Amino acid dipepetide frequency for Veillonella sp. oral taxon 780 str. F0422

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.393AlaAla: 6.393 ± 0.167
0.815AlaCys: 0.815 ± 0.048
3.896AlaAsp: 3.896 ± 0.126
4.711AlaGlu: 4.711 ± 0.111
3.108AlaPhe: 3.108 ± 0.092
5.892AlaGly: 5.892 ± 0.138
1.821AlaHis: 1.821 ± 0.058
6.54AlaIle: 6.54 ± 0.151
5.44AlaLys: 5.44 ± 0.131
8.353AlaLeu: 8.353 ± 0.145
2.664AlaMet: 2.664 ± 0.081
3.175AlaAsn: 3.175 ± 0.111
2.537AlaPro: 2.537 ± 0.073
2.755AlaGln: 2.755 ± 0.086
3.094AlaArg: 3.094 ± 0.083
4.162AlaSer: 4.162 ± 0.099
4.693AlaThr: 4.693 ± 0.108
6.441AlaVal: 6.441 ± 0.141
0.674AlaTrp: 0.674 ± 0.032
2.761AlaTyr: 2.761 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.662CysAla: 0.662 ± 0.041
0.143CysCys: 0.143 ± 0.019
0.507CysAsp: 0.507 ± 0.033
0.616CysGlu: 0.616 ± 0.038
0.305CysPhe: 0.305 ± 0.024
1.005CysGly: 1.005 ± 0.058
0.317CysHis: 0.317 ± 0.027
0.846CysIle: 0.846 ± 0.043
0.466CysLys: 0.466 ± 0.035
0.805CysLeu: 0.805 ± 0.046
0.297CysMet: 0.297 ± 0.025
0.361CysAsn: 0.361 ± 0.026
0.533CysPro: 0.533 ± 0.032
0.361CysGln: 0.361 ± 0.03
0.369CysArg: 0.369 ± 0.03
0.573CysSer: 0.573 ± 0.034
0.606CysThr: 0.606 ± 0.037
0.668CysVal: 0.668 ± 0.038
0.079CysTrp: 0.079 ± 0.013
0.347CysTyr: 0.347 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.352AspAla: 4.352 ± 0.107
0.478AspCys: 0.478 ± 0.03
2.436AspAsp: 2.436 ± 0.069
3.714AspGlu: 3.714 ± 0.098
2.107AspPhe: 2.107 ± 0.066
4.305AspGly: 4.305 ± 0.175
1.195AspHis: 1.195 ± 0.047
4.12AspIle: 4.12 ± 0.108
3.104AspLys: 3.104 ± 0.129
4.372AspLeu: 4.372 ± 0.11
1.863AspMet: 1.863 ± 0.066
1.903AspAsn: 1.903 ± 0.068
2.012AspPro: 2.012 ± 0.067
1.488AspGln: 1.488 ± 0.055
2.43AspArg: 2.43 ± 0.082
2.566AspSer: 2.566 ± 0.07
3.865AspThr: 3.865 ± 0.097
4.883AspVal: 4.883 ± 0.107
0.515AspTrp: 0.515 ± 0.037
2.103AspTyr: 2.103 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
6.102GluAla: 6.102 ± 0.119
0.531GluCys: 0.531 ± 0.038
3.754GluAsp: 3.754 ± 0.094
6.445GluGlu: 6.445 ± 0.162
2.208GluPhe: 2.208 ± 0.069
5.044GluGly: 5.044 ± 0.101
1.556GluHis: 1.556 ± 0.061
4.261GluIle: 4.261 ± 0.099
4.225GluLys: 4.225 ± 0.096
6.518GluLeu: 6.518 ± 0.119
1.978GluMet: 1.978 ± 0.063
2.594GluAsn: 2.594 ± 0.084
2.004GluPro: 2.004 ± 0.069
3.064GluGln: 3.064 ± 0.096
3.708GluArg: 3.708 ± 0.1
3.672GluSer: 3.672 ± 0.08
3.639GluThr: 3.639 ± 0.103
5.325GluVal: 5.325 ± 0.111
0.68GluTrp: 0.68 ± 0.036
2.301GluTyr: 2.301 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
2.559PheAla: 2.559 ± 0.077
0.44PheCys: 0.44 ± 0.033
2.136PheAsp: 2.136 ± 0.067
2.035PheGlu: 2.035 ± 0.071
1.441PhePhe: 1.441 ± 0.06
3.197PheGly: 3.197 ± 0.101
0.854PheHis: 0.854 ± 0.04
2.6PheIle: 2.6 ± 0.085
2.006PheLys: 2.006 ± 0.067
3.217PheLeu: 3.217 ± 0.108
1.12PheMet: 1.12 ± 0.053
1.48PheAsn: 1.48 ± 0.055
1.401PhePro: 1.401 ± 0.055
1.142PheGln: 1.142 ± 0.045
1.391PheArg: 1.391 ± 0.061
2.22PheSer: 2.22 ± 0.064
2.604PheThr: 2.604 ± 0.075
2.709PheVal: 2.709 ± 0.083
0.367PheTrp: 0.367 ± 0.028
1.292PheTyr: 1.292 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
6.265GlyAla: 6.265 ± 0.142
0.947GlyCys: 0.947 ± 0.051
4.096GlyAsp: 4.096 ± 0.129
4.421GlyGlu: 4.421 ± 0.103
3.032GlyPhe: 3.032 ± 0.083
5.484GlyGly: 5.484 ± 0.126
1.891GlyHis: 1.891 ± 0.063
6.314GlyIle: 6.314 ± 0.138
5.224GlyLys: 5.224 ± 0.153
6.8GlyLeu: 6.8 ± 0.144
2.432GlyMet: 2.432 ± 0.074
3.115GlyAsn: 3.115 ± 0.118
2.138GlyPro: 2.138 ± 0.081
2.602GlyGln: 2.602 ± 0.078
3.44GlyArg: 3.44 ± 0.089
4.277GlySer: 4.277 ± 0.088
5.347GlyThr: 5.347 ± 0.142
6.08GlyVal: 6.08 ± 0.102
0.652GlyTrp: 0.652 ± 0.041
2.945GlyTyr: 2.945 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.512HisAla: 1.512 ± 0.06
0.331HisCys: 0.331 ± 0.027
1.161HisAsp: 1.161 ± 0.048
1.401HisGlu: 1.401 ± 0.056
0.805HisPhe: 0.805 ± 0.039
1.801HisGly: 1.801 ± 0.058
0.729HisHis: 0.729 ± 0.042
1.988HisIle: 1.988 ± 0.064
1.195HisLys: 1.195 ± 0.05
1.903HisLeu: 1.903 ± 0.067
0.824HisMet: 0.824 ± 0.039
0.906HisAsn: 0.906 ± 0.048
1.179HisPro: 1.179 ± 0.052
0.82HisGln: 0.82 ± 0.04
1.193HisArg: 1.193 ± 0.054
1.219HisSer: 1.219 ± 0.057
1.447HisThr: 1.447 ± 0.053
1.833HisVal: 1.833 ± 0.069
0.252HisTrp: 0.252 ± 0.024
0.832HisTyr: 0.832 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.033IleAla: 6.033 ± 0.145
0.757IleCys: 0.757 ± 0.042
4.154IleAsp: 4.154 ± 0.097
4.844IleGlu: 4.844 ± 0.089
2.317IlePhe: 2.317 ± 0.087
5.957IleGly: 5.957 ± 0.126
1.734IleHis: 1.734 ± 0.064
5.048IleIle: 5.048 ± 0.144
3.407IleLys: 3.407 ± 0.092
6.259IleLeu: 6.259 ± 0.142
1.837IleMet: 1.837 ± 0.084
2.672IleAsn: 2.672 ± 0.076
3.272IlePro: 3.272 ± 0.08
2.555IleGln: 2.555 ± 0.078
3.191IleArg: 3.191 ± 0.094
4.291IleSer: 4.291 ± 0.106
4.523IleThr: 4.523 ± 0.106
5.827IleVal: 5.827 ± 0.133
0.503IleTrp: 0.503 ± 0.038
2.234IleTyr: 2.234 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
5.434LysAla: 5.434 ± 0.131
0.303LysCys: 0.303 ± 0.027
3.942LysAsp: 3.942 ± 0.142
5.951LysGlu: 5.951 ± 0.112
1.508LysPhe: 1.508 ± 0.061
4.538LysGly: 4.538 ± 0.126
1.193LysHis: 1.193 ± 0.054
3.201LysIle: 3.201 ± 0.097
3.597LysLys: 3.597 ± 0.116
4.39LysLeu: 4.39 ± 0.111
1.722LysMet: 1.722 ± 0.064
2.291LysAsn: 2.291 ± 0.079
1.988LysPro: 1.988 ± 0.087
2.604LysGln: 2.604 ± 0.07
2.888LysArg: 2.888 ± 0.085
3.01LysSer: 3.01 ± 0.07
3.165LysThr: 3.165 ± 0.101
4.762LysVal: 4.762 ± 0.123
0.456LysTrp: 0.456 ± 0.03
1.887LysTyr: 1.887 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
7.642LeuAla: 7.642 ± 0.151
0.985LeuCys: 0.985 ± 0.051
4.996LeuAsp: 4.996 ± 0.118
6.665LeuGlu: 6.665 ± 0.15
3.381LeuPhe: 3.381 ± 0.107
7.787LeuGly: 7.787 ± 0.165
2.158LeuHis: 2.158 ± 0.063
5.155LeuIle: 5.155 ± 0.149
4.398LeuLys: 4.398 ± 0.102
8.484LeuLeu: 8.484 ± 0.215
2.37LeuMet: 2.37 ± 0.079
2.995LeuAsn: 2.995 ± 0.081
3.765LeuPro: 3.765 ± 0.097
4.495LeuGln: 4.495 ± 0.107
4.378LeuArg: 4.378 ± 0.1
5.747LeuSer: 5.747 ± 0.129
4.986LeuThr: 4.986 ± 0.098
6.588LeuVal: 6.588 ± 0.128
0.858LeuTrp: 0.858 ± 0.05
2.705LeuTyr: 2.705 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
2.687MetAla: 2.687 ± 0.078
0.202MetCys: 0.202 ± 0.02
1.689MetAsp: 1.689 ± 0.063
2.146MetGlu: 2.146 ± 0.074
0.809MetPhe: 0.809 ± 0.041
2.293MetGly: 2.293 ± 0.07
0.61MetHis: 0.61 ± 0.034
2.057MetIle: 2.057 ± 0.078
2.372MetLys: 2.372 ± 0.073
2.471MetLeu: 2.471 ± 0.077
0.926MetMet: 0.926 ± 0.053
1.36MetAsn: 1.36 ± 0.051
1.199MetPro: 1.199 ± 0.046
1.011MetGln: 1.011 ± 0.043
1.26MetArg: 1.26 ± 0.053
1.732MetSer: 1.732 ± 0.052
1.784MetThr: 1.784 ± 0.064
2.16MetVal: 2.16 ± 0.065
0.208MetTrp: 0.208 ± 0.021
0.989MetTyr: 0.989 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.06AsnAla: 3.06 ± 0.131
0.351AsnCys: 0.351 ± 0.028
1.855AsnAsp: 1.855 ± 0.074
2.299AsnGlu: 2.299 ± 0.07
1.419AsnPhe: 1.419 ± 0.054
3.082AsnGly: 3.082 ± 0.116
0.957AsnHis: 0.957 ± 0.045
2.868AsnIle: 2.868 ± 0.076
2.222AsnLys: 2.222 ± 0.076
3.478AsnLeu: 3.478 ± 0.092
1.086AsnMet: 1.086 ± 0.046
1.605AsnAsn: 1.605 ± 0.097
2.206AsnPro: 2.206 ± 0.089
1.268AsnGln: 1.268 ± 0.054
1.901AsnArg: 1.901 ± 0.072
2.039AsnSer: 2.039 ± 0.07
2.644AsnThr: 2.644 ± 0.093
3.084AsnVal: 3.084 ± 0.104
0.42AsnTrp: 0.42 ± 0.029
1.451AsnTyr: 1.451 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
2.471ProAla: 2.471 ± 0.075
0.359ProCys: 0.359 ± 0.031
1.833ProAsp: 1.833 ± 0.06
2.973ProGlu: 2.973 ± 0.082
1.552ProPhe: 1.552 ± 0.056
2.23ProGly: 2.23 ± 0.075
0.979ProHis: 0.979 ± 0.045
2.8ProIle: 2.8 ± 0.072
2.376ProLys: 2.376 ± 0.081
3.369ProLeu: 3.369 ± 0.089
1.155ProMet: 1.155 ± 0.055
1.764ProAsn: 1.764 ± 0.065
0.959ProPro: 0.959 ± 0.056
1.28ProGln: 1.28 ± 0.05
1.316ProArg: 1.316 ± 0.054
2.025ProSer: 2.025 ± 0.077
2.63ProThr: 2.63 ± 0.076
3.397ProVal: 3.397 ± 0.1
0.418ProTrp: 0.418 ± 0.03
1.482ProTyr: 1.482 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
3.238GlnAla: 3.238 ± 0.079
0.377GlnCys: 0.377 ± 0.029
1.982GlnAsp: 1.982 ± 0.059
2.925GlnGlu: 2.925 ± 0.089
1.294GlnPhe: 1.294 ± 0.053
2.874GlnGly: 2.874 ± 0.099
0.757GlnHis: 0.757 ± 0.042
2.287GlnIle: 2.287 ± 0.067
1.851GlnLys: 1.851 ± 0.069
3.601GlnLeu: 3.601 ± 0.091
1.058GlnMet: 1.058 ± 0.041
1.181GlnAsn: 1.181 ± 0.057
1.118GlnPro: 1.118 ± 0.05
1.766GlnGln: 1.766 ± 0.061
1.916GlnArg: 1.916 ± 0.067
2.031GlnSer: 2.031 ± 0.06
1.718GlnThr: 1.718 ± 0.061
2.747GlnVal: 2.747 ± 0.067
0.488GlnTrp: 0.488 ± 0.04
1.484GlnTyr: 1.484 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
3.016ArgAla: 3.016 ± 0.075
0.446ArgCys: 0.446 ± 0.032
2.311ArgAsp: 2.311 ± 0.077
3.246ArgGlu: 3.246 ± 0.103
1.776ArgPhe: 1.776 ± 0.057
2.907ArgGly: 2.907 ± 0.082
1.124ArgHis: 1.124 ± 0.054
3.611ArgIle: 3.611 ± 0.09
2.687ArgLys: 2.687 ± 0.085
4.374ArgLeu: 4.374 ± 0.104
1.522ArgMet: 1.522 ± 0.055
1.889ArgAsn: 1.889 ± 0.062
1.548ArgPro: 1.548 ± 0.063
1.782ArgGln: 1.782 ± 0.071
2.245ArgArg: 2.245 ± 0.082
2.343ArgSer: 2.343 ± 0.063
2.362ArgThr: 2.362 ± 0.068
3.201ArgVal: 3.201 ± 0.088
0.484ArgTrp: 0.484 ± 0.035
1.746ArgTyr: 1.746 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
3.995SerAla: 3.995 ± 0.104
0.561SerCys: 0.561 ± 0.038
2.668SerAsp: 2.668 ± 0.077
3.127SerGlu: 3.127 ± 0.071
2.432SerPhe: 2.432 ± 0.072
4.267SerGly: 4.267 ± 0.106
1.474SerHis: 1.474 ± 0.071
4.691SerIle: 4.691 ± 0.114
3.262SerLys: 3.262 ± 0.091
5.341SerLeu: 5.341 ± 0.107
1.839SerMet: 1.839 ± 0.066
2.339SerAsn: 2.339 ± 0.075
1.946SerPro: 1.946 ± 0.06
1.861SerGln: 1.861 ± 0.065
2.311SerArg: 2.311 ± 0.074
3.215SerSer: 3.215 ± 0.086
3.496SerThr: 3.496 ± 0.09
4.338SerVal: 4.338 ± 0.088
0.561SerTrp: 0.561 ± 0.035
2.176SerTyr: 2.176 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
4.828ThrAla: 4.828 ± 0.14
0.585ThrCys: 0.585 ± 0.033
3.092ThrAsp: 3.092 ± 0.085
3.403ThrGlu: 3.403 ± 0.09
2.281ThrPhe: 2.281 ± 0.07
5.004ThrGly: 5.004 ± 0.13
1.288ThrHis: 1.288 ± 0.05
4.854ThrIle: 4.854 ± 0.107
3.46ThrLys: 3.46 ± 0.1
5.694ThrLeu: 5.694 ± 0.099
1.857ThrMet: 1.857 ± 0.071
2.6ThrAsn: 2.6 ± 0.085
2.733ThrPro: 2.733 ± 0.085
1.55ThrGln: 1.55 ± 0.054
2.198ThrArg: 2.198 ± 0.068
3.595ThrSer: 3.595 ± 0.081
3.799ThrThr: 3.799 ± 0.16
5.45ThrVal: 5.45 ± 0.127
0.543ThrTrp: 0.543 ± 0.036
2.321ThrTyr: 2.321 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
6.52ValAla: 6.52 ± 0.116
0.815ValCys: 0.815 ± 0.046
4.586ValAsp: 4.586 ± 0.096
5.547ValGlu: 5.547 ± 0.114
2.592ValPhe: 2.592 ± 0.074
6.181ValGly: 6.181 ± 0.118
1.647ValHis: 1.647 ± 0.06
4.929ValIle: 4.929 ± 0.102
5.0ValLys: 5.0 ± 0.134
7.242ValLeu: 7.242 ± 0.142
2.019ValMet: 2.019 ± 0.063
3.137ValAsn: 3.137 ± 0.128
3.222ValPro: 3.222 ± 0.085
2.884ValGln: 2.884 ± 0.082
3.288ValArg: 3.288 ± 0.087
4.731ValSer: 4.731 ± 0.102
5.175ValThr: 5.175 ± 0.128
6.566ValVal: 6.566 ± 0.139
0.638ValTrp: 0.638 ± 0.039
2.626ValTyr: 2.626 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.652TrpAla: 0.652 ± 0.035
0.085TrpCys: 0.085 ± 0.014
0.537TrpAsp: 0.537 ± 0.033
0.579TrpGlu: 0.579 ± 0.038
0.458TrpPhe: 0.458 ± 0.034
0.618TrpGly: 0.618 ± 0.039
0.22TrpHis: 0.22 ± 0.019
0.676TrpIle: 0.676 ± 0.04
0.7TrpLys: 0.7 ± 0.044
0.846TrpLeu: 0.846 ± 0.045
0.289TrpMet: 0.289 ± 0.027
0.539TrpAsn: 0.539 ± 0.037
0.252TrpPro: 0.252 ± 0.023
0.373TrpGln: 0.373 ± 0.026
0.426TrpArg: 0.426 ± 0.034
0.507TrpSer: 0.507 ± 0.034
0.474TrpThr: 0.474 ± 0.029
0.533TrpVal: 0.533 ± 0.038
0.127TrpTrp: 0.127 ± 0.019
0.367TrpTyr: 0.367 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.507TyrAla: 2.507 ± 0.076
0.353TyrCys: 0.353 ± 0.03
2.182TyrAsp: 2.182 ± 0.064
2.563TyrGlu: 2.563 ± 0.07
1.385TyrPhe: 1.385 ± 0.06
3.034TyrGly: 3.034 ± 0.092
0.828TyrHis: 0.828 ± 0.047
2.572TyrIle: 2.572 ± 0.081
1.837TyrLys: 1.837 ± 0.059
3.02TyrLeu: 3.02 ± 0.094
1.106TyrMet: 1.106 ± 0.051
1.389TyrAsn: 1.389 ± 0.062
1.354TyrPro: 1.354 ± 0.051
1.029TyrGln: 1.029 ± 0.047
1.679TyrArg: 1.679 ± 0.069
1.946TyrSer: 1.946 ± 0.057
2.178TyrThr: 2.178 ± 0.058
2.753TyrVal: 2.753 ± 0.076
0.335TyrTrp: 0.335 ± 0.029
1.324TyrTyr: 1.324 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1585 proteins (495418 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski