Amino acid dipepetide frequency for Tahibacter aquaticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.93AlaAla: 20.93 ± 0.172	1.333AlaCys: 1.333 ± 0.028	7.431AlaAsp: 7.431 ± 0.068	6.992AlaGlu: 6.992 ± 0.066	3.935AlaPhe: 3.935 ± 0.053	11.441AlaGly: 11.441 ± 0.1	2.46AlaHis: 2.46 ± 0.039	5.238AlaIle: 5.238 ± 0.057	3.112AlaLys: 3.112 ± 0.057	15.63AlaLeu: 15.63 ± 0.129	2.664AlaMet: 2.664 ± 0.041	3.417AlaAsn: 3.417 ± 0.052	6.375AlaPro: 6.375 ± 0.083	6.273AlaGln: 6.273 ± 0.079	9.46AlaArg: 9.46 ± 0.098	7.551AlaSer: 7.551 ± 0.088	6.934AlaThr: 6.934 ± 0.098	9.107AlaVal: 9.107 ± 0.07	1.945AlaTrp: 1.945 ± 0.04	2.677AlaTyr: 2.677 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.305CysAla: 1.305 ± 0.028	0.145CysCys: 0.145 ± 0.007	0.546CysAsp: 0.546 ± 0.017	0.477CysGlu: 0.477 ± 0.015	0.302CysPhe: 0.302 ± 0.012	0.98CysGly: 0.98 ± 0.023	0.263CysHis: 0.263 ± 0.015	0.395CysIle: 0.395 ± 0.014	0.206CysLys: 0.206 ± 0.009	0.975CysLeu: 0.975 ± 0.021	0.16CysMet: 0.16 ± 0.009	0.271CysAsn: 0.271 ± 0.011	0.462CysPro: 0.462 ± 0.018	0.273CysGln: 0.273 ± 0.012	0.7CysArg: 0.7 ± 0.02	0.707CysSer: 0.707 ± 0.021	0.574CysThr: 0.574 ± 0.02	0.752CysVal: 0.752 ± 0.02	0.175CysTrp: 0.175 ± 0.016	0.24CysTyr: 0.24 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.117AspAla: 8.117 ± 0.069	0.559AspCys: 0.559 ± 0.019	3.169AspAsp: 3.169 ± 0.049	3.07AspGlu: 3.07 ± 0.051	2.117AspPhe: 2.117 ± 0.036	5.888AspGly: 5.888 ± 0.076	1.025AspHis: 1.025 ± 0.023	2.279AspIle: 2.279 ± 0.035	1.522AspLys: 1.522 ± 0.036	5.56AspLeu: 5.56 ± 0.055	0.946AspMet: 0.946 ± 0.025	1.492AspAsn: 1.492 ± 0.028	3.069AspPro: 3.069 ± 0.04	1.707AspGln: 1.707 ± 0.029	3.55AspArg: 3.55 ± 0.045	3.198AspSer: 3.198 ± 0.043	2.86AspThr: 2.86 ± 0.047	3.805AspVal: 3.805 ± 0.045	1.052AspTrp: 1.052 ± 0.022	1.713AspTyr: 1.713 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.249GluAla: 6.249 ± 0.075	0.39GluCys: 0.39 ± 0.016	1.988GluAsp: 1.988 ± 0.035	2.099GluGlu: 2.099 ± 0.039	1.918GluPhe: 1.918 ± 0.034	3.079GluGly: 3.079 ± 0.044	1.26GluHis: 1.26 ± 0.029	2.531GluIle: 2.531 ± 0.043	1.495GluLys: 1.495 ± 0.036	6.257GluLeu: 6.257 ± 0.067	0.958GluMet: 0.958 ± 0.024	1.283GluAsn: 1.283 ± 0.027	2.362GluPro: 2.362 ± 0.035	2.654GluGln: 2.654 ± 0.047	4.788GluArg: 4.788 ± 0.055	2.611GluSer: 2.611 ± 0.036	2.622GluThr: 2.622 ± 0.04	3.319GluVal: 3.319 ± 0.055	0.7GluTrp: 0.7 ± 0.019	1.033GluTyr: 1.033 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.643PheAla: 4.643 ± 0.059	0.389PheCys: 0.389 ± 0.013	2.681PheAsp: 2.681 ± 0.04	1.823PheGlu: 1.823 ± 0.031	1.17PhePhe: 1.17 ± 0.03	3.327PheGly: 3.327 ± 0.053	0.719PheHis: 0.719 ± 0.017	1.159PheIle: 1.159 ± 0.026	0.752PheLys: 0.752 ± 0.022	3.032PheLeu: 3.032 ± 0.038	0.528PheMet: 0.528 ± 0.015	1.052PheAsn: 1.052 ± 0.024	1.465PhePro: 1.465 ± 0.029	1.035PheGln: 1.035 ± 0.024	2.277PheArg: 2.277 ± 0.034	2.256PheSer: 2.256 ± 0.033	1.68PheThr: 1.68 ± 0.031	2.73PheVal: 2.73 ± 0.037	0.46PheTrp: 0.46 ± 0.018	0.829PheTyr: 0.829 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.017GlyAla: 9.017 ± 0.087	0.882GlyCys: 0.882 ± 0.022	4.693GlyAsp: 4.693 ± 0.064	4.565GlyGlu: 4.565 ± 0.057	3.108GlyPhe: 3.108 ± 0.046	7.292GlyGly: 7.292 ± 0.112	1.802GlyHis: 1.802 ± 0.031	3.638GlyIle: 3.638 ± 0.047	2.863GlyLys: 2.863 ± 0.047	8.597GlyLeu: 8.597 ± 0.081	1.887GlyMet: 1.887 ± 0.032	2.956GlyAsn: 2.956 ± 0.067	3.001GlyPro: 3.001 ± 0.048	3.207GlyGln: 3.207 ± 0.049	5.795GlyArg: 5.795 ± 0.06	5.82GlySer: 5.82 ± 0.076	4.624GlyThr: 4.624 ± 0.076	5.977GlyVal: 5.977 ± 0.064	1.434GlyTrp: 1.434 ± 0.025	2.338GlyTyr: 2.338 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.77HisAla: 2.77 ± 0.041	0.308HisCys: 0.308 ± 0.013	1.164HisAsp: 1.164 ± 0.027	1.109HisGlu: 1.109 ± 0.023	0.839HisPhe: 0.839 ± 0.02	1.999HisGly: 1.999 ± 0.037	0.505HisHis: 0.505 ± 0.017	0.787HisIle: 0.787 ± 0.023	0.428HisLys: 0.428 ± 0.015	2.128HisLeu: 2.128 ± 0.034	0.355HisMet: 0.355 ± 0.013	0.506HisAsn: 0.506 ± 0.016	1.181HisPro: 1.181 ± 0.024	0.636HisGln: 0.636 ± 0.017	1.498HisArg: 1.498 ± 0.027	1.161HisSer: 1.161 ± 0.029	0.962HisThr: 0.962 ± 0.024	1.417HisVal: 1.417 ± 0.025	0.45HisTrp: 0.45 ± 0.014	0.67HisTyr: 0.67 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.697IleAla: 6.697 ± 0.071	0.397IleCys: 0.397 ± 0.012	3.293IleAsp: 3.293 ± 0.041	2.736IleGlu: 2.736 ± 0.041	1.167IlePhe: 1.167 ± 0.026	4.012IleGly: 4.012 ± 0.051	0.801IleHis: 0.801 ± 0.021	1.034IleIle: 1.034 ± 0.026	1.044IleLys: 1.044 ± 0.026	2.897IleLeu: 2.897 ± 0.037	0.458IleMet: 0.458 ± 0.018	1.218IleAsn: 1.218 ± 0.03	1.854IlePro: 1.854 ± 0.037	1.114IleGln: 1.114 ± 0.023	2.492IleArg: 2.492 ± 0.043	2.272IleSer: 2.272 ± 0.041	1.977IleThr: 1.977 ± 0.034	3.473IleVal: 3.473 ± 0.047	0.483IleTrp: 0.483 ± 0.017	0.967IleTyr: 0.967 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.123LysAla: 3.123 ± 0.053	0.16LysCys: 0.16 ± 0.01	1.336LysAsp: 1.336 ± 0.028	1.073LysGlu: 1.073 ± 0.026	0.747LysPhe: 0.747 ± 0.024	1.719LysGly: 1.719 ± 0.032	0.506LysHis: 0.506 ± 0.015	1.078LysIle: 1.078 ± 0.025	0.935LysLys: 0.935 ± 0.033	2.805LysLeu: 2.805 ± 0.05	0.478LysMet: 0.478 ± 0.018	0.76LysAsn: 0.76 ± 0.021	1.935LysPro: 1.935 ± 0.038	0.989LysGln: 0.989 ± 0.025	1.927LysArg: 1.927 ± 0.038	1.479LysSer: 1.479 ± 0.033	1.532LysThr: 1.532 ± 0.03	1.828LysVal: 1.828 ± 0.036	0.256LysTrp: 0.256 ± 0.014	0.527LysTyr: 0.527 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.977LeuAla: 15.977 ± 0.132	1.09LeuCys: 1.09 ± 0.023	6.626LeuAsp: 6.626 ± 0.075	4.767LeuGlu: 4.767 ± 0.059	3.517LeuPhe: 3.517 ± 0.05	8.584LeuGly: 8.584 ± 0.066	2.306LeuHis: 2.306 ± 0.036	4.186LeuIle: 4.186 ± 0.055	2.969LeuLys: 2.969 ± 0.048	12.731LeuLeu: 12.731 ± 0.135	1.765LeuMet: 1.765 ± 0.027	2.687LeuAsn: 2.687 ± 0.041	6.682LeuPro: 6.682 ± 0.062	4.683LeuGln: 4.683 ± 0.066	9.348LeuArg: 9.348 ± 0.085	6.633LeuSer: 6.633 ± 0.059	4.852LeuThr: 4.852 ± 0.053	7.424LeuVal: 7.424 ± 0.071	1.396LeuTrp: 1.396 ± 0.034	2.288LeuTyr: 2.288 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.209MetAla: 2.209 ± 0.034	0.122MetCys: 0.122 ± 0.008	0.871MetAsp: 0.871 ± 0.02	0.683MetGlu: 0.683 ± 0.021	0.519MetPhe: 0.519 ± 0.016	1.153MetGly: 1.153 ± 0.025	0.414MetHis: 0.414 ± 0.014	0.705MetIle: 0.705 ± 0.019	0.635MetLys: 0.635 ± 0.02	2.029MetLeu: 2.029 ± 0.037	0.306MetMet: 0.306 ± 0.012	0.712MetAsn: 0.712 ± 0.019	1.213MetPro: 1.213 ± 0.027	0.835MetGln: 0.835 ± 0.02	1.443MetArg: 1.443 ± 0.028	1.315MetSer: 1.315 ± 0.027	1.084MetThr: 1.084 ± 0.025	1.016MetVal: 1.016 ± 0.024	0.156MetTrp: 0.156 ± 0.009	0.319MetTyr: 0.319 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.634AsnAla: 3.634 ± 0.058	0.322AsnCys: 0.322 ± 0.013	1.588AsnAsp: 1.588 ± 0.045	1.252AsnGlu: 1.252 ± 0.026	1.012AsnPhe: 1.012 ± 0.026	2.841AsnGly: 2.841 ± 0.052	0.502AsnHis: 0.502 ± 0.017	1.087AsnIle: 1.087 ± 0.022	0.601AsnLys: 0.601 ± 0.022	2.88AsnLeu: 2.88 ± 0.042	0.393AsnMet: 0.393 ± 0.013	0.964AsnAsn: 0.964 ± 0.032	1.888AsnPro: 1.888 ± 0.031	0.916AsnGln: 0.916 ± 0.023	1.9AsnArg: 1.9 ± 0.036	1.575AsnSer: 1.575 ± 0.035	1.618AsnThr: 1.618 ± 0.039	1.902AsnVal: 1.902 ± 0.04	0.462AsnTrp: 0.462 ± 0.015	0.845AsnTyr: 0.845 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	8.067ProAla: 8.067 ± 0.091	0.37ProCys: 0.37 ± 0.013	3.173ProAsp: 3.173 ± 0.041	2.722ProGlu: 2.722 ± 0.042	1.574ProPhe: 1.574 ± 0.029	4.67ProGly: 4.67 ± 0.056	1.011ProHis: 1.011 ± 0.023	1.818ProIle: 1.818 ± 0.03	1.105ProLys: 1.105 ± 0.025	5.795ProLeu: 5.795 ± 0.057	1.04ProMet: 1.04 ± 0.023	1.424ProAsn: 1.424 ± 0.032	3.273ProPro: 3.273 ± 0.065	2.315ProGln: 2.315 ± 0.037	3.387ProArg: 3.387 ± 0.045	2.774ProSer: 2.774 ± 0.045	2.414ProThr: 2.414 ± 0.044	3.84ProVal: 3.84 ± 0.05	0.758ProTrp: 0.758 ± 0.019	1.167ProTyr: 1.167 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	5.632GlnAla: 5.632 ± 0.079	0.322GlnCys: 0.322 ± 0.012	1.519GlnAsp: 1.519 ± 0.029	1.475GlnGlu: 1.475 ± 0.036	1.283GlnPhe: 1.283 ± 0.024	2.923GlnGly: 2.923 ± 0.039	0.959GlnHis: 0.959 ± 0.02	1.738GlnIle: 1.738 ± 0.031	0.86GlnLys: 0.86 ± 0.022	4.838GlnLeu: 4.838 ± 0.066	0.727GlnMet: 0.727 ± 0.02	0.944GlnAsn: 0.944 ± 0.02	2.458GlnPro: 2.458 ± 0.035	2.261GlnGln: 2.261 ± 0.041	4.173GlnArg: 4.173 ± 0.056	2.113GlnSer: 2.113 ± 0.036	1.74GlnThr: 1.74 ± 0.031	2.78GlnVal: 2.78 ± 0.038	0.677GlnTrp: 0.677 ± 0.019	0.763GlnTyr: 0.763 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.256ArgAla: 8.256 ± 0.077	0.795ArgCys: 0.795 ± 0.02	4.287ArgAsp: 4.287 ± 0.054	4.463ArgGlu: 4.463 ± 0.062	2.894ArgPhe: 2.894 ± 0.039	5.074ArgGly: 5.074 ± 0.053	1.87ArgHis: 1.87 ± 0.033	3.704ArgIle: 3.704 ± 0.042	1.814ArgLys: 1.814 ± 0.039	9.093ArgLeu: 9.093 ± 0.094	1.448ArgMet: 1.448 ± 0.028	2.087ArgAsn: 2.087 ± 0.035	3.273ArgPro: 3.273 ± 0.047	3.188ArgGln: 3.188 ± 0.048	6.419ArgArg: 6.419 ± 0.075	4.371ArgSer: 4.371 ± 0.055	3.148ArgThr: 3.148 ± 0.038	5.212ArgVal: 5.212 ± 0.059	1.499ArgTrp: 1.499 ± 0.025	2.317ArgTyr: 2.317 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.601SerAla: 7.601 ± 0.083	0.624SerCys: 0.624 ± 0.021	3.252SerAsp: 3.252 ± 0.044	2.709SerGlu: 2.709 ± 0.035	2.046SerPhe: 2.046 ± 0.036	6.295SerGly: 6.295 ± 0.077	1.135SerHis: 1.135 ± 0.023	2.494SerIle: 2.494 ± 0.047	1.307SerLys: 1.307 ± 0.03	6.441SerLeu: 6.441 ± 0.06	1.028SerMet: 1.028 ± 0.026	1.838SerAsn: 1.838 ± 0.04	2.992SerPro: 2.992 ± 0.041	1.9SerGln: 1.9 ± 0.034	3.799SerArg: 3.799 ± 0.044	3.773SerSer: 3.773 ± 0.077	3.13SerThr: 3.13 ± 0.05	4.195SerVal: 4.195 ± 0.055	0.989SerTrp: 0.989 ± 0.022	1.587SerTyr: 1.587 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.795ThrAla: 6.795 ± 0.08	0.53ThrCys: 0.53 ± 0.017	2.552ThrAsp: 2.552 ± 0.045	2.04ThrGlu: 2.04 ± 0.033	1.677ThrPhe: 1.677 ± 0.034	4.308ThrGly: 4.308 ± 0.078	1.007ThrHis: 1.007 ± 0.022	2.099ThrIle: 2.099 ± 0.04	0.928ThrLys: 0.928 ± 0.021	5.978ThrLeu: 5.978 ± 0.057	0.733ThrMet: 0.733 ± 0.021	1.299ThrAsn: 1.299 ± 0.037	3.63ThrPro: 3.63 ± 0.062	1.792ThrGln: 1.792 ± 0.034	3.485ThrArg: 3.485 ± 0.047	2.735ThrSer: 2.735 ± 0.057	3.071ThrThr: 3.071 ± 0.077	4.101ThrVal: 4.101 ± 0.069	0.692ThrTrp: 0.692 ± 0.02	1.216ThrTyr: 1.216 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.44ValAla: 9.44 ± 0.076	0.733ValCys: 0.733 ± 0.019	4.364ValAsp: 4.364 ± 0.048	3.896ValGlu: 3.896 ± 0.048	2.616ValPhe: 2.616 ± 0.036	5.025ValGly: 5.025 ± 0.06	1.468ValHis: 1.468 ± 0.025	3.018ValIle: 3.018 ± 0.046	1.697ValLys: 1.697 ± 0.032	8.121ValLeu: 8.121 ± 0.081	1.222ValMet: 1.222 ± 0.025	1.991ValAsn: 1.991 ± 0.04	3.661ValPro: 3.661 ± 0.051	2.639ValGln: 2.639 ± 0.034	5.093ValArg: 5.093 ± 0.051	4.269ValSer: 4.269 ± 0.055	3.668ValThr: 3.668 ± 0.072	5.679ValVal: 5.679 ± 0.072	0.913ValTrp: 0.913 ± 0.021	1.67ValTyr: 1.67 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.278TrpAla: 1.278 ± 0.029	0.165TrpCys: 0.165 ± 0.009	0.666TrpAsp: 0.666 ± 0.017	0.496TrpGlu: 0.496 ± 0.017	0.585TrpPhe: 0.585 ± 0.016	0.911TrpGly: 0.911 ± 0.025	0.39TrpHis: 0.39 ± 0.015	0.68TrpIle: 0.68 ± 0.018	0.42TrpLys: 0.42 ± 0.014	2.195TrpLeu: 2.195 ± 0.039	0.331TrpMet: 0.331 ± 0.012	0.579TrpAsn: 0.579 ± 0.019	0.784TrpPro: 0.784 ± 0.022	0.926TrpGln: 0.926 ± 0.025	1.462TrpArg: 1.462 ± 0.027	1.026TrpSer: 1.026 ± 0.025	0.82TrpThr: 0.82 ± 0.023	0.853TrpVal: 0.853 ± 0.023	0.264TrpTrp: 0.264 ± 0.012	0.376TrpTyr: 0.376 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.163TyrAla: 3.163 ± 0.043	0.273TyrCys: 0.273 ± 0.012	1.498TyrAsp: 1.498 ± 0.048	1.15TyrGlu: 1.15 ± 0.026	0.981TyrPhe: 0.981 ± 0.022	1.975TyrGly: 1.975 ± 0.032	0.472TyrHis: 0.472 ± 0.016	0.72TyrIle: 0.72 ± 0.019	0.498TyrLys: 0.498 ± 0.017	2.529TyrLeu: 2.529 ± 0.04	0.313TyrMet: 0.313 ± 0.012	0.7TyrAsn: 0.7 ± 0.024	1.14TyrPro: 1.14 ± 0.024	0.842TyrGln: 0.842 ± 0.022	2.217TyrArg: 2.217 ± 0.039	1.495TyrSer: 1.495 ± 0.036	1.359TyrThr: 1.359 ± 0.037	1.772TyrVal: 1.772 ± 0.031	0.446TyrTrp: 0.446 ± 0.015	0.68TyrTyr: 0.68 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5664 proteins (2081458 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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