Amino acid dipepetide frequency for Candidatus Frackibacter sp. WG12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.82AlaAla: 4.82 ± 0.093
0.64AlaCys: 0.64 ± 0.037
3.634AlaAsp: 3.634 ± 0.071
5.062AlaGlu: 5.062 ± 0.088
2.24AlaPhe: 2.24 ± 0.058
5.11AlaGly: 5.11 ± 0.096
0.983AlaHis: 0.983 ± 0.034
5.708AlaIle: 5.708 ± 0.104
5.578AlaLys: 5.578 ± 0.102
6.336AlaLeu: 6.336 ± 0.11
1.582AlaMet: 1.582 ± 0.048
3.064AlaAsn: 3.064 ± 0.059
1.716AlaPro: 1.716 ± 0.054
2.27AlaGln: 2.27 ± 0.052
2.507AlaArg: 2.507 ± 0.057
3.149AlaSer: 3.149 ± 0.06
3.257AlaThr: 3.257 ± 0.069
4.66AlaVal: 4.66 ± 0.087
0.389AlaTrp: 0.389 ± 0.023
2.048AlaTyr: 2.048 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.472CysAla: 0.472 ± 0.025
0.134CysCys: 0.134 ± 0.014
0.426CysAsp: 0.426 ± 0.02
0.53CysGlu: 0.53 ± 0.028
0.234CysPhe: 0.234 ± 0.018
0.909CysGly: 0.909 ± 0.043
0.423CysHis: 0.423 ± 0.047
0.558CysIle: 0.558 ± 0.028
0.572CysLys: 0.572 ± 0.029
0.709CysLeu: 0.709 ± 0.033
0.193CysMet: 0.193 ± 0.016
0.425CysAsn: 0.425 ± 0.023
0.537CysPro: 0.537 ± 0.036
0.385CysGln: 0.385 ± 0.024
0.366CysArg: 0.366 ± 0.023
0.608CysSer: 0.608 ± 0.027
0.439CysThr: 0.439 ± 0.025
0.44CysVal: 0.44 ± 0.026
0.063CysTrp: 0.063 ± 0.01
0.292CysTyr: 0.292 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.03AspAla: 3.03 ± 0.071
0.566AspCys: 0.566 ± 0.031
3.208AspAsp: 3.208 ± 0.071
5.34AspGlu: 5.34 ± 0.097
2.507AspPhe: 2.507 ± 0.061
3.377AspGly: 3.377 ± 0.076
0.799AspHis: 0.799 ± 0.03
5.42AspIle: 5.42 ± 0.082
4.909AspLys: 4.909 ± 0.088
6.605AspLeu: 6.605 ± 0.099
1.267AspMet: 1.267 ± 0.042
3.118AspAsn: 3.118 ± 0.072
1.764AspPro: 1.764 ± 0.043
1.803AspGln: 1.803 ± 0.045
2.431AspArg: 2.431 ± 0.066
2.923AspSer: 2.923 ± 0.064
2.237AspThr: 2.237 ± 0.054
3.588AspVal: 3.588 ± 0.077
0.551AspTrp: 0.551 ± 0.027
2.873AspTyr: 2.873 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.902GluAla: 5.902 ± 0.098
0.557GluCys: 0.557 ± 0.03
4.973GluAsp: 4.973 ± 0.089
10.037GluGlu: 10.037 ± 0.156
3.139GluPhe: 3.139 ± 0.062
4.912GluGly: 4.912 ± 0.087
1.068GluHis: 1.068 ± 0.046
7.618GluIle: 7.618 ± 0.105
6.046GluLys: 6.046 ± 0.104
9.432GluLeu: 9.432 ± 0.12
2.119GluMet: 2.119 ± 0.044
3.397GluAsn: 3.397 ± 0.073
2.038GluPro: 2.038 ± 0.061
2.35GluGln: 2.35 ± 0.057
3.742GluArg: 3.742 ± 0.075
3.414GluSer: 3.414 ± 0.071
3.413GluThr: 3.413 ± 0.069
7.599GluVal: 7.599 ± 0.113
0.551GluTrp: 0.551 ± 0.027
2.995GluTyr: 2.995 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
2.396PheAla: 2.396 ± 0.056
0.354PheCys: 0.354 ± 0.022
2.283PheAsp: 2.283 ± 0.054
2.434PheGlu: 2.434 ± 0.061
1.569PhePhe: 1.569 ± 0.056
2.904PheGly: 2.904 ± 0.077
0.52PheHis: 0.52 ± 0.026
3.32PheIle: 3.32 ± 0.071
3.3PheLys: 3.3 ± 0.082
3.576PheLeu: 3.576 ± 0.08
0.893PheMet: 0.893 ± 0.03
2.434PheAsn: 2.434 ± 0.06
1.19PhePro: 1.19 ± 0.042
0.946PheGln: 0.946 ± 0.033
1.238PheArg: 1.238 ± 0.038
2.448PheSer: 2.448 ± 0.059
2.03PheThr: 2.03 ± 0.049
2.321PheVal: 2.321 ± 0.063
0.343PheTrp: 0.343 ± 0.022
1.328PheTyr: 1.328 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.508GlyAla: 4.508 ± 0.098
0.822GlyCys: 0.822 ± 0.04
3.53GlyAsp: 3.53 ± 0.066
5.094GlyGlu: 5.094 ± 0.08
2.727GlyPhe: 2.727 ± 0.061
4.759GlyGly: 4.759 ± 0.101
1.18GlyHis: 1.18 ± 0.035
6.125GlyIle: 6.125 ± 0.095
4.871GlyLys: 4.871 ± 0.079
7.3GlyLeu: 7.3 ± 0.116
1.775GlyMet: 1.775 ± 0.056
2.756GlyAsn: 2.756 ± 0.057
1.723GlyPro: 1.723 ± 0.048
2.267GlyGln: 2.267 ± 0.059
2.815GlyArg: 2.815 ± 0.062
3.674GlySer: 3.674 ± 0.068
3.541GlyThr: 3.541 ± 0.078
5.487GlyVal: 5.487 ± 0.1
0.581GlyTrp: 0.581 ± 0.027
2.745GlyTyr: 2.745 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
0.863HisAla: 0.863 ± 0.034
0.185HisCys: 0.185 ± 0.015
0.782HisAsp: 0.782 ± 0.036
0.908HisGlu: 0.908 ± 0.034
0.602HisPhe: 0.602 ± 0.028
1.136HisGly: 1.136 ± 0.037
0.354HisHis: 0.354 ± 0.022
1.12HisIle: 1.12 ± 0.036
0.988HisLys: 0.988 ± 0.033
1.491HisLeu: 1.491 ± 0.05
0.303HisMet: 0.303 ± 0.019
0.834HisAsn: 0.834 ± 0.034
0.844HisPro: 0.844 ± 0.031
0.673HisGln: 0.673 ± 0.033
0.634HisArg: 0.634 ± 0.029
0.828HisSer: 0.828 ± 0.033
0.751HisThr: 0.751 ± 0.034
0.765HisVal: 0.765 ± 0.033
0.155HisTrp: 0.155 ± 0.014
0.591HisTyr: 0.591 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.702IleAla: 5.702 ± 0.104
0.656IleCys: 0.656 ± 0.03
5.539IleAsp: 5.539 ± 0.082
6.878IleGlu: 6.878 ± 0.096
3.238IlePhe: 3.238 ± 0.072
5.857IleGly: 5.857 ± 0.108
1.054IleHis: 1.054 ± 0.042
7.779IleIle: 7.779 ± 0.142
7.477IleLys: 7.477 ± 0.106
8.201IleLeu: 8.201 ± 0.129
1.8IleMet: 1.8 ± 0.047
5.125IleAsn: 5.125 ± 0.095
3.17IlePro: 3.17 ± 0.064
2.145IleGln: 2.145 ± 0.056
2.963IleArg: 2.963 ± 0.063
5.147IleSer: 5.147 ± 0.086
4.427IleThr: 4.427 ± 0.07
5.471IleVal: 5.471 ± 0.091
0.51IleTrp: 0.51 ± 0.026
2.621IleTyr: 2.621 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.921LysAla: 4.921 ± 0.088
0.557LysCys: 0.557 ± 0.032
4.883LysAsp: 4.883 ± 0.089
9.479LysGlu: 9.479 ± 0.143
2.776LysPhe: 2.776 ± 0.066
4.485LysGly: 4.485 ± 0.09
0.983LysHis: 0.983 ± 0.035
6.302LysIle: 6.302 ± 0.101
6.663LysLys: 6.663 ± 0.117
8.049LysLeu: 8.049 ± 0.118
1.731LysMet: 1.731 ± 0.049
3.713LysAsn: 3.713 ± 0.075
2.175LysPro: 2.175 ± 0.062
2.698LysGln: 2.698 ± 0.063
3.812LysArg: 3.812 ± 0.075
3.939LysSer: 3.939 ± 0.077
3.307LysThr: 3.307 ± 0.068
6.439LysVal: 6.439 ± 0.088
0.463LysTrp: 0.463 ± 0.023
2.831LysTyr: 2.831 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
7.802LeuAla: 7.802 ± 0.103
0.696LeuCys: 0.696 ± 0.033
6.202LeuAsp: 6.202 ± 0.106
8.503LeuGlu: 8.503 ± 0.112
3.552LeuPhe: 3.552 ± 0.076
7.459LeuGly: 7.459 ± 0.12
1.396LeuHis: 1.396 ± 0.042
8.783LeuIle: 8.783 ± 0.121
8.123LeuLys: 8.123 ± 0.127
9.423LeuLeu: 9.423 ± 0.154
2.097LeuMet: 2.097 ± 0.05
5.614LeuAsn: 5.614 ± 0.086
3.516LeuPro: 3.516 ± 0.069
3.004LeuGln: 3.004 ± 0.071
3.843LeuArg: 3.843 ± 0.07
6.26LeuSer: 6.26 ± 0.083
5.313LeuThr: 5.313 ± 0.086
6.964LeuVal: 6.964 ± 0.105
0.589LeuTrp: 0.589 ± 0.029
2.768LeuTyr: 2.768 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
1.875MetAla: 1.875 ± 0.054
0.126MetCys: 0.126 ± 0.014
1.166MetAsp: 1.166 ± 0.043
1.615MetGlu: 1.615 ± 0.044
0.675MetPhe: 0.675 ± 0.03
1.494MetGly: 1.494 ± 0.047
0.326MetHis: 0.326 ± 0.022
1.813MetIle: 1.813 ± 0.047
2.027MetLys: 2.027 ± 0.041
2.176MetLeu: 2.176 ± 0.054
0.605MetMet: 0.605 ± 0.034
1.177MetAsn: 1.177 ± 0.04
0.807MetPro: 0.807 ± 0.03
0.804MetGln: 0.804 ± 0.03
0.836MetArg: 0.836 ± 0.033
1.391MetSer: 1.391 ± 0.044
1.314MetThr: 1.314 ± 0.044
1.666MetVal: 1.666 ± 0.048
0.107MetTrp: 0.107 ± 0.01
0.486MetTyr: 0.486 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.39AsnAla: 2.39 ± 0.06
0.517AsnCys: 0.517 ± 0.027
2.668AsnAsp: 2.668 ± 0.059
3.837AsnGlu: 3.837 ± 0.078
2.177AsnPhe: 2.177 ± 0.055
2.739AsnGly: 2.739 ± 0.063
0.792AsnHis: 0.792 ± 0.03
4.219AsnIle: 4.219 ± 0.079
4.406AsnLys: 4.406 ± 0.088
6.162AsnLeu: 6.162 ± 0.099
1.056AsnMet: 1.056 ± 0.033
3.335AsnAsn: 3.335 ± 0.076
2.116AsnPro: 2.116 ± 0.053
2.467AsnGln: 2.467 ± 0.057
2.221AsnArg: 2.221 ± 0.062
2.986AsnSer: 2.986 ± 0.064
2.183AsnThr: 2.183 ± 0.059
2.529AsnVal: 2.529 ± 0.057
0.479AsnTrp: 0.479 ± 0.025
2.31AsnTyr: 2.31 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
1.946ProAla: 1.946 ± 0.051
0.255ProCys: 0.255 ± 0.017
1.87ProAsp: 1.87 ± 0.053
2.917ProGlu: 2.917 ± 0.061
1.313ProPhe: 1.313 ± 0.045
2.327ProGly: 2.327 ± 0.056
0.62ProHis: 0.62 ± 0.032
2.561ProIle: 2.561 ± 0.062
2.36ProLys: 2.36 ± 0.062
3.005ProLeu: 3.005 ± 0.067
0.642ProMet: 0.642 ± 0.028
1.603ProAsn: 1.603 ± 0.045
0.9ProPro: 0.9 ± 0.038
1.259ProGln: 1.259 ± 0.041
1.109ProArg: 1.109 ± 0.038
1.577ProSer: 1.577 ± 0.053
1.844ProThr: 1.844 ± 0.053
2.426ProVal: 2.426 ± 0.056
0.274ProTrp: 0.274 ± 0.02
1.21ProTyr: 1.21 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.443GlnAla: 2.443 ± 0.054
0.244GlnCys: 0.244 ± 0.019
1.966GlnAsp: 1.966 ± 0.048
3.301GlnGlu: 3.301 ± 0.063
1.129GlnPhe: 1.129 ± 0.034
2.228GlnGly: 2.228 ± 0.056
0.413GlnHis: 0.413 ± 0.026
2.779GlnIle: 2.779 ± 0.056
2.708GlnLys: 2.708 ± 0.064
3.294GlnLeu: 3.294 ± 0.077
0.765GlnMet: 0.765 ± 0.032
1.62GlnAsn: 1.62 ± 0.047
0.976GlnPro: 0.976 ± 0.035
1.589GlnGln: 1.589 ± 0.055
1.481GlnArg: 1.481 ± 0.044
1.422GlnSer: 1.422 ± 0.043
1.472GlnThr: 1.472 ± 0.041
2.628GlnVal: 2.628 ± 0.056
0.188GlnTrp: 0.188 ± 0.015
0.872GlnTyr: 0.872 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.199ArgAla: 2.199 ± 0.053
0.358ArgCys: 0.358 ± 0.025
2.171ArgAsp: 2.171 ± 0.051
3.347ArgGlu: 3.347 ± 0.076
1.585ArgPhe: 1.585 ± 0.044
2.531ArgGly: 2.531 ± 0.054
0.605ArgHis: 0.605 ± 0.03
3.584ArgIle: 3.584 ± 0.073
3.2ArgLys: 3.2 ± 0.075
4.557ArgLeu: 4.557 ± 0.072
1.049ArgMet: 1.049 ± 0.034
1.882ArgAsn: 1.882 ± 0.053
1.33ArgPro: 1.33 ± 0.04
1.425ArgGln: 1.425 ± 0.041
1.984ArgArg: 1.984 ± 0.057
1.954ArgSer: 1.954 ± 0.05
1.737ArgThr: 1.737 ± 0.05
3.032ArgVal: 3.032 ± 0.063
0.285ArgTrp: 0.285 ± 0.018
1.483ArgTyr: 1.483 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
2.993SerAla: 2.993 ± 0.063
0.545SerCys: 0.545 ± 0.03
3.0SerAsp: 3.0 ± 0.065
3.77SerGlu: 3.77 ± 0.068
2.279SerPhe: 2.279 ± 0.055
3.991SerGly: 3.991 ± 0.078
0.816SerHis: 0.816 ± 0.031
4.456SerIle: 4.456 ± 0.082
4.475SerLys: 4.475 ± 0.085
5.989SerLeu: 5.989 ± 0.08
1.237SerMet: 1.237 ± 0.035
3.06SerAsn: 3.06 ± 0.071
1.664SerPro: 1.664 ± 0.041
2.107SerGln: 2.107 ± 0.055
2.207SerArg: 2.207 ± 0.051
3.408SerSer: 3.408 ± 0.066
2.709SerThr: 2.709 ± 0.059
3.065SerVal: 3.065 ± 0.068
0.5SerTrp: 0.5 ± 0.027
1.892SerTyr: 1.892 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
3.402ThrAla: 3.402 ± 0.075
0.435ThrCys: 0.435 ± 0.027
2.916ThrAsp: 2.916 ± 0.059
3.603ThrGlu: 3.603 ± 0.077
1.772ThrPhe: 1.772 ± 0.051
4.087ThrGly: 4.087 ± 0.078
0.722ThrHis: 0.722 ± 0.028
4.148ThrIle: 4.148 ± 0.076
3.647ThrLys: 3.647 ± 0.065
4.516ThrLeu: 4.516 ± 0.086
1.008ThrMet: 1.008 ± 0.031
2.432ThrAsn: 2.432 ± 0.058
1.915ThrPro: 1.915 ± 0.049
1.284ThrGln: 1.284 ± 0.044
1.723ThrArg: 1.723 ± 0.044
2.694ThrSer: 2.694 ± 0.061
2.848ThrThr: 2.848 ± 0.072
3.403ThrVal: 3.403 ± 0.07
0.285ThrTrp: 0.285 ± 0.017
1.508ThrTyr: 1.508 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
5.054ValAla: 5.054 ± 0.096
0.628ValCys: 0.628 ± 0.035
4.546ValAsp: 4.546 ± 0.082
5.719ValGlu: 5.719 ± 0.094
2.355ValPhe: 2.355 ± 0.057
5.116ValGly: 5.116 ± 0.109
0.924ValHis: 0.924 ± 0.032
6.304ValIle: 6.304 ± 0.093
5.846ValLys: 5.846 ± 0.095
6.384ValLeu: 6.384 ± 0.087
1.608ValMet: 1.608 ± 0.043
3.645ValAsn: 3.645 ± 0.07
2.254ValPro: 2.254 ± 0.054
1.79ValGln: 1.79 ± 0.05
2.529ValArg: 2.529 ± 0.054
3.899ValSer: 3.899 ± 0.066
3.678ValThr: 3.678 ± 0.078
5.515ValVal: 5.515 ± 0.105
0.398ValTrp: 0.398 ± 0.025
1.926ValTyr: 1.926 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.393TrpAla: 0.393 ± 0.024
0.066TrpCys: 0.066 ± 0.009
0.392TrpAsp: 0.392 ± 0.023
0.553TrpGlu: 0.553 ± 0.022
0.337TrpPhe: 0.337 ± 0.026
0.52TrpGly: 0.52 ± 0.031
0.119TrpHis: 0.119 ± 0.013
0.527TrpIle: 0.527 ± 0.029
0.513TrpLys: 0.513 ± 0.026
0.773TrpLeu: 0.773 ± 0.031
0.154TrpMet: 0.154 ± 0.013
0.351TrpAsn: 0.351 ± 0.021
0.201TrpPro: 0.201 ± 0.017
0.441TrpGln: 0.441 ± 0.023
0.323TrpArg: 0.323 ± 0.021
0.382TrpSer: 0.382 ± 0.022
0.31TrpThr: 0.31 ± 0.021
0.419TrpVal: 0.419 ± 0.026
0.116TrpTrp: 0.116 ± 0.013
0.229TrpTyr: 0.229 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.642TyrAla: 1.642 ± 0.045
0.374TyrCys: 0.374 ± 0.021
2.161TyrAsp: 2.161 ± 0.059
2.376TyrGlu: 2.376 ± 0.058
1.623TyrPhe: 1.623 ± 0.047
2.336TyrGly: 2.336 ± 0.058
0.709TyrHis: 0.709 ± 0.03
2.638TyrIle: 2.638 ± 0.061
2.497TyrLys: 2.497 ± 0.067
3.93TyrLeu: 3.93 ± 0.074
0.602TyrMet: 0.602 ± 0.027
2.004TyrAsn: 2.004 ± 0.056
1.18TyrPro: 1.18 ± 0.034
1.808TyrGln: 1.808 ± 0.058
1.539TyrArg: 1.539 ± 0.048
2.056TyrSer: 2.056 ± 0.048
1.537TyrThr: 1.537 ± 0.04
1.701TyrVal: 1.701 ± 0.047
0.295TyrTrp: 0.295 ± 0.021
1.462TyrTyr: 1.462 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2687 proteins (804300 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski