Amino acid dipepetide frequency for Porphyromonas endodontalis (strain ATCC 35406 / BCRC 14492 / JCM 8526 / NCTC 13058 / HG 370)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.875AlaAla: 5.875 ± 0.127
0.791AlaCys: 0.791 ± 0.037
3.793AlaAsp: 3.793 ± 0.086
5.239AlaGlu: 5.239 ± 0.112
3.433AlaPhe: 3.433 ± 0.083
4.824AlaGly: 4.824 ± 0.106
1.663AlaHis: 1.663 ± 0.05
5.336AlaIle: 5.336 ± 0.101
4.254AlaLys: 4.254 ± 0.094
9.179AlaLeu: 9.179 ± 0.151
1.843AlaMet: 1.843 ± 0.061
2.737AlaAsn: 2.737 ± 0.069
3.412AlaPro: 3.412 ± 0.084
3.684AlaGln: 3.684 ± 0.089
4.123AlaArg: 4.123 ± 0.088
5.019AlaSer: 5.019 ± 0.098
4.717AlaThr: 4.717 ± 0.102
4.601AlaVal: 4.601 ± 0.093
0.754AlaTrp: 0.754 ± 0.036
2.781AlaTyr: 2.781 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.751CysAla: 0.751 ± 0.036
0.16CysCys: 0.16 ± 0.017
0.575CysAsp: 0.575 ± 0.029
0.567CysGlu: 0.567 ± 0.028
0.489CysPhe: 0.489 ± 0.028
0.935CysGly: 0.935 ± 0.042
0.318CysHis: 0.318 ± 0.026
0.636CysIle: 0.636 ± 0.034
0.543CysLys: 0.543 ± 0.032
0.958CysLeu: 0.958 ± 0.042
0.212CysMet: 0.212 ± 0.019
0.507CysAsn: 0.507 ± 0.03
0.61CysPro: 0.61 ± 0.036
0.323CysGln: 0.323 ± 0.024
0.715CysArg: 0.715 ± 0.035
0.911CysSer: 0.911 ± 0.042
0.67CysThr: 0.67 ± 0.035
0.583CysVal: 0.583 ± 0.03
0.12CysTrp: 0.12 ± 0.016
0.468CysTyr: 0.468 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.076AspAla: 4.076 ± 0.086
0.572AspCys: 0.572 ± 0.036
2.051AspAsp: 2.051 ± 0.064
3.538AspGlu: 3.538 ± 0.088
2.684AspPhe: 2.684 ± 0.058
3.653AspGly: 3.653 ± 0.086
0.901AspHis: 0.901 ± 0.042
3.176AspIle: 3.176 ± 0.08
3.278AspLys: 3.278 ± 0.085
5.42AspLeu: 5.42 ± 0.096
1.222AspMet: 1.222 ± 0.045
2.157AspAsn: 2.157 ± 0.067
2.117AspPro: 2.117 ± 0.064
1.302AspGln: 1.302 ± 0.057
2.85AspArg: 2.85 ± 0.076
2.887AspSer: 2.887 ± 0.072
2.56AspThr: 2.56 ± 0.067
2.999AspVal: 2.999 ± 0.08
0.717AspTrp: 0.717 ± 0.032
2.256AspTyr: 2.256 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
6.054GluAla: 6.054 ± 0.121
0.648GluCys: 0.648 ± 0.032
3.277GluAsp: 3.277 ± 0.071
6.571GluGlu: 6.571 ± 0.136
2.23GluPhe: 2.23 ± 0.067
5.518GluGly: 5.518 ± 0.111
1.478GluHis: 1.478 ± 0.047
4.38GluIle: 4.38 ± 0.094
4.656GluLys: 4.656 ± 0.096
6.321GluLeu: 6.321 ± 0.118
1.993GluMet: 1.993 ± 0.068
2.652GluAsn: 2.652 ± 0.066
1.928GluPro: 1.928 ± 0.054
2.944GluGln: 2.944 ± 0.075
4.375GluArg: 4.375 ± 0.099
3.585GluSer: 3.585 ± 0.088
3.343GluThr: 3.343 ± 0.081
5.137GluVal: 5.137 ± 0.09
0.778GluTrp: 0.778 ± 0.037
2.442GluTyr: 2.442 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
3.362PheAla: 3.362 ± 0.071
0.559PheCys: 0.559 ± 0.028
2.621PheAsp: 2.621 ± 0.065
2.432PheGlu: 2.432 ± 0.064
2.199PhePhe: 2.199 ± 0.075
3.023PheGly: 3.023 ± 0.089
0.798PheHis: 0.798 ± 0.031
2.463PheIle: 2.463 ± 0.067
1.689PheLys: 1.689 ± 0.058
3.966PheLeu: 3.966 ± 0.09
1.021PheMet: 1.021 ± 0.045
1.676PheAsn: 1.676 ± 0.052
1.673PhePro: 1.673 ± 0.054
0.919PheGln: 0.919 ± 0.045
2.225PheArg: 2.225 ± 0.062
3.743PheSer: 3.743 ± 0.084
2.429PheThr: 2.429 ± 0.067
3.194PheVal: 3.194 ± 0.077
0.465PheTrp: 0.465 ± 0.03
1.636PheTyr: 1.636 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
5.405GlyAla: 5.405 ± 0.107
0.959GlyCys: 0.959 ± 0.048
3.635GlyAsp: 3.635 ± 0.074
4.772GlyGlu: 4.772 ± 0.09
2.971GlyPhe: 2.971 ± 0.079
5.168GlyGly: 5.168 ± 0.121
1.36GlyHis: 1.36 ± 0.054
4.925GlyIle: 4.925 ± 0.104
4.812GlyLys: 4.812 ± 0.092
6.053GlyLeu: 6.053 ± 0.111
1.888GlyMet: 1.888 ± 0.06
2.91GlyAsn: 2.91 ± 0.072
1.195GlyPro: 1.195 ± 0.049
2.065GlyGln: 2.065 ± 0.063
3.549GlyArg: 3.549 ± 0.078
4.451GlySer: 4.451 ± 0.093
3.745GlyThr: 3.745 ± 0.082
5.129GlyVal: 5.129 ± 0.107
0.854GlyTrp: 0.854 ± 0.037
3.062GlyTyr: 3.062 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.374HisAla: 1.374 ± 0.038
0.333HisCys: 0.333 ± 0.023
0.925HisAsp: 0.925 ± 0.036
1.101HisGlu: 1.101 ± 0.043
1.084HisPhe: 1.084 ± 0.043
1.252HisGly: 1.252 ± 0.047
0.622HisHis: 0.622 ± 0.036
1.46HisIle: 1.46 ± 0.042
1.055HisLys: 1.055 ± 0.048
2.626HisLeu: 2.626 ± 0.079
0.328HisMet: 0.328 ± 0.022
0.903HisAsn: 0.903 ± 0.034
1.431HisPro: 1.431 ± 0.052
0.73HisGln: 0.73 ± 0.032
1.234HisArg: 1.234 ± 0.047
1.342HisSer: 1.342 ± 0.049
1.218HisThr: 1.218 ± 0.045
1.061HisVal: 1.061 ± 0.042
0.262HisTrp: 0.262 ± 0.021
0.982HisTyr: 0.982 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.02IleAla: 6.02 ± 0.115
0.635IleCys: 0.635 ± 0.03
4.026IleAsp: 4.026 ± 0.088
4.796IleGlu: 4.796 ± 0.091
2.384IlePhe: 2.384 ± 0.068
4.375IleGly: 4.375 ± 0.088
1.342IleHis: 1.342 ± 0.042
3.726IleIle: 3.726 ± 0.086
3.351IleLys: 3.351 ± 0.076
5.828IleLeu: 5.828 ± 0.107
1.222IleMet: 1.222 ± 0.046
2.627IleAsn: 2.627 ± 0.065
3.352IlePro: 3.352 ± 0.075
1.965IleGln: 1.965 ± 0.056
3.377IleArg: 3.377 ± 0.083
4.162IleSer: 4.162 ± 0.09
3.952IleThr: 3.952 ± 0.088
4.481IleVal: 4.481 ± 0.103
0.462IleTrp: 0.462 ± 0.023
2.279IleTyr: 2.279 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
4.493LysAla: 4.493 ± 0.088
0.459LysCys: 0.459 ± 0.027
2.895LysAsp: 2.895 ± 0.076
5.134LysGlu: 5.134 ± 0.111
1.558LysPhe: 1.558 ± 0.046
4.363LysGly: 4.363 ± 0.088
1.082LysHis: 1.082 ± 0.043
3.57LysIle: 3.57 ± 0.087
4.173LysLys: 4.173 ± 0.1
4.735LysLeu: 4.735 ± 0.081
1.752LysMet: 1.752 ± 0.06
2.472LysAsn: 2.472 ± 0.078
2.112LysPro: 2.112 ± 0.056
2.166LysGln: 2.166 ± 0.063
3.257LysArg: 3.257 ± 0.071
3.419LysSer: 3.419 ± 0.088
3.004LysThr: 3.004 ± 0.083
3.952LysVal: 3.952 ± 0.087
0.581LysTrp: 0.581 ± 0.032
1.99LysTyr: 1.99 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
7.924LeuAla: 7.924 ± 0.138
1.174LeuCys: 1.174 ± 0.052
4.887LeuAsp: 4.887 ± 0.095
6.345LeuGlu: 6.345 ± 0.128
4.93LeuPhe: 4.93 ± 0.106
6.728LeuGly: 6.728 ± 0.113
2.34LeuHis: 2.34 ± 0.065
5.786LeuIle: 5.786 ± 0.104
5.095LeuLys: 5.095 ± 0.101
11.378LeuLeu: 11.378 ± 0.195
2.372LeuMet: 2.372 ± 0.063
3.499LeuAsn: 3.499 ± 0.079
5.219LeuPro: 5.219 ± 0.106
3.753LeuGln: 3.753 ± 0.087
6.143LeuArg: 6.143 ± 0.116
8.711LeuSer: 8.711 ± 0.143
5.458LeuThr: 5.458 ± 0.107
5.92LeuVal: 5.92 ± 0.132
1.053LeuTrp: 1.053 ± 0.047
3.835LeuTyr: 3.835 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
2.175MetAla: 2.175 ± 0.062
0.223MetCys: 0.223 ± 0.017
1.138MetAsp: 1.138 ± 0.043
1.616MetGlu: 1.616 ± 0.057
0.652MetPhe: 0.652 ± 0.033
1.983MetGly: 1.983 ± 0.064
0.478MetHis: 0.478 ± 0.03
1.279MetIle: 1.279 ± 0.048
1.549MetLys: 1.549 ± 0.049
2.348MetLeu: 2.348 ± 0.061
0.651MetMet: 0.651 ± 0.031
1.105MetAsn: 1.105 ± 0.043
1.326MetPro: 1.326 ± 0.056
1.101MetGln: 1.101 ± 0.039
1.361MetArg: 1.361 ± 0.049
1.302MetSer: 1.302 ± 0.049
1.287MetThr: 1.287 ± 0.045
1.52MetVal: 1.52 ± 0.051
0.192MetTrp: 0.192 ± 0.018
0.667MetTyr: 0.667 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.141AsnAla: 3.141 ± 0.07
0.43AsnCys: 0.43 ± 0.028
1.886AsnAsp: 1.886 ± 0.063
2.518AsnGlu: 2.518 ± 0.073
1.56AsnPhe: 1.56 ± 0.053
2.765AsnGly: 2.765 ± 0.083
0.799AsnHis: 0.799 ± 0.035
2.737AsnIle: 2.737 ± 0.075
2.535AsnLys: 2.535 ± 0.078
3.866AsnLeu: 3.866 ± 0.086
0.94AsnMet: 0.94 ± 0.039
1.907AsnAsn: 1.907 ± 0.065
2.288AsnPro: 2.288 ± 0.069
1.282AsnGln: 1.282 ± 0.045
2.157AsnArg: 2.157 ± 0.058
2.337AsnSer: 2.337 ± 0.064
2.232AsnThr: 2.232 ± 0.072
2.371AsnVal: 2.371 ± 0.068
0.473AsnTrp: 0.473 ± 0.029
1.667AsnTyr: 1.667 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
2.65ProAla: 2.65 ± 0.065
0.386ProCys: 0.386 ± 0.027
2.269ProAsp: 2.269 ± 0.056
3.701ProGlu: 3.701 ± 0.081
1.994ProPhe: 1.994 ± 0.056
2.271ProGly: 2.271 ± 0.062
1.074ProHis: 1.074 ± 0.048
2.979ProIle: 2.979 ± 0.068
2.482ProLys: 2.482 ± 0.066
4.61ProLeu: 4.61 ± 0.096
0.993ProMet: 0.993 ± 0.043
1.939ProAsn: 1.939 ± 0.053
1.428ProPro: 1.428 ± 0.053
1.98ProGln: 1.98 ± 0.055
1.873ProArg: 1.873 ± 0.056
3.409ProSer: 3.409 ± 0.079
2.564ProThr: 2.564 ± 0.063
2.29ProVal: 2.29 ± 0.06
0.43ProTrp: 0.43 ± 0.029
1.755ProTyr: 1.755 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
2.648GlnAla: 2.648 ± 0.065
0.365GlnCys: 0.365 ± 0.025
1.752GlnAsp: 1.752 ± 0.059
2.989GlnGlu: 2.989 ± 0.083
1.282GlnPhe: 1.282 ± 0.054
2.522GlnGly: 2.522 ± 0.067
0.769GlnHis: 0.769 ± 0.033
2.321GlnIle: 2.321 ± 0.057
2.325GlnLys: 2.325 ± 0.065
3.876GlnLeu: 3.876 ± 0.081
0.977GlnMet: 0.977 ± 0.037
1.289GlnAsn: 1.289 ± 0.045
1.35GlnPro: 1.35 ± 0.043
1.681GlnGln: 1.681 ± 0.055
2.206GlnArg: 2.206 ± 0.074
2.148GlnSer: 2.148 ± 0.067
1.909GlnThr: 1.909 ± 0.055
2.086GlnVal: 2.086 ± 0.064
0.428GlnTrp: 0.428 ± 0.027
1.334GlnTyr: 1.334 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.923ArgAla: 3.923 ± 0.079
0.644ArgCys: 0.644 ± 0.035
2.621ArgAsp: 2.621 ± 0.068
4.195ArgGlu: 4.195 ± 0.11
2.422ArgPhe: 2.422 ± 0.063
3.285ArgGly: 3.285 ± 0.081
1.297ArgHis: 1.297 ± 0.047
4.029ArgIle: 4.029 ± 0.081
3.235ArgLys: 3.235 ± 0.079
5.754ArgLeu: 5.754 ± 0.109
1.503ArgMet: 1.503 ± 0.055
2.322ArgAsn: 2.322 ± 0.065
2.082ArgPro: 2.082 ± 0.061
2.099ArgGln: 2.099 ± 0.063
3.331ArgArg: 3.331 ± 0.091
3.312ArgSer: 3.312 ± 0.086
2.836ArgThr: 2.836 ± 0.067
3.299ArgVal: 3.299 ± 0.082
0.61ArgTrp: 0.61 ± 0.034
2.527ArgTyr: 2.527 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
4.778SerAla: 4.778 ± 0.11
0.775SerCys: 0.775 ± 0.038
3.113SerAsp: 3.113 ± 0.082
3.892SerGlu: 3.892 ± 0.074
3.209SerPhe: 3.209 ± 0.085
4.51SerGly: 4.51 ± 0.098
1.403SerHis: 1.403 ± 0.046
4.854SerIle: 4.854 ± 0.093
3.404SerLys: 3.404 ± 0.075
7.808SerLeu: 7.808 ± 0.135
1.491SerMet: 1.491 ± 0.052
2.563SerAsn: 2.563 ± 0.067
3.194SerPro: 3.194 ± 0.074
2.304SerGln: 2.304 ± 0.066
3.367SerArg: 3.367 ± 0.079
4.956SerSer: 4.956 ± 0.115
3.528SerThr: 3.528 ± 0.087
4.249SerVal: 4.249 ± 0.087
0.764SerTrp: 0.764 ± 0.037
2.76SerTyr: 2.76 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
4.149ThrAla: 4.149 ± 0.079
0.499ThrCys: 0.499 ± 0.029
2.69ThrAsp: 2.69 ± 0.059
3.585ThrGlu: 3.585 ± 0.084
2.459ThrPhe: 2.459 ± 0.062
3.608ThrGly: 3.608 ± 0.076
1.145ThrHis: 1.145 ± 0.04
4.108ThrIle: 4.108 ± 0.079
2.829ThrLys: 2.829 ± 0.075
6.668ThrLeu: 6.668 ± 0.104
1.092ThrMet: 1.092 ± 0.041
2.002ThrAsn: 2.002 ± 0.069
3.755ThrPro: 3.755 ± 0.088
1.918ThrGln: 1.918 ± 0.056
2.393ThrArg: 2.393 ± 0.066
3.619ThrSer: 3.619 ± 0.075
3.343ThrThr: 3.343 ± 0.077
2.837ThrVal: 2.837 ± 0.072
0.496ThrTrp: 0.496 ± 0.032
2.002ThrTyr: 2.002 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.773ValAla: 5.773 ± 0.109
0.822ValCys: 0.822 ± 0.035
3.504ValAsp: 3.504 ± 0.08
4.551ValGlu: 4.551 ± 0.101
2.477ValPhe: 2.477 ± 0.063
4.654ValGly: 4.654 ± 0.092
1.232ValHis: 1.232 ± 0.044
3.47ValIle: 3.47 ± 0.077
3.134ValLys: 3.134 ± 0.087
6.199ValLeu: 6.199 ± 0.118
1.382ValMet: 1.382 ± 0.045
2.267ValAsn: 2.267 ± 0.062
2.571ValPro: 2.571 ± 0.059
2.08ValGln: 2.08 ± 0.068
3.654ValArg: 3.654 ± 0.079
4.439ValSer: 4.439 ± 0.092
3.415ValThr: 3.415 ± 0.076
5.061ValVal: 5.061 ± 0.102
0.681ValTrp: 0.681 ± 0.033
2.225ValTyr: 2.225 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.723TrpAla: 0.723 ± 0.035
0.145TrpCys: 0.145 ± 0.016
0.562TrpAsp: 0.562 ± 0.033
0.644TrpGlu: 0.644 ± 0.031
0.4TrpPhe: 0.4 ± 0.028
0.862TrpGly: 0.862 ± 0.044
0.328TrpHis: 0.328 ± 0.026
0.709TrpIle: 0.709 ± 0.04
0.567TrpLys: 0.567 ± 0.031
1.09TrpLeu: 1.09 ± 0.042
0.317TrpMet: 0.317 ± 0.021
0.449TrpAsn: 0.449 ± 0.027
0.17TrpPro: 0.17 ± 0.02
0.63TrpGln: 0.63 ± 0.033
0.706TrpArg: 0.706 ± 0.035
0.623TrpSer: 0.623 ± 0.036
0.514TrpThr: 0.514 ± 0.03
0.732TrpVal: 0.732 ± 0.038
0.145TrpTrp: 0.145 ± 0.014
0.368TrpTyr: 0.368 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.761TyrAla: 2.761 ± 0.076
0.473TyrCys: 0.473 ± 0.033
2.195TyrAsp: 2.195 ± 0.063
2.12TyrGlu: 2.12 ± 0.054
1.673TyrPhe: 1.673 ± 0.053
2.611TyrGly: 2.611 ± 0.062
0.891TyrHis: 0.891 ± 0.032
2.416TyrIle: 2.416 ± 0.063
2.201TyrLys: 2.201 ± 0.064
3.869TyrLeu: 3.869 ± 0.078
0.754TyrMet: 0.754 ± 0.033
1.906TyrAsn: 1.906 ± 0.059
1.865TyrPro: 1.865 ± 0.06
1.331TyrGln: 1.331 ± 0.055
2.429TyrArg: 2.429 ± 0.061
2.55TyrSer: 2.55 ± 0.067
2.476TyrThr: 2.476 ± 0.067
2.094TyrVal: 2.094 ± 0.059
0.418TyrTrp: 0.418 ± 0.029
1.831TyrTyr: 1.831 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1965 proteins (619246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski