Amino acid dipepetide frequency for Mycobacterium phage NothingSpecial

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.423AlaAla: 11.423 ± 1.075
0.617AlaCys: 0.617 ± 0.216
6.792AlaAsp: 6.792 ± 0.653
7.348AlaGlu: 7.348 ± 0.785
3.952AlaPhe: 3.952 ± 0.505
7.348AlaGly: 7.348 ± 0.808
1.667AlaHis: 1.667 ± 0.294
5.31AlaIle: 5.31 ± 0.681
5.619AlaLys: 5.619 ± 0.731
8.521AlaLeu: 8.521 ± 0.869
3.026AlaMet: 3.026 ± 0.39
2.47AlaAsn: 2.47 ± 0.433
5.187AlaPro: 5.187 ± 0.565
3.273AlaGln: 3.273 ± 0.566
5.743AlaArg: 5.743 ± 0.594
5.249AlaSer: 5.249 ± 0.445
5.99AlaThr: 5.99 ± 0.695
7.471AlaVal: 7.471 ± 0.732
1.914AlaTrp: 1.914 ± 0.39
3.458AlaTyr: 3.458 ± 0.44
0.0AlaXaa: 0.0 ± 0.0
Cys
0.617CysAla: 0.617 ± 0.171
0.0CysCys: 0.0 ± 0.0
0.617CysAsp: 0.617 ± 0.185
0.432CysGlu: 0.432 ± 0.141
0.494CysPhe: 0.494 ± 0.147
0.679CysGly: 0.679 ± 0.214
0.123CysHis: 0.123 ± 0.086
0.247CysIle: 0.247 ± 0.168
0.556CysLys: 0.556 ± 0.177
0.679CysLeu: 0.679 ± 0.212
0.062CysMet: 0.062 ± 0.055
0.432CysAsn: 0.432 ± 0.135
0.432CysPro: 0.432 ± 0.178
0.247CysGln: 0.247 ± 0.103
0.432CysArg: 0.432 ± 0.156
0.309CysSer: 0.309 ± 0.167
0.679CysThr: 0.679 ± 0.237
0.432CysVal: 0.432 ± 0.167
0.432CysTrp: 0.432 ± 0.175
0.37CysTyr: 0.37 ± 0.145
0.0CysXaa: 0.0 ± 0.0
Asp
6.792AspAla: 6.792 ± 0.725
0.37AspCys: 0.37 ± 0.15
4.014AspAsp: 4.014 ± 0.486
4.631AspGlu: 4.631 ± 0.662
2.717AspPhe: 2.717 ± 0.384
6.298AspGly: 6.298 ± 0.644
1.297AspHis: 1.297 ± 0.328
4.014AspIle: 4.014 ± 0.553
2.593AspLys: 2.593 ± 0.448
5.372AspLeu: 5.372 ± 0.673
1.605AspMet: 1.605 ± 0.329
1.358AspAsn: 1.358 ± 0.293
4.755AspPro: 4.755 ± 0.564
1.667AspGln: 1.667 ± 0.316
2.717AspArg: 2.717 ± 0.38
3.026AspSer: 3.026 ± 0.503
3.211AspThr: 3.211 ± 0.49
4.014AspVal: 4.014 ± 0.399
0.864AspTrp: 0.864 ± 0.226
2.346AspTyr: 2.346 ± 0.279
0.0AspXaa: 0.0 ± 0.0
Glu
7.471GluAla: 7.471 ± 0.871
0.556GluCys: 0.556 ± 0.187
4.322GluAsp: 4.322 ± 0.603
4.693GluGlu: 4.693 ± 0.502
2.593GluPhe: 2.593 ± 0.337
4.816GluGly: 4.816 ± 0.646
1.791GluHis: 1.791 ± 0.383
3.334GluIle: 3.334 ± 0.38
1.791GluLys: 1.791 ± 0.333
7.348GluLeu: 7.348 ± 0.75
2.47GluMet: 2.47 ± 0.466
1.852GluAsn: 1.852 ± 0.307
3.334GluPro: 3.334 ± 0.509
2.408GluGln: 2.408 ± 0.36
4.816GluArg: 4.816 ± 0.634
3.273GluSer: 3.273 ± 0.504
3.458GluThr: 3.458 ± 0.427
3.273GluVal: 3.273 ± 0.395
1.544GluTrp: 1.544 ± 0.295
2.099GluTyr: 2.099 ± 0.359
0.0GluXaa: 0.0 ± 0.0
Phe
3.89PheAla: 3.89 ± 0.435
0.185PheCys: 0.185 ± 0.099
2.161PheAsp: 2.161 ± 0.425
2.717PheGlu: 2.717 ± 0.375
0.741PhePhe: 0.741 ± 0.247
3.087PheGly: 3.087 ± 0.417
0.741PheHis: 0.741 ± 0.263
1.297PheIle: 1.297 ± 0.25
0.988PheLys: 0.988 ± 0.287
2.717PheLeu: 2.717 ± 0.541
0.617PheMet: 0.617 ± 0.179
1.791PheAsn: 1.791 ± 0.323
1.852PhePro: 1.852 ± 0.348
0.926PheGln: 0.926 ± 0.248
2.346PheArg: 2.346 ± 0.431
1.791PheSer: 1.791 ± 0.376
2.408PheThr: 2.408 ± 0.369
2.223PheVal: 2.223 ± 0.381
0.37PheTrp: 0.37 ± 0.136
0.864PheTyr: 0.864 ± 0.23
0.0PheXaa: 0.0 ± 0.0
Gly
6.916GlyAla: 6.916 ± 0.88
0.556GlyCys: 0.556 ± 0.184
6.607GlyAsp: 6.607 ± 1.234
4.446GlyGlu: 4.446 ± 0.546
3.581GlyPhe: 3.581 ± 0.463
6.483GlyGly: 6.483 ± 1.029
1.852GlyHis: 1.852 ± 0.338
4.446GlyIle: 4.446 ± 0.714
3.643GlyLys: 3.643 ± 0.487
6.545GlyLeu: 6.545 ± 0.842
1.667GlyMet: 1.667 ± 0.298
3.026GlyAsn: 3.026 ± 0.5
4.755GlyPro: 4.755 ± 2.007
3.643GlyGln: 3.643 ± 0.382
3.828GlyArg: 3.828 ± 0.455
3.89GlySer: 3.89 ± 0.462
5.372GlyThr: 5.372 ± 0.811
6.175GlyVal: 6.175 ± 0.68
1.605GlyTrp: 1.605 ± 0.325
2.655GlyTyr: 2.655 ± 0.357
0.0GlyXaa: 0.0 ± 0.0
His
1.605HisAla: 1.605 ± 0.331
0.37HisCys: 0.37 ± 0.153
1.235HisAsp: 1.235 ± 0.279
1.42HisGlu: 1.42 ± 0.312
0.494HisPhe: 0.494 ± 0.185
1.914HisGly: 1.914 ± 0.467
0.494HisHis: 0.494 ± 0.183
0.988HisIle: 0.988 ± 0.24
1.235HisLys: 1.235 ± 0.261
1.544HisLeu: 1.544 ± 0.309
0.432HisMet: 0.432 ± 0.161
0.617HisAsn: 0.617 ± 0.268
1.482HisPro: 1.482 ± 0.272
0.864HisGln: 0.864 ± 0.209
1.173HisArg: 1.173 ± 0.303
0.679HisSer: 0.679 ± 0.202
0.926HisThr: 0.926 ± 0.221
1.111HisVal: 1.111 ± 0.258
0.494HisTrp: 0.494 ± 0.198
0.741HisTyr: 0.741 ± 0.288
0.0HisXaa: 0.0 ± 0.0
Ile
5.249IleAla: 5.249 ± 0.708
0.37IleCys: 0.37 ± 0.126
3.087IleAsp: 3.087 ± 0.436
4.631IleGlu: 4.631 ± 0.449
0.926IlePhe: 0.926 ± 0.198
3.828IleGly: 3.828 ± 0.511
1.05IleHis: 1.05 ± 0.253
1.791IleIle: 1.791 ± 0.294
2.408IleLys: 2.408 ± 0.337
3.767IleLeu: 3.767 ± 0.519
0.679IleMet: 0.679 ± 0.216
1.852IleAsn: 1.852 ± 0.381
3.89IlePro: 3.89 ± 0.5
1.667IleGln: 1.667 ± 0.319
3.273IleArg: 3.273 ± 0.411
2.717IleSer: 2.717 ± 0.456
3.396IleThr: 3.396 ± 0.456
2.902IleVal: 2.902 ± 0.448
0.803IleTrp: 0.803 ± 0.189
1.235IleTyr: 1.235 ± 0.297
0.0IleXaa: 0.0 ± 0.0
Lys
5.372LysAla: 5.372 ± 0.716
0.185LysCys: 0.185 ± 0.105
2.47LysAsp: 2.47 ± 0.377
2.655LysGlu: 2.655 ± 0.509
0.926LysPhe: 0.926 ± 0.218
4.569LysGly: 4.569 ± 1.162
0.741LysHis: 0.741 ± 0.207
2.223LysIle: 2.223 ± 0.407
3.087LysLys: 3.087 ± 0.49
4.261LysLeu: 4.261 ± 0.527
0.988LysMet: 0.988 ± 0.242
1.42LysAsn: 1.42 ± 0.306
3.334LysPro: 3.334 ± 0.575
1.42LysGln: 1.42 ± 0.307
3.334LysArg: 3.334 ± 0.492
2.346LysSer: 2.346 ± 0.366
2.223LysThr: 2.223 ± 0.359
4.446LysVal: 4.446 ± 0.517
0.679LysTrp: 0.679 ± 0.189
1.544LysTyr: 1.544 ± 0.275
0.0LysXaa: 0.0 ± 0.0
Leu
9.2LeuAla: 9.2 ± 0.997
0.864LeuCys: 0.864 ± 0.226
4.631LeuAsp: 4.631 ± 0.55
5.063LeuGlu: 5.063 ± 0.632
2.84LeuPhe: 2.84 ± 0.391
5.804LeuGly: 5.804 ± 0.698
1.729LeuHis: 1.729 ± 0.415
4.508LeuIle: 4.508 ± 0.51
3.767LeuLys: 3.767 ± 0.482
6.483LeuLeu: 6.483 ± 0.912
2.655LeuMet: 2.655 ± 0.43
2.84LeuAsn: 2.84 ± 0.427
4.755LeuPro: 4.755 ± 0.47
2.408LeuGln: 2.408 ± 0.397
6.051LeuArg: 6.051 ± 0.697
5.31LeuSer: 5.31 ± 0.614
5.187LeuThr: 5.187 ± 0.614
4.693LeuVal: 4.693 ± 0.686
1.358LeuTrp: 1.358 ± 0.284
2.285LeuTyr: 2.285 ± 0.341
0.0LeuXaa: 0.0 ± 0.0
Met
3.396MetAla: 3.396 ± 0.444
0.123MetCys: 0.123 ± 0.086
0.864MetAsp: 0.864 ± 0.249
1.111MetGlu: 1.111 ± 0.184
0.679MetPhe: 0.679 ± 0.19
1.729MetGly: 1.729 ± 0.293
0.617MetHis: 0.617 ± 0.207
1.235MetIle: 1.235 ± 0.268
1.729MetLys: 1.729 ± 0.321
1.42MetLeu: 1.42 ± 0.279
0.741MetMet: 0.741 ± 0.199
0.617MetAsn: 0.617 ± 0.204
1.482MetPro: 1.482 ± 0.351
0.988MetGln: 0.988 ± 0.246
1.605MetArg: 1.605 ± 0.288
1.852MetSer: 1.852 ± 0.31
2.285MetThr: 2.285 ± 0.344
1.605MetVal: 1.605 ± 0.345
0.185MetTrp: 0.185 ± 0.103
0.803MetTyr: 0.803 ± 0.205
0.0MetXaa: 0.0 ± 0.0
Asn
3.149AsnAla: 3.149 ± 0.574
0.432AsnCys: 0.432 ± 0.169
1.791AsnAsp: 1.791 ± 0.257
2.47AsnGlu: 2.47 ± 0.437
1.05AsnPhe: 1.05 ± 0.319
3.149AsnGly: 3.149 ± 0.513
0.926AsnHis: 0.926 ± 0.201
1.358AsnIle: 1.358 ± 0.264
1.111AsnLys: 1.111 ± 0.256
3.149AsnLeu: 3.149 ± 0.47
0.679AsnMet: 0.679 ± 0.215
0.556AsnAsn: 0.556 ± 0.149
1.976AsnPro: 1.976 ± 0.323
0.679AsnGln: 0.679 ± 0.203
1.729AsnArg: 1.729 ± 0.328
1.482AsnSer: 1.482 ± 0.268
1.729AsnThr: 1.729 ± 0.379
2.779AsnVal: 2.779 ± 0.419
0.432AsnTrp: 0.432 ± 0.177
0.864AsnTyr: 0.864 ± 0.197
0.0AsnXaa: 0.0 ± 0.0
Pro
5.619ProAla: 5.619 ± 0.536
0.309ProCys: 0.309 ± 0.151
4.075ProAsp: 4.075 ± 0.529
4.878ProGlu: 4.878 ± 0.635
1.482ProPhe: 1.482 ± 0.322
4.693ProGly: 4.693 ± 0.846
0.803ProHis: 0.803 ± 0.218
2.593ProIle: 2.593 ± 0.359
2.964ProLys: 2.964 ± 0.735
3.952ProLeu: 3.952 ± 0.465
1.235ProMet: 1.235 ± 0.333
2.223ProAsn: 2.223 ± 0.408
2.655ProPro: 2.655 ± 0.498
2.902ProGln: 2.902 ± 0.832
3.89ProArg: 3.89 ± 0.563
2.84ProSer: 2.84 ± 0.379
3.705ProThr: 3.705 ± 0.39
3.581ProVal: 3.581 ± 0.496
0.988ProTrp: 0.988 ± 0.39
1.729ProTyr: 1.729 ± 0.274
0.0ProXaa: 0.0 ± 0.0
Gln
4.446GlnAla: 4.446 ± 0.691
0.123GlnCys: 0.123 ± 0.079
1.297GlnAsp: 1.297 ± 0.321
1.791GlnGlu: 1.791 ± 0.325
1.235GlnPhe: 1.235 ± 0.218
4.322GlnGly: 4.322 ± 1.561
0.494GlnHis: 0.494 ± 0.165
2.346GlnIle: 2.346 ± 0.436
1.729GlnLys: 1.729 ± 0.391
2.964GlnLeu: 2.964 ± 0.499
1.05GlnMet: 1.05 ± 0.229
0.679GlnAsn: 0.679 ± 0.2
1.235GlnPro: 1.235 ± 0.361
1.914GlnGln: 1.914 ± 0.347
2.47GlnArg: 2.47 ± 0.399
1.729GlnSer: 1.729 ± 0.262
1.667GlnThr: 1.667 ± 0.275
2.655GlnVal: 2.655 ± 0.386
0.556GlnTrp: 0.556 ± 0.211
0.864GlnTyr: 0.864 ± 0.213
0.0GlnXaa: 0.0 ± 0.0
Arg
5.804ArgAla: 5.804 ± 0.708
0.741ArgCys: 0.741 ± 0.195
3.89ArgAsp: 3.89 ± 0.473
4.569ArgGlu: 4.569 ± 0.563
2.47ArgPhe: 2.47 ± 0.485
4.631ArgGly: 4.631 ± 0.625
1.482ArgHis: 1.482 ± 0.296
3.705ArgIle: 3.705 ± 0.459
3.767ArgLys: 3.767 ± 0.495
5.372ArgLeu: 5.372 ± 0.568
1.729ArgMet: 1.729 ± 0.348
2.223ArgAsn: 2.223 ± 0.36
2.964ArgPro: 2.964 ± 0.374
1.852ArgGln: 1.852 ± 0.322
4.631ArgArg: 4.631 ± 0.575
2.47ArgSer: 2.47 ± 0.412
2.779ArgThr: 2.779 ± 0.416
4.508ArgVal: 4.508 ± 0.511
1.358ArgTrp: 1.358 ± 0.338
2.099ArgTyr: 2.099 ± 0.427
0.0ArgXaa: 0.0 ± 0.0
Ser
5.187SerAla: 5.187 ± 0.495
0.432SerCys: 0.432 ± 0.144
3.334SerAsp: 3.334 ± 0.466
3.52SerGlu: 3.52 ± 0.344
1.914SerPhe: 1.914 ± 0.308
4.075SerGly: 4.075 ± 0.524
0.741SerHis: 0.741 ± 0.236
2.593SerIle: 2.593 ± 0.348
2.717SerLys: 2.717 ± 0.467
4.878SerLeu: 4.878 ± 0.597
1.42SerMet: 1.42 ± 0.286
1.05SerAsn: 1.05 ± 0.251
3.273SerPro: 3.273 ± 0.418
2.038SerGln: 2.038 ± 0.316
3.89SerArg: 3.89 ± 0.543
2.285SerSer: 2.285 ± 0.418
2.902SerThr: 2.902 ± 0.358
3.643SerVal: 3.643 ± 0.475
1.111SerTrp: 1.111 ± 0.252
1.482SerTyr: 1.482 ± 0.371
0.0SerXaa: 0.0 ± 0.0
Thr
5.372ThrAla: 5.372 ± 0.524
0.741ThrCys: 0.741 ± 0.215
4.075ThrAsp: 4.075 ± 0.634
3.458ThrGlu: 3.458 ± 0.492
1.729ThrPhe: 1.729 ± 0.345
5.928ThrGly: 5.928 ± 0.873
0.926ThrHis: 0.926 ± 0.251
1.914ThrIle: 1.914 ± 0.355
3.026ThrLys: 3.026 ± 0.504
5.002ThrLeu: 5.002 ± 0.541
1.235ThrMet: 1.235 ± 0.283
1.544ThrAsn: 1.544 ± 0.314
4.014ThrPro: 4.014 ± 0.465
2.038ThrGln: 2.038 ± 0.276
2.84ThrArg: 2.84 ± 0.375
3.273ThrSer: 3.273 ± 0.469
3.396ThrThr: 3.396 ± 0.46
5.187ThrVal: 5.187 ± 0.548
1.42ThrTrp: 1.42 ± 0.244
1.729ThrTyr: 1.729 ± 0.27
0.0ThrXaa: 0.0 ± 0.0
Val
6.607ValAla: 6.607 ± 0.847
0.617ValCys: 0.617 ± 0.217
5.249ValAsp: 5.249 ± 0.594
3.828ValGlu: 3.828 ± 0.469
2.532ValPhe: 2.532 ± 0.422
4.816ValGly: 4.816 ± 0.586
1.235ValHis: 1.235 ± 0.272
3.273ValIle: 3.273 ± 0.456
3.334ValLys: 3.334 ± 0.507
4.631ValLeu: 4.631 ± 0.54
1.482ValMet: 1.482 ± 0.325
2.902ValAsn: 2.902 ± 0.39
3.396ValPro: 3.396 ± 0.437
2.532ValGln: 2.532 ± 0.485
4.94ValArg: 4.94 ± 0.589
5.125ValSer: 5.125 ± 0.569
4.322ValThr: 4.322 ± 0.496
6.236ValVal: 6.236 ± 0.558
1.482ValTrp: 1.482 ± 0.339
1.852ValTyr: 1.852 ± 0.371
0.0ValXaa: 0.0 ± 0.0
Trp
1.544TrpAla: 1.544 ± 0.388
0.37TrpCys: 0.37 ± 0.191
0.988TrpAsp: 0.988 ± 0.255
1.173TrpGlu: 1.173 ± 0.208
0.741TrpPhe: 0.741 ± 0.19
1.297TrpGly: 1.297 ± 0.283
0.556TrpHis: 0.556 ± 0.239
1.111TrpIle: 1.111 ± 0.291
0.741TrpLys: 0.741 ± 0.234
1.235TrpLeu: 1.235 ± 0.258
0.617TrpMet: 0.617 ± 0.191
0.803TrpAsn: 0.803 ± 0.266
0.803TrpPro: 0.803 ± 0.26
1.111TrpGln: 1.111 ± 0.308
1.05TrpArg: 1.05 ± 0.216
1.05TrpSer: 1.05 ± 0.295
1.42TrpThr: 1.42 ± 0.297
1.05TrpVal: 1.05 ± 0.216
0.37TrpTrp: 0.37 ± 0.145
0.556TrpTyr: 0.556 ± 0.18
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.779TyrAla: 2.779 ± 0.515
0.309TyrCys: 0.309 ± 0.152
2.161TyrAsp: 2.161 ± 0.282
2.408TyrGlu: 2.408 ± 0.331
0.617TyrPhe: 0.617 ± 0.185
2.223TyrGly: 2.223 ± 0.381
0.556TyrHis: 0.556 ± 0.164
1.235TyrIle: 1.235 ± 0.248
1.42TyrLys: 1.42 ± 0.356
2.593TyrLeu: 2.593 ± 0.333
0.617TyrMet: 0.617 ± 0.203
1.235TyrAsn: 1.235 ± 0.289
1.544TyrPro: 1.544 ± 0.362
0.988TyrGln: 0.988 ± 0.237
2.285TyrArg: 2.285 ± 0.497
1.791TyrSer: 1.791 ± 0.324
1.791TyrThr: 1.791 ± 0.309
2.408TyrVal: 2.408 ± 0.457
0.617TyrTrp: 0.617 ± 0.204
0.864TyrTyr: 0.864 ± 0.259
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 88 proteins (16196 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski