Amino acid dipepetide frequency for Ferrithrix thermotolerans DSM 19514

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.434AlaAla: 8.434 ± 0.135	0.79AlaCys: 0.79 ± 0.033	3.807AlaAsp: 3.807 ± 0.077	5.329AlaGlu: 5.329 ± 0.09	3.263AlaPhe: 3.263 ± 0.071	6.198AlaGly: 6.198 ± 0.114	1.692AlaHis: 1.692 ± 0.05	5.284AlaIle: 5.284 ± 0.096	4.724AlaLys: 4.724 ± 0.09	10.651AlaLeu: 10.651 ± 0.133	2.289AlaMet: 2.289 ± 0.058	2.691AlaAsn: 2.691 ± 0.056	3.445AlaPro: 3.445 ± 0.073	3.272AlaGln: 3.272 ± 0.081	5.187AlaArg: 5.187 ± 0.096	6.95AlaSer: 6.95 ± 0.104	5.204AlaThr: 5.204 ± 0.082	7.615AlaVal: 7.615 ± 0.13	0.835AlaTrp: 0.835 ± 0.034	2.497AlaTyr: 2.497 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.757CysAla: 0.757 ± 0.034	0.112CysCys: 0.112 ± 0.013	0.572CysAsp: 0.572 ± 0.031	0.534CysGlu: 0.534 ± 0.028	0.323CysPhe: 0.323 ± 0.023	0.858CysGly: 0.858 ± 0.031	0.207CysHis: 0.207 ± 0.02	0.345CysIle: 0.345 ± 0.021	0.348CysLys: 0.348 ± 0.024	0.654CysLeu: 0.654 ± 0.035	0.14CysMet: 0.14 ± 0.014	0.277CysAsn: 0.277 ± 0.021	0.432CysPro: 0.432 ± 0.024	0.214CysGln: 0.214 ± 0.017	0.471CysArg: 0.471 ± 0.026	0.732CysSer: 0.732 ± 0.03	0.425CysThr: 0.425 ± 0.029	0.653CysVal: 0.653 ± 0.032	0.095CysTrp: 0.095 ± 0.011	0.276CysTyr: 0.276 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.372AspAla: 4.372 ± 0.086	0.384AspCys: 0.384 ± 0.024	2.642AspAsp: 2.642 ± 0.071	3.814AspGlu: 3.814 ± 0.081	1.966AspPhe: 1.966 ± 0.06	3.926AspGly: 3.926 ± 0.079	1.138AspHis: 1.138 ± 0.039	2.713AspIle: 2.713 ± 0.056	1.927AspLys: 1.927 ± 0.046	6.806AspLeu: 6.806 ± 0.1	1.018AspMet: 1.018 ± 0.047	1.203AspAsn: 1.203 ± 0.042	3.412AspPro: 3.412 ± 0.082	1.823AspGln: 1.823 ± 0.054	3.493AspArg: 3.493 ± 0.072	3.494AspSer: 3.494 ± 0.075	2.632AspThr: 2.632 ± 0.059	4.414AspVal: 4.414 ± 0.08	0.525AspTrp: 0.525 ± 0.031	1.433AspTyr: 1.433 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.153GluAla: 6.153 ± 0.113	0.379GluCys: 0.379 ± 0.023	3.106GluAsp: 3.106 ± 0.076	4.722GluGlu: 4.722 ± 0.092	2.224GluPhe: 2.224 ± 0.059	4.533GluGly: 4.533 ± 0.095	1.259GluHis: 1.259 ± 0.043	4.848GluIle: 4.848 ± 0.083	2.329GluLys: 2.329 ± 0.062	7.375GluLeu: 7.375 ± 0.118	1.683GluMet: 1.683 ± 0.046	1.61GluAsn: 1.61 ± 0.046	2.361GluPro: 2.361 ± 0.057	1.916GluGln: 1.916 ± 0.054	4.84GluArg: 4.84 ± 0.085	4.168GluSer: 4.168 ± 0.077	3.294GluThr: 3.294 ± 0.071	6.047GluVal: 6.047 ± 0.1	0.578GluTrp: 0.578 ± 0.029	1.396GluTyr: 1.396 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.524PheAla: 3.524 ± 0.078	0.365PheCys: 0.365 ± 0.024	2.578PheAsp: 2.578 ± 0.055	2.662PheGlu: 2.662 ± 0.067	1.436PhePhe: 1.436 ± 0.049	3.616PheGly: 3.616 ± 0.07	0.75PheHis: 0.75 ± 0.034	1.848PheIle: 1.848 ± 0.056	1.145PheLys: 1.145 ± 0.039	3.471PheLeu: 3.471 ± 0.083	0.672PheMet: 0.672 ± 0.032	1.049PheAsn: 1.049 ± 0.045	1.547PhePro: 1.547 ± 0.048	1.084PheGln: 1.084 ± 0.047	2.095PheArg: 2.095 ± 0.053	2.956PheSer: 2.956 ± 0.061	1.931PheThr: 1.931 ± 0.058	3.198PheVal: 3.198 ± 0.074	0.416PheTrp: 0.416 ± 0.023	1.072PheTyr: 1.072 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	7.021GlyAla: 7.021 ± 0.11	0.719GlyCys: 0.719 ± 0.034	4.073GlyAsp: 4.073 ± 0.092	4.58GlyGlu: 4.58 ± 0.085	3.326GlyPhe: 3.326 ± 0.064	6.413GlyGly: 6.413 ± 0.12	1.628GlyHis: 1.628 ± 0.054	3.886GlyIle: 3.886 ± 0.078	3.27GlyLys: 3.27 ± 0.067	7.42GlyLeu: 7.42 ± 0.101	1.641GlyMet: 1.641 ± 0.05	2.03GlyAsn: 2.03 ± 0.054	2.898GlyPro: 2.898 ± 0.067	2.206GlyGln: 2.206 ± 0.059	4.642GlyArg: 4.642 ± 0.08	6.484GlySer: 6.484 ± 0.102	4.28GlyThr: 4.28 ± 0.085	7.882GlyVal: 7.882 ± 0.116	1.026GlyTrp: 1.026 ± 0.039	2.652GlyTyr: 2.652 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	1.304HisAla: 1.304 ± 0.041	0.185HisCys: 0.185 ± 0.015	0.891HisAsp: 0.891 ± 0.038	1.049HisGlu: 1.049 ± 0.042	0.876HisPhe: 0.876 ± 0.033	1.624HisGly: 1.624 ± 0.052	0.538HisHis: 0.538 ± 0.028	1.039HisIle: 1.039 ± 0.038	0.712HisLys: 0.712 ± 0.035	2.543HisLeu: 2.543 ± 0.062	0.425HisMet: 0.425 ± 0.024	0.541HisAsn: 0.541 ± 0.028	1.269HisPro: 1.269 ± 0.042	0.614HisGln: 0.614 ± 0.032	1.396HisArg: 1.396 ± 0.046	1.38HisSer: 1.38 ± 0.048	0.817HisThr: 0.817 ± 0.037	1.325HisVal: 1.325 ± 0.045	0.198HisTrp: 0.198 ± 0.017	0.568HisTyr: 0.568 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.235IleAla: 5.235 ± 0.091	0.522IleCys: 0.522 ± 0.026	3.787IleAsp: 3.787 ± 0.069	4.147IleGlu: 4.147 ± 0.081	2.081IlePhe: 2.081 ± 0.053	4.235IleGly: 4.235 ± 0.087	1.022IleHis: 1.022 ± 0.043	1.716IleIle: 1.716 ± 0.056	2.036IleLys: 2.036 ± 0.055	4.431IleLeu: 4.431 ± 0.088	0.868IleMet: 0.868 ± 0.036	1.462IleAsn: 1.462 ± 0.048	2.482IlePro: 2.482 ± 0.068	1.39IleGln: 1.39 ± 0.052	2.857IleArg: 2.857 ± 0.067	4.669IleSer: 4.669 ± 0.086	3.069IleThr: 3.069 ± 0.072	4.777IleVal: 4.777 ± 0.079	0.613IleTrp: 0.613 ± 0.031	1.637IleTyr: 1.637 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.135LysAla: 4.135 ± 0.077	0.242LysCys: 0.242 ± 0.017	2.853LysAsp: 2.853 ± 0.069	3.426LysGlu: 3.426 ± 0.076	0.917LysPhe: 0.917 ± 0.034	3.311LysGly: 3.311 ± 0.082	0.599LysHis: 0.599 ± 0.032	2.329LysIle: 2.329 ± 0.058	1.784LysLys: 1.784 ± 0.055	3.522LysLeu: 3.522 ± 0.066	0.997LysMet: 0.997 ± 0.035	1.15LysAsn: 1.15 ± 0.041	1.591LysPro: 1.591 ± 0.046	0.984LysGln: 0.984 ± 0.043	2.911LysArg: 2.911 ± 0.068	2.747LysSer: 2.747 ± 0.056	2.473LysThr: 2.473 ± 0.063	4.509LysVal: 4.509 ± 0.077	0.435LysTrp: 0.435 ± 0.026	0.851LysTyr: 0.851 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	10.533LeuAla: 10.533 ± 0.123	1.093LeuCys: 1.093 ± 0.045	5.982LeuAsp: 5.982 ± 0.098	7.243LeuGlu: 7.243 ± 0.114	3.596LeuPhe: 3.596 ± 0.083	9.096LeuGly: 9.096 ± 0.135	1.914LeuHis: 1.914 ± 0.052	5.309LeuIle: 5.309 ± 0.09	4.101LeuLys: 4.101 ± 0.077	10.181LeuLeu: 10.181 ± 0.151	2.027LeuMet: 2.027 ± 0.055	2.655LeuAsn: 2.655 ± 0.06	4.665LeuPro: 4.665 ± 0.086	2.877LeuGln: 2.877 ± 0.061	6.866LeuArg: 6.866 ± 0.092	9.498LeuSer: 9.498 ± 0.12	5.468LeuThr: 5.468 ± 0.099	8.602LeuVal: 8.602 ± 0.133	1.11LeuTrp: 1.11 ± 0.037	2.908LeuTyr: 2.908 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.308MetAla: 2.308 ± 0.057	0.163MetCys: 0.163 ± 0.014	1.038MetAsp: 1.038 ± 0.042	1.307MetGlu: 1.307 ± 0.046	0.599MetPhe: 0.599 ± 0.034	1.681MetGly: 1.681 ± 0.05	0.341MetHis: 0.341 ± 0.022	1.069MetIle: 1.069 ± 0.039	1.012MetLys: 1.012 ± 0.039	1.884MetLeu: 1.884 ± 0.051	0.395MetMet: 0.395 ± 0.027	0.689MetAsn: 0.689 ± 0.032	0.954MetPro: 0.954 ± 0.037	0.653MetGln: 0.653 ± 0.036	1.338MetArg: 1.338 ± 0.039	1.753MetSer: 1.753 ± 0.046	1.339MetThr: 1.339 ± 0.041	1.821MetVal: 1.821 ± 0.05	0.205MetTrp: 0.205 ± 0.017	0.479MetTyr: 0.479 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.415AsnAla: 2.415 ± 0.063	0.238AsnCys: 0.238 ± 0.018	1.322AsnAsp: 1.322 ± 0.043	1.53AsnGlu: 1.53 ± 0.042	1.215AsnPhe: 1.215 ± 0.039	2.146AsnGly: 2.146 ± 0.06	0.548AsnHis: 0.548 ± 0.028	1.403AsnIle: 1.403 ± 0.043	1.072AsnLys: 1.072 ± 0.039	3.122AsnLeu: 3.122 ± 0.081	0.527AsnMet: 0.527 ± 0.029	0.847AsnAsn: 0.847 ± 0.034	1.918AsnPro: 1.918 ± 0.059	0.995AsnGln: 0.995 ± 0.038	1.494AsnArg: 1.494 ± 0.043	2.231AsnSer: 2.231 ± 0.054	1.526AsnThr: 1.526 ± 0.051	2.126AsnVal: 2.126 ± 0.058	0.388AsnTrp: 0.388 ± 0.026	0.957AsnTyr: 0.957 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.153ProAla: 3.153 ± 0.083	0.29ProCys: 0.29 ± 0.022	2.357ProAsp: 2.357 ± 0.075	2.888ProGlu: 2.888 ± 0.073	1.829ProPhe: 1.829 ± 0.049	3.47ProGly: 3.47 ± 0.072	0.883ProHis: 0.883 ± 0.036	2.571ProIle: 2.571 ± 0.06	2.596ProLys: 2.596 ± 0.062	4.628ProLeu: 4.628 ± 0.085	1.028ProMet: 1.028 ± 0.04	1.624ProAsn: 1.624 ± 0.051	2.125ProPro: 2.125 ± 0.058	1.477ProGln: 1.477 ± 0.046	2.243ProArg: 2.243 ± 0.061	3.988ProSer: 3.988 ± 0.094	2.894ProThr: 2.894 ± 0.071	3.211ProVal: 3.211 ± 0.07	0.595ProTrp: 0.595 ± 0.03	1.552ProTyr: 1.552 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.904GlnAla: 2.904 ± 0.074	0.194GlnCys: 0.194 ± 0.017	1.447GlnAsp: 1.447 ± 0.047	1.886GlnGlu: 1.886 ± 0.049	0.84GlnPhe: 0.84 ± 0.033	2.657GlnGly: 2.657 ± 0.067	0.532GlnHis: 0.532 ± 0.028	2.128GlnIle: 2.128 ± 0.059	1.018GlnLys: 1.018 ± 0.042	3.374GlnLeu: 3.374 ± 0.065	0.765GlnMet: 0.765 ± 0.032	0.891GlnAsn: 0.891 ± 0.037	1.21GlnPro: 1.21 ± 0.037	1.072GlnGln: 1.072 ± 0.051	2.516GlnArg: 2.516 ± 0.057	2.425GlnSer: 2.425 ± 0.06	1.342GlnThr: 1.342 ± 0.048	2.647GlnVal: 2.647 ± 0.056	0.336GlnTrp: 0.336 ± 0.023	0.74GlnTyr: 0.74 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.992ArgAla: 4.992 ± 0.085	0.6ArgCys: 0.6 ± 0.029	3.313ArgAsp: 3.313 ± 0.067	4.012ArgGlu: 4.012 ± 0.085	2.701ArgPhe: 2.701 ± 0.066	3.915ArgGly: 3.915 ± 0.084	1.332ArgHis: 1.332 ± 0.047	2.816ArgIle: 2.816 ± 0.065	2.393ArgLys: 2.393 ± 0.057	6.531ArgLeu: 6.531 ± 0.103	1.24ArgMet: 1.24 ± 0.039	1.615ArgAsn: 1.615 ± 0.049	2.536ArgPro: 2.536 ± 0.06	1.891ArgGln: 1.891 ± 0.06	4.747ArgArg: 4.747 ± 0.096	5.72ArgSer: 5.72 ± 0.109	2.84ArgThr: 2.84 ± 0.062	5.084ArgVal: 5.084 ± 0.088	0.878ArgTrp: 0.878 ± 0.033	2.261ArgTyr: 2.261 ± 0.062	0.001ArgXaa: 0.001 ± 0.002
Ser	6.503SerAla: 6.503 ± 0.104	0.674SerCys: 0.674 ± 0.029	4.05SerAsp: 4.05 ± 0.086	4.731SerGlu: 4.731 ± 0.095	3.265SerPhe: 3.265 ± 0.069	6.167SerGly: 6.167 ± 0.099	1.465SerHis: 1.465 ± 0.043	4.366SerIle: 4.366 ± 0.083	4.114SerLys: 4.114 ± 0.091	8.788SerLeu: 8.788 ± 0.121	1.832SerMet: 1.832 ± 0.054	2.398SerAsn: 2.398 ± 0.07	3.582SerPro: 3.582 ± 0.08	2.909SerGln: 2.909 ± 0.08	4.215SerArg: 4.215 ± 0.089	7.012SerSer: 7.012 ± 0.133	4.319SerThr: 4.319 ± 0.08	6.283SerVal: 6.283 ± 0.099	0.967SerTrp: 0.967 ± 0.037	2.662SerTyr: 2.662 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	4.424ThrAla: 4.424 ± 0.081	0.452ThrCys: 0.452 ± 0.026	2.442ThrAsp: 2.442 ± 0.057	2.919ThrGlu: 2.919 ± 0.07	2.04ThrPhe: 2.04 ± 0.054	3.878ThrGly: 3.878 ± 0.087	1.072ThrHis: 1.072 ± 0.04	2.781ThrIle: 2.781 ± 0.062	2.633ThrLys: 2.633 ± 0.062	6.379ThrLeu: 6.379 ± 0.095	1.014ThrMet: 1.014 ± 0.038	1.737ThrAsn: 1.737 ± 0.05	3.11ThrPro: 3.11 ± 0.07	1.836ThrGln: 1.836 ± 0.055	2.567ThrArg: 2.567 ± 0.066	4.097ThrSer: 4.097 ± 0.084	3.484ThrThr: 3.484 ± 0.105	4.632ThrVal: 4.632 ± 0.081	0.627ThrTrp: 0.627 ± 0.035	1.821ThrTyr: 1.821 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	9.045ValAla: 9.045 ± 0.123	0.684ValCys: 0.684 ± 0.027	4.799ValAsp: 4.799 ± 0.085	5.626ValGlu: 5.626 ± 0.103	3.294ValPhe: 3.294 ± 0.076	7.093ValGly: 7.093 ± 0.11	1.54ValHis: 1.54 ± 0.057	4.554ValIle: 4.554 ± 0.082	3.059ValLys: 3.059 ± 0.069	8.953ValLeu: 8.953 ± 0.136	1.642ValMet: 1.642 ± 0.052	2.226ValAsn: 2.226 ± 0.062	4.041ValPro: 4.041 ± 0.087	2.213ValGln: 2.213 ± 0.059	4.774ValArg: 4.774 ± 0.08	6.94ValSer: 6.94 ± 0.122	4.957ValThr: 4.957 ± 0.097	9.469ValVal: 9.469 ± 0.166	0.665ValTrp: 0.665 ± 0.033	1.795ValTyr: 1.795 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.83TrpAla: 0.83 ± 0.03	0.102TrpCys: 0.102 ± 0.011	0.494TrpAsp: 0.494 ± 0.032	0.572TrpGlu: 0.572 ± 0.03	0.426TrpPhe: 0.426 ± 0.026	0.79TrpGly: 0.79 ± 0.038	0.253TrpHis: 0.253 ± 0.019	0.813TrpIle: 0.813 ± 0.034	0.445TrpLys: 0.445 ± 0.025	1.237TrpLeu: 1.237 ± 0.052	0.34TrpMet: 0.34 ± 0.023	0.463TrpAsn: 0.463 ± 0.027	0.48TrpPro: 0.48 ± 0.028	0.401TrpGln: 0.401 ± 0.023	0.746TrpArg: 0.746 ± 0.038	0.888TrpSer: 0.888 ± 0.037	0.562TrpThr: 0.562 ± 0.031	0.77TrpVal: 0.77 ± 0.029	0.212TrpTrp: 0.212 ± 0.019	0.272TrpTyr: 0.272 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.117TyrAla: 2.117 ± 0.057	0.236TyrCys: 0.236 ± 0.018	1.581TyrAsp: 1.581 ± 0.047	1.843TyrGlu: 1.843 ± 0.049	1.199TyrPhe: 1.199 ± 0.039	2.47TyrGly: 2.47 ± 0.062	0.579TyrHis: 0.579 ± 0.031	1.22TyrIle: 1.22 ± 0.039	1.046TyrLys: 1.046 ± 0.038	3.774TyrLeu: 3.774 ± 0.072	0.483TyrMet: 0.483 ± 0.027	0.862TyrAsn: 0.862 ± 0.036	1.344TyrPro: 1.344 ± 0.045	1.096TyrGln: 1.096 ± 0.044	2.02TyrArg: 2.02 ± 0.058	2.172TyrSer: 2.172 ± 0.055	1.089TyrThr: 1.089 ± 0.043	2.303TyrVal: 2.303 ± 0.057	0.391TyrTrp: 0.391 ± 0.027	0.807TyrTyr: 0.807 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.005

Statistics based on 2339 proteins (706337 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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