	0.939LysMet: 0.939 ± 0.036	1.401LysAsn: 1.401 ± 0.038	1.95LysPro: 1.95 ± 0.054	2.084LysGln: 2.084 ± 0.056	2.461LysArg: 2.461 ± 0.06	2.342LysSer: 2.342 ± 0.062	2.008LysThr: 2.008 ± 0.048	2.882LysVal: 2.882 ± 0.07	0.411LysTrp: 0.411 ± 0.023	0.916LysTyr: 0.916 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.807LeuAla: 10.807 ± 0.132	0.895LeuCys: 0.895 ± 0.032	5.881LeuAsp: 5.881 ± 0.077	6.204LeuGlu: 6.204 ± 0.089	3.879LeuPhe: 3.879 ± 0.077	7.011LeuGly: 7.011 ± 0.089	2.508LeuHis: 2.508 ± 0.05	5.799LeuIle: 5.799 ± 0.083	4.111LeuLys: 4.111 ± 0.078	12.01LeuLeu: 12.01 ± 0.216	2.664LeuMet: 2.664 ± 0.057	4.267LeuAsn: 4.267 ± 0.076	5.214LeuPro: 5.214 ± 0.085	6.078LeuGln: 6.078 ± 0.098	6.05LeuArg: 6.05 ± 0.099	7.498LeuSer: 7.498 ± 0.115	5.903LeuThr: 5.903 ± 0.083	6.986LeuVal: 6.986 ± 0.094	1.24LeuTrp: 1.24 ± 0.042	2.754LeuTyr: 2.754 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.596MetAla: 2.596 ± 0.058	0.151MetCys: 0.151 ± 0.014	1.181MetAsp: 1.181 ± 0.041	1.263MetGlu: 1.263 ± 0.041	0.79MetPhe: 0.79 ± 0.034	1.671MetGly: 1.671 ± 0.042	0.611MetHis: 0.611 ± 0.026	1.209MetIle: 1.209 ± 0.034	1.229MetLys: 1.229 ± 0.038	2.848MetLeu: 2.848 ± 0.06	0.645MetMet: 0.645 ± 0.027	1.004MetAsn: 1.004 ± 0.037	1.31MetPro: 1.31 ± 0.04	1.631MetGln: 1.631 ± 0.041	1.537MetArg: 1.537 ± 0.04	1.783MetSer: 1.783 ± 0.046	1.585MetThr: 1.585 ± 0.047	1.726MetVal: 1.726 ± 0.049	0.211MetTrp: 0.211 ± 0.017	0.536MetTyr: 0.536 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.156AsnAla: 3.156 ± 0.063	0.324AsnCys: 0.324 ± 0.018	2.082AsnAsp: 2.082 ± 0.051	2.348AsnGlu: 2.348 ± 0.052	1.462AsnPhe: 1.462 ± 0.041	2.371AsnGly: 2.371 ± 0.059	0.794AsnHis: 0.794 ± 0.028	2.196AsnIle: 2.196 ± 0.054	1.535AsnLys: 1.535 ± 0.043	3.823AsnLeu: 3.823 ± 0.066	1.001AsnMet: 1.001 ± 0.037	1.528AsnAsn: 1.528 ± 0.057	1.924AsnPro: 1.924 ± 0.051	2.068AsnGln: 2.068 ± 0.056	2.058AsnArg: 2.058 ± 0.048	2.152AsnSer: 2.152 ± 0.05	1.839AsnThr: 1.839 ± 0.045	2.143AsnVal: 2.143 ± 0.055	0.686AsnTrp: 0.686 ± 0.028	1.236AsnTyr: 1.236 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.997ProAla: 3.997 ± 0.074	0.304ProCys: 0.304 ± 0.02	2.963ProAsp: 2.963 ± 0.06	3.616ProGlu: 3.616 ± 0.07	1.7ProPhe: 1.7 ± 0.047	3.266ProGly: 3.266 ± 0.064	0.858ProHis: 0.858 ± 0.03	1.883ProIle: 1.883 ± 0.05	1.323ProLys: 1.323 ± 0.05	4.441ProLeu: 4.441 ± 0.069	0.991ProMet: 0.991 ± 0.03	1.274ProAsn: 1.274 ± 0.04	1.413ProPro: 1.413 ± 0.042	2.037ProGln: 2.037 ± 0.047	1.941ProArg: 1.941 ± 0.054	2.2ProSer: 2.2 ± 0.046	1.904ProThr: 1.904 ± 0.052	3.505ProVal: 3.505 ± 0.067	0.599ProTrp: 0.599 ± 0.026	1.252ProTyr: 1.252 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	5.266GlnAla: 5.266 ± 0.086	0.307GlnCys: 0.307 ± 0.018	2.481GlnAsp: 2.481 ± 0.056	2.969GlnGlu: 2.969 ± 0.07	1.706GlnPhe: 1.706 ± 0.048	3.654GlnGly: 3.654 ± 0.071	1.509GlnHis: 1.509 ± 0.044	2.434GlnIle: 2.434 ± 0.057	1.818GlnLys: 1.818 ± 0.051	6.533GlnLeu: 6.533 ± 0.122	1.14GlnMet: 1.14 ± 0.033	1.634GlnAsn: 1.634 ± 0.043	2.299GlnPro: 2.299 ± 0.057	4.841GlnGln: 4.841 ± 0.109	3.877GlnArg: 3.877 ± 0.073	3.035GlnSer: 3.035 ± 0.058	2.135GlnThr: 2.135 ± 0.048	3.951GlnVal: 3.951 ± 0.07	0.735GlnTrp: 0.735 ± 0.033	1.26GlnTyr: 1.26 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	4.641ArgAla: 4.641 ± 0.081	0.419ArgCys: 0.419 ± 0.019	3.31ArgAsp: 3.31 ± 0.063	4.17ArgGlu: 4.17 ± 0.079	2.571ArgPhe: 2.571 ± 0.058	3.441ArgGly: 3.441 ± 0.07	1.46ArgHis: 1.46 ± 0.042	3.598ArgIle: 3.598 ± 0.069	2.175ArgLys: 2.175 ± 0.062	6.642ArgLeu: 6.642 ± 0.096	1.551ArgMet: 1.551 ± 0.046	2.074ArgAsn: 2.074 ± 0.046	2.094ArgPro: 2.094 ± 0.045	3.25ArgGln: 3.25 ± 0.056	3.584ArgArg: 3.584 ± 0.081	3.26ArgSer: 3.26 ± 0.071	2.473ArgThr: 2.473 ± 0.054	3.984ArgVal: 3.984 ± 0.065	0.908ArgTrp: 0.908 ± 0.033	1.952ArgTyr: 1.952 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.958SerAla: 5.958 ± 0.087	0.514SerCys: 0.514 ± 0.027	3.729SerAsp: 3.729 ± 0.07	4.192SerGlu: 4.192 ± 0.073	2.56SerPhe: 2.56 ± 0.058	5.253SerGly: 5.253 ± 0.081	1.366SerHis: 1.366 ± 0.038	3.545SerIle: 3.545 ± 0.06	2.231SerLys: 2.231 ± 0.054	6.882SerLeu: 6.882 ± 0.087	1.735SerMet: 1.735 ± 0.043	2.146SerAsn: 2.146 ± 0.045	2.415SerPro: 2.415 ± 0.05	2.843SerGln: 2.843 ± 0.058	3.497SerArg: 3.497 ± 0.073	4.145SerSer: 4.145 ± 0.071	2.913SerThr: 2.913 ± 0.062	4.372SerVal: 4.372 ± 0.07	0.975SerTrp: 0.975 ± 0.036	1.934SerTyr: 1.934 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.55ThrAla: 4.55 ± 0.072	0.401ThrCys: 0.401 ± 0.021	2.934ThrAsp: 2.934 ± 0.058	3.451ThrGlu: 3.451 ± 0.064	1.879ThrPhe: 1.879 ± 0.052	4.074ThrGly: 4.074 ± 0.071	1.117ThrHis: 1.117 ± 0.038	2.654ThrIle: 2.654 ± 0.057	1.426ThrLys: 1.426 ± 0.042	5.891ThrLeu: 5.891 ± 0.072	1.039ThrMet: 1.039 ± 0.036	1.55ThrAsn: 1.55 ± 0.042	2.582ThrPro: 2.582 ± 0.054	2.481ThrGln: 2.481 ± 0.06	2.747ThrArg: 2.747 ± 0.058	2.967ThrSer: 2.967 ± 0.061	2.509ThrThr: 2.509 ± 0.058	3.216ThrVal: 3.216 ± 0.074	0.57ThrTrp: 0.57 ± 0.028	1.33ThrTyr: 1.33 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.632ValAla: 6.632 ± 0.1	0.606ValCys: 0.606 ± 0.026	3.868ValAsp: 3.868 ± 0.077	4.546ValGlu: 4.546 ± 0.091	2.622ValPhe: 2.622 ± 0.056	4.436ValGly: 4.436 ± 0.082	1.442ValHis: 1.442 ± 0.04	4.376ValIle: 4.376 ± 0.07	2.627ValLys: 2.627 ± 0.063	7.022ValLeu: 7.022 ± 0.091	1.843ValMet: 1.843 ± 0.044	2.658ValAsn: 2.658 ± 0.058	2.857ValPro: 2.857 ± 0.06	2.811ValGln: 2.811 ± 0.061	3.846ValArg: 3.846 ± 0.068	4.791ValSer: 4.791 ± 0.067	3.977ValThr: 3.977 ± 0.065	5.095ValVal: 5.095 ± 0.084	0.739ValTrp: 0.739 ± 0.032	1.804ValTyr: 1.804 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.908TrpAla: 0.908 ± 0.036	0.133TrpCys: 0.133 ± 0.014	0.576TrpAsp: 0.576 ± 0.026	0.573TrpGlu: 0.573 ± 0.029	0.634TrpPhe: 0.634 ± 0.03	0.751TrpGly: 0.751 ± 0.029	0.412TrpHis: 0.412 ± 0.02	0.678TrpIle: 0.678 ± 0.028	0.385TrpLys: 0.385 ± 0.023	2.105TrpLeu: 2.105 ± 0.057	0.35TrpMet: 0.35 ± 0.019	0.42TrpAsn: 0.42 ± 0.021	0.602TrpPro: 0.602 ± 0.029	1.248TrpGln: 1.248 ± 0.046	0.929TrpArg: 0.929 ± 0.037	0.808TrpSer: 0.808 ± 0.033	0.509TrpThr: 0.509 ± 0.026	0.903TrpVal: 0.903 ± 0.032	0.275TrpTrp: 0.275 ± 0.017	0.406TrpTyr: 0.406 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.457TyrAla: 2.457 ± 0.053	0.299TyrCys: 0.299 ± 0.015	1.629TyrAsp: 1.629 ± 0.048	1.741TyrGlu: 1.741 ± 0.046	1.333TyrPhe: 1.333 ± 0.041	2.032TyrGly: 2.032 ± 0.052	0.765TyrHis: 0.765 ± 0.029	1.487TyrIle: 1.487 ± 0.035	0.999TyrLys: 0.999 ± 0.037	3.294TyrLeu: 3.294 ± 0.069	0.634TyrMet: 0.634 ± 0.027	1.023TyrAsn: 1.023 ± 0.037	1.316TyrPro: 1.316 ± 0.037	1.99TyrGln: 1.99 ± 0.051	1.973TyrArg: 1.973 ± 0.047	1.895TyrSer: 1.895 ± 0.049	1.337TyrThr: 1.337 ± 0.04	1.746TyrVal: 1.746 ± 0.049	0.49TyrTrp: 0.49 ± 0.023	0.951TyrTyr: 0.951 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2751 proteins (902465 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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