Amino acid dipepetide frequency for Weissella halotolerans DSM 20190

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.658AlaAla: 9.658 ± 0.228
0.219AlaCys: 0.219 ± 0.026
6.397AlaAsp: 6.397 ± 0.13
4.973AlaGlu: 4.973 ± 0.12
3.729AlaPhe: 3.729 ± 0.093
7.435AlaGly: 7.435 ± 0.149
1.796AlaHis: 1.796 ± 0.069
6.111AlaIle: 6.111 ± 0.119
6.066AlaLys: 6.066 ± 0.117
10.687AlaLeu: 10.687 ± 0.181
2.586AlaMet: 2.586 ± 0.092
4.039AlaAsn: 4.039 ± 0.11
2.839AlaPro: 2.839 ± 0.088
5.237AlaGln: 5.237 ± 0.14
3.878AlaArg: 3.878 ± 0.104
4.862AlaSer: 4.862 ± 0.118
5.44AlaThr: 5.44 ± 0.126
6.7AlaVal: 6.7 ± 0.146
1.086AlaTrp: 1.086 ± 0.058
3.227AlaTyr: 3.227 ± 0.104
0.0AlaXaa: 0.0 ± 0.0
Cys
0.154CysAla: 0.154 ± 0.021
0.022CysCys: 0.022 ± 0.008
0.107CysAsp: 0.107 ± 0.017
0.082CysGlu: 0.082 ± 0.015
0.137CysPhe: 0.137 ± 0.021
0.206CysGly: 0.206 ± 0.025
0.06CysHis: 0.06 ± 0.014
0.112CysIle: 0.112 ± 0.016
0.045CysLys: 0.045 ± 0.01
0.39CysLeu: 0.39 ± 0.036
0.067CysMet: 0.067 ± 0.012
0.065CysAsn: 0.065 ± 0.013
0.122CysPro: 0.122 ± 0.017
0.152CysGln: 0.152 ± 0.024
0.079CysArg: 0.079 ± 0.017
0.097CysSer: 0.097 ± 0.018
0.122CysThr: 0.122 ± 0.018
0.127CysVal: 0.127 ± 0.015
0.035CysTrp: 0.035 ± 0.009
0.075CysTyr: 0.075 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.785AspAla: 4.785 ± 0.114
0.129AspCys: 0.129 ± 0.016
3.356AspAsp: 3.356 ± 0.11
3.992AspGlu: 3.992 ± 0.108
2.641AspPhe: 2.641 ± 0.091
3.821AspGly: 3.821 ± 0.113
1.389AspHis: 1.389 ± 0.052
3.508AspIle: 3.508 ± 0.11
2.666AspLys: 2.666 ± 0.097
6.384AspLeu: 6.384 ± 0.126
1.553AspMet: 1.553 ± 0.063
1.908AspAsn: 1.908 ± 0.069
2.452AspPro: 2.452 ± 0.082
3.888AspGln: 3.888 ± 0.114
2.608AspArg: 2.608 ± 0.071
2.372AspSer: 2.372 ± 0.085
2.847AspThr: 2.847 ± 0.094
4.052AspVal: 4.052 ± 0.112
0.845AspTrp: 0.845 ± 0.048
2.646AspTyr: 2.646 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
4.919GluAla: 4.919 ± 0.121
0.089GluCys: 0.089 ± 0.017
2.74GluAsp: 2.74 ± 0.087
3.18GluGlu: 3.18 ± 0.103
1.784GluPhe: 1.784 ± 0.075
2.887GluGly: 2.887 ± 0.09
1.503GluHis: 1.503 ± 0.072
3.138GluIle: 3.138 ± 0.094
3.021GluLys: 3.021 ± 0.1
5.408GluLeu: 5.408 ± 0.125
1.52GluMet: 1.52 ± 0.063
2.243GluAsn: 2.243 ± 0.075
1.992GluPro: 1.992 ± 0.084
3.54GluGln: 3.54 ± 0.101
3.257GluArg: 3.257 ± 0.107
2.216GluSer: 2.216 ± 0.08
3.252GluThr: 3.252 ± 0.082
3.888GluVal: 3.888 ± 0.12
0.514GluTrp: 0.514 ± 0.038
1.371GluTyr: 1.371 ± 0.056
0.002GluXaa: 0.002 ± 0.003
Phe
3.622PheAla: 3.622 ± 0.11
0.132PheCys: 0.132 ± 0.02
2.68PheAsp: 2.68 ± 0.078
1.908PheGlu: 1.908 ± 0.069
1.774PhePhe: 1.774 ± 0.077
3.321PheGly: 3.321 ± 0.115
0.763PheHis: 0.763 ± 0.04
2.75PheIle: 2.75 ± 0.108
2.236PheLys: 2.236 ± 0.087
3.602PheLeu: 3.602 ± 0.109
1.205PheMet: 1.205 ± 0.059
1.751PheAsn: 1.751 ± 0.07
1.423PhePro: 1.423 ± 0.054
1.309PheGln: 1.309 ± 0.05
1.24PheArg: 1.24 ± 0.062
2.39PheSer: 2.39 ± 0.081
2.362PheThr: 2.362 ± 0.09
2.924PheVal: 2.924 ± 0.092
0.564PheTrp: 0.564 ± 0.035
1.443PheTyr: 1.443 ± 0.064
0.002PheXaa: 0.002 ± 0.002
Gly
5.761GlyAla: 5.761 ± 0.133
0.152GlyCys: 0.152 ± 0.02
3.672GlyAsp: 3.672 ± 0.105
3.388GlyGlu: 3.388 ± 0.116
2.931GlyPhe: 2.931 ± 0.09
4.511GlyGly: 4.511 ± 0.127
1.804GlyHis: 1.804 ± 0.067
4.881GlyIle: 4.881 ± 0.117
3.808GlyLys: 3.808 ± 0.109
7.994GlyLeu: 7.994 ± 0.166
2.213GlyMet: 2.213 ± 0.089
2.325GlyAsn: 2.325 ± 0.079
1.987GlyPro: 1.987 ± 0.069
4.39GlyGln: 4.39 ± 0.107
3.361GlyArg: 3.361 ± 0.107
3.719GlySer: 3.719 ± 0.099
4.173GlyThr: 4.173 ± 0.111
5.204GlyVal: 5.204 ± 0.122
0.939GlyTrp: 0.939 ± 0.05
2.844GlyTyr: 2.844 ± 0.101
0.0GlyXaa: 0.0 ± 0.0
His
1.679HisAla: 1.679 ± 0.072
0.042HisCys: 0.042 ± 0.01
1.327HisAsp: 1.327 ± 0.057
1.083HisGlu: 1.083 ± 0.052
1.1HisPhe: 1.1 ± 0.051
1.572HisGly: 1.572 ± 0.071
0.715HisHis: 0.715 ± 0.045
1.262HisIle: 1.262 ± 0.061
0.84HisLys: 0.84 ± 0.042
2.405HisLeu: 2.405 ± 0.073
0.581HisMet: 0.581 ± 0.034
0.728HisAsn: 0.728 ± 0.041
1.207HisPro: 1.207 ± 0.061
1.433HisGln: 1.433 ± 0.064
0.979HisArg: 0.979 ± 0.05
1.046HisSer: 1.046 ± 0.055
1.036HisThr: 1.036 ± 0.056
1.404HisVal: 1.404 ± 0.06
0.345HisTrp: 0.345 ± 0.029
1.197HisTyr: 1.197 ± 0.057
0.0HisXaa: 0.0 ± 0.0
Ile
5.892IleAla: 5.892 ± 0.123
0.152IleCys: 0.152 ± 0.02
3.915IleAsp: 3.915 ± 0.098
3.47IleGlu: 3.47 ± 0.107
2.653IlePhe: 2.653 ± 0.111
4.991IleGly: 4.991 ± 0.137
1.163IleHis: 1.163 ± 0.06
3.898IleIle: 3.898 ± 0.114
3.438IleLys: 3.438 ± 0.1
5.786IleLeu: 5.786 ± 0.141
1.751IleMet: 1.751 ± 0.065
2.623IleAsn: 2.623 ± 0.089
2.511IlePro: 2.511 ± 0.082
2.815IleGln: 2.815 ± 0.073
2.628IleArg: 2.628 ± 0.09
3.381IleSer: 3.381 ± 0.092
3.721IleThr: 3.721 ± 0.089
4.568IleVal: 4.568 ± 0.115
0.678IleTrp: 0.678 ± 0.044
1.833IleTyr: 1.833 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
5.224LysAla: 5.224 ± 0.128
0.04LysCys: 0.04 ± 0.012
2.78LysAsp: 2.78 ± 0.08
3.532LysGlu: 3.532 ± 0.108
1.349LysPhe: 1.349 ± 0.066
3.197LysGly: 3.197 ± 0.099
1.163LysHis: 1.163 ± 0.056
3.1LysIle: 3.1 ± 0.096
3.359LysLys: 3.359 ± 0.14
4.688LysLeu: 4.688 ± 0.115
1.749LysMet: 1.749 ± 0.062
2.072LysAsn: 2.072 ± 0.08
2.154LysPro: 2.154 ± 0.079
3.388LysGln: 3.388 ± 0.101
3.065LysArg: 3.065 ± 0.091
2.387LysSer: 2.387 ± 0.09
3.669LysThr: 3.669 ± 0.1
3.776LysVal: 3.776 ± 0.103
0.529LysTrp: 0.529 ± 0.034
1.493LysTyr: 1.493 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
12.642LeuAla: 12.642 ± 0.191
0.276LeuCys: 0.276 ± 0.031
5.721LeuAsp: 5.721 ± 0.128
4.506LeuGlu: 4.506 ± 0.132
3.729LeuPhe: 3.729 ± 0.12
7.527LeuGly: 7.527 ± 0.156
1.955LeuHis: 1.955 ± 0.067
6.275LeuIle: 6.275 ± 0.15
5.435LeuLys: 5.435 ± 0.127
10.21LeuLeu: 10.21 ± 0.219
2.81LeuMet: 2.81 ± 0.098
4.278LeuAsn: 4.278 ± 0.115
5.025LeuPro: 5.025 ± 0.119
4.238LeuGln: 4.238 ± 0.11
4.121LeuArg: 4.121 ± 0.104
6.2LeuSer: 6.2 ± 0.137
7.992LeuThr: 7.992 ± 0.167
8.451LeuVal: 8.451 ± 0.168
0.914LeuTrp: 0.914 ± 0.056
2.71LeuTyr: 2.71 ± 0.095
0.0LeuXaa: 0.0 ± 0.0
Met
3.016MetAla: 3.016 ± 0.082
0.045MetCys: 0.045 ± 0.012
1.471MetAsp: 1.471 ± 0.067
1.215MetGlu: 1.215 ± 0.059
0.879MetPhe: 0.879 ± 0.048
1.893MetGly: 1.893 ± 0.072
0.499MetHis: 0.499 ± 0.033
1.764MetIle: 1.764 ± 0.072
1.411MetLys: 1.411 ± 0.052
2.584MetLeu: 2.584 ± 0.087
1.028MetMet: 1.028 ± 0.052
1.143MetAsn: 1.143 ± 0.052
1.133MetPro: 1.133 ± 0.054
1.659MetGln: 1.659 ± 0.06
1.235MetArg: 1.235 ± 0.055
1.468MetSer: 1.468 ± 0.057
2.268MetThr: 2.268 ± 0.078
2.236MetVal: 2.236 ± 0.067
0.234MetTrp: 0.234 ± 0.026
0.626MetTyr: 0.626 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.172AsnAla: 3.172 ± 0.099
0.079AsnCys: 0.079 ± 0.019
2.228AsnAsp: 2.228 ± 0.074
2.159AsnGlu: 2.159 ± 0.079
1.607AsnPhe: 1.607 ± 0.07
2.906AsnGly: 2.906 ± 0.087
1.041AsnHis: 1.041 ± 0.052
2.251AsnIle: 2.251 ± 0.08
1.754AsnLys: 1.754 ± 0.071
3.823AsnLeu: 3.823 ± 0.098
1.177AsnMet: 1.177 ± 0.051
1.299AsnAsn: 1.299 ± 0.071
2.077AsnPro: 2.077 ± 0.077
2.767AsnGln: 2.767 ± 0.089
1.823AsnArg: 1.823 ± 0.062
1.5AsnSer: 1.5 ± 0.064
1.948AsnThr: 1.948 ± 0.073
2.695AsnVal: 2.695 ± 0.075
0.589AsnTrp: 0.589 ± 0.035
1.446AsnTyr: 1.446 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
4.203ProAla: 4.203 ± 0.12
0.077ProCys: 0.077 ± 0.014
2.584ProAsp: 2.584 ± 0.076
2.422ProGlu: 2.422 ± 0.076
1.702ProPhe: 1.702 ± 0.068
2.601ProGly: 2.601 ± 0.093
0.795ProHis: 0.795 ± 0.046
2.422ProIle: 2.422 ± 0.079
2.305ProLys: 2.305 ± 0.073
4.002ProLeu: 4.002 ± 0.101
0.892ProMet: 0.892 ± 0.052
1.736ProAsn: 1.736 ± 0.066
0.584ProPro: 0.584 ± 0.035
1.724ProGln: 1.724 ± 0.065
1.394ProArg: 1.394 ± 0.059
2.077ProSer: 2.077 ± 0.068
2.598ProThr: 2.598 ± 0.077
3.359ProVal: 3.359 ± 0.105
0.43ProTrp: 0.43 ± 0.032
1.476ProTyr: 1.476 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
7.169GlnAla: 7.169 ± 0.193
0.067GlnCys: 0.067 ± 0.011
2.623GlnAsp: 2.623 ± 0.078
2.725GlnGlu: 2.725 ± 0.083
1.746GlnPhe: 1.746 ± 0.074
3.451GlnGly: 3.451 ± 0.093
1.418GlnHis: 1.418 ± 0.067
2.822GlnIle: 2.822 ± 0.081
2.596GlnLys: 2.596 ± 0.091
6.151GlnLeu: 6.151 ± 0.148
1.336GlnMet: 1.336 ± 0.059
1.707GlnAsn: 1.707 ± 0.06
2.482GlnPro: 2.482 ± 0.081
3.212GlnGln: 3.212 ± 0.121
2.882GlnArg: 2.882 ± 0.098
2.474GlnSer: 2.474 ± 0.079
3.694GlnThr: 3.694 ± 0.093
4.747GlnVal: 4.747 ± 0.106
0.604GlnTrp: 0.604 ± 0.038
1.518GlnTyr: 1.518 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
3.711ArgAla: 3.711 ± 0.101
0.097ArgCys: 0.097 ± 0.018
2.467ArgAsp: 2.467 ± 0.075
2.489ArgGlu: 2.489 ± 0.085
1.958ArgPhe: 1.958 ± 0.069
2.74ArgGly: 2.74 ± 0.082
1.143ArgHis: 1.143 ± 0.059
2.688ArgIle: 2.688 ± 0.093
2.149ArgLys: 2.149 ± 0.075
5.182ArgLeu: 5.182 ± 0.134
1.17ArgMet: 1.17 ± 0.057
1.538ArgAsn: 1.538 ± 0.058
1.838ArgPro: 1.838 ± 0.062
3.21ArgGln: 3.21 ± 0.088
2.531ArgArg: 2.531 ± 0.082
2.087ArgSer: 2.087 ± 0.069
2.325ArgThr: 2.325 ± 0.09
3.133ArgVal: 3.133 ± 0.096
0.542ArgTrp: 0.542 ± 0.041
1.876ArgTyr: 1.876 ± 0.074
0.0ArgXaa: 0.0 ± 0.0
Ser
4.424SerAla: 4.424 ± 0.109
0.132SerCys: 0.132 ± 0.024
2.946SerAsp: 2.946 ± 0.088
2.462SerGlu: 2.462 ± 0.07
2.275SerPhe: 2.275 ± 0.09
3.836SerGly: 3.836 ± 0.11
1.103SerHis: 1.103 ± 0.05
3.292SerIle: 3.292 ± 0.101
2.633SerLys: 2.633 ± 0.091
5.733SerLeu: 5.733 ± 0.127
1.433SerMet: 1.433 ± 0.061
1.804SerAsn: 1.804 ± 0.076
1.918SerPro: 1.918 ± 0.069
3.023SerGln: 3.023 ± 0.091
2.3SerArg: 2.3 ± 0.072
2.656SerSer: 2.656 ± 0.114
2.894SerThr: 2.894 ± 0.091
3.582SerVal: 3.582 ± 0.106
0.591SerTrp: 0.591 ± 0.034
1.744SerTyr: 1.744 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
5.701ThrAla: 5.701 ± 0.117
0.147ThrCys: 0.147 ± 0.018
3.736ThrAsp: 3.736 ± 0.1
2.983ThrGlu: 2.983 ± 0.09
2.611ThrPhe: 2.611 ± 0.086
4.894ThrGly: 4.894 ± 0.113
1.125ThrHis: 1.125 ± 0.046
4.263ThrIle: 4.263 ± 0.106
3.279ThrLys: 3.279 ± 0.094
6.528ThrLeu: 6.528 ± 0.138
1.53ThrMet: 1.53 ± 0.057
2.459ThrAsn: 2.459 ± 0.082
2.666ThrPro: 2.666 ± 0.068
2.524ThrGln: 2.524 ± 0.079
2.114ThrArg: 2.114 ± 0.078
3.359ThrSer: 3.359 ± 0.082
3.838ThrThr: 3.838 ± 0.116
5.376ThrVal: 5.376 ± 0.118
0.77ThrTrp: 0.77 ± 0.046
2.03ThrTyr: 2.03 ± 0.075
0.002ThrXaa: 0.002 ± 0.002
Val
7.557ValAla: 7.557 ± 0.153
0.221ValCys: 0.221 ± 0.022
4.63ValAsp: 4.63 ± 0.116
3.863ValGlu: 3.863 ± 0.101
2.777ValPhe: 2.777 ± 0.091
5.222ValGly: 5.222 ± 0.105
1.314ValHis: 1.314 ± 0.06
5.006ValIle: 5.006 ± 0.114
4.268ValLys: 4.268 ± 0.12
7.703ValLeu: 7.703 ± 0.141
2.082ValMet: 2.082 ± 0.069
3.167ValAsn: 3.167 ± 0.074
3.083ValPro: 3.083 ± 0.082
3.046ValGln: 3.046 ± 0.094
2.899ValArg: 2.899 ± 0.079
4.181ValSer: 4.181 ± 0.101
5.343ValThr: 5.343 ± 0.107
6.188ValVal: 6.188 ± 0.135
0.76ValTrp: 0.76 ± 0.044
2.156ValTyr: 2.156 ± 0.083
0.0ValXaa: 0.0 ± 0.0
Trp
0.842TrpAla: 0.842 ± 0.047
0.042TrpCys: 0.042 ± 0.01
0.46TrpAsp: 0.46 ± 0.035
0.4TrpGlu: 0.4 ± 0.032
0.517TrpPhe: 0.517 ± 0.037
0.661TrpGly: 0.661 ± 0.043
0.338TrpHis: 0.338 ± 0.027
0.596TrpIle: 0.596 ± 0.041
0.311TrpLys: 0.311 ± 0.035
1.833TrpLeu: 1.833 ± 0.076
0.363TrpMet: 0.363 ± 0.029
0.36TrpAsn: 0.36 ± 0.031
0.455TrpPro: 0.455 ± 0.037
1.098TrpGln: 1.098 ± 0.066
0.658TrpArg: 0.658 ± 0.047
0.725TrpSer: 0.725 ± 0.042
0.646TrpThr: 0.646 ± 0.048
0.72TrpVal: 0.72 ± 0.046
0.211TrpTrp: 0.211 ± 0.023
0.383TrpTyr: 0.383 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.827TyrAla: 2.827 ± 0.08
0.094TyrCys: 0.094 ± 0.016
2.0TyrAsp: 2.0 ± 0.074
1.63TyrGlu: 1.63 ± 0.063
1.503TyrPhe: 1.503 ± 0.062
2.385TyrGly: 2.385 ± 0.084
0.899TyrHis: 0.899 ± 0.052
1.731TyrIle: 1.731 ± 0.071
1.096TyrLys: 1.096 ± 0.058
3.923TyrLeu: 3.923 ± 0.121
0.755TyrMet: 0.755 ± 0.043
1.098TyrAsn: 1.098 ± 0.056
1.433TyrPro: 1.433 ± 0.065
2.772TyrGln: 2.772 ± 0.094
1.818TyrArg: 1.818 ± 0.067
1.585TyrSer: 1.585 ± 0.064
1.766TyrThr: 1.766 ± 0.063
2.338TyrVal: 2.338 ± 0.073
0.44TyrTrp: 0.44 ± 0.037
1.312TyrTyr: 1.312 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.005XaaAla: 0.005 ± 0.003
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.4XaaXaa: 0.4 ± 0.204
Statistics based on 1304 proteins (402550 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski