Amino acid dipepetide frequency for Spongiivirga citrea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.662AlaAla: 4.662 ± 0.086	0.553AlaCys: 0.553 ± 0.027	3.799AlaAsp: 3.799 ± 0.08	3.785AlaGlu: 3.785 ± 0.06	3.386AlaPhe: 3.386 ± 0.059	4.539AlaGly: 4.539 ± 0.093	1.036AlaHis: 1.036 ± 0.034	5.587AlaIle: 5.587 ± 0.081	4.517AlaLys: 4.517 ± 0.073	6.146AlaLeu: 6.146 ± 0.093	1.521AlaMet: 1.521 ± 0.044	3.699AlaAsn: 3.699 ± 0.072	2.028AlaPro: 2.028 ± 0.051	2.449AlaGln: 2.449 ± 0.047	2.116AlaArg: 2.116 ± 0.044	4.53AlaSer: 4.53 ± 0.074	4.061AlaThr: 4.061 ± 0.115	4.306AlaVal: 4.306 ± 0.077	0.615AlaTrp: 0.615 ± 0.025	2.42AlaTyr: 2.42 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.442CysAla: 0.442 ± 0.026	0.093CysCys: 0.093 ± 0.009	0.461CysAsp: 0.461 ± 0.023	0.456CysGlu: 0.456 ± 0.024	0.403CysPhe: 0.403 ± 0.025	0.573CysGly: 0.573 ± 0.027	0.175CysHis: 0.175 ± 0.015	0.583CysIle: 0.583 ± 0.022	0.43CysLys: 0.43 ± 0.019	0.624CysLeu: 0.624 ± 0.024	0.129CysMet: 0.129 ± 0.011	0.398CysAsn: 0.398 ± 0.024	0.329CysPro: 0.329 ± 0.02	0.213CysGln: 0.213 ± 0.01	0.192CysArg: 0.192 ± 0.013	0.555CysSer: 0.555 ± 0.023	0.461CysThr: 0.461 ± 0.031	0.404CysVal: 0.404 ± 0.02	0.074CysTrp: 0.074 ± 0.011	0.273CysTyr: 0.273 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.08AspAla: 4.08 ± 0.087	0.419AspCys: 0.419 ± 0.023	3.559AspAsp: 3.559 ± 0.105	4.002AspGlu: 4.002 ± 0.06	3.728AspPhe: 3.728 ± 0.065	4.453AspGly: 4.453 ± 0.14	1.084AspHis: 1.084 ± 0.032	4.638AspIle: 4.638 ± 0.063	3.903AspLys: 3.903 ± 0.074	5.255AspLeu: 5.255 ± 0.071	1.156AspMet: 1.156 ± 0.038	3.446AspAsn: 3.446 ± 0.095	2.059AspPro: 2.059 ± 0.063	1.947AspGln: 1.947 ± 0.046	2.128AspArg: 2.128 ± 0.041	3.507AspSer: 3.507 ± 0.063	3.136AspThr: 3.136 ± 0.086	3.891AspVal: 3.891 ± 0.087	0.755AspTrp: 0.755 ± 0.025	2.808AspTyr: 2.808 ± 0.085	0.0AspXaa: 0.0 ± 0.0
Glu	4.317GluAla: 4.317 ± 0.068	0.326GluCys: 0.326 ± 0.017	3.584GluAsp: 3.584 ± 0.054	4.744GluGlu: 4.744 ± 0.088	2.862GluPhe: 2.862 ± 0.049	3.695GluGly: 3.695 ± 0.061	1.087GluHis: 1.087 ± 0.038	5.022GluIle: 5.022 ± 0.068	5.352GluLys: 5.352 ± 0.095	6.089GluLeu: 6.089 ± 0.082	1.505GluMet: 1.505 ± 0.037	4.237GluAsn: 4.237 ± 0.057	1.59GluPro: 1.59 ± 0.042	2.329GluGln: 2.329 ± 0.047	2.51GluArg: 2.51 ± 0.052	3.384GluSer: 3.384 ± 0.052	3.648GluThr: 3.648 ± 0.069	4.449GluVal: 4.449 ± 0.066	0.603GluTrp: 0.603 ± 0.027	2.236GluTyr: 2.236 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.104PheAla: 3.104 ± 0.054	0.384PheCys: 0.384 ± 0.017	3.552PheAsp: 3.552 ± 0.057	3.372PheGlu: 3.372 ± 0.053	2.708PhePhe: 2.708 ± 0.075	3.619PheGly: 3.619 ± 0.064	0.756PheHis: 0.756 ± 0.028	3.688PheIle: 3.688 ± 0.073	3.779PheLys: 3.779 ± 0.069	4.555PheLeu: 4.555 ± 0.085	1.1PheMet: 1.1 ± 0.033	3.361PheAsn: 3.361 ± 0.07	1.666PhePro: 1.666 ± 0.041	1.573PheGln: 1.573 ± 0.039	1.695PheArg: 1.695 ± 0.042	3.976PheSer: 3.976 ± 0.066	3.264PheThr: 3.264 ± 0.095	3.163PheVal: 3.163 ± 0.06	0.597PheTrp: 0.597 ± 0.023	2.07PheTyr: 2.07 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.372GlyAla: 4.372 ± 0.074	0.658GlyCys: 0.658 ± 0.041	3.915GlyAsp: 3.915 ± 0.092	3.552GlyGlu: 3.552 ± 0.055	3.775GlyPhe: 3.775 ± 0.057	4.912GlyGly: 4.912 ± 0.122	1.143GlyHis: 1.143 ± 0.032	5.53GlyIle: 5.53 ± 0.074	4.68GlyLys: 4.68 ± 0.082	6.039GlyLeu: 6.039 ± 0.078	1.567GlyMet: 1.567 ± 0.046	3.865GlyAsn: 3.865 ± 0.081	1.54GlyPro: 1.54 ± 0.05	2.004GlyGln: 2.004 ± 0.044	2.287GlyArg: 2.287 ± 0.046	4.159GlySer: 4.159 ± 0.082	4.43GlyThr: 4.43 ± 0.201	4.441GlyVal: 4.441 ± 0.064	0.839GlyTrp: 0.839 ± 0.028	2.676GlyTyr: 2.676 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	0.935HisAla: 0.935 ± 0.031	0.141HisCys: 0.141 ± 0.01	0.89HisAsp: 0.89 ± 0.029	0.935HisGlu: 0.935 ± 0.031	1.099HisPhe: 1.099 ± 0.031	1.005HisGly: 1.005 ± 0.024	0.427HisHis: 0.427 ± 0.021	1.381HisIle: 1.381 ± 0.04	1.14HisLys: 1.14 ± 0.035	1.784HisLeu: 1.784 ± 0.049	0.34HisMet: 0.34 ± 0.017	0.864HisAsn: 0.864 ± 0.026	0.822HisPro: 0.822 ± 0.028	0.685HisGln: 0.685 ± 0.025	0.635HisArg: 0.635 ± 0.023	1.039HisSer: 1.039 ± 0.032	0.919HisThr: 0.919 ± 0.027	0.877HisVal: 0.877 ± 0.026	0.211HisTrp: 0.211 ± 0.016	0.802HisTyr: 0.802 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.753IleAla: 5.753 ± 0.079	0.575IleCys: 0.575 ± 0.018	5.231IleAsp: 5.231 ± 0.08	5.179IleGlu: 5.179 ± 0.067	3.497IlePhe: 3.497 ± 0.069	5.106IleGly: 5.106 ± 0.078	1.222IleHis: 1.222 ± 0.032	5.604IleIle: 5.604 ± 0.097	5.415IleLys: 5.415 ± 0.089	6.449IleLeu: 6.449 ± 0.099	1.346IleMet: 1.346 ± 0.036	4.718IleAsn: 4.718 ± 0.077	3.277IlePro: 3.277 ± 0.059	2.498IleGln: 2.498 ± 0.046	2.573IleArg: 2.573 ± 0.051	5.624IleSer: 5.624 ± 0.073	5.08IleThr: 5.08 ± 0.13	4.711IleVal: 4.711 ± 0.069	0.752IleTrp: 0.752 ± 0.024	2.566IleTyr: 2.566 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.717LysAla: 4.717 ± 0.085	0.299LysCys: 0.299 ± 0.016	4.236LysAsp: 4.236 ± 0.065	5.861LysGlu: 5.861 ± 0.104	2.503LysPhe: 2.503 ± 0.054	4.445LysGly: 4.445 ± 0.07	1.287LysHis: 1.287 ± 0.035	5.29LysIle: 5.29 ± 0.09	6.801LysLys: 6.801 ± 0.121	6.351LysLeu: 6.351 ± 0.095	1.938LysMet: 1.938 ± 0.043	4.787LysAsn: 4.787 ± 0.07	2.316LysPro: 2.316 ± 0.044	2.862LysGln: 2.862 ± 0.065	3.016LysArg: 3.016 ± 0.064	4.453LysSer: 4.453 ± 0.082	4.27LysThr: 4.27 ± 0.068	4.537LysVal: 4.537 ± 0.073	0.802LysTrp: 0.802 ± 0.029	2.689LysTyr: 2.689 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	5.838LeuAla: 5.838 ± 0.085	0.662LeuCys: 0.662 ± 0.019	5.267LeuAsp: 5.267 ± 0.072	5.589LeuGlu: 5.589 ± 0.083	4.904LeuPhe: 4.904 ± 0.094	5.801LeuGly: 5.801 ± 0.073	1.456LeuHis: 1.456 ± 0.042	6.84LeuIle: 6.84 ± 0.114	7.351LeuLys: 7.351 ± 0.115	8.733LeuLeu: 8.733 ± 0.114	1.932LeuMet: 1.932 ± 0.051	5.475LeuAsn: 5.475 ± 0.073	3.355LeuPro: 3.355 ± 0.059	3.086LeuGln: 3.086 ± 0.054	3.279LeuArg: 3.279 ± 0.057	6.612LeuSer: 6.612 ± 0.089	5.285LeuThr: 5.285 ± 0.087	5.885LeuVal: 5.885 ± 0.082	0.828LeuTrp: 0.828 ± 0.031	3.02LeuTyr: 3.02 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.551MetAla: 1.551 ± 0.043	0.126MetCys: 0.126 ± 0.01	1.058MetAsp: 1.058 ± 0.032	1.21MetGlu: 1.21 ± 0.037	0.856MetPhe: 0.856 ± 0.037	1.394MetGly: 1.394 ± 0.036	0.42MetHis: 0.42 ± 0.02	1.596MetIle: 1.596 ± 0.043	2.029MetLys: 2.029 ± 0.045	1.915MetLeu: 1.915 ± 0.043	0.547MetMet: 0.547 ± 0.024	1.361MetAsn: 1.361 ± 0.032	0.847MetPro: 0.847 ± 0.03	0.825MetGln: 0.825 ± 0.027	0.893MetArg: 0.893 ± 0.032	1.347MetSer: 1.347 ± 0.037	1.198MetThr: 1.198 ± 0.034	1.366MetVal: 1.366 ± 0.039	0.149MetTrp: 0.149 ± 0.012	0.659MetTyr: 0.659 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.014AsnAla: 4.014 ± 0.062	0.463AsnCys: 0.463 ± 0.027	3.776AsnAsp: 3.776 ± 0.11	3.978AsnGlu: 3.978 ± 0.069	2.954AsnPhe: 2.954 ± 0.062	4.37AsnGly: 4.37 ± 0.091	0.964AsnHis: 0.964 ± 0.028	4.432AsnIle: 4.432 ± 0.067	3.941AsnLys: 3.941 ± 0.066	4.933AsnLeu: 4.933 ± 0.076	1.256AsnMet: 1.256 ± 0.035	3.79AsnAsn: 3.79 ± 0.083	2.791AsnPro: 2.791 ± 0.069	2.219AsnGln: 2.219 ± 0.05	2.326AsnArg: 2.326 ± 0.051	3.754AsnSer: 3.754 ± 0.073	3.899AsnThr: 3.899 ± 0.082	3.57AsnVal: 3.57 ± 0.066	0.8AsnTrp: 0.8 ± 0.032	2.634AsnTyr: 2.634 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	2.043ProAla: 2.043 ± 0.058	0.192ProCys: 0.192 ± 0.012	2.363ProAsp: 2.363 ± 0.063	2.7ProGlu: 2.7 ± 0.051	1.926ProPhe: 1.926 ± 0.043	2.117ProGly: 2.117 ± 0.053	0.587ProHis: 0.587 ± 0.021	2.789ProIle: 2.789 ± 0.049	2.457ProLys: 2.457 ± 0.055	2.864ProLeu: 2.864 ± 0.056	0.711ProMet: 0.711 ± 0.026	2.3ProAsn: 2.3 ± 0.054	0.936ProPro: 0.936 ± 0.043	1.051ProGln: 1.051 ± 0.031	0.968ProArg: 0.968 ± 0.031	2.282ProSer: 2.282 ± 0.05	2.105ProThr: 2.105 ± 0.059	2.291ProVal: 2.291 ± 0.049	0.36ProTrp: 0.36 ± 0.018	1.343ProTyr: 1.343 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.078GlnAla: 2.078 ± 0.047	0.206GlnCys: 0.206 ± 0.014	1.781GlnAsp: 1.781 ± 0.041	2.347GlnGlu: 2.347 ± 0.049	1.815GlnPhe: 1.815 ± 0.039	1.94GlnGly: 1.94 ± 0.067	0.627GlnHis: 0.627 ± 0.024	2.564GlnIle: 2.564 ± 0.045	2.58GlnLys: 2.58 ± 0.055	3.92GlnLeu: 3.92 ± 0.068	0.766GlnMet: 0.766 ± 0.029	2.086GlnAsn: 2.086 ± 0.046	1.175GlnPro: 1.175 ± 0.036	1.64GlnGln: 1.64 ± 0.047	1.279GlnArg: 1.279 ± 0.037	1.935GlnSer: 1.935 ± 0.048	1.94GlnThr: 1.94 ± 0.056	2.109GlnVal: 2.109 ± 0.044	0.427GlnTrp: 0.427 ± 0.024	1.427GlnTyr: 1.427 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.176ArgAla: 2.176 ± 0.044	0.195ArgCys: 0.195 ± 0.012	1.944ArgAsp: 1.944 ± 0.044	2.056ArgGlu: 2.056 ± 0.045	2.098ArgPhe: 2.098 ± 0.046	2.019ArgGly: 2.019 ± 0.04	0.597ArgHis: 0.597 ± 0.023	2.927ArgIle: 2.927 ± 0.052	2.947ArgLys: 2.947 ± 0.06	3.402ArgLeu: 3.402 ± 0.065	0.881ArgMet: 0.881 ± 0.029	2.17ArgAsn: 2.17 ± 0.042	1.106ArgPro: 1.106 ± 0.032	1.179ArgGln: 1.179 ± 0.034	1.5ArgArg: 1.5 ± 0.042	2.275ArgSer: 2.275 ± 0.052	2.006ArgThr: 2.006 ± 0.04	2.243ArgVal: 2.243 ± 0.043	0.424ArgTrp: 0.424 ± 0.021	1.602ArgTyr: 1.602 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.993SerAla: 3.993 ± 0.066	0.701SerCys: 0.701 ± 0.029	3.644SerAsp: 3.644 ± 0.062	3.727SerGlu: 3.727 ± 0.058	4.014SerPhe: 4.014 ± 0.068	4.811SerGly: 4.811 ± 0.09	1.037SerHis: 1.037 ± 0.029	5.284SerIle: 5.284 ± 0.077	4.618SerLys: 4.618 ± 0.076	6.089SerLeu: 6.089 ± 0.076	1.327SerMet: 1.327 ± 0.036	3.952SerAsn: 3.952 ± 0.066	2.138SerPro: 2.138 ± 0.045	2.129SerGln: 2.129 ± 0.039	2.261SerArg: 2.261 ± 0.045	4.34SerSer: 4.34 ± 0.086	3.832SerThr: 3.832 ± 0.08	3.965SerVal: 3.965 ± 0.066	0.746SerTrp: 0.746 ± 0.029	2.772SerTyr: 2.772 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.356ThrAla: 4.356 ± 0.15	0.364ThrCys: 0.364 ± 0.034	3.692ThrAsp: 3.692 ± 0.107	3.35ThrGlu: 3.35 ± 0.064	3.132ThrPhe: 3.132 ± 0.098	4.211ThrGly: 4.211 ± 0.114	0.953ThrHis: 0.953 ± 0.03	5.304ThrIle: 5.304 ± 0.134	3.866ThrLys: 3.866 ± 0.061	5.338ThrLeu: 5.338 ± 0.108	1.037ThrMet: 1.037 ± 0.031	3.623ThrAsn: 3.623 ± 0.088	2.49ThrPro: 2.49 ± 0.065	1.858ThrGln: 1.858 ± 0.05	1.762ThrArg: 1.762 ± 0.04	4.006ThrSer: 4.006 ± 0.071	3.82ThrThr: 3.82 ± 0.102	4.19ThrVal: 4.19 ± 0.174	0.594ThrTrp: 0.594 ± 0.028	2.432ThrTyr: 2.432 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	4.386ValAla: 4.386 ± 0.064	0.506ValCys: 0.506 ± 0.021	4.092ValAsp: 4.092 ± 0.071	3.732ValGlu: 3.732 ± 0.058	3.449ValPhe: 3.449 ± 0.056	4.092ValGly: 4.092 ± 0.067	1.019ValHis: 1.019 ± 0.031	4.801ValIle: 4.801 ± 0.068	4.163ValLys: 4.163 ± 0.077	6.142ValLeu: 6.142 ± 0.081	1.272ValMet: 1.272 ± 0.037	3.681ValAsn: 3.681 ± 0.079	2.214ValPro: 2.214 ± 0.049	1.986ValGln: 1.986 ± 0.05	2.159ValArg: 2.159 ± 0.048	4.598ValSer: 4.598 ± 0.064	4.078ValThr: 4.078 ± 0.181	4.579ValVal: 4.579 ± 0.076	0.613ValTrp: 0.613 ± 0.022	2.273ValTyr: 2.273 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.581TrpAla: 0.581 ± 0.024	0.097TrpCys: 0.097 ± 0.009	0.681TrpAsp: 0.681 ± 0.025	0.674TrpGlu: 0.674 ± 0.025	0.604TrpPhe: 0.604 ± 0.027	0.739TrpGly: 0.739 ± 0.027	0.238TrpHis: 0.238 ± 0.016	0.762TrpIle: 0.762 ± 0.027	0.783TrpLys: 0.783 ± 0.03	1.0TrpLeu: 1.0 ± 0.03	0.315TrpMet: 0.315 ± 0.017	0.71TrpAsn: 0.71 ± 0.034	0.276TrpPro: 0.276 ± 0.018	0.437TrpGln: 0.437 ± 0.023	0.469TrpArg: 0.469 ± 0.018	0.639TrpSer: 0.639 ± 0.022	0.579TrpThr: 0.579 ± 0.024	0.649TrpVal: 0.649 ± 0.027	0.181TrpTrp: 0.181 ± 0.012	0.457TrpTyr: 0.457 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.356TyrAla: 2.356 ± 0.042	0.308TyrCys: 0.308 ± 0.014	2.431TyrAsp: 2.431 ± 0.05	2.32TyrGlu: 2.32 ± 0.048	2.268TyrPhe: 2.268 ± 0.049	2.542TyrGly: 2.542 ± 0.053	0.815TyrHis: 0.815 ± 0.029	2.556TyrIle: 2.556 ± 0.043	2.709TyrLys: 2.709 ± 0.053	3.572TyrLeu: 3.572 ± 0.064	0.701TyrMet: 0.701 ± 0.025	2.341TyrAsn: 2.341 ± 0.054	1.43TyrPro: 1.43 ± 0.037	1.668TyrGln: 1.668 ± 0.044	1.698TyrArg: 1.698 ± 0.036	2.365TyrSer: 2.365 ± 0.044	2.369TyrThr: 2.369 ± 0.074	2.21TyrVal: 2.21 ± 0.044	0.5TyrTrp: 0.5 ± 0.023	1.712TyrTyr: 1.712 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3588 proteins (1259079 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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