Amino acid dipepetide frequency for Colwellia chukchiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.475AlaAla: 8.475 ± 0.117
1.037AlaCys: 1.037 ± 0.036
5.08AlaAsp: 5.08 ± 0.072
5.734AlaGlu: 5.734 ± 0.083
3.58AlaPhe: 3.58 ± 0.045
5.956AlaGly: 5.956 ± 0.081
1.82AlaHis: 1.82 ± 0.045
7.269AlaIle: 7.269 ± 0.088
6.095AlaLys: 6.095 ± 0.09
10.677AlaLeu: 10.677 ± 0.105
2.694AlaMet: 2.694 ± 0.054
4.673AlaAsn: 4.673 ± 0.069
2.945AlaPro: 2.945 ± 0.055
5.084AlaGln: 5.084 ± 0.084
3.56AlaArg: 3.56 ± 0.056
5.974AlaSer: 5.974 ± 0.087
4.822AlaThr: 4.822 ± 0.068
5.637AlaVal: 5.637 ± 0.077
0.976AlaTrp: 0.976 ± 0.031
2.53AlaTyr: 2.53 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.849CysAla: 0.849 ± 0.027
0.183CysCys: 0.183 ± 0.013
0.539CysAsp: 0.539 ± 0.027
0.505CysGlu: 0.505 ± 0.026
0.433CysPhe: 0.433 ± 0.019
0.784CysGly: 0.784 ± 0.03
0.394CysHis: 0.394 ± 0.018
0.602CysIle: 0.602 ± 0.024
0.36CysLys: 0.36 ± 0.018
1.033CysLeu: 1.033 ± 0.031
0.192CysMet: 0.192 ± 0.013
0.37CysAsn: 0.37 ± 0.018
0.454CysPro: 0.454 ± 0.022
0.791CysGln: 0.791 ± 0.028
0.461CysArg: 0.461 ± 0.022
0.654CysSer: 0.654 ± 0.025
0.439CysThr: 0.439 ± 0.021
0.562CysVal: 0.562 ± 0.022
0.148CysTrp: 0.148 ± 0.012
0.355CysTyr: 0.355 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.366AspAla: 4.366 ± 0.065
0.541AspCys: 0.541 ± 0.024
3.18AspAsp: 3.18 ± 0.066
3.41AspGlu: 3.41 ± 0.062
2.584AspPhe: 2.584 ± 0.048
3.445AspGly: 3.445 ± 0.069
1.115AspHis: 1.115 ± 0.033
4.42AspIle: 4.42 ± 0.065
3.354AspLys: 3.354 ± 0.058
4.958AspLeu: 4.958 ± 0.061
1.316AspMet: 1.316 ± 0.035
2.886AspAsn: 2.886 ± 0.061
1.731AspPro: 1.731 ± 0.037
1.819AspGln: 1.819 ± 0.043
1.905AspArg: 1.905 ± 0.047
3.285AspSer: 3.285 ± 0.065
2.515AspThr: 2.515 ± 0.048
3.632AspVal: 3.632 ± 0.063
0.773AspTrp: 0.773 ± 0.028
1.978AspTyr: 1.978 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
4.307GluAla: 4.307 ± 0.071
0.412GluCys: 0.412 ± 0.021
2.399GluAsp: 2.399 ± 0.054
2.645GluGlu: 2.645 ± 0.068
2.381GluPhe: 2.381 ± 0.049
2.65GluGly: 2.65 ± 0.055
1.7GluHis: 1.7 ± 0.039
3.843GluIle: 3.843 ± 0.063
3.731GluLys: 3.731 ± 0.064
6.681GluLeu: 6.681 ± 0.088
1.402GluMet: 1.402 ± 0.034
2.903GluAsn: 2.903 ± 0.057
1.771GluPro: 1.771 ± 0.041
4.573GluGln: 4.573 ± 0.087
2.756GluArg: 2.756 ± 0.05
3.222GluSer: 3.222 ± 0.055
2.579GluThr: 2.579 ± 0.056
3.736GluVal: 3.736 ± 0.064
0.472GluTrp: 0.472 ± 0.02
1.641GluTyr: 1.641 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.013PheAla: 4.013 ± 0.058
0.538PheCys: 0.538 ± 0.025
2.738PheAsp: 2.738 ± 0.051
2.369PheGlu: 2.369 ± 0.053
1.775PhePhe: 1.775 ± 0.048
2.888PheGly: 2.888 ± 0.055
0.833PheHis: 0.833 ± 0.028
3.186PheIle: 3.186 ± 0.061
2.173PheLys: 2.173 ± 0.051
3.452PheLeu: 3.452 ± 0.07
0.918PheMet: 0.918 ± 0.028
2.312PheAsn: 2.312 ± 0.044
1.336PhePro: 1.336 ± 0.034
1.455PheGln: 1.455 ± 0.038
1.448PheArg: 1.448 ± 0.037
3.601PheSer: 3.601 ± 0.057
2.412PheThr: 2.412 ± 0.047
2.563PheVal: 2.563 ± 0.051
0.499PheTrp: 0.499 ± 0.022
1.457PheTyr: 1.457 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
5.18GlyAla: 5.18 ± 0.09
0.836GlyCys: 0.836 ± 0.027
3.403GlyAsp: 3.403 ± 0.064
3.775GlyGlu: 3.775 ± 0.055
3.229GlyPhe: 3.229 ± 0.054
4.214GlyGly: 4.214 ± 0.085
1.468GlyHis: 1.468 ± 0.037
4.372GlyIle: 4.372 ± 0.068
3.906GlyLys: 3.906 ± 0.071
6.321GlyLeu: 6.321 ± 0.086
1.672GlyMet: 1.672 ± 0.047
2.533GlyAsn: 2.533 ± 0.063
1.532GlyPro: 1.532 ± 0.043
2.836GlyGln: 2.836 ± 0.05
2.651GlyArg: 2.651 ± 0.053
3.734GlySer: 3.734 ± 0.063
3.084GlyThr: 3.084 ± 0.062
4.638GlyVal: 4.638 ± 0.079
0.767GlyTrp: 0.767 ± 0.025
2.371GlyTyr: 2.371 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.766HisAla: 1.766 ± 0.042
0.324HisCys: 0.324 ± 0.017
1.161HisAsp: 1.161 ± 0.033
1.09HisGlu: 1.09 ± 0.029
1.154HisPhe: 1.154 ± 0.034
1.619HisGly: 1.619 ± 0.04
0.709HisHis: 0.709 ± 0.025
1.525HisIle: 1.525 ± 0.036
1.129HisLys: 1.129 ± 0.036
2.343HisLeu: 2.343 ± 0.052
0.488HisMet: 0.488 ± 0.019
1.021HisAsn: 1.021 ± 0.031
0.997HisPro: 0.997 ± 0.031
1.491HisGln: 1.491 ± 0.038
0.944HisArg: 0.944 ± 0.029
1.445HisSer: 1.445 ± 0.041
0.992HisThr: 0.992 ± 0.028
1.264HisVal: 1.264 ± 0.035
0.402HisTrp: 0.402 ± 0.02
0.964HisTyr: 0.964 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
7.623IleAla: 7.623 ± 0.083
0.685IleCys: 0.685 ± 0.026
4.434IleAsp: 4.434 ± 0.066
4.524IleGlu: 4.524 ± 0.069
2.546IlePhe: 2.546 ± 0.052
4.433IleGly: 4.433 ± 0.082
1.3IleHis: 1.3 ± 0.034
4.343IleIle: 4.343 ± 0.074
4.137IleLys: 4.137 ± 0.048
5.389IleLeu: 5.389 ± 0.093
1.321IleMet: 1.321 ± 0.041
3.727IleAsn: 3.727 ± 0.055
2.418IlePro: 2.418 ± 0.046
2.116IleGln: 2.116 ± 0.041
2.679IleArg: 2.679 ± 0.052
5.05IleSer: 5.05 ± 0.07
4.047IleThr: 4.047 ± 0.058
4.194IleVal: 4.194 ± 0.07
0.618IleTrp: 0.618 ± 0.026
1.908IleTyr: 1.908 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
5.699LysAla: 5.699 ± 0.079
0.369LysCys: 0.369 ± 0.02
2.648LysAsp: 2.648 ± 0.053
2.839LysGlu: 2.839 ± 0.057
1.91LysPhe: 1.91 ± 0.035
2.969LysGly: 2.969 ± 0.054
1.383LysHis: 1.383 ± 0.038
3.531LysIle: 3.531 ± 0.061
3.31LysLys: 3.31 ± 0.065
5.931LysLeu: 5.931 ± 0.081
1.377LysMet: 1.377 ± 0.037
2.837LysAsn: 2.837 ± 0.047
2.282LysPro: 2.282 ± 0.041
3.441LysGln: 3.441 ± 0.061
2.719LysArg: 2.719 ± 0.056
3.597LysSer: 3.597 ± 0.061
3.179LysThr: 3.179 ± 0.052
3.98LysVal: 3.98 ± 0.06
0.534LysTrp: 0.534 ± 0.022
1.661LysTyr: 1.661 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
11.908LeuAla: 11.908 ± 0.128
1.009LeuCys: 1.009 ± 0.032
5.382LeuAsp: 5.382 ± 0.082
5.071LeuGlu: 5.071 ± 0.081
4.132LeuPhe: 4.132 ± 0.069
6.312LeuGly: 6.312 ± 0.08
2.047LeuHis: 2.047 ± 0.046
6.53LeuIle: 6.53 ± 0.083
5.592LeuLys: 5.592 ± 0.077
11.2LeuLeu: 11.2 ± 0.171
2.605LeuMet: 2.605 ± 0.048
4.929LeuAsn: 4.929 ± 0.072
4.67LeuPro: 4.67 ± 0.071
4.243LeuGln: 4.243 ± 0.088
4.063LeuArg: 4.063 ± 0.061
8.165LeuSer: 8.165 ± 0.095
6.675LeuThr: 6.675 ± 0.092
6.746LeuVal: 6.746 ± 0.082
1.035LeuTrp: 1.035 ± 0.033
2.693LeuTyr: 2.693 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.609MetAla: 2.609 ± 0.051
0.194MetCys: 0.194 ± 0.011
1.005MetAsp: 1.005 ± 0.035
0.983MetGlu: 0.983 ± 0.031
0.893MetPhe: 0.893 ± 0.027
1.423MetGly: 1.423 ± 0.041
0.482MetHis: 0.482 ± 0.022
1.345MetIle: 1.345 ± 0.04
1.381MetLys: 1.381 ± 0.034
2.6MetLeu: 2.6 ± 0.057
0.689MetMet: 0.689 ± 0.03
0.985MetAsn: 0.985 ± 0.03
1.256MetPro: 1.256 ± 0.033
1.213MetGln: 1.213 ± 0.028
1.103MetArg: 1.103 ± 0.033
1.861MetSer: 1.861 ± 0.042
1.564MetThr: 1.564 ± 0.035
1.619MetVal: 1.619 ± 0.04
0.204MetTrp: 0.204 ± 0.016
0.511MetTyr: 0.511 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
4.129AsnAla: 4.129 ± 0.064
0.494AsnCys: 0.494 ± 0.022
2.489AsnAsp: 2.489 ± 0.051
2.6AsnGlu: 2.6 ± 0.055
1.908AsnPhe: 1.908 ± 0.041
3.005AsnGly: 3.005 ± 0.07
1.029AsnHis: 1.029 ± 0.032
3.666AsnIle: 3.666 ± 0.057
2.911AsnLys: 2.911 ± 0.058
4.375AsnLeu: 4.375 ± 0.073
1.055AsnMet: 1.055 ± 0.029
2.695AsnAsn: 2.695 ± 0.05
1.875AsnPro: 1.875 ± 0.038
2.375AsnGln: 2.375 ± 0.05
2.001AsnArg: 2.001 ± 0.04
3.062AsnSer: 3.062 ± 0.054
2.593AsnThr: 2.593 ± 0.049
2.833AsnVal: 2.833 ± 0.054
0.607AsnTrp: 0.607 ± 0.024
1.584AsnTyr: 1.584 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
3.233ProAla: 3.233 ± 0.054
0.314ProCys: 0.314 ± 0.017
2.107ProAsp: 2.107 ± 0.041
2.945ProGlu: 2.945 ± 0.054
1.622ProPhe: 1.622 ± 0.033
2.108ProGly: 2.108 ± 0.054
0.755ProHis: 0.755 ± 0.026
2.398ProIle: 2.398 ± 0.045
2.039ProLys: 2.039 ± 0.043
3.939ProLeu: 3.939 ± 0.059
0.879ProMet: 0.879 ± 0.031
1.72ProAsn: 1.72 ± 0.039
1.012ProPro: 1.012 ± 0.033
1.502ProGln: 1.502 ± 0.039
1.267ProArg: 1.267 ± 0.032
2.489ProSer: 2.489 ± 0.05
1.939ProThr: 1.939 ± 0.04
2.667ProVal: 2.667 ± 0.048
0.484ProTrp: 0.484 ± 0.02
1.252ProTyr: 1.252 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
5.967GlnAla: 5.967 ± 0.093
0.477GlnCys: 0.477 ± 0.022
2.201GlnAsp: 2.201 ± 0.047
2.461GlnGlu: 2.461 ± 0.055
1.788GlnPhe: 1.788 ± 0.043
3.285GlnGly: 3.285 ± 0.054
1.594GlnHis: 1.594 ± 0.049
2.542GlnIle: 2.542 ± 0.047
2.199GlnLys: 2.199 ± 0.048
6.215GlnLeu: 6.215 ± 0.102
1.069GlnMet: 1.069 ± 0.027
1.783GlnAsn: 1.783 ± 0.037
1.865GlnPro: 1.865 ± 0.041
4.915GlnGln: 4.915 ± 0.119
2.491GlnArg: 2.491 ± 0.047
2.933GlnSer: 2.933 ± 0.054
2.436GlnThr: 2.436 ± 0.054
3.714GlnVal: 3.714 ± 0.062
0.753GlnTrp: 0.753 ± 0.026
1.596GlnTyr: 1.596 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.494ArgAla: 3.494 ± 0.051
0.411ArgCys: 0.411 ± 0.02
2.201ArgAsp: 2.201 ± 0.044
2.441ArgGlu: 2.441 ± 0.047
2.083ArgPhe: 2.083 ± 0.041
2.375ArgGly: 2.375 ± 0.05
1.077ArgHis: 1.077 ± 0.032
2.912ArgIle: 2.912 ± 0.047
2.327ArgLys: 2.327 ± 0.049
4.687ArgLeu: 4.687 ± 0.07
1.02ArgMet: 1.02 ± 0.029
1.842ArgAsn: 1.842 ± 0.041
1.396ArgPro: 1.396 ± 0.037
2.27ArgGln: 2.27 ± 0.045
2.105ArgArg: 2.105 ± 0.049
2.39ArgSer: 2.39 ± 0.048
1.785ArgThr: 1.785 ± 0.039
2.838ArgVal: 2.838 ± 0.056
0.574ArgTrp: 0.574 ± 0.024
1.721ArgTyr: 1.721 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.528SerAla: 6.528 ± 0.077
0.599SerCys: 0.599 ± 0.027
3.536SerAsp: 3.536 ± 0.067
3.762SerGlu: 3.762 ± 0.07
3.05SerPhe: 3.05 ± 0.05
4.542SerGly: 4.542 ± 0.073
1.618SerHis: 1.618 ± 0.039
4.176SerIle: 4.176 ± 0.065
3.565SerLys: 3.565 ± 0.057
7.006SerLeu: 7.006 ± 0.074
1.527SerMet: 1.527 ± 0.033
2.99SerAsn: 2.99 ± 0.055
2.362SerPro: 2.362 ± 0.047
3.312SerGln: 3.312 ± 0.06
2.774SerArg: 2.774 ± 0.054
4.449SerSer: 4.449 ± 0.07
3.474SerThr: 3.474 ± 0.062
4.397SerVal: 4.397 ± 0.064
0.799SerTrp: 0.799 ± 0.025
2.29SerTyr: 2.29 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.9ThrAla: 4.9 ± 0.07
0.474ThrCys: 0.474 ± 0.021
2.845ThrAsp: 2.845 ± 0.05
3.097ThrGlu: 3.097 ± 0.052
2.085ThrPhe: 2.085 ± 0.047
3.848ThrGly: 3.848 ± 0.057
1.062ThrHis: 1.062 ± 0.035
3.591ThrIle: 3.591 ± 0.057
2.625ThrLys: 2.625 ± 0.049
6.341ThrLeu: 6.341 ± 0.07
1.166ThrMet: 1.166 ± 0.035
2.122ThrAsn: 2.122 ± 0.052
2.56ThrPro: 2.56 ± 0.052
2.542ThrGln: 2.542 ± 0.05
2.17ThrArg: 2.17 ± 0.046
3.392ThrSer: 3.392 ± 0.065
2.951ThrThr: 2.951 ± 0.062
3.488ThrVal: 3.488 ± 0.062
0.567ThrTrp: 0.567 ± 0.022
1.327ThrTyr: 1.327 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
6.462ValAla: 6.462 ± 0.077
0.682ValCys: 0.682 ± 0.026
3.815ValAsp: 3.815 ± 0.062
3.875ValGlu: 3.875 ± 0.068
2.725ValPhe: 2.725 ± 0.05
3.958ValGly: 3.958 ± 0.074
1.168ValHis: 1.168 ± 0.036
4.833ValIle: 4.833 ± 0.066
3.685ValLys: 3.685 ± 0.062
6.485ValLeu: 6.485 ± 0.09
1.686ValMet: 1.686 ± 0.043
3.345ValAsn: 3.345 ± 0.055
2.401ValPro: 2.401 ± 0.048
2.282ValGln: 2.282 ± 0.04
2.504ValArg: 2.504 ± 0.051
4.635ValSer: 4.635 ± 0.074
3.839ValThr: 3.839 ± 0.058
4.756ValVal: 4.756 ± 0.072
0.628ValTrp: 0.628 ± 0.025
1.84ValTyr: 1.84 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.746TrpAla: 0.746 ± 0.025
0.133TrpCys: 0.133 ± 0.011
0.452TrpAsp: 0.452 ± 0.021
0.336TrpGlu: 0.336 ± 0.019
0.514TrpPhe: 0.514 ± 0.021
0.682TrpGly: 0.682 ± 0.026
0.405TrpHis: 0.405 ± 0.02
0.559TrpIle: 0.559 ± 0.022
0.339TrpLys: 0.339 ± 0.017
1.86TrpLeu: 1.86 ± 0.045
0.22TrpMet: 0.22 ± 0.015
0.358TrpAsn: 0.358 ± 0.017
0.467TrpPro: 0.467 ± 0.022
1.425TrpGln: 1.425 ± 0.038
0.661TrpArg: 0.661 ± 0.023
0.71TrpSer: 0.71 ± 0.024
0.429TrpThr: 0.429 ± 0.022
0.642TrpVal: 0.642 ± 0.025
0.151TrpTrp: 0.151 ± 0.01
0.354TrpTyr: 0.354 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.36TyrAla: 2.36 ± 0.048
0.395TyrCys: 0.395 ± 0.019
1.601TyrAsp: 1.601 ± 0.042
1.343TyrGlu: 1.343 ± 0.033
1.575TyrPhe: 1.575 ± 0.035
2.028TyrGly: 2.028 ± 0.046
0.87TyrHis: 0.87 ± 0.026
1.85TyrIle: 1.85 ± 0.04
1.34TyrLys: 1.34 ± 0.034
3.517TyrLeu: 3.517 ± 0.06
0.623TyrMet: 0.623 ± 0.024
1.258TyrAsn: 1.258 ± 0.038
1.339TyrPro: 1.339 ± 0.036
2.597TyrGln: 2.597 ± 0.052
1.688TyrArg: 1.688 ± 0.037
2.107TyrSer: 2.107 ± 0.042
1.396TyrThr: 1.396 ± 0.039
1.697TyrVal: 1.697 ± 0.036
0.45TyrTrp: 0.45 ± 0.021
1.15TyrTyr: 1.15 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3563 proteins (1168915 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski