Amino acid dipepetide frequency for Rotavirus B (isolate RVB/Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.553AlaAla: 4.553 ± 0.715
0.876AlaCys: 0.876 ± 0.295
3.152AlaAsp: 3.152 ± 1.203
4.027AlaGlu: 4.027 ± 0.712
1.926AlaPhe: 1.926 ± 0.472
1.576AlaGly: 1.576 ± 0.702
1.051AlaHis: 1.051 ± 0.507
4.553AlaIle: 4.553 ± 0.619
3.152AlaLys: 3.152 ± 0.752
5.428AlaLeu: 5.428 ± 0.882
1.226AlaMet: 1.226 ± 0.524
2.276AlaAsn: 2.276 ± 0.531
1.401AlaPro: 1.401 ± 0.782
3.152AlaGln: 3.152 ± 0.682
2.977AlaArg: 2.977 ± 0.882
5.078AlaSer: 5.078 ± 1.129
4.903AlaThr: 4.903 ± 0.716
3.327AlaVal: 3.327 ± 0.74
1.051AlaTrp: 1.051 ± 0.31
2.101AlaTyr: 2.101 ± 0.429
0.0AlaXaa: 0.0 ± 0.0
Cys
0.876CysAla: 0.876 ± 0.344
0.525CysCys: 0.525 ± 0.271
0.7CysAsp: 0.7 ± 0.43
0.876CysGlu: 0.876 ± 0.393
0.7CysPhe: 0.7 ± 0.34
2.101CysGly: 2.101 ± 0.68
0.35CysHis: 0.35 ± 0.228
0.175CysIle: 0.175 ± 0.156
0.0CysLys: 0.0 ± 0.0
0.7CysLeu: 0.7 ± 0.426
0.175CysMet: 0.175 ± 0.185
1.051CysAsn: 1.051 ± 0.402
0.7CysPro: 0.7 ± 0.587
0.876CysGln: 0.876 ± 0.307
0.7CysArg: 0.7 ± 0.323
1.401CysSer: 1.401 ± 0.589
0.35CysThr: 0.35 ± 0.232
0.876CysVal: 0.876 ± 0.476
0.0CysTrp: 0.0 ± 0.0
0.525CysTyr: 0.525 ± 0.328
0.0CysXaa: 0.0 ± 0.0
Asp
4.378AspAla: 4.378 ± 1.351
0.175AspCys: 0.175 ± 0.18
5.078AspAsp: 5.078 ± 1.564
3.327AspGlu: 3.327 ± 0.774
2.451AspPhe: 2.451 ± 0.729
2.802AspGly: 2.802 ± 0.789
1.576AspHis: 1.576 ± 0.614
5.078AspIle: 5.078 ± 0.744
4.027AspLys: 4.027 ± 0.741
5.778AspLeu: 5.778 ± 0.733
1.576AspMet: 1.576 ± 0.581
3.327AspAsn: 3.327 ± 0.783
1.576AspPro: 1.576 ± 0.643
1.926AspGln: 1.926 ± 0.483
4.378AspArg: 4.378 ± 0.896
5.253AspSer: 5.253 ± 0.462
2.802AspThr: 2.802 ± 0.419
5.253AspVal: 5.253 ± 0.748
1.576AspTrp: 1.576 ± 0.439
3.152AspTyr: 3.152 ± 0.593
0.0AspXaa: 0.0 ± 0.0
Glu
2.802GluAla: 2.802 ± 0.893
0.876GluCys: 0.876 ± 0.324
4.378GluAsp: 4.378 ± 0.821
4.553GluGlu: 4.553 ± 1.452
2.101GluPhe: 2.101 ± 0.553
1.576GluGly: 1.576 ± 0.635
1.226GluHis: 1.226 ± 0.49
5.428GluIle: 5.428 ± 1.067
3.677GluLys: 3.677 ± 0.737
3.677GluLeu: 3.677 ± 0.739
2.627GluMet: 2.627 ± 0.586
2.451GluAsn: 2.451 ± 1.069
1.051GluPro: 1.051 ± 0.356
2.451GluGln: 2.451 ± 0.592
3.152GluArg: 3.152 ± 0.653
2.977GluSer: 2.977 ± 0.489
3.502GluThr: 3.502 ± 1.037
2.802GluVal: 2.802 ± 0.651
0.7GluTrp: 0.7 ± 0.25
2.101GluTyr: 2.101 ± 0.478
0.0GluXaa: 0.0 ± 0.0
Phe
2.977PheAla: 2.977 ± 0.685
0.7PheCys: 0.7 ± 0.436
2.101PheAsp: 2.101 ± 1.105
3.327PheGlu: 3.327 ± 0.652
1.576PhePhe: 1.576 ± 0.611
2.627PheGly: 2.627 ± 0.794
1.576PheHis: 1.576 ± 0.525
2.627PheIle: 2.627 ± 0.627
2.451PheLys: 2.451 ± 0.721
2.101PheLeu: 2.101 ± 0.528
1.226PheMet: 1.226 ± 0.471
3.502PheAsn: 3.502 ± 1.081
1.751PhePro: 1.751 ± 0.546
1.576PheGln: 1.576 ± 0.512
2.101PheArg: 2.101 ± 0.574
5.078PheSer: 5.078 ± 1.392
4.027PheThr: 4.027 ± 0.573
1.926PheVal: 1.926 ± 0.919
0.35PheTrp: 0.35 ± 0.257
1.226PheTyr: 1.226 ± 0.392
0.0PheXaa: 0.0 ± 0.0
Gly
1.401GlyAla: 1.401 ± 0.252
0.525GlyCys: 0.525 ± 0.341
2.627GlyAsp: 2.627 ± 0.726
1.926GlyGlu: 1.926 ± 0.935
2.451GlyPhe: 2.451 ± 0.999
2.276GlyGly: 2.276 ± 0.53
0.876GlyHis: 0.876 ± 0.451
2.451GlyIle: 2.451 ± 0.451
2.802GlyLys: 2.802 ± 0.677
2.802GlyLeu: 2.802 ± 0.623
2.276GlyMet: 2.276 ± 0.567
3.327GlyAsn: 3.327 ± 0.644
0.7GlyPro: 0.7 ± 0.183
1.226GlyGln: 1.226 ± 0.673
1.576GlyArg: 1.576 ± 0.482
1.751GlySer: 1.751 ± 0.547
2.802GlyThr: 2.802 ± 0.681
3.677GlyVal: 3.677 ± 0.747
0.35GlyTrp: 0.35 ± 0.299
1.751GlyTyr: 1.751 ± 0.447
0.0GlyXaa: 0.0 ± 0.0
His
0.876HisAla: 0.876 ± 0.301
0.0HisCys: 0.0 ± 0.0
1.226HisAsp: 1.226 ± 0.454
1.226HisGlu: 1.226 ± 0.583
0.876HisPhe: 0.876 ± 0.61
1.401HisGly: 1.401 ± 0.591
0.525HisHis: 0.525 ± 0.297
2.802HisIle: 2.802 ± 0.819
0.525HisLys: 0.525 ± 0.252
2.627HisLeu: 2.627 ± 0.864
0.876HisMet: 0.876 ± 0.23
0.876HisAsn: 0.876 ± 0.322
0.876HisPro: 0.876 ± 0.512
0.7HisGln: 0.7 ± 0.275
2.101HisArg: 2.101 ± 0.414
1.401HisSer: 1.401 ± 0.482
1.226HisThr: 1.226 ± 0.607
1.401HisVal: 1.401 ± 0.437
0.0HisTrp: 0.0 ± 0.0
0.7HisTyr: 0.7 ± 0.329
0.0HisXaa: 0.0 ± 0.0
Ile
4.728IleAla: 4.728 ± 0.902
0.525IleCys: 0.525 ± 0.299
5.078IleAsp: 5.078 ± 0.741
5.603IleGlu: 5.603 ± 1.141
2.627IlePhe: 2.627 ± 0.703
2.276IleGly: 2.276 ± 0.708
1.226IleHis: 1.226 ± 0.368
6.654IleIle: 6.654 ± 0.995
5.078IleLys: 5.078 ± 1.457
6.654IleLeu: 6.654 ± 0.847
2.276IleMet: 2.276 ± 0.497
5.428IleAsn: 5.428 ± 0.715
3.677IlePro: 3.677 ± 0.595
4.728IleGln: 4.728 ± 0.72
4.553IleArg: 4.553 ± 0.644
5.953IleSer: 5.953 ± 0.689
3.852IleThr: 3.852 ± 1.055
3.327IleVal: 3.327 ± 0.606
0.175IleTrp: 0.175 ± 0.185
2.276IleTyr: 2.276 ± 0.692
0.0IleXaa: 0.0 ± 0.0
Lys
3.852LysAla: 3.852 ± 0.872
1.051LysCys: 1.051 ± 0.432
2.977LysAsp: 2.977 ± 0.749
3.852LysGlu: 3.852 ± 0.873
3.502LysPhe: 3.502 ± 0.87
1.401LysGly: 1.401 ± 0.358
1.051LysHis: 1.051 ± 0.505
6.129LysIle: 6.129 ± 1.22
3.152LysLys: 3.152 ± 0.563
7.529LysLeu: 7.529 ± 0.978
1.751LysMet: 1.751 ± 0.747
2.977LysAsn: 2.977 ± 0.868
2.276LysPro: 2.276 ± 0.432
3.677LysGln: 3.677 ± 0.924
3.852LysArg: 3.852 ± 0.834
3.502LysSer: 3.502 ± 0.618
5.428LysThr: 5.428 ± 0.392
1.926LysVal: 1.926 ± 0.538
0.7LysTrp: 0.7 ± 0.455
2.276LysTyr: 2.276 ± 0.502
0.0LysXaa: 0.0 ± 0.0
Leu
5.253LeuAla: 5.253 ± 1.406
1.401LeuCys: 1.401 ± 0.687
5.078LeuAsp: 5.078 ± 1.18
4.027LeuGlu: 4.027 ± 0.998
3.152LeuPhe: 3.152 ± 0.656
3.852LeuGly: 3.852 ± 0.875
2.627LeuHis: 2.627 ± 0.601
6.479LeuIle: 6.479 ± 1.203
5.428LeuLys: 5.428 ± 0.66
9.631LeuLeu: 9.631 ± 2.261
1.226LeuMet: 1.226 ± 0.616
5.953LeuAsn: 5.953 ± 0.794
2.802LeuPro: 2.802 ± 0.7
2.977LeuGln: 2.977 ± 0.365
4.378LeuArg: 4.378 ± 0.887
9.455LeuSer: 9.455 ± 1.19
5.253LeuThr: 5.253 ± 0.926
4.903LeuVal: 4.903 ± 0.802
0.525LeuTrp: 0.525 ± 0.228
4.027LeuTyr: 4.027 ± 1.697
0.0LeuXaa: 0.0 ± 0.0
Met
1.926MetAla: 1.926 ± 0.528
0.876MetCys: 0.876 ± 0.432
1.926MetAsp: 1.926 ± 0.728
1.051MetGlu: 1.051 ± 0.565
1.226MetPhe: 1.226 ± 0.439
0.876MetGly: 0.876 ± 0.334
0.525MetHis: 0.525 ± 0.207
1.751MetIle: 1.751 ± 0.497
1.576MetLys: 1.576 ± 0.543
2.977MetLeu: 2.977 ± 0.564
0.7MetMet: 0.7 ± 0.526
2.276MetAsn: 2.276 ± 0.749
0.876MetPro: 0.876 ± 0.435
1.051MetGln: 1.051 ± 0.505
1.576MetArg: 1.576 ± 0.499
2.101MetSer: 2.101 ± 0.45
2.451MetThr: 2.451 ± 0.481
0.876MetVal: 0.876 ± 0.438
0.0MetTrp: 0.0 ± 0.0
1.576MetTyr: 1.576 ± 0.313
0.0MetXaa: 0.0 ± 0.0
Asn
4.553AsnAla: 4.553 ± 0.845
1.051AsnCys: 1.051 ± 0.352
3.152AsnAsp: 3.152 ± 0.871
1.751AsnGlu: 1.751 ± 0.612
3.502AsnPhe: 3.502 ± 0.621
2.276AsnGly: 2.276 ± 0.69
1.226AsnHis: 1.226 ± 0.4
4.728AsnIle: 4.728 ± 1.261
2.977AsnLys: 2.977 ± 0.85
5.778AsnLeu: 5.778 ± 0.757
1.576AsnMet: 1.576 ± 0.533
2.276AsnAsn: 2.276 ± 0.471
2.276AsnPro: 2.276 ± 0.621
2.276AsnGln: 2.276 ± 0.926
3.502AsnArg: 3.502 ± 0.854
6.129AsnSer: 6.129 ± 1.425
3.152AsnThr: 3.152 ± 0.554
4.903AsnVal: 4.903 ± 0.856
1.051AsnTrp: 1.051 ± 0.481
2.276AsnTyr: 2.276 ± 0.849
0.0AsnXaa: 0.0 ± 0.0
Pro
2.101ProAla: 2.101 ± 0.614
0.35ProCys: 0.35 ± 0.237
1.751ProAsp: 1.751 ± 0.645
2.627ProGlu: 2.627 ± 0.43
1.226ProPhe: 1.226 ± 0.615
2.101ProGly: 2.101 ± 0.67
0.0ProHis: 0.0 ± 0.0
2.276ProIle: 2.276 ± 0.704
2.101ProLys: 2.101 ± 0.727
2.627ProLeu: 2.627 ± 0.596
1.401ProMet: 1.401 ± 0.48
2.451ProAsn: 2.451 ± 0.676
0.525ProPro: 0.525 ± 0.29
1.051ProGln: 1.051 ± 0.329
1.401ProArg: 1.401 ± 0.566
3.677ProSer: 3.677 ± 0.649
3.502ProThr: 3.502 ± 0.845
1.926ProVal: 1.926 ± 0.653
0.525ProTrp: 0.525 ± 0.21
2.276ProTyr: 2.276 ± 0.422
0.0ProXaa: 0.0 ± 0.0
Gln
1.751GlnAla: 1.751 ± 0.599
0.7GlnCys: 0.7 ± 0.327
1.751GlnAsp: 1.751 ± 0.437
1.576GlnGlu: 1.576 ± 0.558
1.926GlnPhe: 1.926 ± 0.335
1.751GlnGly: 1.751 ± 0.644
1.751GlnHis: 1.751 ± 0.544
4.027GlnIle: 4.027 ± 0.727
3.327GlnLys: 3.327 ± 0.75
3.852GlnLeu: 3.852 ± 0.641
1.226GlnMet: 1.226 ± 0.493
2.101GlnAsn: 2.101 ± 0.968
1.576GlnPro: 1.576 ± 0.542
1.751GlnGln: 1.751 ± 0.479
2.101GlnArg: 2.101 ± 0.544
4.378GlnSer: 4.378 ± 0.661
2.101GlnThr: 2.101 ± 0.309
1.576GlnVal: 1.576 ± 0.537
0.525GlnTrp: 0.525 ± 0.313
1.576GlnTyr: 1.576 ± 0.347
0.0GlnXaa: 0.0 ± 0.0
Arg
2.451ArgAla: 2.451 ± 0.453
0.7ArgCys: 0.7 ± 0.306
2.802ArgAsp: 2.802 ± 0.768
3.677ArgGlu: 3.677 ± 1.374
3.152ArgPhe: 3.152 ± 0.812
1.576ArgGly: 1.576 ± 0.522
1.051ArgHis: 1.051 ± 0.476
4.027ArgIle: 4.027 ± 0.728
3.677ArgLys: 3.677 ± 0.819
4.378ArgLeu: 4.378 ± 0.931
1.576ArgMet: 1.576 ± 0.532
3.677ArgAsn: 3.677 ± 0.51
2.977ArgPro: 2.977 ± 0.732
2.101ArgGln: 2.101 ± 0.58
2.101ArgArg: 2.101 ± 0.588
3.152ArgSer: 3.152 ± 0.782
3.677ArgThr: 3.677 ± 1.061
3.152ArgVal: 3.152 ± 0.956
0.525ArgTrp: 0.525 ± 0.275
1.401ArgTyr: 1.401 ± 0.379
0.0ArgXaa: 0.0 ± 0.0
Ser
4.027SerAla: 4.027 ± 1.124
1.751SerCys: 1.751 ± 0.382
8.755SerAsp: 8.755 ± 1.058
2.802SerGlu: 2.802 ± 0.922
4.378SerPhe: 4.378 ± 0.634
2.977SerGly: 2.977 ± 0.9
1.576SerHis: 1.576 ± 0.544
6.479SerIle: 6.479 ± 0.65
7.529SerLys: 7.529 ± 1.181
5.953SerLeu: 5.953 ± 0.708
2.627SerMet: 2.627 ± 0.453
4.378SerAsn: 4.378 ± 0.834
4.378SerPro: 4.378 ± 1.018
3.152SerGln: 3.152 ± 0.709
3.327SerArg: 3.327 ± 1.0
7.179SerSer: 7.179 ± 1.734
3.852SerThr: 3.852 ± 0.621
4.378SerVal: 4.378 ± 0.944
0.175SerTrp: 0.175 ± 0.156
3.327SerTyr: 3.327 ± 0.936
0.0SerXaa: 0.0 ± 0.0
Thr
3.677ThrAla: 3.677 ± 0.619
0.525ThrCys: 0.525 ± 0.397
4.027ThrAsp: 4.027 ± 0.783
2.802ThrGlu: 2.802 ± 0.766
3.502ThrPhe: 3.502 ± 0.593
2.977ThrGly: 2.977 ± 0.743
0.876ThrHis: 0.876 ± 0.382
4.728ThrIle: 4.728 ± 0.906
3.677ThrLys: 3.677 ± 0.926
6.304ThrLeu: 6.304 ± 0.705
1.226ThrMet: 1.226 ± 0.243
3.327ThrAsn: 3.327 ± 0.842
2.627ThrPro: 2.627 ± 0.63
3.152ThrGln: 3.152 ± 0.826
2.802ThrArg: 2.802 ± 0.655
5.428ThrSer: 5.428 ± 0.711
3.852ThrThr: 3.852 ± 0.783
5.253ThrVal: 5.253 ± 0.697
0.525ThrTrp: 0.525 ± 0.357
3.327ThrTyr: 3.327 ± 0.472
0.0ThrXaa: 0.0 ± 0.0
Val
2.977ValAla: 2.977 ± 0.966
0.525ValCys: 0.525 ± 0.227
4.553ValAsp: 4.553 ± 0.981
3.152ValGlu: 3.152 ± 0.481
2.977ValPhe: 2.977 ± 0.809
1.576ValGly: 1.576 ± 0.37
1.401ValHis: 1.401 ± 0.479
2.802ValIle: 2.802 ± 0.792
3.852ValLys: 3.852 ± 0.784
5.603ValLeu: 5.603 ± 0.864
0.876ValMet: 0.876 ± 0.331
5.078ValAsn: 5.078 ± 0.953
2.802ValPro: 2.802 ± 0.584
1.401ValGln: 1.401 ± 0.442
2.276ValArg: 2.276 ± 0.704
4.903ValSer: 4.903 ± 0.786
4.027ValThr: 4.027 ± 0.632
3.502ValVal: 3.502 ± 0.734
0.876ValTrp: 0.876 ± 0.357
3.152ValTyr: 3.152 ± 0.702
0.0ValXaa: 0.0 ± 0.0
Trp
0.876TrpAla: 0.876 ± 0.329
0.175TrpCys: 0.175 ± 0.185
0.35TrpAsp: 0.35 ± 0.197
0.0TrpGlu: 0.0 ± 0.0
0.175TrpPhe: 0.175 ± 0.181
0.175TrpGly: 0.175 ± 0.181
0.175TrpHis: 0.175 ± 0.185
0.876TrpIle: 0.876 ± 0.458
1.226TrpLys: 1.226 ± 0.409
1.226TrpLeu: 1.226 ± 0.412
0.175TrpMet: 0.175 ± 0.156
1.051TrpAsn: 1.051 ± 0.42
0.175TrpPro: 0.175 ± 0.185
0.525TrpGln: 0.525 ± 0.328
0.7TrpArg: 0.7 ± 0.24
0.525TrpSer: 0.525 ± 0.274
0.7TrpThr: 0.7 ± 0.344
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.525TrpTyr: 0.525 ± 0.271
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.751TyrAla: 1.751 ± 0.541
0.35TyrCys: 0.35 ± 0.223
4.027TyrAsp: 4.027 ± 0.654
1.926TyrGlu: 1.926 ± 0.437
1.401TyrPhe: 1.401 ± 0.228
1.401TyrGly: 1.401 ± 0.592
1.576TyrHis: 1.576 ± 0.439
2.627TyrIle: 2.627 ± 0.914
2.627TyrLys: 2.627 ± 0.396
2.802TyrLeu: 2.802 ± 0.685
1.401TyrMet: 1.401 ± 0.431
2.802TyrAsn: 2.802 ± 0.625
0.876TyrPro: 0.876 ± 0.265
1.576TyrGln: 1.576 ± 0.375
2.276TyrArg: 2.276 ± 0.684
3.677TyrSer: 3.677 ± 1.02
3.152TyrThr: 3.152 ± 0.754
3.327TyrVal: 3.327 ± 0.895
0.0TyrTrp: 0.0 ± 0.0
1.576TyrTyr: 1.576 ± 0.489
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (5712 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski