Amino acid dipepetide frequency for Pigmentiphaga humi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.256AlaAla: 19.256 ± 0.184	1.513AlaCys: 1.513 ± 0.034	7.18AlaAsp: 7.18 ± 0.084	6.926AlaGlu: 6.926 ± 0.077	3.87AlaPhe: 3.87 ± 0.051	12.271AlaGly: 12.271 ± 0.108	2.674AlaHis: 2.674 ± 0.04	5.451AlaIle: 5.451 ± 0.068	3.255AlaLys: 3.255 ± 0.064	14.367AlaLeu: 14.367 ± 0.132	3.528AlaMet: 3.528 ± 0.058	2.672AlaAsn: 2.672 ± 0.047	6.659AlaPro: 6.659 ± 0.076	5.412AlaGln: 5.412 ± 0.068	10.539AlaArg: 10.539 ± 0.116	6.832AlaSer: 6.832 ± 0.076	5.444AlaThr: 5.444 ± 0.063	9.195AlaVal: 9.195 ± 0.081	1.971AlaTrp: 1.971 ± 0.042	2.712AlaTyr: 2.712 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.225CysAla: 1.225 ± 0.03	0.126CysCys: 0.126 ± 0.01	0.514CysAsp: 0.514 ± 0.023	0.486CysGlu: 0.486 ± 0.018	0.31CysPhe: 0.31 ± 0.014	1.029CysGly: 1.029 ± 0.032	0.257CysHis: 0.257 ± 0.014	0.378CysIle: 0.378 ± 0.017	0.189CysLys: 0.189 ± 0.01	0.896CysLeu: 0.896 ± 0.027	0.212CysMet: 0.212 ± 0.012	0.237CysAsn: 0.237 ± 0.013	0.51CysPro: 0.51 ± 0.019	0.247CysGln: 0.247 ± 0.012	0.684CysArg: 0.684 ± 0.022	0.455CysSer: 0.455 ± 0.019	0.486CysThr: 0.486 ± 0.02	0.733CysVal: 0.733 ± 0.021	0.132CysTrp: 0.132 ± 0.009	0.217CysTyr: 0.217 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.315AspAla: 7.315 ± 0.116	0.462AspCys: 0.462 ± 0.019	2.877AspAsp: 2.877 ± 0.053	3.234AspGlu: 3.234 ± 0.044	2.081AspPhe: 2.081 ± 0.037	4.856AspGly: 4.856 ± 0.079	1.101AspHis: 1.101 ± 0.031	2.588AspIle: 2.588 ± 0.052	1.47AspLys: 1.47 ± 0.035	5.596AspLeu: 5.596 ± 0.057	1.361AspMet: 1.361 ± 0.029	1.116AspAsn: 1.116 ± 0.029	3.444AspPro: 3.444 ± 0.053	1.525AspGln: 1.525 ± 0.03	3.71AspArg: 3.71 ± 0.053	2.205AspSer: 2.205 ± 0.041	2.696AspThr: 2.696 ± 0.061	4.111AspVal: 4.111 ± 0.06	0.959AspTrp: 0.959 ± 0.025	1.546AspTyr: 1.546 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.982GluAla: 6.982 ± 0.081	0.389GluCys: 0.389 ± 0.019	2.373GluAsp: 2.373 ± 0.064	2.727GluGlu: 2.727 ± 0.05	1.82GluPhe: 1.82 ± 0.039	3.715GluGly: 3.715 ± 0.052	1.398GluHis: 1.398 ± 0.031	2.755GluIle: 2.755 ± 0.046	1.568GluLys: 1.568 ± 0.035	6.189GluLeu: 6.189 ± 0.074	1.245GluMet: 1.245 ± 0.028	1.358GluAsn: 1.358 ± 0.033	2.647GluPro: 2.647 ± 0.048	2.64GluGln: 2.64 ± 0.04	5.012GluArg: 5.012 ± 0.062	2.734GluSer: 2.734 ± 0.052	2.743GluThr: 2.743 ± 0.059	3.764GluVal: 3.764 ± 0.048	0.719GluTrp: 0.719 ± 0.025	1.114GluTyr: 1.114 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.02PheAla: 4.02 ± 0.055	0.405PheCys: 0.405 ± 0.017	2.402PheAsp: 2.402 ± 0.041	2.036PheGlu: 2.036 ± 0.035	1.189PhePhe: 1.189 ± 0.034	3.156PheGly: 3.156 ± 0.052	0.755PheHis: 0.755 ± 0.02	1.394PheIle: 1.394 ± 0.033	0.979PheLys: 0.979 ± 0.025	2.967PheLeu: 2.967 ± 0.048	0.737PheMet: 0.737 ± 0.019	0.969PheAsn: 0.969 ± 0.026	1.631PhePro: 1.631 ± 0.031	0.972PheGln: 0.972 ± 0.026	2.057PheArg: 2.057 ± 0.038	2.066PheSer: 2.066 ± 0.037	1.764PheThr: 1.764 ± 0.053	2.607PheVal: 2.607 ± 0.043	0.425PheTrp: 0.425 ± 0.019	0.837PheTyr: 0.837 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.74GlyAla: 9.74 ± 0.101	0.86GlyCys: 0.86 ± 0.024	3.897GlyAsp: 3.897 ± 0.059	4.482GlyGlu: 4.482 ± 0.056	3.056GlyPhe: 3.056 ± 0.045	7.401GlyGly: 7.401 ± 0.103	1.956GlyHis: 1.956 ± 0.041	4.149GlyIle: 4.149 ± 0.058	3.089GlyLys: 3.089 ± 0.048	8.941GlyLeu: 8.941 ± 0.09	2.606GlyMet: 2.606 ± 0.038	2.166GlyAsn: 2.166 ± 0.047	3.484GlyPro: 3.484 ± 0.056	3.412GlyGln: 3.412 ± 0.072	6.519GlyArg: 6.519 ± 0.078	5.002GlySer: 5.002 ± 0.077	4.715GlyThr: 4.715 ± 0.091	6.409GlyVal: 6.409 ± 0.073	1.412GlyTrp: 1.412 ± 0.032	2.549GlyTyr: 2.549 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	3.05HisAla: 3.05 ± 0.047	0.249HisCys: 0.249 ± 0.013	1.206HisAsp: 1.206 ± 0.033	1.122HisGlu: 1.122 ± 0.034	0.844HisPhe: 0.844 ± 0.021	2.238HisGly: 2.238 ± 0.044	0.588HisHis: 0.588 ± 0.021	1.019HisIle: 1.019 ± 0.031	0.422HisLys: 0.422 ± 0.018	2.19HisLeu: 2.19 ± 0.038	0.49HisMet: 0.49 ± 0.019	0.458HisAsn: 0.458 ± 0.016	1.714HisPro: 1.714 ± 0.033	0.626HisGln: 0.626 ± 0.02	1.616HisArg: 1.616 ± 0.04	0.959HisSer: 0.959 ± 0.027	1.025HisThr: 1.025 ± 0.026	1.77HisVal: 1.77 ± 0.038	0.342HisTrp: 0.342 ± 0.016	0.606HisTyr: 0.606 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.256IleAla: 6.256 ± 0.067	0.383IleCys: 0.383 ± 0.016	3.104IleAsp: 3.104 ± 0.065	3.043IleGlu: 3.043 ± 0.044	1.201IlePhe: 1.201 ± 0.027	4.173IleGly: 4.173 ± 0.058	0.885IleHis: 0.885 ± 0.023	1.493IleIle: 1.493 ± 0.034	1.293IleLys: 1.293 ± 0.033	3.452IleLeu: 3.452 ± 0.051	0.8IleMet: 0.8 ± 0.024	1.172IleAsn: 1.172 ± 0.029	2.239IlePro: 2.239 ± 0.042	1.289IleGln: 1.289 ± 0.029	2.996IleArg: 2.996 ± 0.044	2.316IleSer: 2.316 ± 0.04	2.098IleThr: 2.098 ± 0.087	3.856IleVal: 3.856 ± 0.065	0.473IleTrp: 0.473 ± 0.016	0.963IleTyr: 0.963 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.315LysAla: 3.315 ± 0.059	0.13LysCys: 0.13 ± 0.009	1.363LysAsp: 1.363 ± 0.034	1.394LysGlu: 1.394 ± 0.037	0.715LysPhe: 0.715 ± 0.022	2.02LysGly: 2.02 ± 0.04	0.543LysHis: 0.543 ± 0.023	1.23LysIle: 1.23 ± 0.032	0.996LysLys: 0.996 ± 0.038	3.18LysLeu: 3.18 ± 0.051	0.665LysMet: 0.665 ± 0.021	0.795LysAsn: 0.795 ± 0.024	1.808LysPro: 1.808 ± 0.038	1.156LysGln: 1.156 ± 0.033	2.036LysArg: 2.036 ± 0.04	1.555LysSer: 1.555 ± 0.036	1.583LysThr: 1.583 ± 0.034	2.103LysVal: 2.103 ± 0.035	0.378LysTrp: 0.378 ± 0.014	0.603LysTyr: 0.603 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.787LeuAla: 15.787 ± 0.128	1.016LeuCys: 1.016 ± 0.023	6.347LeuAsp: 6.347 ± 0.073	5.48LeuGlu: 5.48 ± 0.081	3.4LeuPhe: 3.4 ± 0.058	8.794LeuGly: 8.794 ± 0.079	2.329LeuHis: 2.329 ± 0.044	4.01LeuIle: 4.01 ± 0.061	3.025LeuLys: 3.025 ± 0.05	10.653LeuLeu: 10.653 ± 0.129	2.284LeuMet: 2.284 ± 0.042	2.5LeuAsn: 2.5 ± 0.038	6.47LeuPro: 6.47 ± 0.073	3.546LeuGln: 3.546 ± 0.05	8.175LeuArg: 8.175 ± 0.096	5.913LeuSer: 5.913 ± 0.065	4.833LeuThr: 4.833 ± 0.074	7.543LeuVal: 7.543 ± 0.082	1.19LeuTrp: 1.19 ± 0.027	2.161LeuTyr: 2.161 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.1MetAla: 3.1 ± 0.048	0.171MetCys: 0.171 ± 0.011	1.131MetAsp: 1.131 ± 0.028	1.079MetGlu: 1.079 ± 0.031	0.684MetPhe: 0.684 ± 0.022	1.771MetGly: 1.771 ± 0.038	0.547MetHis: 0.547 ± 0.018	0.959MetIle: 0.959 ± 0.027	0.896MetLys: 0.896 ± 0.031	2.823MetLeu: 2.823 ± 0.048	0.586MetMet: 0.586 ± 0.019	0.839MetAsn: 0.839 ± 0.025	1.616MetPro: 1.616 ± 0.035	1.07MetGln: 1.07 ± 0.028	1.898MetArg: 1.898 ± 0.035	1.562MetSer: 1.562 ± 0.033	1.475MetThr: 1.475 ± 0.027	1.633MetVal: 1.633 ± 0.033	0.203MetTrp: 0.203 ± 0.012	0.359MetTyr: 0.359 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.883AsnAla: 2.883 ± 0.047	0.214AsnCys: 0.214 ± 0.011	1.269AsnAsp: 1.269 ± 0.041	1.121AsnGlu: 1.121 ± 0.024	0.85AsnPhe: 0.85 ± 0.025	2.1AsnGly: 2.1 ± 0.048	0.508AsnHis: 0.508 ± 0.016	1.146AsnIle: 1.146 ± 0.029	0.659AsnLys: 0.659 ± 0.022	2.441AsnLeu: 2.441 ± 0.04	0.56AsnMet: 0.56 ± 0.02	0.628AsnAsn: 0.628 ± 0.019	1.704AsnPro: 1.704 ± 0.036	0.77AsnGln: 0.77 ± 0.024	1.796AsnArg: 1.796 ± 0.035	1.091AsnSer: 1.091 ± 0.031	1.242AsnThr: 1.242 ± 0.027	1.892AsnVal: 1.892 ± 0.036	0.412AsnTrp: 0.412 ± 0.021	0.688AsnTyr: 0.688 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	8.27ProAla: 8.27 ± 0.091	0.383ProCys: 0.383 ± 0.015	3.79ProAsp: 3.79 ± 0.051	3.591ProGlu: 3.591 ± 0.048	1.843ProPhe: 1.843 ± 0.037	5.455ProGly: 5.455 ± 0.062	1.26ProHis: 1.26 ± 0.03	2.125ProIle: 2.125 ± 0.039	1.19ProLys: 1.19 ± 0.032	5.341ProLeu: 5.341 ± 0.063	1.29ProMet: 1.29 ± 0.03	1.19ProAsn: 1.19 ± 0.036	2.972ProPro: 2.972 ± 0.059	2.009ProGln: 2.009 ± 0.036	3.402ProArg: 3.402 ± 0.053	2.958ProSer: 2.958 ± 0.05	2.353ProThr: 2.353 ± 0.035	4.63ProVal: 4.63 ± 0.062	0.798ProTrp: 0.798 ± 0.024	1.551ProTyr: 1.551 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	6.022GlnAla: 6.022 ± 0.072	0.298GlnCys: 0.298 ± 0.014	1.701GlnAsp: 1.701 ± 0.038	1.839GlnGlu: 1.839 ± 0.038	1.09GlnPhe: 1.09 ± 0.025	2.967GlnGly: 2.967 ± 0.041	0.807GlnHis: 0.807 ± 0.021	1.634GlnIle: 1.634 ± 0.038	0.863GlnLys: 0.863 ± 0.025	3.633GlnLeu: 3.633 ± 0.05	0.896GlnMet: 0.896 ± 0.025	0.73GlnAsn: 0.73 ± 0.022	2.282GlnPro: 2.282 ± 0.037	1.556GlnGln: 1.556 ± 0.042	3.096GlnArg: 3.096 ± 0.051	1.828GlnSer: 1.828 ± 0.04	1.7GlnThr: 1.7 ± 0.034	2.725GlnVal: 2.725 ± 0.044	0.604GlnTrp: 0.604 ± 0.019	0.786GlnTyr: 0.786 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.862ArgAla: 8.862 ± 0.102	0.666ArgCys: 0.666 ± 0.021	3.928ArgAsp: 3.928 ± 0.055	4.456ArgGlu: 4.456 ± 0.052	2.778ArgPhe: 2.778 ± 0.045	5.182ArgGly: 5.182 ± 0.07	2.117ArgHis: 2.117 ± 0.045	4.032ArgIle: 4.032 ± 0.054	2.183ArgLys: 2.183 ± 0.042	8.589ArgLeu: 8.589 ± 0.095	2.073ArgMet: 2.073 ± 0.034	1.924ArgAsn: 1.924 ± 0.035	3.974ArgPro: 3.974 ± 0.054	3.281ArgGln: 3.281 ± 0.058	6.188ArgArg: 6.188 ± 0.094	3.803ArgSer: 3.803 ± 0.055	3.611ArgThr: 3.611 ± 0.051	5.147ArgVal: 5.147 ± 0.074	1.159ArgTrp: 1.159 ± 0.029	2.196ArgTyr: 2.196 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.438SerAla: 6.438 ± 0.074	0.496SerCys: 0.496 ± 0.019	2.499SerAsp: 2.499 ± 0.039	2.467SerGlu: 2.467 ± 0.046	2.009SerPhe: 2.009 ± 0.038	5.39SerGly: 5.39 ± 0.077	1.19SerHis: 1.19 ± 0.026	2.334SerIle: 2.334 ± 0.044	1.289SerLys: 1.289 ± 0.035	5.602SerLeu: 5.602 ± 0.072	1.435SerMet: 1.435 ± 0.029	1.269SerAsn: 1.269 ± 0.031	3.032SerPro: 3.032 ± 0.045	1.769SerGln: 1.769 ± 0.036	3.943SerArg: 3.943 ± 0.053	3.171SerSer: 3.171 ± 0.048	2.73SerThr: 2.73 ± 0.055	3.919SerVal: 3.919 ± 0.057	0.792SerTrp: 0.792 ± 0.024	1.337SerTyr: 1.337 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.425ThrAla: 5.425 ± 0.066	0.385ThrCys: 0.385 ± 0.015	2.479ThrAsp: 2.479 ± 0.078	2.253ThrGlu: 2.253 ± 0.047	1.61ThrPhe: 1.61 ± 0.045	4.637ThrGly: 4.637 ± 0.086	1.119ThrHis: 1.119 ± 0.034	2.133ThrIle: 2.133 ± 0.09	0.948ThrLys: 0.948 ± 0.026	6.055ThrLeu: 6.055 ± 0.071	1.113ThrMet: 1.113 ± 0.028	1.011ThrAsn: 1.011 ± 0.031	3.528ThrPro: 3.528 ± 0.054	1.586ThrGln: 1.586 ± 0.031	3.399ThrArg: 3.399 ± 0.049	2.578ThrSer: 2.578 ± 0.057	2.315ThrThr: 2.315 ± 0.045	4.143ThrVal: 4.143 ± 0.082	0.675ThrTrp: 0.675 ± 0.021	1.099ThrTyr: 1.099 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	9.585ValAla: 9.585 ± 0.087	0.766ValCys: 0.766 ± 0.023	4.135ValAsp: 4.135 ± 0.055	4.295ValGlu: 4.295 ± 0.059	2.647ValPhe: 2.647 ± 0.041	5.551ValGly: 5.551 ± 0.067	1.599ValHis: 1.599 ± 0.033	3.22ValIle: 3.22 ± 0.053	2.106ValLys: 2.106 ± 0.048	8.126ValLeu: 8.126 ± 0.087	1.694ValMet: 1.694 ± 0.034	1.949ValAsn: 1.949 ± 0.036	4.594ValPro: 4.594 ± 0.063	2.678ValGln: 2.678 ± 0.049	5.694ValArg: 5.694 ± 0.063	4.164ValSer: 4.164 ± 0.05	3.585ValThr: 3.585 ± 0.094	6.19ValVal: 6.19 ± 0.08	0.857ValTrp: 0.857 ± 0.027	1.599ValTyr: 1.599 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.304TrpAla: 1.304 ± 0.031	0.139TrpCys: 0.139 ± 0.01	0.58TrpAsp: 0.58 ± 0.02	0.606TrpGlu: 0.606 ± 0.019	0.544TrpPhe: 0.544 ± 0.019	0.922TrpGly: 0.922 ± 0.026	0.401TrpHis: 0.401 ± 0.016	0.648TrpIle: 0.648 ± 0.02	0.461TrpLys: 0.461 ± 0.018	1.948TrpLeu: 1.948 ± 0.044	0.41TrpMet: 0.41 ± 0.017	0.442TrpAsn: 0.442 ± 0.017	0.718TrpPro: 0.718 ± 0.023	0.697TrpGln: 0.697 ± 0.022	1.324TrpArg: 1.324 ± 0.032	0.768TrpSer: 0.768 ± 0.022	0.754TrpThr: 0.754 ± 0.035	0.924TrpVal: 0.924 ± 0.026	0.23TrpTrp: 0.23 ± 0.012	0.292TrpTyr: 0.292 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.892TyrAla: 2.892 ± 0.049	0.272TyrCys: 0.272 ± 0.014	1.478TyrAsp: 1.478 ± 0.032	1.254TyrGlu: 1.254 ± 0.026	0.828TyrPhe: 0.828 ± 0.023	2.219TyrGly: 2.219 ± 0.041	0.501TyrHis: 0.501 ± 0.019	0.787TyrIle: 0.787 ± 0.022	0.688TyrLys: 0.688 ± 0.023	2.466TyrLeu: 2.466 ± 0.038	0.414TyrMet: 0.414 ± 0.016	0.547TyrAsn: 0.547 ± 0.018	1.377TyrPro: 1.377 ± 0.025	0.816TyrGln: 0.816 ± 0.023	2.066TyrArg: 2.066 ± 0.042	1.151TyrSer: 1.151 ± 0.028	1.341TyrThr: 1.341 ± 0.04	1.741TyrVal: 1.741 ± 0.035	0.379TyrTrp: 0.379 ± 0.015	0.593TyrTyr: 0.593 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4682 proteins (1541785 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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