Amino acid dipepetide frequency for Streptococcus satellite phage Javan757

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.573AlaAla: 0.573 ± 0.337
0.86AlaCys: 0.86 ± 0.479
3.153AlaAsp: 3.153 ± 0.848
5.732AlaGlu: 5.732 ± 1.612
3.439AlaPhe: 3.439 ± 1.114
3.726AlaGly: 3.726 ± 0.902
0.86AlaHis: 0.86 ± 0.477
3.153AlaIle: 3.153 ± 0.681
4.586AlaLys: 4.586 ± 0.704
6.306AlaLeu: 6.306 ± 1.548
2.58AlaMet: 2.58 ± 1.12
2.58AlaAsn: 2.58 ± 0.601
0.86AlaPro: 0.86 ± 0.491
1.146AlaGln: 1.146 ± 0.609
2.293AlaArg: 2.293 ± 1.13
2.006AlaSer: 2.006 ± 0.784
2.866AlaThr: 2.866 ± 0.874
2.293AlaVal: 2.293 ± 0.763
0.573AlaTrp: 0.573 ± 0.341
1.146AlaTyr: 1.146 ± 0.425
0.0AlaXaa: 0.0 ± 0.0
Cys
0.287CysAla: 0.287 ± 0.294
0.0CysCys: 0.0 ± 0.0
0.573CysAsp: 0.573 ± 0.37
0.573CysGlu: 0.573 ± 0.48
0.287CysPhe: 0.287 ± 0.229
0.287CysGly: 0.287 ± 0.321
0.573CysHis: 0.573 ± 0.618
0.573CysIle: 0.573 ± 0.336
0.86CysLys: 0.86 ± 0.396
0.86CysLeu: 0.86 ± 0.499
0.0CysMet: 0.0 ± 0.0
0.573CysAsn: 0.573 ± 0.465
0.0CysPro: 0.0 ± 0.0
0.573CysGln: 0.573 ± 0.488
0.573CysArg: 0.573 ± 0.416
0.573CysSer: 0.573 ± 0.48
0.0CysThr: 0.0 ± 0.0
0.287CysVal: 0.287 ± 0.24
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.287AspAla: 0.287 ± 0.284
0.573AspCys: 0.573 ± 0.436
1.72AspAsp: 1.72 ± 0.577
2.866AspGlu: 2.866 ± 0.884
4.013AspPhe: 4.013 ± 0.829
2.293AspGly: 2.293 ± 0.645
0.287AspHis: 0.287 ± 0.311
5.159AspIle: 5.159 ± 1.448
6.019AspLys: 6.019 ± 1.463
4.872AspLeu: 4.872 ± 0.952
1.72AspMet: 1.72 ± 0.649
4.586AspAsn: 4.586 ± 1.404
1.72AspPro: 1.72 ± 0.711
0.86AspGln: 0.86 ± 0.594
3.439AspArg: 3.439 ± 0.826
4.299AspSer: 4.299 ± 1.367
2.58AspThr: 2.58 ± 0.706
2.58AspVal: 2.58 ± 0.993
0.287AspTrp: 0.287 ± 0.233
3.439AspTyr: 3.439 ± 0.887
0.0AspXaa: 0.0 ± 0.0
Glu
6.592GluAla: 6.592 ± 1.203
0.573GluCys: 0.573 ± 0.358
3.726GluAsp: 3.726 ± 0.996
5.446GluGlu: 5.446 ± 1.085
4.013GluPhe: 4.013 ± 1.3
2.293GluGly: 2.293 ± 1.018
2.293GluHis: 2.293 ± 0.712
5.446GluIle: 5.446 ± 0.96
9.745GluLys: 9.745 ± 1.529
9.458GluLeu: 9.458 ± 1.37
1.72GluMet: 1.72 ± 0.771
5.446GluAsn: 5.446 ± 1.256
2.866GluPro: 2.866 ± 0.997
2.866GluGln: 2.866 ± 0.827
4.586GluArg: 4.586 ± 1.37
4.586GluSer: 4.586 ± 1.155
3.726GluThr: 3.726 ± 0.86
3.726GluVal: 3.726 ± 1.229
0.573GluTrp: 0.573 ± 0.465
4.872GluTyr: 4.872 ± 0.956
0.0GluXaa: 0.0 ± 0.0
Phe
2.006PheAla: 2.006 ± 0.59
0.0PheCys: 0.0 ± 0.0
2.58PheAsp: 2.58 ± 0.76
5.446PheGlu: 5.446 ± 1.444
2.866PhePhe: 2.866 ± 1.224
1.72PheGly: 1.72 ± 0.556
0.573PheHis: 0.573 ± 0.358
4.299PheIle: 4.299 ± 0.897
3.726PheLys: 3.726 ± 1.104
4.299PheLeu: 4.299 ± 1.311
0.86PheMet: 0.86 ± 0.586
2.866PheAsn: 2.866 ± 0.976
1.146PhePro: 1.146 ± 0.427
2.58PheGln: 2.58 ± 0.781
2.293PheArg: 2.293 ± 0.814
4.299PheSer: 4.299 ± 0.862
2.293PheThr: 2.293 ± 0.908
1.433PheVal: 1.433 ± 0.553
0.86PheTrp: 0.86 ± 0.419
2.293PheTyr: 2.293 ± 0.505
0.0PheXaa: 0.0 ± 0.0
Gly
2.293GlyAla: 2.293 ± 0.924
0.573GlyCys: 0.573 ± 0.345
3.439GlyAsp: 3.439 ± 0.974
3.153GlyGlu: 3.153 ± 0.897
2.006GlyPhe: 2.006 ± 0.856
3.153GlyGly: 3.153 ± 0.95
1.146GlyHis: 1.146 ± 0.574
4.872GlyIle: 4.872 ± 0.998
3.153GlyLys: 3.153 ± 0.903
5.159GlyLeu: 5.159 ± 1.386
1.146GlyMet: 1.146 ± 0.554
1.72GlyAsn: 1.72 ± 0.776
0.0GlyPro: 0.0 ± 0.0
1.146GlyGln: 1.146 ± 0.454
2.293GlyArg: 2.293 ± 0.568
0.86GlySer: 0.86 ± 0.565
4.299GlyThr: 4.299 ± 1.274
3.153GlyVal: 3.153 ± 0.873
0.86GlyTrp: 0.86 ± 0.52
2.58GlyTyr: 2.58 ± 1.085
0.0GlyXaa: 0.0 ± 0.0
His
2.006HisAla: 2.006 ± 0.753
0.0HisCys: 0.0 ± 0.0
0.287HisAsp: 0.287 ± 0.294
1.146HisGlu: 1.146 ± 0.592
1.146HisPhe: 1.146 ± 0.591
1.433HisGly: 1.433 ± 0.68
0.0HisHis: 0.0 ± 0.0
1.72HisIle: 1.72 ± 0.757
1.72HisLys: 1.72 ± 0.807
2.006HisLeu: 2.006 ± 0.562
0.0HisMet: 0.0 ± 0.0
1.433HisAsn: 1.433 ± 0.463
0.86HisPro: 0.86 ± 0.349
0.0HisGln: 0.0 ± 0.0
2.58HisArg: 2.58 ± 0.98
2.58HisSer: 2.58 ± 0.468
1.146HisThr: 1.146 ± 0.555
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.72HisTyr: 1.72 ± 0.528
0.0HisXaa: 0.0 ± 0.0
Ile
3.726IleAla: 3.726 ± 1.044
1.146IleCys: 1.146 ± 0.517
5.446IleAsp: 5.446 ± 1.066
5.446IleGlu: 5.446 ± 1.547
3.439IlePhe: 3.439 ± 0.875
2.866IleGly: 2.866 ± 0.657
1.72IleHis: 1.72 ± 0.664
3.153IleIle: 3.153 ± 0.797
7.739IleLys: 7.739 ± 1.346
4.586IleLeu: 4.586 ± 0.808
1.146IleMet: 1.146 ± 0.593
4.872IleAsn: 4.872 ± 1.467
4.013IlePro: 4.013 ± 0.98
1.72IleGln: 1.72 ± 0.765
1.72IleArg: 1.72 ± 0.575
6.019IleSer: 6.019 ± 1.176
4.299IleThr: 4.299 ± 1.115
3.439IleVal: 3.439 ± 0.816
0.287IleTrp: 0.287 ± 0.366
3.726IleTyr: 3.726 ± 1.04
0.0IleXaa: 0.0 ± 0.0
Lys
5.732LysAla: 5.732 ± 1.992
0.0LysCys: 0.0 ± 0.0
4.586LysAsp: 4.586 ± 1.6
12.038LysGlu: 12.038 ± 1.549
3.726LysPhe: 3.726 ± 0.777
5.732LysGly: 5.732 ± 1.268
4.013LysHis: 4.013 ± 1.349
8.025LysIle: 8.025 ± 1.112
6.879LysLys: 6.879 ± 1.826
8.312LysLeu: 8.312 ± 1.772
1.72LysMet: 1.72 ± 0.569
4.586LysAsn: 4.586 ± 1.1
5.159LysPro: 5.159 ± 1.009
3.439LysGln: 3.439 ± 0.736
6.019LysArg: 6.019 ± 1.231
3.726LysSer: 3.726 ± 1.14
5.446LysThr: 5.446 ± 1.25
5.446LysVal: 5.446 ± 1.055
0.86LysTrp: 0.86 ± 0.485
2.866LysTyr: 2.866 ± 0.972
0.0LysXaa: 0.0 ± 0.0
Leu
5.159LeuAla: 5.159 ± 1.433
0.86LeuCys: 0.86 ± 0.396
9.745LeuAsp: 9.745 ± 1.445
9.458LeuGlu: 9.458 ± 2.244
3.726LeuPhe: 3.726 ± 1.115
2.866LeuGly: 2.866 ± 1.12
1.433LeuHis: 1.433 ± 0.531
8.885LeuIle: 8.885 ± 1.847
8.598LeuLys: 8.598 ± 1.142
9.458LeuLeu: 9.458 ± 1.837
1.146LeuMet: 1.146 ± 0.531
6.879LeuAsn: 6.879 ± 1.185
2.866LeuPro: 2.866 ± 1.021
3.153LeuGln: 3.153 ± 1.016
5.159LeuArg: 5.159 ± 1.349
6.019LeuSer: 6.019 ± 1.391
4.586LeuThr: 4.586 ± 0.901
5.159LeuVal: 5.159 ± 1.039
1.146LeuTrp: 1.146 ± 0.431
4.299LeuTyr: 4.299 ± 0.904
0.0LeuXaa: 0.0 ± 0.0
Met
2.006MetAla: 2.006 ± 0.847
0.287MetCys: 0.287 ± 0.24
1.433MetAsp: 1.433 ± 0.652
1.433MetGlu: 1.433 ± 0.57
0.86MetPhe: 0.86 ± 0.546
0.287MetGly: 0.287 ± 0.233
0.287MetHis: 0.287 ± 0.284
1.146MetIle: 1.146 ± 0.435
3.153MetLys: 3.153 ± 0.856
1.146MetLeu: 1.146 ± 0.412
0.0MetMet: 0.0 ± 0.31
1.72MetAsn: 1.72 ± 0.775
0.573MetPro: 0.573 ± 0.344
0.86MetGln: 0.86 ± 0.402
1.72MetArg: 1.72 ± 0.662
1.146MetSer: 1.146 ± 0.535
3.439MetThr: 3.439 ± 1.238
0.86MetVal: 0.86 ± 0.462
0.0MetTrp: 0.0 ± 0.0
0.573MetTyr: 0.573 ± 0.358
0.0MetXaa: 0.0 ± 0.0
Asn
3.439AsnAla: 3.439 ± 0.709
0.0AsnCys: 0.0 ± 0.0
3.153AsnAsp: 3.153 ± 0.908
3.726AsnGlu: 3.726 ± 0.787
0.86AsnPhe: 0.86 ± 0.462
4.299AsnGly: 4.299 ± 1.058
1.146AsnHis: 1.146 ± 0.442
3.153AsnIle: 3.153 ± 1.065
5.446AsnLys: 5.446 ± 0.871
6.592AsnLeu: 6.592 ± 1.4
0.573AsnMet: 0.573 ± 0.479
2.293AsnAsn: 2.293 ± 0.723
1.72AsnPro: 1.72 ± 0.576
2.866AsnGln: 2.866 ± 0.702
3.153AsnArg: 3.153 ± 0.797
4.299AsnSer: 4.299 ± 1.265
2.866AsnThr: 2.866 ± 0.958
2.58AsnVal: 2.58 ± 0.599
0.0AsnTrp: 0.0 ± 0.0
2.006AsnTyr: 2.006 ± 0.557
0.0AsnXaa: 0.0 ± 0.0
Pro
1.72ProAla: 1.72 ± 0.564
0.0ProCys: 0.0 ± 0.0
1.433ProAsp: 1.433 ± 0.576
2.293ProGlu: 2.293 ± 0.725
2.866ProPhe: 2.866 ± 1.072
0.573ProGly: 0.573 ± 0.488
0.287ProHis: 0.287 ± 0.24
1.72ProIle: 1.72 ± 0.476
4.013ProLys: 4.013 ± 1.121
2.006ProLeu: 2.006 ± 0.668
0.86ProMet: 0.86 ± 0.486
2.866ProAsn: 2.866 ± 1.151
0.573ProPro: 0.573 ± 0.404
1.72ProGln: 1.72 ± 0.751
2.866ProArg: 2.866 ± 0.655
2.006ProSer: 2.006 ± 0.706
2.006ProThr: 2.006 ± 0.56
2.293ProVal: 2.293 ± 0.772
0.287ProTrp: 0.287 ± 0.233
1.146ProTyr: 1.146 ± 0.536
0.0ProXaa: 0.0 ± 0.0
Gln
3.153GlnAla: 3.153 ± 1.001
0.0GlnCys: 0.0 ± 0.0
1.433GlnAsp: 1.433 ± 0.613
4.299GlnGlu: 4.299 ± 0.993
1.433GlnPhe: 1.433 ± 0.574
1.72GlnGly: 1.72 ± 0.627
0.573GlnHis: 0.573 ± 0.372
1.146GlnIle: 1.146 ± 0.519
5.159GlnLys: 5.159 ± 1.592
2.293GlnLeu: 2.293 ± 0.619
0.287GlnMet: 0.287 ± 0.284
1.146GlnAsn: 1.146 ± 0.388
0.86GlnPro: 0.86 ± 0.758
1.433GlnGln: 1.433 ± 0.607
2.58GlnArg: 2.58 ± 0.84
0.86GlnSer: 0.86 ± 0.432
2.006GlnThr: 2.006 ± 0.629
2.006GlnVal: 2.006 ± 0.859
0.287GlnTrp: 0.287 ± 0.339
2.006GlnTyr: 2.006 ± 0.821
0.0GlnXaa: 0.0 ± 0.0
Arg
2.58ArgAla: 2.58 ± 0.813
0.287ArgCys: 0.287 ± 0.24
2.866ArgAsp: 2.866 ± 0.839
4.872ArgGlu: 4.872 ± 0.988
2.293ArgPhe: 2.293 ± 0.965
2.866ArgGly: 2.866 ± 1.145
2.006ArgHis: 2.006 ± 0.915
4.013ArgIle: 4.013 ± 0.812
4.586ArgLys: 4.586 ± 0.897
4.299ArgLeu: 4.299 ± 1.483
1.433ArgMet: 1.433 ± 0.696
2.58ArgAsn: 2.58 ± 0.708
1.433ArgPro: 1.433 ± 0.668
2.866ArgGln: 2.866 ± 0.747
2.293ArgArg: 2.293 ± 0.777
2.58ArgSer: 2.58 ± 1.011
2.293ArgThr: 2.293 ± 0.672
4.013ArgVal: 4.013 ± 0.783
0.287ArgTrp: 0.287 ± 0.358
3.439ArgTyr: 3.439 ± 0.931
0.0ArgXaa: 0.0 ± 0.0
Ser
3.153SerAla: 3.153 ± 1.079
0.573SerCys: 0.573 ± 0.397
2.866SerAsp: 2.866 ± 0.686
4.872SerGlu: 4.872 ± 0.905
3.439SerPhe: 3.439 ± 1.01
3.439SerGly: 3.439 ± 0.821
1.146SerHis: 1.146 ± 0.465
4.013SerIle: 4.013 ± 0.77
4.872SerLys: 4.872 ± 0.812
7.452SerLeu: 7.452 ± 1.293
2.293SerMet: 2.293 ± 0.651
2.58SerAsn: 2.58 ± 0.84
2.58SerPro: 2.58 ± 0.739
0.86SerGln: 0.86 ± 0.456
2.006SerArg: 2.006 ± 0.767
3.439SerSer: 3.439 ± 1.244
3.439SerThr: 3.439 ± 0.823
2.293SerVal: 2.293 ± 0.969
0.573SerTrp: 0.573 ± 0.341
2.006SerTyr: 2.006 ± 0.868
0.0SerXaa: 0.0 ± 0.0
Thr
2.006ThrAla: 2.006 ± 0.709
0.287ThrCys: 0.287 ± 0.321
1.146ThrAsp: 1.146 ± 0.589
3.726ThrGlu: 3.726 ± 0.798
4.586ThrPhe: 4.586 ± 1.783
4.013ThrGly: 4.013 ± 0.711
1.72ThrHis: 1.72 ± 0.82
3.153ThrIle: 3.153 ± 0.88
4.586ThrLys: 4.586 ± 1.079
9.745ThrLeu: 9.745 ± 1.554
1.433ThrMet: 1.433 ± 0.553
1.146ThrAsn: 1.146 ± 0.585
2.293ThrPro: 2.293 ± 0.767
2.293ThrGln: 2.293 ± 0.83
3.153ThrArg: 3.153 ± 0.703
2.866ThrSer: 2.866 ± 0.852
2.293ThrThr: 2.293 ± 0.886
3.153ThrVal: 3.153 ± 0.824
0.86ThrTrp: 0.86 ± 0.398
2.006ThrTyr: 2.006 ± 1.044
0.0ThrXaa: 0.0 ± 0.0
Val
3.153ValAla: 3.153 ± 0.827
0.573ValCys: 0.573 ± 0.301
2.006ValAsp: 2.006 ± 0.689
4.013ValGlu: 4.013 ± 1.429
1.72ValPhe: 1.72 ± 0.884
1.433ValGly: 1.433 ± 0.962
0.287ValHis: 0.287 ± 0.281
2.58ValIle: 2.58 ± 0.945
7.165ValLys: 7.165 ± 1.627
4.586ValLeu: 4.586 ± 1.333
2.006ValMet: 2.006 ± 1.081
2.58ValAsn: 2.58 ± 1.054
2.006ValPro: 2.006 ± 0.739
1.433ValGln: 1.433 ± 0.732
1.72ValArg: 1.72 ± 0.667
2.293ValSer: 2.293 ± 0.631
4.872ValThr: 4.872 ± 1.271
3.726ValVal: 3.726 ± 0.892
0.0ValTrp: 0.0 ± 0.0
2.58ValTyr: 2.58 ± 0.61
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.573TrpAsp: 0.573 ± 0.301
1.146TrpGlu: 1.146 ± 0.754
0.0TrpPhe: 0.0 ± 0.0
0.573TrpGly: 0.573 ± 0.307
0.287TrpHis: 0.287 ± 0.233
0.86TrpIle: 0.86 ± 0.466
0.573TrpLys: 0.573 ± 0.447
1.146TrpLeu: 1.146 ± 0.487
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.287TrpPro: 0.287 ± 0.233
0.287TrpGln: 0.287 ± 0.233
0.287TrpArg: 0.287 ± 0.233
0.86TrpSer: 0.86 ± 0.48
0.287TrpThr: 0.287 ± 0.339
0.573TrpVal: 0.573 ± 0.315
0.0TrpTrp: 0.0 ± 0.0
0.287TrpTyr: 0.287 ± 0.233
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.86TyrAla: 0.86 ± 0.498
0.86TyrCys: 0.86 ± 0.471
1.433TyrAsp: 1.433 ± 0.478
2.866TyrGlu: 2.866 ± 0.828
1.72TyrPhe: 1.72 ± 0.612
1.433TyrGly: 1.433 ± 0.748
1.146TyrHis: 1.146 ± 0.516
3.439TyrIle: 3.439 ± 0.802
5.732TyrLys: 5.732 ± 1.461
6.019TyrLeu: 6.019 ± 1.244
2.006TyrMet: 2.006 ± 0.897
1.72TyrAsn: 1.72 ± 0.64
1.72TyrPro: 1.72 ± 0.824
2.58TyrGln: 2.58 ± 0.942
3.153TyrArg: 3.153 ± 1.134
2.58TyrSer: 2.58 ± 0.602
1.72TyrThr: 1.72 ± 0.744
1.72TyrVal: 1.72 ± 0.495
0.287TyrTrp: 0.287 ± 0.321
1.72TyrTyr: 1.72 ± 0.939
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (3490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski