Amino acid dipepetide frequency for Podoviridae sp. ctDWo9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.397AlaAla: 13.397 ± 3.224
0.634AlaCys: 0.634 ± 0.335
6.699AlaAsp: 6.699 ± 0.83
8.509AlaGlu: 8.509 ± 2.065
3.259AlaPhe: 3.259 ± 0.533
8.056AlaGly: 8.056 ± 1.408
1.991AlaHis: 1.991 ± 0.456
3.349AlaIle: 3.349 ± 0.585
6.88AlaLys: 6.88 ± 1.576
9.324AlaLeu: 9.324 ± 1.383
2.987AlaMet: 2.987 ± 0.582
3.983AlaAsn: 3.983 ± 0.751
3.349AlaPro: 3.349 ± 0.685
4.074AlaGln: 4.074 ± 0.625
8.328AlaArg: 8.328 ± 1.656
7.332AlaSer: 7.332 ± 0.784
6.427AlaThr: 6.427 ± 0.779
6.337AlaVal: 6.337 ± 0.769
1.358AlaTrp: 1.358 ± 0.37
2.535AlaTyr: 2.535 ± 0.811
0.0AlaXaa: 0.0 ± 0.0
Cys
0.815CysAla: 0.815 ± 0.29
0.181CysCys: 0.181 ± 0.146
1.086CysAsp: 1.086 ± 0.489
0.453CysGlu: 0.453 ± 0.275
0.181CysPhe: 0.181 ± 0.153
1.358CysGly: 1.358 ± 0.575
0.362CysHis: 0.362 ± 0.204
0.362CysIle: 0.362 ± 0.246
0.272CysLys: 0.272 ± 0.197
0.815CysLeu: 0.815 ± 0.382
0.181CysMet: 0.181 ± 0.147
0.091CysAsn: 0.091 ± 0.102
0.362CysPro: 0.362 ± 0.239
0.181CysGln: 0.181 ± 0.135
0.362CysArg: 0.362 ± 0.27
0.272CysSer: 0.272 ± 0.176
0.453CysThr: 0.453 ± 0.251
0.362CysVal: 0.362 ± 0.249
0.0CysTrp: 0.0 ± 0.0
0.091CysTyr: 0.091 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
6.608AspAla: 6.608 ± 1.005
0.724AspCys: 0.724 ± 0.376
4.164AspAsp: 4.164 ± 0.546
5.522AspGlu: 5.522 ± 0.954
1.901AspPhe: 1.901 ± 0.41
5.16AspGly: 5.16 ± 0.572
0.634AspHis: 0.634 ± 0.346
2.354AspIle: 2.354 ± 0.378
2.625AspLys: 2.625 ± 0.386
4.074AspLeu: 4.074 ± 0.588
1.448AspMet: 1.448 ± 0.39
2.444AspAsn: 2.444 ± 0.648
2.173AspPro: 2.173 ± 0.406
1.086AspGln: 1.086 ± 0.304
3.349AspArg: 3.349 ± 0.514
2.806AspSer: 2.806 ± 0.465
3.44AspThr: 3.44 ± 0.691
3.711AspVal: 3.711 ± 0.493
1.267AspTrp: 1.267 ± 0.332
2.806AspTyr: 2.806 ± 0.39
0.0AspXaa: 0.0 ± 0.0
Glu
8.69GluAla: 8.69 ± 1.45
0.453GluCys: 0.453 ± 0.222
2.173GluAsp: 2.173 ± 0.372
3.802GluGlu: 3.802 ± 0.698
2.716GluPhe: 2.716 ± 0.369
3.621GluGly: 3.621 ± 0.62
0.272GluHis: 0.272 ± 0.164
2.716GluIle: 2.716 ± 0.5
3.259GluLys: 3.259 ± 0.441
6.608GluLeu: 6.608 ± 0.933
2.444GluMet: 2.444 ± 0.548
2.806GluAsn: 2.806 ± 0.572
1.901GluPro: 1.901 ± 0.418
2.897GluGln: 2.897 ± 0.548
4.526GluArg: 4.526 ± 0.54
4.617GluSer: 4.617 ± 0.752
3.168GluThr: 3.168 ± 0.559
2.897GluVal: 2.897 ± 0.625
1.177GluTrp: 1.177 ± 0.505
2.897GluTyr: 2.897 ± 0.545
0.0GluXaa: 0.0 ± 0.0
Phe
2.625PheAla: 2.625 ± 0.562
0.543PheCys: 0.543 ± 0.231
2.444PheAsp: 2.444 ± 0.518
1.358PheGlu: 1.358 ± 0.24
0.905PhePhe: 0.905 ± 0.444
3.078PheGly: 3.078 ± 0.466
0.815PheHis: 0.815 ± 0.243
1.629PheIle: 1.629 ± 0.394
1.448PheLys: 1.448 ± 0.346
2.082PheLeu: 2.082 ± 0.324
1.177PheMet: 1.177 ± 0.386
1.086PheAsn: 1.086 ± 0.485
0.724PhePro: 0.724 ± 0.356
1.177PheGln: 1.177 ± 0.324
2.535PheArg: 2.535 ± 0.405
2.535PheSer: 2.535 ± 0.405
2.082PheThr: 2.082 ± 0.724
2.987PheVal: 2.987 ± 0.602
0.453PheTrp: 0.453 ± 0.199
0.634PheTyr: 0.634 ± 0.27
0.0PheXaa: 0.0 ± 0.0
Gly
8.509GlyAla: 8.509 ± 1.256
0.543GlyCys: 0.543 ± 0.229
5.25GlyAsp: 5.25 ± 0.636
5.522GlyGlu: 5.522 ± 0.574
2.625GlyPhe: 2.625 ± 0.464
10.591GlyGly: 10.591 ± 4.441
1.086GlyHis: 1.086 ± 0.267
3.892GlyIle: 3.892 ± 0.848
3.44GlyLys: 3.44 ± 0.408
6.156GlyLeu: 6.156 ± 0.934
2.263GlyMet: 2.263 ± 0.458
3.078GlyAsn: 3.078 ± 0.591
1.991GlyPro: 1.991 ± 0.635
2.625GlyGln: 2.625 ± 0.628
5.25GlyArg: 5.25 ± 0.795
6.699GlySer: 6.699 ± 0.966
5.16GlyThr: 5.16 ± 1.197
5.612GlyVal: 5.612 ± 0.746
2.082GlyTrp: 2.082 ± 0.526
3.621GlyTyr: 3.621 ± 0.857
0.0GlyXaa: 0.0 ± 0.0
His
1.539HisAla: 1.539 ± 0.471
0.272HisCys: 0.272 ± 0.201
1.086HisAsp: 1.086 ± 0.353
0.905HisGlu: 0.905 ± 0.36
0.634HisPhe: 0.634 ± 0.195
2.535HisGly: 2.535 ± 0.607
0.362HisHis: 0.362 ± 0.148
1.086HisIle: 1.086 ± 0.405
0.815HisLys: 0.815 ± 0.245
1.81HisLeu: 1.81 ± 0.525
0.453HisMet: 0.453 ± 0.221
0.905HisAsn: 0.905 ± 0.391
0.815HisPro: 0.815 ± 0.198
0.543HisGln: 0.543 ± 0.218
0.996HisArg: 0.996 ± 0.423
0.815HisSer: 0.815 ± 0.246
0.634HisThr: 0.634 ± 0.269
0.996HisVal: 0.996 ± 0.276
0.362HisTrp: 0.362 ± 0.169
0.724HisTyr: 0.724 ± 0.353
0.0HisXaa: 0.0 ± 0.0
Ile
3.802IleAla: 3.802 ± 0.534
0.181IleCys: 0.181 ± 0.148
2.897IleAsp: 2.897 ± 0.625
2.354IleGlu: 2.354 ± 0.425
1.267IlePhe: 1.267 ± 0.319
3.621IleGly: 3.621 ± 0.569
0.905IleHis: 0.905 ± 0.278
1.629IleIle: 1.629 ± 0.282
1.81IleLys: 1.81 ± 0.373
1.539IleLeu: 1.539 ± 0.395
0.724IleMet: 0.724 ± 0.384
2.535IleAsn: 2.535 ± 0.404
1.267IlePro: 1.267 ± 0.316
1.177IleGln: 1.177 ± 0.405
2.535IleArg: 2.535 ± 0.447
2.806IleSer: 2.806 ± 0.354
2.716IleThr: 2.716 ± 0.529
3.802IleVal: 3.802 ± 0.6
0.634IleTrp: 0.634 ± 0.178
0.996IleTyr: 0.996 ± 0.451
0.0IleXaa: 0.0 ± 0.0
Lys
5.612LysAla: 5.612 ± 1.254
0.272LysCys: 0.272 ± 0.168
2.082LysAsp: 2.082 ± 0.381
2.354LysGlu: 2.354 ± 0.595
1.539LysPhe: 1.539 ± 0.431
2.987LysGly: 2.987 ± 0.49
1.358LysHis: 1.358 ± 0.318
2.082LysIle: 2.082 ± 0.439
3.44LysLys: 3.44 ± 0.738
3.983LysLeu: 3.983 ± 0.542
1.539LysMet: 1.539 ± 0.368
2.082LysAsn: 2.082 ± 0.385
2.173LysPro: 2.173 ± 0.658
2.897LysGln: 2.897 ± 0.59
4.255LysArg: 4.255 ± 0.729
2.444LysSer: 2.444 ± 0.493
3.078LysThr: 3.078 ± 0.393
3.168LysVal: 3.168 ± 0.781
0.905LysTrp: 0.905 ± 0.347
2.263LysTyr: 2.263 ± 0.479
0.0LysXaa: 0.0 ± 0.0
Leu
8.871LeuAla: 8.871 ± 0.949
0.815LeuCys: 0.815 ± 0.373
4.979LeuAsp: 4.979 ± 0.798
5.341LeuGlu: 5.341 ± 0.99
2.625LeuPhe: 2.625 ± 0.468
6.065LeuGly: 6.065 ± 0.636
1.629LeuHis: 1.629 ± 0.431
2.173LeuIle: 2.173 ± 0.509
3.802LeuLys: 3.802 ± 0.81
7.151LeuLeu: 7.151 ± 0.891
1.81LeuMet: 1.81 ± 0.364
3.621LeuAsn: 3.621 ± 0.477
3.892LeuPro: 3.892 ± 0.589
1.81LeuGln: 1.81 ± 0.394
5.612LeuArg: 5.612 ± 0.873
5.793LeuSer: 5.793 ± 0.952
5.16LeuThr: 5.16 ± 0.833
5.612LeuVal: 5.612 ± 0.875
1.448LeuTrp: 1.448 ± 0.366
1.991LeuTyr: 1.991 ± 0.485
0.0LeuXaa: 0.0 ± 0.0
Met
2.806MetAla: 2.806 ± 0.504
0.181MetCys: 0.181 ± 0.162
0.815MetAsp: 0.815 ± 0.354
2.082MetGlu: 2.082 ± 0.397
0.543MetPhe: 0.543 ± 0.199
1.81MetGly: 1.81 ± 0.327
0.272MetHis: 0.272 ± 0.114
0.815MetIle: 0.815 ± 0.242
0.543MetLys: 0.543 ± 0.184
2.354MetLeu: 2.354 ± 0.524
1.086MetMet: 1.086 ± 0.441
1.086MetAsn: 1.086 ± 0.356
1.901MetPro: 1.901 ± 0.773
0.815MetGln: 0.815 ± 0.349
2.625MetArg: 2.625 ± 0.578
2.444MetSer: 2.444 ± 0.525
1.267MetThr: 1.267 ± 0.238
0.996MetVal: 0.996 ± 0.253
0.543MetTrp: 0.543 ± 0.249
0.905MetTyr: 0.905 ± 0.238
0.0MetXaa: 0.0 ± 0.0
Asn
4.074AsnAla: 4.074 ± 0.436
0.453AsnCys: 0.453 ± 0.337
2.263AsnAsp: 2.263 ± 0.336
2.173AsnGlu: 2.173 ± 0.375
1.539AsnPhe: 1.539 ± 0.344
3.259AsnGly: 3.259 ± 0.796
0.634AsnHis: 0.634 ± 0.236
1.539AsnIle: 1.539 ± 0.343
1.72AsnLys: 1.72 ± 0.363
3.711AsnLeu: 3.711 ± 0.662
0.905AsnMet: 0.905 ± 0.301
2.263AsnAsn: 2.263 ± 0.557
2.897AsnPro: 2.897 ± 0.489
1.539AsnGln: 1.539 ± 0.467
3.53AsnArg: 3.53 ± 0.565
2.444AsnSer: 2.444 ± 0.462
2.263AsnThr: 2.263 ± 0.49
1.991AsnVal: 1.991 ± 0.478
0.453AsnTrp: 0.453 ± 0.196
1.267AsnTyr: 1.267 ± 0.518
0.0AsnXaa: 0.0 ± 0.0
Pro
3.078ProAla: 3.078 ± 0.687
0.091ProCys: 0.091 ± 0.099
2.987ProAsp: 2.987 ± 0.423
2.987ProGlu: 2.987 ± 0.619
1.358ProPhe: 1.358 ± 0.374
2.354ProGly: 2.354 ± 0.761
1.086ProHis: 1.086 ± 0.299
1.901ProIle: 1.901 ± 0.423
2.625ProLys: 2.625 ± 0.518
3.711ProLeu: 3.711 ± 0.833
0.724ProMet: 0.724 ± 0.346
1.358ProAsn: 1.358 ± 0.52
2.173ProPro: 2.173 ± 0.763
1.539ProGln: 1.539 ± 0.392
2.173ProArg: 2.173 ± 0.423
2.716ProSer: 2.716 ± 0.521
3.711ProThr: 3.711 ± 0.836
2.806ProVal: 2.806 ± 0.747
0.724ProTrp: 0.724 ± 0.322
1.177ProTyr: 1.177 ± 0.285
0.0ProXaa: 0.0 ± 0.0
Gln
4.164GlnAla: 4.164 ± 0.693
0.0GlnCys: 0.0 ± 0.0
1.086GlnAsp: 1.086 ± 0.355
2.897GlnGlu: 2.897 ± 0.452
1.448GlnPhe: 1.448 ± 0.42
1.629GlnGly: 1.629 ± 0.465
1.086GlnHis: 1.086 ± 0.416
1.448GlnIle: 1.448 ± 0.258
1.358GlnLys: 1.358 ± 0.339
2.535GlnLeu: 2.535 ± 0.433
1.177GlnMet: 1.177 ± 0.307
1.086GlnAsn: 1.086 ± 0.428
1.448GlnPro: 1.448 ± 0.39
1.901GlnGln: 1.901 ± 0.41
2.444GlnArg: 2.444 ± 0.44
2.263GlnSer: 2.263 ± 0.557
1.901GlnThr: 1.901 ± 0.52
2.444GlnVal: 2.444 ± 0.607
0.453GlnTrp: 0.453 ± 0.175
0.996GlnTyr: 0.996 ± 0.291
0.0GlnXaa: 0.0 ± 0.0
Arg
7.332ArgAla: 7.332 ± 1.307
0.905ArgCys: 0.905 ± 0.387
3.078ArgAsp: 3.078 ± 0.623
4.707ArgGlu: 4.707 ± 0.86
2.625ArgPhe: 2.625 ± 0.56
4.979ArgGly: 4.979 ± 0.734
1.358ArgHis: 1.358 ± 0.319
3.078ArgIle: 3.078 ± 1.057
3.349ArgLys: 3.349 ± 0.548
5.793ArgLeu: 5.793 ± 0.709
2.173ArgMet: 2.173 ± 0.473
3.349ArgAsn: 3.349 ± 0.569
2.535ArgPro: 2.535 ± 0.654
2.625ArgGln: 2.625 ± 0.588
5.25ArgArg: 5.25 ± 0.926
5.069ArgSer: 5.069 ± 0.653
3.53ArgThr: 3.53 ± 0.666
4.345ArgVal: 4.345 ± 0.678
1.629ArgTrp: 1.629 ± 0.505
2.535ArgTyr: 2.535 ± 0.488
0.0ArgXaa: 0.0 ± 0.0
Ser
6.97SerAla: 6.97 ± 0.883
0.181SerCys: 0.181 ± 0.137
4.074SerAsp: 4.074 ± 0.519
3.621SerGlu: 3.621 ± 0.467
1.539SerPhe: 1.539 ± 0.513
8.328SerGly: 8.328 ± 1.313
1.086SerHis: 1.086 ± 0.295
3.349SerIle: 3.349 ± 0.61
3.983SerLys: 3.983 ± 0.679
4.798SerLeu: 4.798 ± 0.628
1.177SerMet: 1.177 ± 0.328
3.078SerAsn: 3.078 ± 0.635
3.711SerPro: 3.711 ± 0.66
1.991SerGln: 1.991 ± 0.487
4.255SerArg: 4.255 ± 0.514
5.25SerSer: 5.25 ± 1.012
3.349SerThr: 3.349 ± 0.544
4.798SerVal: 4.798 ± 0.554
0.996SerTrp: 0.996 ± 0.457
2.354SerTyr: 2.354 ± 0.655
0.0SerXaa: 0.0 ± 0.0
Thr
7.966ThrAla: 7.966 ± 0.883
0.362ThrCys: 0.362 ± 0.235
3.168ThrAsp: 3.168 ± 0.585
2.716ThrGlu: 2.716 ± 0.463
1.72ThrPhe: 1.72 ± 0.351
5.069ThrGly: 5.069 ± 1.302
1.358ThrHis: 1.358 ± 0.562
2.173ThrIle: 2.173 ± 0.45
3.44ThrLys: 3.44 ± 0.747
4.888ThrLeu: 4.888 ± 0.849
0.905ThrMet: 0.905 ± 0.292
1.539ThrAsn: 1.539 ± 0.495
3.53ThrPro: 3.53 ± 0.752
2.625ThrGln: 2.625 ± 0.555
3.078ThrArg: 3.078 ± 0.472
3.349ThrSer: 3.349 ± 0.794
5.431ThrThr: 5.431 ± 0.866
3.892ThrVal: 3.892 ± 0.59
0.543ThrTrp: 0.543 ± 0.263
1.901ThrTyr: 1.901 ± 0.579
0.0ThrXaa: 0.0 ± 0.0
Val
6.699ValAla: 6.699 ± 1.006
0.724ValCys: 0.724 ± 0.393
4.707ValAsp: 4.707 ± 0.86
3.53ValGlu: 3.53 ± 0.627
2.535ValPhe: 2.535 ± 0.782
6.246ValGly: 6.246 ± 0.795
0.905ValHis: 0.905 ± 0.277
2.173ValIle: 2.173 ± 0.603
2.806ValLys: 2.806 ± 0.727
4.798ValLeu: 4.798 ± 0.671
1.72ValMet: 1.72 ± 0.447
2.716ValAsn: 2.716 ± 0.566
3.078ValPro: 3.078 ± 0.718
1.086ValGln: 1.086 ± 0.384
5.703ValArg: 5.703 ± 0.731
5.25ValSer: 5.25 ± 0.769
3.621ValThr: 3.621 ± 0.718
3.802ValVal: 3.802 ± 0.805
0.724ValTrp: 0.724 ± 0.299
1.629ValTyr: 1.629 ± 0.483
0.0ValXaa: 0.0 ± 0.0
Trp
1.358TrpAla: 1.358 ± 0.342
0.272TrpCys: 0.272 ± 0.165
0.815TrpAsp: 0.815 ± 0.247
0.815TrpGlu: 0.815 ± 0.309
0.634TrpPhe: 0.634 ± 0.337
1.539TrpGly: 1.539 ± 0.529
0.634TrpHis: 0.634 ± 0.238
0.453TrpIle: 0.453 ± 0.26
0.724TrpLys: 0.724 ± 0.221
2.082TrpLeu: 2.082 ± 0.553
0.453TrpMet: 0.453 ± 0.2
0.543TrpAsn: 0.543 ± 0.258
0.091TrpPro: 0.091 ± 0.107
0.543TrpGln: 0.543 ± 0.181
1.448TrpArg: 1.448 ± 0.409
1.629TrpSer: 1.629 ± 0.559
0.634TrpThr: 0.634 ± 0.278
1.448TrpVal: 1.448 ± 0.346
0.362TrpTrp: 0.362 ± 0.2
0.453TrpTyr: 0.453 ± 0.238
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.892TyrAla: 3.892 ± 0.733
0.453TyrCys: 0.453 ± 0.242
2.444TyrAsp: 2.444 ± 0.752
1.991TyrGlu: 1.991 ± 0.499
0.724TyrPhe: 0.724 ± 0.264
3.711TyrGly: 3.711 ± 0.7
0.453TyrHis: 0.453 ± 0.233
0.996TyrIle: 0.996 ± 0.404
2.173TyrLys: 2.173 ± 0.43
1.991TyrLeu: 1.991 ± 0.415
0.453TyrMet: 0.453 ± 0.181
1.267TyrAsn: 1.267 ± 0.318
1.267TyrPro: 1.267 ± 0.448
0.634TyrGln: 0.634 ± 0.238
1.991TyrArg: 1.991 ± 0.501
2.444TyrSer: 2.444 ± 0.566
1.629TyrThr: 1.629 ± 0.393
2.444TyrVal: 2.444 ± 0.425
0.815TyrTrp: 0.815 ± 0.347
0.724TyrTyr: 0.724 ± 0.291
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (11048 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski