Amino acid dipepetide frequency for Eggerthellaceae bacterium zg-1050

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.598AlaAla: 18.598 ± 0.348	2.299AlaCys: 2.299 ± 0.085	7.915AlaAsp: 7.915 ± 0.154	7.65AlaGlu: 7.65 ± 0.134	4.631AlaPhe: 4.631 ± 0.104	11.485AlaGly: 11.485 ± 0.166	2.629AlaHis: 2.629 ± 0.079	5.213AlaIle: 5.213 ± 0.115	3.528AlaLys: 3.528 ± 0.1	13.9AlaLeu: 13.9 ± 0.24	2.775AlaMet: 2.775 ± 0.078	2.616AlaAsn: 2.616 ± 0.082	5.849AlaPro: 5.849 ± 0.159	4.983AlaGln: 4.983 ± 0.118	9.845AlaArg: 9.845 ± 0.202	7.593AlaSer: 7.593 ± 0.151	5.841AlaThr: 5.841 ± 0.113	10.24AlaVal: 10.24 ± 0.165	1.288AlaTrp: 1.288 ± 0.047	2.979AlaTyr: 2.979 ± 0.087	0.0AlaXaa: 0.0 ± 0.0
Cys	2.14CysAla: 2.14 ± 0.069	0.273CysCys: 0.273 ± 0.026	1.003CysAsp: 1.003 ± 0.051	0.852CysGlu: 0.852 ± 0.046	0.458CysPhe: 0.458 ± 0.029	1.601CysGly: 1.601 ± 0.061	0.362CysHis: 0.362 ± 0.034	0.584CysIle: 0.584 ± 0.033	0.301CysLys: 0.301 ± 0.028	1.263CysLeu: 1.263 ± 0.051	0.405CysMet: 0.405 ± 0.031	0.323CysAsn: 0.323 ± 0.028	0.818CysPro: 0.818 ± 0.045	0.378CysGln: 0.378 ± 0.028	0.81CysArg: 0.81 ± 0.042	0.844CysSer: 0.844 ± 0.037	0.763CysThr: 0.763 ± 0.04	1.351CysVal: 1.351 ± 0.058	0.142CysTrp: 0.142 ± 0.018	0.317CysTyr: 0.317 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	8.69AspAla: 8.69 ± 0.152	0.682AspCys: 0.682 ± 0.035	3.797AspAsp: 3.797 ± 0.105	5.052AspGlu: 5.052 ± 0.12	1.925AspPhe: 1.925 ± 0.073	4.85AspGly: 4.85 ± 0.116	1.058AspHis: 1.058 ± 0.044	2.472AspIle: 2.472 ± 0.073	1.522AspLys: 1.522 ± 0.069	5.363AspLeu: 5.363 ± 0.093	1.306AspMet: 1.306 ± 0.047	1.16AspAsn: 1.16 ± 0.053	3.349AspPro: 3.349 ± 0.097	1.906AspGln: 1.906 ± 0.059	3.902AspArg: 3.902 ± 0.09	2.533AspSer: 2.533 ± 0.072	2.56AspThr: 2.56 ± 0.104	4.745AspVal: 4.745 ± 0.108	0.578AspTrp: 0.578 ± 0.034	1.528AspTyr: 1.528 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	8.523GluAla: 8.523 ± 0.171	0.676GluCys: 0.676 ± 0.039	2.753GluAsp: 2.753 ± 0.077	3.398GluGlu: 3.398 ± 0.116	1.744GluPhe: 1.744 ± 0.061	6.362GluGly: 6.362 ± 0.108	1.251GluHis: 1.251 ± 0.057	1.481GluIle: 1.481 ± 0.062	2.037GluLys: 2.037 ± 0.089	5.79GluLeu: 5.79 ± 0.135	1.443GluMet: 1.443 ± 0.056	1.538GluAsn: 1.538 ± 0.056	2.59GluPro: 2.59 ± 0.08	2.37GluGln: 2.37 ± 0.079	6.138GluArg: 6.138 ± 0.14	2.914GluSer: 2.914 ± 0.083	2.503GluThr: 2.503 ± 0.073	5.253GluVal: 5.253 ± 0.113	0.572GluTrp: 0.572 ± 0.041	1.278GluTyr: 1.278 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	4.234PheAla: 4.234 ± 0.109	0.58PheCys: 0.58 ± 0.035	2.59PheAsp: 2.59 ± 0.067	2.346PheGlu: 2.346 ± 0.069	1.213PhePhe: 1.213 ± 0.055	3.369PheGly: 3.369 ± 0.087	0.586PheHis: 0.586 ± 0.032	1.54PheIle: 1.54 ± 0.067	1.042PheLys: 1.042 ± 0.051	2.928PheLeu: 2.928 ± 0.08	0.855PheMet: 0.855 ± 0.042	0.991PheAsn: 0.991 ± 0.059	1.39PhePro: 1.39 ± 0.053	0.964PheGln: 0.964 ± 0.048	1.67PheArg: 1.67 ± 0.057	2.246PheSer: 2.246 ± 0.075	2.077PheThr: 2.077 ± 0.067	2.857PheVal: 2.857 ± 0.088	0.397PheTrp: 0.397 ± 0.027	0.936PheTyr: 0.936 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	10.838GlyAla: 10.838 ± 0.178	1.593GlyCys: 1.593 ± 0.067	4.694GlyAsp: 4.694 ± 0.119	4.625GlyGlu: 4.625 ± 0.113	3.42GlyPhe: 3.42 ± 0.091	7.182GlyGly: 7.182 ± 0.169	1.491GlyHis: 1.491 ± 0.054	4.37GlyIle: 4.37 ± 0.107	3.274GlyLys: 3.274 ± 0.102	7.986GlyLeu: 7.986 ± 0.149	2.562GlyMet: 2.562 ± 0.083	2.159GlyAsn: 2.159 ± 0.085	3.05GlyPro: 3.05 ± 0.073	2.486GlyGln: 2.486 ± 0.071	5.589GlyArg: 5.589 ± 0.105	5.609GlySer: 5.609 ± 0.121	4.95GlyThr: 4.95 ± 0.103	7.491GlyVal: 7.491 ± 0.124	0.942GlyTrp: 0.942 ± 0.046	2.458GlyTyr: 2.458 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	2.647HisAla: 2.647 ± 0.071	0.307HisCys: 0.307 ± 0.022	1.154HisAsp: 1.154 ± 0.053	1.16HisGlu: 1.16 ± 0.043	0.612HisPhe: 0.612 ± 0.033	1.642HisGly: 1.642 ± 0.063	0.442HisHis: 0.442 ± 0.032	0.755HisIle: 0.755 ± 0.041	0.419HisLys: 0.419 ± 0.027	1.701HisLeu: 1.701 ± 0.055	0.393HisMet: 0.393 ± 0.029	0.401HisAsn: 0.401 ± 0.026	1.121HisPro: 1.121 ± 0.047	0.551HisGln: 0.551 ± 0.031	1.27HisArg: 1.27 ± 0.045	0.96HisSer: 0.96 ± 0.047	0.901HisThr: 0.901 ± 0.04	1.587HisVal: 1.587 ± 0.06	0.161HisTrp: 0.161 ± 0.019	0.503HisTyr: 0.503 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.945IleAla: 5.945 ± 0.125	0.673IleCys: 0.673 ± 0.037	3.736IleAsp: 3.736 ± 0.093	3.55IleGlu: 3.55 ± 0.095	0.991IlePhe: 0.991 ± 0.051	3.776IleGly: 3.776 ± 0.093	0.7IleHis: 0.7 ± 0.038	1.77IleIle: 1.77 ± 0.069	1.318IleLys: 1.318 ± 0.059	2.96IleLeu: 2.96 ± 0.079	1.117IleMet: 1.117 ± 0.057	1.145IleAsn: 1.145 ± 0.051	2.163IlePro: 2.163 ± 0.069	1.125IleGln: 1.125 ± 0.045	2.195IleArg: 2.195 ± 0.086	2.427IleSer: 2.427 ± 0.081	2.381IleThr: 2.381 ± 0.071	3.858IleVal: 3.858 ± 0.092	0.315IleTrp: 0.315 ± 0.027	0.812IleTyr: 0.812 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	3.721LysAla: 3.721 ± 0.123	0.281LysCys: 0.281 ± 0.028	1.597LysAsp: 1.597 ± 0.073	1.615LysGlu: 1.615 ± 0.075	0.743LysPhe: 0.743 ± 0.042	2.828LysGly: 2.828 ± 0.087	0.462LysHis: 0.462 ± 0.036	1.233LysIle: 1.233 ± 0.051	1.463LysLys: 1.463 ± 0.073	2.708LysLeu: 2.708 ± 0.078	0.753LysMet: 0.753 ± 0.046	0.944LysAsn: 0.944 ± 0.04	1.51LysPro: 1.51 ± 0.067	1.013LysGln: 1.013 ± 0.047	2.464LysArg: 2.464 ± 0.081	1.829LysSer: 1.829 ± 0.065	1.607LysThr: 1.607 ± 0.058	2.814LysVal: 2.814 ± 0.092	0.271LysTrp: 0.271 ± 0.023	0.641LysTyr: 0.641 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	12.452LeuAla: 12.452 ± 0.185	1.428LeuCys: 1.428 ± 0.06	5.902LeuAsp: 5.902 ± 0.117	5.015LeuGlu: 5.015 ± 0.102	3.316LeuPhe: 3.316 ± 0.088	7.76LeuGly: 7.76 ± 0.142	1.514LeuHis: 1.514 ± 0.049	3.97LeuIle: 3.97 ± 0.109	2.794LeuLys: 2.794 ± 0.083	8.181LeuLeu: 8.181 ± 0.17	2.82LeuMet: 2.82 ± 0.084	2.262LeuAsn: 2.262 ± 0.069	4.592LeuPro: 4.592 ± 0.098	2.452LeuGln: 2.452 ± 0.074	6.59LeuArg: 6.59 ± 0.149	6.415LeuSer: 6.415 ± 0.129	4.881LeuThr: 4.881 ± 0.104	8.09LeuVal: 8.09 ± 0.159	0.802LeuTrp: 0.802 ± 0.037	2.071LeuTyr: 2.071 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	3.003MetAla: 3.003 ± 0.09	0.328MetCys: 0.328 ± 0.028	1.152MetAsp: 1.152 ± 0.053	1.371MetGlu: 1.371 ± 0.056	0.769MetPhe: 0.769 ± 0.05	2.305MetGly: 2.305 ± 0.07	0.423MetHis: 0.423 ± 0.028	1.093MetIle: 1.093 ± 0.05	1.023MetLys: 1.023 ± 0.043	2.33MetLeu: 2.33 ± 0.076	0.649MetMet: 0.649 ± 0.038	0.838MetAsn: 0.838 ± 0.044	1.237MetPro: 1.237 ± 0.045	0.779MetGln: 0.779 ± 0.039	1.941MetArg: 1.941 ± 0.059	1.795MetSer: 1.795 ± 0.056	1.575MetThr: 1.575 ± 0.058	1.98MetVal: 1.98 ± 0.066	0.197MetTrp: 0.197 ± 0.02	0.5MetTyr: 0.5 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.044AsnAla: 3.044 ± 0.077	0.315AsnCys: 0.315 ± 0.024	1.329AsnAsp: 1.329 ± 0.051	1.495AsnGlu: 1.495 ± 0.059	0.678AsnPhe: 0.678 ± 0.038	2.171AsnGly: 2.171 ± 0.078	0.537AsnHis: 0.537 ± 0.032	1.172AsnIle: 1.172 ± 0.053	0.698AsnLys: 0.698 ± 0.039	2.301AsnLeu: 2.301 ± 0.066	0.627AsnMet: 0.627 ± 0.035	0.639AsnAsn: 0.639 ± 0.037	1.762AsnPro: 1.762 ± 0.064	0.735AsnGln: 0.735 ± 0.044	1.691AsnArg: 1.691 ± 0.055	1.119AsnSer: 1.119 ± 0.048	1.219AsnThr: 1.219 ± 0.054	2.126AsnVal: 2.126 ± 0.069	0.293AsnTrp: 0.293 ± 0.025	0.69AsnTyr: 0.69 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	6.558ProAla: 6.558 ± 0.157	0.627ProCys: 0.627 ± 0.042	3.3ProAsp: 3.3 ± 0.092	3.237ProGlu: 3.237 ± 0.086	1.774ProPhe: 1.774 ± 0.052	3.815ProGly: 3.815 ± 0.094	1.103ProHis: 1.103 ± 0.047	1.847ProIle: 1.847 ± 0.067	1.229ProLys: 1.229 ± 0.063	4.23ProLeu: 4.23 ± 0.092	0.773ProMet: 0.773 ± 0.037	1.056ProAsn: 1.056 ± 0.047	1.426ProPro: 1.426 ± 0.065	1.78ProGln: 1.78 ± 0.059	2.722ProArg: 2.722 ± 0.081	2.816ProSer: 2.816 ± 0.079	2.527ProThr: 2.527 ± 0.087	3.734ProVal: 3.734 ± 0.123	0.444ProTrp: 0.444 ± 0.029	1.231ProTyr: 1.231 ± 0.051	0.0ProXaa: 0.0 ± 0.0
Gln	4.484GlnAla: 4.484 ± 0.105	0.326GlnCys: 0.326 ± 0.027	1.227GlnAsp: 1.227 ± 0.052	1.489GlnGlu: 1.489 ± 0.053	0.832GlnPhe: 0.832 ± 0.042	2.962GlnGly: 2.962 ± 0.075	0.562GlnHis: 0.562 ± 0.034	1.77GlnIle: 1.77 ± 0.06	1.076GlnLys: 1.076 ± 0.049	3.062GlnLeu: 3.062 ± 0.082	0.822GlnMet: 0.822 ± 0.042	0.883GlnAsn: 0.883 ± 0.043	1.379GlnPro: 1.379 ± 0.062	1.3GlnGln: 1.3 ± 0.058	2.704GlnArg: 2.704 ± 0.069	1.457GlnSer: 1.457 ± 0.058	1.384GlnThr: 1.384 ± 0.055	2.962GlnVal: 2.962 ± 0.077	0.311GlnTrp: 0.311 ± 0.026	0.661GlnTyr: 0.661 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	9.325ArgAla: 9.325 ± 0.188	0.928ArgCys: 0.928 ± 0.047	3.795ArgAsp: 3.795 ± 0.09	4.655ArgGlu: 4.655 ± 0.116	3.013ArgPhe: 3.013 ± 0.076	4.952ArgGly: 4.952 ± 0.107	1.459ArgHis: 1.459 ± 0.051	3.622ArgIle: 3.622 ± 0.083	2.144ArgLys: 2.144 ± 0.072	6.387ArgLeu: 6.387 ± 0.139	2.232ArgMet: 2.232 ± 0.062	1.648ArgAsn: 1.648 ± 0.054	3.101ArgPro: 3.101 ± 0.086	2.191ArgGln: 2.191 ± 0.068	5.418ArgArg: 5.418 ± 0.142	3.733ArgSer: 3.733 ± 0.086	3.658ArgThr: 3.658 ± 0.095	5.573ArgVal: 5.573 ± 0.117	0.665ArgTrp: 0.665 ± 0.038	1.835ArgTyr: 1.835 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	7.325SerAla: 7.325 ± 0.143	0.879SerCys: 0.879 ± 0.045	3.306SerAsp: 3.306 ± 0.099	3.135SerGlu: 3.135 ± 0.087	2.537SerPhe: 2.537 ± 0.071	5.05SerGly: 5.05 ± 0.102	1.019SerHis: 1.019 ± 0.042	2.8SerIle: 2.8 ± 0.069	1.705SerLys: 1.705 ± 0.066	5.691SerLeu: 5.691 ± 0.111	1.689SerMet: 1.689 ± 0.064	1.388SerAsn: 1.388 ± 0.055	2.523SerPro: 2.523 ± 0.078	1.911SerGln: 1.911 ± 0.061	3.599SerArg: 3.599 ± 0.093	3.772SerSer: 3.772 ± 0.11	3.048SerThr: 3.048 ± 0.074	4.588SerVal: 4.588 ± 0.103	0.704SerTrp: 0.704 ± 0.039	1.703SerTyr: 1.703 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	5.815ThrAla: 5.815 ± 0.099	0.863ThrCys: 0.863 ± 0.043	2.781ThrAsp: 2.781 ± 0.089	2.568ThrGlu: 2.568 ± 0.079	1.965ThrPhe: 1.965 ± 0.062	4.645ThrGly: 4.645 ± 0.116	1.023ThrHis: 1.023 ± 0.038	2.22ThrIle: 2.22 ± 0.071	1.461ThrLys: 1.461 ± 0.063	5.009ThrLeu: 5.009 ± 0.09	1.129ThrMet: 1.129 ± 0.045	1.359ThrAsn: 1.359 ± 0.062	2.928ThrPro: 2.928 ± 0.074	1.489ThrGln: 1.489 ± 0.056	2.907ThrArg: 2.907 ± 0.082	2.84ThrSer: 2.84 ± 0.082	2.576ThrThr: 2.576 ± 0.086	5.001ThrVal: 5.001 ± 0.138	0.57ThrTrp: 0.57 ± 0.031	1.445ThrTyr: 1.445 ± 0.067	0.0ThrXaa: 0.0 ± 0.0
Val	10.525ValAla: 10.525 ± 0.185	1.404ValCys: 1.404 ± 0.057	4.547ValAsp: 4.547 ± 0.123	5.202ValGlu: 5.202 ± 0.12	2.885ValPhe: 2.885 ± 0.085	6.946ValGly: 6.946 ± 0.16	1.404ValHis: 1.404 ± 0.058	3.795ValIle: 3.795 ± 0.09	2.568ValLys: 2.568 ± 0.098	7.986ValLeu: 7.986 ± 0.157	2.189ValMet: 2.189 ± 0.069	2.299ValAsn: 2.299 ± 0.067	4.012ValPro: 4.012 ± 0.086	2.088ValGln: 2.088 ± 0.067	6.26ValArg: 6.26 ± 0.113	5.821ValSer: 5.821 ± 0.111	4.48ValThr: 4.48 ± 0.166	7.813ValVal: 7.813 ± 0.16	0.826ValTrp: 0.826 ± 0.045	1.974ValTyr: 1.974 ± 0.074	0.0ValXaa: 0.0 ± 0.0
Trp	1.084TrpAla: 1.084 ± 0.049	0.163TrpCys: 0.163 ± 0.019	0.684TrpAsp: 0.684 ± 0.043	0.596TrpGlu: 0.596 ± 0.038	0.393TrpPhe: 0.393 ± 0.029	0.92TrpGly: 0.92 ± 0.045	0.238TrpHis: 0.238 ± 0.02	0.409TrpIle: 0.409 ± 0.032	0.313TrpLys: 0.313 ± 0.027	0.962TrpLeu: 0.962 ± 0.044	0.309TrpMet: 0.309 ± 0.026	0.368TrpAsn: 0.368 ± 0.028	0.372TrpPro: 0.372 ± 0.025	0.332TrpGln: 0.332 ± 0.026	0.635TrpArg: 0.635 ± 0.038	0.505TrpSer: 0.505 ± 0.032	0.391TrpThr: 0.391 ± 0.03	0.842TrpVal: 0.842 ± 0.043	0.147TrpTrp: 0.147 ± 0.018	0.236TrpTyr: 0.236 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.905TyrAla: 2.905 ± 0.075	0.358TyrCys: 0.358 ± 0.027	1.715TyrAsp: 1.715 ± 0.072	1.607TyrGlu: 1.607 ± 0.061	0.912TyrPhe: 0.912 ± 0.044	2.151TyrGly: 2.151 ± 0.06	0.425TyrHis: 0.425 ± 0.029	0.838TyrIle: 0.838 ± 0.041	0.582TyrLys: 0.582 ± 0.037	2.57TyrLeu: 2.57 ± 0.069	0.437TyrMet: 0.437 ± 0.033	0.627TyrAsn: 0.627 ± 0.039	1.058TyrPro: 1.058 ± 0.051	0.82TyrGln: 0.82 ± 0.038	1.986TyrArg: 1.986 ± 0.064	1.147TyrSer: 1.147 ± 0.052	1.27TyrThr: 1.27 ± 0.057	2.118TyrVal: 2.118 ± 0.067	0.273TyrTrp: 0.273 ± 0.024	0.702TyrTyr: 0.702 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1403 proteins (508505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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