Amino acid dipepetide frequency for Leptolyngbya sp. hensonii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.086AlaAla: 9.086 ± 0.102	1.026AlaCys: 1.026 ± 0.027	4.741AlaAsp: 4.741 ± 0.057	5.761AlaGlu: 5.761 ± 0.066	2.957AlaPhe: 2.957 ± 0.044	6.45AlaGly: 6.45 ± 0.078	1.669AlaHis: 1.669 ± 0.034	6.831AlaIle: 6.831 ± 0.074	2.954AlaLys: 2.954 ± 0.046	10.536AlaLeu: 10.536 ± 0.098	1.945AlaMet: 1.945 ± 0.034	2.9AlaAsn: 2.9 ± 0.074	3.845AlaPro: 3.845 ± 0.069	5.031AlaGln: 5.031 ± 0.069	4.809AlaArg: 4.809 ± 0.058	4.89AlaSer: 4.89 ± 0.063	5.237AlaThr: 5.237 ± 0.067	5.969AlaVal: 5.969 ± 0.063	1.159AlaTrp: 1.159 ± 0.025	2.629AlaTyr: 2.629 ± 0.05	0.006AlaXaa: 0.006 ± 0.003
Cys	0.684CysAla: 0.684 ± 0.019	0.169CysCys: 0.169 ± 0.01	0.567CysAsp: 0.567 ± 0.017	0.463CysGlu: 0.463 ± 0.016	0.424CysPhe: 0.424 ± 0.015	0.812CysGly: 0.812 ± 0.021	0.326CysHis: 0.326 ± 0.014	0.485CysIle: 0.485 ± 0.018	0.273CysLys: 0.273 ± 0.014	1.27CysLeu: 1.27 ± 0.031	0.165CysMet: 0.165 ± 0.009	0.345CysAsn: 0.345 ± 0.016	0.58CysPro: 0.58 ± 0.023	0.624CysGln: 0.624 ± 0.019	0.662CysArg: 0.662 ± 0.02	0.65CysSer: 0.65 ± 0.023	0.485CysThr: 0.485 ± 0.018	0.555CysVal: 0.555 ± 0.02	0.158CysTrp: 0.158 ± 0.009	0.367CysTyr: 0.367 ± 0.016	0.001CysXaa: 0.001 ± 0.001
Asp	3.84AspAla: 3.84 ± 0.054	0.552AspCys: 0.552 ± 0.019	2.137AspAsp: 2.137 ± 0.046	2.649AspGlu: 2.649 ± 0.04	2.059AspPhe: 2.059 ± 0.038	3.33AspGly: 3.33 ± 0.054	0.994AspHis: 0.994 ± 0.031	2.631AspIle: 2.631 ± 0.039	1.345AspLys: 1.345 ± 0.031	6.794AspLeu: 6.794 ± 0.074	0.786AspMet: 0.786 ± 0.022	1.333AspAsn: 1.333 ± 0.033	3.093AspPro: 3.093 ± 0.046	2.634AspGln: 2.634 ± 0.046	4.906AspArg: 4.906 ± 0.064	2.555AspSer: 2.555 ± 0.039	2.141AspThr: 2.141 ± 0.035	2.887AspVal: 2.887 ± 0.047	0.984AspTrp: 0.984 ± 0.026	1.83AspTyr: 1.83 ± 0.032	0.002AspXaa: 0.002 ± 0.001
Glu	6.207GluAla: 6.207 ± 0.069	0.408GluCys: 0.408 ± 0.017	2.714GluAsp: 2.714 ± 0.039	3.53GluGlu: 3.53 ± 0.058	2.138GluPhe: 2.138 ± 0.033	3.486GluGly: 3.486 ± 0.05	1.08GluHis: 1.08 ± 0.03	3.869GluIle: 3.869 ± 0.053	2.408GluLys: 2.408 ± 0.044	6.667GluLeu: 6.667 ± 0.074	1.314GluMet: 1.314 ± 0.028	1.773GluAsn: 1.773 ± 0.035	2.686GluPro: 2.686 ± 0.044	3.88GluGln: 3.88 ± 0.054	3.647GluArg: 3.647 ± 0.057	3.083GluSer: 3.083 ± 0.048	3.439GluThr: 3.439 ± 0.051	4.415GluVal: 4.415 ± 0.056	0.745GluTrp: 0.745 ± 0.022	1.413GluTyr: 1.413 ± 0.031	0.004GluXaa: 0.004 ± 0.002
Phe	2.873PheAla: 2.873 ± 0.049	0.538PheCys: 0.538 ± 0.018	2.008PheAsp: 2.008 ± 0.039	2.03PheGlu: 2.03 ± 0.036	1.473PhePhe: 1.473 ± 0.032	2.642PheGly: 2.642 ± 0.044	0.757PheHis: 0.757 ± 0.021	1.861PheIle: 1.861 ± 0.036	1.214PheLys: 1.214 ± 0.024	4.144PheLeu: 4.144 ± 0.056	0.69PheMet: 0.69 ± 0.02	1.396PheAsn: 1.396 ± 0.031	1.872PhePro: 1.872 ± 0.038	1.983PheGln: 1.983 ± 0.033	2.031PheArg: 2.031 ± 0.036	2.728PheSer: 2.728 ± 0.049	2.126PheThr: 2.126 ± 0.038	2.231PheVal: 2.231 ± 0.035	0.709PheTrp: 0.709 ± 0.021	1.234PheTyr: 1.234 ± 0.029	0.001PheXaa: 0.001 ± 0.001
Gly	5.536GlyAla: 5.536 ± 0.079	0.824GlyCys: 0.824 ± 0.023	3.517GlyAsp: 3.517 ± 0.049	3.935GlyGlu: 3.935 ± 0.054	3.003GlyPhe: 3.003 ± 0.045	4.827GlyGly: 4.827 ± 0.074	1.469GlyHis: 1.469 ± 0.036	4.609GlyIle: 4.609 ± 0.061	3.172GlyLys: 3.172 ± 0.043	8.085GlyLeu: 8.085 ± 0.075	1.702GlyMet: 1.702 ± 0.036	2.597GlyAsn: 2.597 ± 0.066	2.238GlyPro: 2.238 ± 0.042	4.087GlyGln: 4.087 ± 0.052	3.899GlyArg: 3.899 ± 0.049	4.438GlySer: 4.438 ± 0.061	4.215GlyThr: 4.215 ± 0.068	4.75GlyVal: 4.75 ± 0.062	1.228GlyTrp: 1.228 ± 0.03	2.374GlyTyr: 2.374 ± 0.042	0.004GlyXaa: 0.004 ± 0.002
His	1.31HisAla: 1.31 ± 0.026	0.326HisCys: 0.326 ± 0.016	0.837HisAsp: 0.837 ± 0.024	0.979HisGlu: 0.979 ± 0.027	0.848HisPhe: 0.848 ± 0.026	1.299HisGly: 1.299 ± 0.031	0.728HisHis: 0.728 ± 0.025	0.951HisIle: 0.951 ± 0.024	0.545HisLys: 0.545 ± 0.018	2.941HisLeu: 2.941 ± 0.053	0.276HisMet: 0.276 ± 0.013	0.611HisAsn: 0.611 ± 0.017	1.808HisPro: 1.808 ± 0.033	1.419HisGln: 1.419 ± 0.036	1.455HisArg: 1.455 ± 0.033	1.109HisSer: 1.109 ± 0.029	0.94HisThr: 0.94 ± 0.025	0.881HisVal: 0.881 ± 0.021	0.381HisTrp: 0.381 ± 0.015	0.715HisTyr: 0.715 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.493IleAla: 6.493 ± 0.066	0.623IleCys: 0.623 ± 0.022	3.072IleAsp: 3.072 ± 0.042	3.588IleGlu: 3.588 ± 0.051	1.899IlePhe: 1.899 ± 0.038	4.528IleGly: 4.528 ± 0.059	1.302IleHis: 1.302 ± 0.032	2.35IleIle: 2.35 ± 0.043	1.801IleLys: 1.801 ± 0.037	6.486IleLeu: 6.486 ± 0.067	0.736IleMet: 0.736 ± 0.022	1.9IleAsn: 1.9 ± 0.037	3.446IlePro: 3.446 ± 0.041	3.204IleGln: 3.204 ± 0.052	3.516IleArg: 3.516 ± 0.051	3.534IleSer: 3.534 ± 0.049	3.306IleThr: 3.306 ± 0.053	4.105IleVal: 4.105 ± 0.05	0.812IleTrp: 0.812 ± 0.024	1.577IleTyr: 1.577 ± 0.035	0.002IleXaa: 0.002 ± 0.001
Lys	3.349LysAla: 3.349 ± 0.052	0.215LysCys: 0.215 ± 0.011	1.599LysAsp: 1.599 ± 0.033	1.698LysGlu: 1.698 ± 0.037	1.208LysPhe: 1.208 ± 0.026	2.175LysGly: 2.175 ± 0.038	0.637LysHis: 0.637 ± 0.019	2.083LysIle: 2.083 ± 0.038	1.266LysLys: 1.266 ± 0.038	3.972LysLeu: 3.972 ± 0.058	0.695LysMet: 0.695 ± 0.022	1.052LysAsn: 1.052 ± 0.026	2.143LysPro: 2.143 ± 0.043	2.225LysGln: 2.225 ± 0.039	2.008LysArg: 2.008 ± 0.038	1.999LysSer: 1.999 ± 0.036	2.325LysThr: 2.325 ± 0.039	2.42LysVal: 2.42 ± 0.044	0.334LysTrp: 0.334 ± 0.013	0.867LysTyr: 0.867 ± 0.025	0.001LysXaa: 0.001 ± 0.001
Leu	11.132LeuAla: 11.132 ± 0.101	1.121LeuCys: 1.121 ± 0.025	5.684LeuAsp: 5.684 ± 0.07	7.606LeuGlu: 7.606 ± 0.079	3.815LeuPhe: 3.815 ± 0.047	8.363LeuGly: 8.363 ± 0.093	2.23LeuHis: 2.23 ± 0.039	6.388LeuIle: 6.388 ± 0.067	4.796LeuLys: 4.796 ± 0.063	12.842LeuLeu: 12.842 ± 0.13	2.424LeuMet: 2.424 ± 0.04	4.086LeuAsn: 4.086 ± 0.062	6.633LeuPro: 6.633 ± 0.068	7.11LeuGln: 7.11 ± 0.079	6.641LeuArg: 6.641 ± 0.064	7.45LeuSer: 7.45 ± 0.078	7.096LeuThr: 7.096 ± 0.063	7.601LeuVal: 7.601 ± 0.07	1.645LeuTrp: 1.645 ± 0.037	2.872LeuTyr: 2.872 ± 0.04	0.002LeuXaa: 0.002 ± 0.001
Met	2.278MetAla: 2.278 ± 0.038	0.106MetCys: 0.106 ± 0.008	0.956MetAsp: 0.956 ± 0.027	1.07MetGlu: 1.07 ± 0.026	0.478MetPhe: 0.478 ± 0.017	1.628MetGly: 1.628 ± 0.031	0.325MetHis: 0.325 ± 0.014	1.015MetIle: 1.015 ± 0.024	0.758MetLys: 0.758 ± 0.02	1.967MetLeu: 1.967 ± 0.04	0.464MetMet: 0.464 ± 0.016	0.714MetAsn: 0.714 ± 0.023	1.13MetPro: 1.13 ± 0.023	1.033MetGln: 1.033 ± 0.027	1.004MetArg: 1.004 ± 0.022	1.168MetSer: 1.168 ± 0.028	1.502MetThr: 1.502 ± 0.029	1.504MetVal: 1.504 ± 0.031	0.122MetTrp: 0.122 ± 0.009	0.31MetTyr: 0.31 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.451AsnAla: 2.451 ± 0.047	0.373AsnCys: 0.373 ± 0.014	1.299AsnAsp: 1.299 ± 0.032	1.252AsnGlu: 1.252 ± 0.028	1.309AsnPhe: 1.309 ± 0.03	2.229AsnGly: 2.229 ± 0.053	0.765AsnHis: 0.765 ± 0.024	1.576AsnIle: 1.576 ± 0.04	0.806AsnLys: 0.806 ± 0.022	4.769AsnLeu: 4.769 ± 0.088	0.466AsnMet: 0.466 ± 0.017	1.084AsnAsn: 1.084 ± 0.037	2.709AsnPro: 2.709 ± 0.046	2.192AsnGln: 2.192 ± 0.04	2.367AsnArg: 2.367 ± 0.044	1.953AsnSer: 1.953 ± 0.038	1.586AsnThr: 1.586 ± 0.038	1.692AsnVal: 1.692 ± 0.036	0.611AsnTrp: 0.611 ± 0.02	0.999AsnTyr: 0.999 ± 0.027	0.001AsnXaa: 0.001 ± 0.001
Pro	4.893ProAla: 4.893 ± 0.075	0.43ProCys: 0.43 ± 0.019	3.713ProAsp: 3.713 ± 0.051	4.231ProGlu: 4.231 ± 0.061	1.939ProPhe: 1.939 ± 0.039	3.842ProGly: 3.842 ± 0.055	1.022ProHis: 1.022 ± 0.028	3.356ProIle: 3.356 ± 0.041	1.731ProLys: 1.731 ± 0.034	5.656ProLeu: 5.656 ± 0.068	1.019ProMet: 1.019 ± 0.025	1.805ProAsn: 1.805 ± 0.032	3.003ProPro: 3.003 ± 0.061	2.791ProGln: 2.791 ± 0.047	2.271ProArg: 2.271 ± 0.035	3.225ProSer: 3.225 ± 0.058	3.24ProThr: 3.24 ± 0.056	3.88ProVal: 3.88 ± 0.055	0.769ProTrp: 0.769 ± 0.023	1.439ProTyr: 1.439 ± 0.031	0.003ProXaa: 0.003 ± 0.001
Gln	6.425GlnAla: 6.425 ± 0.079	0.36GlnCys: 0.36 ± 0.016	2.534GlnAsp: 2.534 ± 0.043	3.494GlnGlu: 3.494 ± 0.053	2.058GlnPhe: 2.058 ± 0.034	4.178GlnGly: 4.178 ± 0.059	1.053GlnHis: 1.053 ± 0.025	3.694GlnIle: 3.694 ± 0.052	2.075GlnLys: 2.075 ± 0.042	6.092GlnLeu: 6.092 ± 0.066	1.291GlnMet: 1.291 ± 0.026	1.718GlnAsn: 1.718 ± 0.032	3.233GlnPro: 3.233 ± 0.052	4.314GlnGln: 4.314 ± 0.071	3.738GlnArg: 3.738 ± 0.054	3.334GlnSer: 3.334 ± 0.051	3.41GlnThr: 3.41 ± 0.053	4.854GlnVal: 4.854 ± 0.052	0.802GlnTrp: 0.802 ± 0.024	1.282GlnTyr: 1.282 ± 0.027	0.001GlnXaa: 0.001 ± 0.001
Arg	4.393ArgAla: 4.393 ± 0.056	0.609ArgCys: 0.609 ± 0.02	2.953ArgAsp: 2.953 ± 0.045	3.619ArgGlu: 3.619 ± 0.059	2.398ArgPhe: 2.398 ± 0.037	3.599ArgGly: 3.599 ± 0.05	1.333ArgHis: 1.333 ± 0.034	3.591ArgIle: 3.591 ± 0.044	2.036ArgLys: 2.036 ± 0.04	7.464ArgLeu: 7.464 ± 0.08	1.29ArgMet: 1.29 ± 0.028	1.883ArgAsn: 1.883 ± 0.032	2.697ArgPro: 2.697 ± 0.044	4.369ArgGln: 4.369 ± 0.069	3.769ArgArg: 3.769 ± 0.057	4.121ArgSer: 4.121 ± 0.053	2.996ArgThr: 2.996 ± 0.038	4.067ArgVal: 4.067 ± 0.051	1.01ArgTrp: 1.01 ± 0.025	2.098ArgTyr: 2.098 ± 0.037	0.002ArgXaa: 0.002 ± 0.001
Ser	4.679SerAla: 4.679 ± 0.061	0.546SerCys: 0.546 ± 0.02	2.873SerAsp: 2.873 ± 0.042	3.336SerGlu: 3.336 ± 0.055	2.268SerPhe: 2.268 ± 0.041	4.774SerGly: 4.774 ± 0.06	1.368SerHis: 1.368 ± 0.027	3.22SerIle: 3.22 ± 0.046	1.777SerLys: 1.777 ± 0.033	7.554SerLeu: 7.554 ± 0.071	1.146SerMet: 1.146 ± 0.029	1.902SerAsn: 1.902 ± 0.038	3.959SerPro: 3.959 ± 0.075	3.387SerGln: 3.387 ± 0.05	3.596SerArg: 3.596 ± 0.051	4.072SerSer: 4.072 ± 0.061	3.34SerThr: 3.34 ± 0.057	3.557SerVal: 3.557 ± 0.047	0.887SerTrp: 0.887 ± 0.024	1.632SerTyr: 1.632 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	5.352ThrAla: 5.352 ± 0.079	0.597ThrCys: 0.597 ± 0.021	2.743ThrAsp: 2.743 ± 0.045	3.077ThrGlu: 3.077 ± 0.043	2.049ThrPhe: 2.049 ± 0.036	4.649ThrGly: 4.649 ± 0.062	1.17ThrHis: 1.17 ± 0.03	3.606ThrIle: 3.606 ± 0.05	1.451ThrLys: 1.451 ± 0.033	7.151ThrLeu: 7.151 ± 0.07	0.857ThrMet: 0.857 ± 0.024	1.597ThrAsn: 1.597 ± 0.037	3.559ThrPro: 3.559 ± 0.062	2.972ThrGln: 2.972 ± 0.045	2.811ThrArg: 2.811 ± 0.045	3.119ThrSer: 3.119 ± 0.056	3.398ThrThr: 3.398 ± 0.054	4.257ThrVal: 4.257 ± 0.055	0.829ThrTrp: 0.829 ± 0.024	1.678ThrTyr: 1.678 ± 0.034	0.001ThrXaa: 0.001 ± 0.001
Val	6.196ValAla: 6.196 ± 0.069	0.705ValCys: 0.705 ± 0.019	3.466ValAsp: 3.466 ± 0.048	4.215ValGlu: 4.215 ± 0.049	2.458ValPhe: 2.458 ± 0.038	4.614ValGly: 4.614 ± 0.053	1.169ValHis: 1.169 ± 0.028	4.01ValIle: 4.01 ± 0.045	2.5ValLys: 2.5 ± 0.041	7.66ValLeu: 7.66 ± 0.073	1.517ValMet: 1.517 ± 0.031	2.346ValAsn: 2.346 ± 0.043	3.452ValPro: 3.452 ± 0.055	3.465ValGln: 3.465 ± 0.045	3.948ValArg: 3.948 ± 0.048	3.961ValSer: 3.961 ± 0.049	4.037ValThr: 4.037 ± 0.06	4.919ValVal: 4.919 ± 0.058	0.834ValTrp: 0.834 ± 0.023	1.707ValTyr: 1.707 ± 0.031	0.001ValXaa: 0.001 ± 0.001
Trp	1.084TrpAla: 1.084 ± 0.026	0.156TrpCys: 0.156 ± 0.01	0.649TrpAsp: 0.649 ± 0.021	0.856TrpGlu: 0.856 ± 0.023	0.617TrpPhe: 0.617 ± 0.022	0.996TrpGly: 0.996 ± 0.022	0.323TrpHis: 0.323 ± 0.015	0.826TrpIle: 0.826 ± 0.022	0.585TrpLys: 0.585 ± 0.019	1.937TrpLeu: 1.937 ± 0.037	0.352TrpMet: 0.352 ± 0.015	0.542TrpAsn: 0.542 ± 0.018	0.487TrpPro: 0.487 ± 0.018	1.251TrpGln: 1.251 ± 0.028	0.882TrpArg: 0.882 ± 0.024	0.843TrpSer: 0.843 ± 0.022	0.715TrpThr: 0.715 ± 0.021	1.048TrpVal: 1.048 ± 0.024	0.242TrpTrp: 0.242 ± 0.013	0.365TrpTyr: 0.365 ± 0.017	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.165TyrAla: 2.165 ± 0.037	0.379TyrCys: 0.379 ± 0.014	1.421TyrAsp: 1.421 ± 0.03	1.514TyrGlu: 1.514 ± 0.034	1.143TyrPhe: 1.143 ± 0.025	2.088TyrGly: 2.088 ± 0.041	0.638TyrHis: 0.638 ± 0.019	1.326TyrIle: 1.326 ± 0.029	0.774TyrLys: 0.774 ± 0.023	3.54TyrLeu: 3.54 ± 0.045	0.392TyrMet: 0.392 ± 0.015	0.904TyrAsn: 0.904 ± 0.026	1.685TyrPro: 1.685 ± 0.037	1.965TyrGln: 1.965 ± 0.037	2.337TyrArg: 2.337 ± 0.043	1.643TyrSer: 1.643 ± 0.032	1.388TyrThr: 1.388 ± 0.029	1.587TyrVal: 1.587 ± 0.032	0.498TyrTrp: 0.498 ± 0.017	0.938TyrTyr: 0.938 ± 0.025	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.005XaaAla: 0.005 ± 0.003	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.003XaaGlu: 0.003 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.004XaaLys: 0.004 ± 0.002	0.005XaaLeu: 0.005 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.004XaaSer: 0.004 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 5119 proteins (1680074 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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