Amino acid dipepetide frequency for Soboliphyme baturini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.343AlaAla: 6.343 ± 0.068	1.543AlaCys: 1.543 ± 0.02	3.655AlaAsp: 3.655 ± 0.034	4.334AlaGlu: 4.334 ± 0.044	2.89AlaPhe: 2.89 ± 0.03	3.564AlaGly: 3.564 ± 0.04	1.316AlaHis: 1.316 ± 0.021	3.325AlaIle: 3.325 ± 0.033	3.673AlaLys: 3.673 ± 0.036	6.182AlaLeu: 6.182 ± 0.048	1.722AlaMet: 1.722 ± 0.023	2.607AlaAsn: 2.607 ± 0.028	2.544AlaPro: 2.544 ± 0.029	2.138AlaGln: 2.138 ± 0.023	3.228AlaArg: 3.228 ± 0.029	5.664AlaSer: 5.664 ± 0.05	3.989AlaThr: 3.989 ± 0.033	5.631AlaVal: 5.631 ± 0.039	0.631AlaTrp: 0.631 ± 0.014	1.799AlaTyr: 1.799 ± 0.024	0.038AlaXaa: 0.038 ± 0.004
Cys	1.569CysAla: 1.569 ± 0.025	0.956CysCys: 0.956 ± 0.024	1.492CysAsp: 1.492 ± 0.026	1.371CysGlu: 1.371 ± 0.027	1.369CysPhe: 1.369 ± 0.022	1.612CysGly: 1.612 ± 0.024	0.79CysHis: 0.79 ± 0.016	1.366CysIle: 1.366 ± 0.024	1.277CysLys: 1.277 ± 0.023	2.64CysLeu: 2.64 ± 0.03	0.671CysMet: 0.671 ± 0.036	1.057CysAsn: 1.057 ± 0.021	1.374CysPro: 1.374 ± 0.038	1.082CysGln: 1.082 ± 0.02	1.784CysArg: 1.784 ± 0.024	2.532CysSer: 2.532 ± 0.034	1.325CysThr: 1.325 ± 0.02	1.755CysVal: 1.755 ± 0.025	0.304CysTrp: 0.304 ± 0.009	0.802CysTyr: 0.802 ± 0.015	0.009CysXaa: 0.009 ± 0.002
Asp	3.375AspAla: 3.375 ± 0.028	1.313AspCys: 1.313 ± 0.024	3.755AspAsp: 3.755 ± 0.044	3.934AspGlu: 3.934 ± 0.039	2.43AspPhe: 2.43 ± 0.022	3.486AspGly: 3.486 ± 0.034	1.264AspHis: 1.264 ± 0.017	2.876AspIle: 2.876 ± 0.029	2.444AspLys: 2.444 ± 0.026	4.722AspLeu: 4.722 ± 0.033	1.291AspMet: 1.291 ± 0.019	1.853AspAsn: 1.853 ± 0.024	2.184AspPro: 2.184 ± 0.026	1.892AspGln: 1.892 ± 0.022	3.173AspArg: 3.173 ± 0.033	4.344AspSer: 4.344 ± 0.036	2.327AspThr: 2.327 ± 0.023	3.933AspVal: 3.933 ± 0.033	0.642AspTrp: 0.642 ± 0.013	1.667AspTyr: 1.667 ± 0.02	0.021AspXaa: 0.021 ± 0.002
Glu	4.025GluAla: 4.025 ± 0.038	1.364GluCys: 1.364 ± 0.027	3.208GluAsp: 3.208 ± 0.032	4.803GluGlu: 4.803 ± 0.06	2.277GluPhe: 2.277 ± 0.03	2.629GluGly: 2.629 ± 0.029	1.336GluHis: 1.336 ± 0.019	3.163GluIle: 3.163 ± 0.035	4.179GluLys: 4.179 ± 0.048	5.281GluLeu: 5.281 ± 0.051	1.647GluMet: 1.647 ± 0.021	2.979GluAsn: 2.979 ± 0.033	2.188GluPro: 2.188 ± 0.027	2.512GluGln: 2.512 ± 0.03	3.614GluArg: 3.614 ± 0.035	4.209GluSer: 4.209 ± 0.04	3.296GluThr: 3.296 ± 0.038	3.984GluVal: 3.984 ± 0.041	0.677GluTrp: 0.677 ± 0.014	1.741GluTyr: 1.741 ± 0.025	0.022GluXaa: 0.022 ± 0.002
Phe	3.057PheAla: 3.057 ± 0.031	1.384PheCys: 1.384 ± 0.02	2.653PheAsp: 2.653 ± 0.025	2.423PheGlu: 2.423 ± 0.023	2.088PhePhe: 2.088 ± 0.027	2.703PheGly: 2.703 ± 0.034	1.157PheHis: 1.157 ± 0.017	2.337PheIle: 2.337 ± 0.027	1.947PheLys: 1.947 ± 0.022	4.509PheLeu: 4.509 ± 0.04	1.054PheMet: 1.054 ± 0.017	1.689PheAsn: 1.689 ± 0.022	1.941PhePro: 1.941 ± 0.023	1.659PheGln: 1.659 ± 0.019	2.738PheArg: 2.738 ± 0.027	3.927PheSer: 3.927 ± 0.033	2.36PheThr: 2.36 ± 0.025	3.478PheVal: 3.478 ± 0.035	0.575PheTrp: 0.575 ± 0.014	1.653PheTyr: 1.653 ± 0.024	0.018PheXaa: 0.018 ± 0.002
Gly	3.039GlyAla: 3.039 ± 0.031	1.377GlyCys: 1.377 ± 0.022	2.961GlyAsp: 2.961 ± 0.028	2.966GlyGlu: 2.966 ± 0.038	2.456GlyPhe: 2.456 ± 0.027	3.947GlyGly: 3.947 ± 0.056	1.435GlyHis: 1.435 ± 0.02	3.015GlyIle: 3.015 ± 0.03	3.164GlyLys: 3.164 ± 0.032	4.354GlyLeu: 4.354 ± 0.041	1.325GlyMet: 1.325 ± 0.023	2.303GlyAsn: 2.303 ± 0.027	2.164GlyPro: 2.164 ± 0.048	2.029GlyGln: 2.029 ± 0.028	3.564GlyArg: 3.564 ± 0.041	4.696GlySer: 4.696 ± 0.045	3.028GlyThr: 3.028 ± 0.034	3.53GlyVal: 3.53 ± 0.033	0.68GlyTrp: 0.68 ± 0.015	1.86GlyTyr: 1.86 ± 0.029	0.027GlyXaa: 0.027 ± 0.003
His	1.361HisAla: 1.361 ± 0.019	0.838HisCys: 0.838 ± 0.017	1.115HisAsp: 1.115 ± 0.019	1.288HisGlu: 1.288 ± 0.021	1.202HisPhe: 1.202 ± 0.021	1.391HisGly: 1.391 ± 0.021	0.694HisHis: 0.694 ± 0.022	1.19HisIle: 1.19 ± 0.018	1.068HisLys: 1.068 ± 0.017	2.471HisLeu: 2.471 ± 0.03	0.628HisMet: 0.628 ± 0.014	0.893HisAsn: 0.893 ± 0.015	1.234HisPro: 1.234 ± 0.02	0.928HisGln: 0.928 ± 0.016	1.724HisArg: 1.724 ± 0.022	2.024HisSer: 2.024 ± 0.021	1.051HisThr: 1.051 ± 0.018	1.723HisVal: 1.723 ± 0.024	0.343HisTrp: 0.343 ± 0.01	0.819HisTyr: 0.819 ± 0.014	0.008HisXaa: 0.008 ± 0.001
Ile	3.62IleAla: 3.62 ± 0.033	1.502IleCys: 1.502 ± 0.022	3.015IleAsp: 3.015 ± 0.031	2.971IleGlu: 2.971 ± 0.031	2.406IlePhe: 2.406 ± 0.028	2.919IleGly: 2.919 ± 0.034	1.174IleHis: 1.174 ± 0.019	2.8IleIle: 2.8 ± 0.036	2.52IleLys: 2.52 ± 0.029	4.618IleLeu: 4.618 ± 0.038	1.196IleMet: 1.196 ± 0.019	2.117IleAsn: 2.117 ± 0.026	2.408IlePro: 2.408 ± 0.025	1.762IleGln: 1.762 ± 0.022	3.068IleArg: 3.068 ± 0.032	4.291IleSer: 4.291 ± 0.037	2.701IleThr: 2.701 ± 0.026	3.659IleVal: 3.659 ± 0.032	0.561IleTrp: 0.561 ± 0.014	1.633IleTyr: 1.633 ± 0.021	0.018IleXaa: 0.018 ± 0.002
Lys	3.535LysAla: 3.535 ± 0.03	1.394LysCys: 1.394 ± 0.02	2.596LysAsp: 2.596 ± 0.03	3.608LysGlu: 3.608 ± 0.039	2.262LysPhe: 2.262 ± 0.026	2.42LysGly: 2.42 ± 0.035	1.31LysHis: 1.31 ± 0.022	2.994LysIle: 2.994 ± 0.033	3.533LysLys: 3.533 ± 0.049	5.342LysLeu: 5.342 ± 0.042	1.492LysMet: 1.492 ± 0.022	2.498LysAsn: 2.498 ± 0.031	2.533LysPro: 2.533 ± 0.05	2.368LysGln: 2.368 ± 0.026	3.585LysArg: 3.585 ± 0.036	3.982LysSer: 3.982 ± 0.04	3.032LysThr: 3.032 ± 0.036	3.536LysVal: 3.536 ± 0.036	0.687LysTrp: 0.687 ± 0.013	1.785LysTyr: 1.785 ± 0.026	0.016LysXaa: 0.016 ± 0.002
Leu	5.966LeuAla: 5.966 ± 0.043	2.601LeuCys: 2.601 ± 0.031	4.378LeuAsp: 4.378 ± 0.038	5.093LeuGlu: 5.093 ± 0.05	4.305LeuPhe: 4.305 ± 0.042	4.062LeuGly: 4.062 ± 0.038	2.416LeuHis: 2.416 ± 0.029	4.854LeuIle: 4.854 ± 0.041	5.841LeuLys: 5.841 ± 0.048	10.025LeuLeu: 10.025 ± 0.082	2.433LeuMet: 2.433 ± 0.026	4.291LeuAsn: 4.291 ± 0.037	5.067LeuPro: 5.067 ± 0.043	4.212LeuGln: 4.212 ± 0.037	5.995LeuArg: 5.995 ± 0.04	8.056LeuSer: 8.056 ± 0.056	5.06LeuThr: 5.06 ± 0.041	5.846LeuVal: 5.846 ± 0.043	1.068LeuTrp: 1.068 ± 0.018	2.896LeuTyr: 2.896 ± 0.032	0.039LeuXaa: 0.039 ± 0.003
Met	1.84MetAla: 1.84 ± 0.025	0.611MetCys: 0.611 ± 0.013	1.274MetAsp: 1.274 ± 0.019	1.407MetGlu: 1.407 ± 0.019	1.15MetPhe: 1.15 ± 0.016	1.031MetGly: 1.031 ± 0.019	0.594MetHis: 0.594 ± 0.015	1.297MetIle: 1.297 ± 0.021	1.593MetLys: 1.593 ± 0.026	2.405MetLeu: 2.405 ± 0.026	0.695MetMet: 0.695 ± 0.018	1.249MetAsn: 1.249 ± 0.02	1.23MetPro: 1.23 ± 0.019	1.019MetGln: 1.019 ± 0.018	1.404MetArg: 1.404 ± 0.02	1.93MetSer: 1.93 ± 0.021	1.515MetThr: 1.515 ± 0.022	1.612MetVal: 1.612 ± 0.022	0.275MetTrp: 0.275 ± 0.009	0.792MetTyr: 0.792 ± 0.036	0.008MetXaa: 0.008 ± 0.001
Asn	2.926AsnAla: 2.926 ± 0.03	1.164AsnCys: 1.164 ± 0.021	2.539AsnAsp: 2.539 ± 0.032	2.735AsnGlu: 2.735 ± 0.03	2.037AsnPhe: 2.037 ± 0.023	2.964AsnGly: 2.964 ± 0.031	0.927AsnHis: 0.927 ± 0.014	2.23AsnIle: 2.23 ± 0.03	1.893AsnLys: 1.893 ± 0.023	3.883AsnLeu: 3.883 ± 0.036	1.028AsnMet: 1.028 ± 0.017	1.674AsnAsn: 1.674 ± 0.022	1.856AsnPro: 1.856 ± 0.023	1.398AsnGln: 1.398 ± 0.023	2.502AsnArg: 2.502 ± 0.029	3.329AsnSer: 3.329 ± 0.034	1.839AsnThr: 1.839 ± 0.021	3.199AsnVal: 3.199 ± 0.028	0.488AsnTrp: 0.488 ± 0.011	1.388AsnTyr: 1.388 ± 0.021	0.01AsnXaa: 0.01 ± 0.002
Pro	3.014ProAla: 3.014 ± 0.033	1.109ProCys: 1.109 ± 0.022	2.4ProAsp: 2.4 ± 0.027	2.804ProGlu: 2.804 ± 0.031	2.131ProPhe: 2.131 ± 0.029	2.67ProGly: 2.67 ± 0.068	1.068ProHis: 1.068 ± 0.019	1.951ProIle: 1.951 ± 0.025	2.382ProLys: 2.382 ± 0.042	4.289ProLeu: 4.289 ± 0.041	1.039ProMet: 1.039 ± 0.019	1.888ProAsn: 1.888 ± 0.026	3.53ProPro: 3.53 ± 0.056	1.734ProGln: 1.734 ± 0.025	2.361ProArg: 2.361 ± 0.03	4.43ProSer: 4.43 ± 0.044	2.539ProThr: 2.539 ± 0.032	3.497ProVal: 3.497 ± 0.036	0.537ProTrp: 0.537 ± 0.012	1.475ProTyr: 1.475 ± 0.023	0.022ProXaa: 0.022 ± 0.002
Gln	2.225GlnAla: 2.225 ± 0.025	1.081GlnCys: 1.081 ± 0.023	1.468GlnAsp: 1.468 ± 0.019	2.138GlnGlu: 2.138 ± 0.028	1.56GlnPhe: 1.56 ± 0.022	1.555GlnGly: 1.555 ± 0.025	0.997GlnHis: 0.997 ± 0.018	1.989GlnIle: 1.989 ± 0.026	2.4GlnLys: 2.4 ± 0.027	4.22GlnLeu: 4.22 ± 0.037	1.117GlnMet: 1.117 ± 0.019	1.804GlnAsn: 1.804 ± 0.025	1.952GlnPro: 1.952 ± 0.028	2.278GlnGln: 2.278 ± 0.043	2.706GlnArg: 2.706 ± 0.03	2.832GlnSer: 2.832 ± 0.034	2.003GlnThr: 2.003 ± 0.024	2.35GlnVal: 2.35 ± 0.024	0.53GlnTrp: 0.53 ± 0.013	1.177GlnTyr: 1.177 ± 0.016	0.013GlnXaa: 0.013 ± 0.002
Arg	3.119ArgAla: 3.119 ± 0.029	1.872ArgCys: 1.872 ± 0.027	2.585ArgAsp: 2.585 ± 0.026	3.016ArgGlu: 3.016 ± 0.036	2.833ArgPhe: 2.833 ± 0.029	2.835ArgGly: 2.835 ± 0.033	1.765ArgHis: 1.765 ± 0.023	3.079ArgIle: 3.079 ± 0.027	3.807ArgLys: 3.807 ± 0.039	6.073ArgLeu: 6.073 ± 0.045	1.547ArgMet: 1.547 ± 0.024	2.825ArgAsn: 2.825 ± 0.029	2.826ArgPro: 2.826 ± 0.033	2.66ArgGln: 2.66 ± 0.029	5.137ArgArg: 5.137 ± 0.055	5.192ArgSer: 5.192 ± 0.047	3.113ArgThr: 3.113 ± 0.032	3.358ArgVal: 3.358 ± 0.032	0.91ArgTrp: 0.91 ± 0.017	1.981ArgTyr: 1.981 ± 0.025	0.036ArgXaa: 0.036 ± 0.003
Ser	5.93SerAla: 5.93 ± 0.04	2.271SerCys: 2.271 ± 0.029	4.761SerAsp: 4.761 ± 0.041	4.7SerGlu: 4.7 ± 0.043	4.009SerPhe: 4.009 ± 0.037	4.947SerGly: 4.947 ± 0.042	1.867SerHis: 1.867 ± 0.024	3.823SerIle: 3.823 ± 0.032	4.195SerLys: 4.195 ± 0.037	7.817SerLeu: 7.817 ± 0.05	1.929SerMet: 1.929 ± 0.025	3.391SerAsn: 3.391 ± 0.033	4.081SerPro: 4.081 ± 0.048	2.899SerGln: 2.899 ± 0.03	4.645SerArg: 4.645 ± 0.045	9.522SerSer: 9.522 ± 0.083	4.842SerThr: 4.842 ± 0.042	6.105SerVal: 6.105 ± 0.041	0.935SerTrp: 0.935 ± 0.018	2.375SerTyr: 2.375 ± 0.029	0.037SerXaa: 0.037 ± 0.003
Thr	4.309ThrAla: 4.309 ± 0.041	1.461ThrCys: 1.461 ± 0.028	2.942ThrAsp: 2.942 ± 0.029	3.166ThrGlu: 3.166 ± 0.035	2.467ThrPhe: 2.467 ± 0.026	3.176ThrGly: 3.176 ± 0.033	1.054ThrHis: 1.054 ± 0.02	2.599ThrIle: 2.599 ± 0.027	2.703ThrLys: 2.703 ± 0.031	4.759ThrLeu: 4.759 ± 0.043	1.327ThrMet: 1.327 ± 0.021	2.114ThrAsn: 2.114 ± 0.025	2.543ThrPro: 2.543 ± 0.033	1.532ThrGln: 1.532 ± 0.02	2.572ThrArg: 2.572 ± 0.025	4.77ThrSer: 4.77 ± 0.039	3.539ThrThr: 3.539 ± 0.053	4.516ThrVal: 4.516 ± 0.036	0.593ThrTrp: 0.593 ± 0.013	1.547ThrTyr: 1.547 ± 0.022	0.026ThrXaa: 0.026 ± 0.002
Val	5.007ValAla: 5.007 ± 0.037	2.013ValCys: 2.013 ± 0.045	3.841ValAsp: 3.841 ± 0.032	4.029ValGlu: 4.029 ± 0.042	3.189ValPhe: 3.189 ± 0.03	3.552ValGly: 3.552 ± 0.04	1.683ValHis: 1.683 ± 0.02	3.823ValIle: 3.823 ± 0.031	3.632ValLys: 3.632 ± 0.036	6.51ValLeu: 6.51 ± 0.048	1.658ValMet: 1.658 ± 0.022	2.916ValAsn: 2.916 ± 0.029	3.322ValPro: 3.322 ± 0.035	2.626ValGln: 2.626 ± 0.028	3.988ValArg: 3.988 ± 0.033	5.896ValSer: 5.896 ± 0.051	4.041ValThr: 4.041 ± 0.038	5.539ValVal: 5.539 ± 0.059	0.739ValTrp: 0.739 ± 0.014	2.11ValTyr: 2.11 ± 0.026	0.036ValXaa: 0.036 ± 0.003
Trp	0.557TrpAla: 0.557 ± 0.014	0.316TrpCys: 0.316 ± 0.011	0.506TrpAsp: 0.506 ± 0.013	0.56TrpGlu: 0.56 ± 0.014	0.57TrpPhe: 0.57 ± 0.013	0.433TrpGly: 0.433 ± 0.011	0.332TrpHis: 0.332 ± 0.01	0.673TrpIle: 0.673 ± 0.015	0.795TrpLys: 0.795 ± 0.015	1.288TrpLeu: 1.288 ± 0.019	0.364TrpMet: 0.364 ± 0.01	0.604TrpAsn: 0.604 ± 0.013	0.535TrpPro: 0.535 ± 0.011	0.55TrpGln: 0.55 ± 0.013	0.784TrpArg: 0.784 ± 0.017	1.023TrpSer: 1.023 ± 0.018	0.713TrpThr: 0.713 ± 0.016	0.57TrpVal: 0.57 ± 0.013	0.207TrpTrp: 0.207 ± 0.01	0.413TrpTyr: 0.413 ± 0.012	0.005TrpXaa: 0.005 ± 0.001
Tyr	1.968TyrAla: 1.968 ± 0.024	0.959TyrCys: 0.959 ± 0.018	1.762TyrAsp: 1.762 ± 0.023	1.767TyrGlu: 1.767 ± 0.024	1.699TyrPhe: 1.699 ± 0.024	2.001TyrGly: 2.001 ± 0.027	0.798TyrHis: 0.798 ± 0.017	1.559TyrIle: 1.559 ± 0.021	1.443TyrLys: 1.443 ± 0.022	3.08TyrLeu: 3.08 ± 0.032	0.756TyrMet: 0.756 ± 0.014	1.237TyrAsn: 1.237 ± 0.022	1.335TyrPro: 1.335 ± 0.021	1.101TyrGln: 1.101 ± 0.018	1.97TyrArg: 1.97 ± 0.025	2.393TyrSer: 2.393 ± 0.025	1.372TyrThr: 1.372 ± 0.019	2.3TyrVal: 2.3 ± 0.045	0.408TyrTrp: 0.408 ± 0.013	1.183TyrTyr: 1.183 ± 0.02	0.014TyrXaa: 0.014 ± 0.002
Xaa	0.03XaaAla: 0.03 ± 0.003	0.009XaaCys: 0.009 ± 0.001	0.019XaaAsp: 0.019 ± 0.002	0.024XaaGlu: 0.024 ± 0.003	0.019XaaPhe: 0.019 ± 0.002	0.024XaaGly: 0.024 ± 0.003	0.015XaaHis: 0.015 ± 0.002	0.018XaaIle: 0.018 ± 0.002	0.018XaaLys: 0.018 ± 0.002	0.04XaaLeu: 0.04 ± 0.003	0.012XaaMet: 0.012 ± 0.002	0.017XaaAsn: 0.017 ± 0.002	0.026XaaPro: 0.026 ± 0.003	0.016XaaGln: 0.016 ± 0.002	0.03XaaArg: 0.03 ± 0.003	0.037XaaSer: 0.037 ± 0.003	0.028XaaThr: 0.028 ± 0.003	0.026XaaVal: 0.026 ± 0.003	0.006XaaTrp: 0.006 ± 0.001	0.01XaaTyr: 0.01 ± 0.002	5.71XaaXaa: 5.71 ± 0.177

Statistics based on 13153 proteins (3707980 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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