Amino acid dipepetide frequency for Hubei virga-like virus 15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.866AlaAla: 4.866 ± 1.816
2.433AlaCys: 2.433 ± 0.711
3.345AlaAsp: 3.345 ± 0.166
3.65AlaGlu: 3.65 ± 1.254
2.433AlaPhe: 2.433 ± 1.158
2.737AlaGly: 2.737 ± 0.813
1.521AlaHis: 1.521 ± 1.055
3.345AlaIle: 3.345 ± 0.166
2.433AlaLys: 2.433 ± 0.778
6.995AlaLeu: 6.995 ± 2.068
1.521AlaMet: 1.521 ± 0.329
3.041AlaAsn: 3.041 ± 0.306
1.521AlaPro: 1.521 ± 0.597
1.217AlaGln: 1.217 ± 0.604
4.258AlaArg: 4.258 ± 1.692
4.562AlaSer: 4.562 ± 0.473
2.737AlaThr: 2.737 ± 2.021
4.866AlaVal: 4.866 ± 0.688
0.608AlaTrp: 0.608 ± 0.722
3.345AlaTyr: 3.345 ± 1.092
0.0AlaXaa: 0.0 ± 0.0
Cys
1.521CysAla: 1.521 ± 0.759
1.217CysCys: 1.217 ± 0.607
1.825CysAsp: 1.825 ± 0.542
0.912CysGlu: 0.912 ± 0.82
1.217CysPhe: 1.217 ± 0.261
1.521CysGly: 1.521 ± 0.759
0.608CysHis: 0.608 ± 0.353
0.608CysIle: 0.608 ± 0.353
0.912CysLys: 0.912 ± 0.82
0.912CysLeu: 0.912 ± 0.455
0.0CysMet: 0.0 ± 0.0
0.608CysAsn: 0.608 ± 0.303
1.825CysPro: 1.825 ± 0.442
0.304CysGln: 0.304 ± 0.152
1.825CysArg: 1.825 ± 0.91
2.129CysSer: 2.129 ± 0.509
0.912CysThr: 0.912 ± 0.82
1.217CysVal: 1.217 ± 0.261
0.0CysTrp: 0.0 ± 0.0
1.217CysTyr: 1.217 ± 0.261
0.0CysXaa: 0.0 ± 0.0
Asp
4.562AspAla: 4.562 ± 1.822
1.825AspCys: 1.825 ± 1.06
3.65AspAsp: 3.65 ± 0.978
2.433AspGlu: 2.433 ± 1.214
4.258AspPhe: 4.258 ± 0.289
3.65AspGly: 3.65 ± 0.883
1.825AspHis: 1.825 ± 1.06
3.65AspIle: 3.65 ± 0.087
2.433AspLys: 2.433 ± 0.711
10.036AspLeu: 10.036 ± 2.287
2.129AspMet: 2.129 ± 1.062
1.825AspAsn: 1.825 ± 0.91
4.562AspPro: 4.562 ± 0.473
2.129AspGln: 2.129 ± 0.572
5.17AspArg: 5.17 ± 0.684
2.737AspSer: 2.737 ± 1.116
2.433AspThr: 2.433 ± 0.521
5.17AspVal: 5.17 ± 1.362
0.304AspTrp: 0.304 ± 0.472
3.041AspTyr: 3.041 ± 1.517
0.304AspXaa: 0.304 ± 0.152
Glu
2.737GluAla: 2.737 ± 0.855
1.521GluCys: 1.521 ± 0.329
2.737GluAsp: 2.737 ± 0.574
2.737GluGlu: 2.737 ± 1.366
3.65GluPhe: 3.65 ± 1.167
4.562GluGly: 4.562 ± 1.07
1.217GluHis: 1.217 ± 0.738
6.691GluIle: 6.691 ± 0.601
4.258GluLys: 4.258 ± 0.289
2.433GluLeu: 2.433 ± 0.778
1.217GluMet: 1.217 ± 0.604
3.954GluAsn: 3.954 ± 1.011
1.217GluPro: 1.217 ± 0.261
0.608GluGln: 0.608 ± 0.303
4.562GluArg: 4.562 ± 1.282
0.912GluSer: 0.912 ± 0.648
3.041GluThr: 3.041 ± 1.517
3.65GluVal: 3.65 ± 0.655
0.608GluTrp: 0.608 ± 0.303
3.65GluTyr: 3.65 ± 1.297
0.0GluXaa: 0.0 ± 0.0
Phe
3.345PheAla: 3.345 ± 1.837
1.217PheCys: 1.217 ± 0.607
3.345PheAsp: 3.345 ± 1.31
4.562PheGlu: 4.562 ± 1.965
3.954PhePhe: 3.954 ± 1.632
2.129PheGly: 2.129 ± 0.69
1.521PheHis: 1.521 ± 0.611
2.433PheIle: 2.433 ± 1.906
5.17PheLys: 5.17 ± 0.276
4.258PheLeu: 4.258 ± 0.891
0.608PheMet: 0.608 ± 0.353
3.041PheAsn: 3.041 ± 0.859
3.65PhePro: 3.65 ± 0.087
0.912PheGln: 0.912 ± 0.455
3.345PheArg: 3.345 ± 1.145
5.474PheSer: 5.474 ± 1.148
2.433PheThr: 2.433 ± 0.521
3.345PheVal: 3.345 ± 0.764
0.912PheTrp: 0.912 ± 0.82
0.912PheTyr: 0.912 ± 0.455
0.0PheXaa: 0.0 ± 0.0
Gly
4.562GlyAla: 4.562 ± 2.657
0.912GlyCys: 0.912 ± 0.271
6.387GlyAsp: 6.387 ± 2.149
2.129GlyGlu: 2.129 ± 0.395
4.562GlyPhe: 4.562 ± 1.019
5.779GlyGly: 5.779 ± 1.657
0.608GlyHis: 0.608 ± 0.303
3.345GlyIle: 3.345 ± 0.166
3.954GlyLys: 3.954 ± 1.011
5.474GlyLeu: 5.474 ± 1.325
1.521GlyMet: 1.521 ± 0.597
2.737GlyAsn: 2.737 ± 0.356
0.608GlyPro: 0.608 ± 0.722
0.608GlyGln: 0.608 ± 0.353
1.521GlyArg: 1.521 ± 0.759
3.954GlySer: 3.954 ± 0.184
1.825GlyThr: 1.825 ± 0.489
4.866GlyVal: 4.866 ± 1.042
0.0GlyTrp: 0.0 ± 0.0
3.041GlyTyr: 3.041 ± 1.001
0.0GlyXaa: 0.0 ± 0.0
His
1.825HisAla: 1.825 ± 0.489
0.304HisCys: 0.304 ± 0.152
0.912HisAsp: 0.912 ± 0.271
0.0HisGlu: 0.0 ± 0.0
2.129HisPhe: 2.129 ± 0.509
2.433HisGly: 2.433 ± 0.521
0.912HisHis: 0.912 ± 0.82
0.304HisIle: 0.304 ± 0.152
1.521HisLys: 1.521 ± 1.363
1.521HisLeu: 1.521 ± 1.171
1.217HisMet: 1.217 ± 0.607
1.521HisAsn: 1.521 ± 1.055
0.304HisPro: 0.304 ± 0.472
0.0HisGln: 0.0 ± 0.0
2.433HisArg: 2.433 ± 0.521
1.217HisSer: 1.217 ± 1.29
2.433HisThr: 2.433 ± 1.158
1.521HisVal: 1.521 ± 0.329
0.0HisTrp: 0.0 ± 0.0
1.521HisTyr: 1.521 ± 0.759
0.0HisXaa: 0.0 ± 0.0
Ile
4.562IleAla: 4.562 ± 0.903
0.608IleCys: 0.608 ± 0.944
3.041IleAsp: 3.041 ± 0.658
2.129IleGlu: 2.129 ± 0.395
4.866IlePhe: 4.866 ± 0.18
2.737IleGly: 2.737 ± 0.356
2.129IleHis: 2.129 ± 0.509
4.258IleIle: 4.258 ± 1.04
3.345IleLys: 3.345 ± 0.531
6.691IleLeu: 6.691 ± 0.836
1.521IleMet: 1.521 ± 0.721
1.217IleAsn: 1.217 ± 0.607
3.345IlePro: 3.345 ± 0.984
1.217IleGln: 1.217 ± 0.738
3.65IleArg: 3.65 ± 0.883
4.866IleSer: 4.866 ± 1.042
3.345IleThr: 3.345 ± 1.837
3.041IleVal: 3.041 ± 0.306
1.217IleTrp: 1.217 ± 0.604
4.562IleTyr: 4.562 ± 1.019
0.0IleXaa: 0.0 ± 0.0
Lys
2.129LysAla: 2.129 ± 0.572
2.433LysCys: 2.433 ± 0.711
5.474LysAsp: 5.474 ± 0.457
2.433LysGlu: 2.433 ± 1.205
3.65LysPhe: 3.65 ± 0.883
3.65LysGly: 3.65 ± 0.948
0.912LysHis: 0.912 ± 0.271
3.041LysIle: 3.041 ± 1.517
3.041LysLys: 3.041 ± 0.306
6.387LysLeu: 6.387 ± 1.418
1.217LysMet: 1.217 ± 0.414
1.825LysAsn: 1.825 ± 2.165
3.65LysPro: 3.65 ± 2.213
1.217LysGln: 1.217 ± 0.607
2.129LysArg: 2.129 ± 1.062
1.825LysSer: 1.825 ± 0.91
2.737LysThr: 2.737 ± 0.884
3.954LysVal: 3.954 ± 1.011
0.608LysTrp: 0.608 ± 0.353
3.041LysTyr: 3.041 ± 1.001
0.0LysXaa: 0.0 ± 0.0
Leu
7.603LeuAla: 7.603 ± 1.764
0.608LeuCys: 0.608 ± 0.303
6.691LeuAsp: 6.691 ± 1.401
8.516LeuGlu: 8.516 ± 1.252
3.954LeuPhe: 3.954 ± 4.053
3.345LeuGly: 3.345 ± 1.148
1.521LeuHis: 1.521 ± 1.171
4.258LeuIle: 4.258 ± 1.495
6.387LeuLys: 6.387 ± 1.717
7.603LeuLeu: 7.603 ± 1.947
3.345LeuMet: 3.345 ± 0.764
2.737LeuAsn: 2.737 ± 0.574
3.041LeuPro: 3.041 ± 1.001
1.217LeuGln: 1.217 ± 0.707
7.299LeuArg: 7.299 ± 0.7
5.474LeuSer: 5.474 ± 0.457
5.779LeuThr: 5.779 ± 2.556
8.212LeuVal: 8.212 ± 3.696
1.521LeuTrp: 1.521 ± 0.597
1.217LeuTyr: 1.217 ± 0.707
0.0LeuXaa: 0.0 ± 0.0
Met
0.912MetAla: 0.912 ± 0.648
0.304MetCys: 0.304 ± 0.472
0.912MetAsp: 0.912 ± 0.455
1.217MetGlu: 1.217 ± 0.607
1.217MetPhe: 1.217 ± 0.607
0.0MetGly: 0.0 ± 0.0
0.608MetHis: 0.608 ± 0.303
1.217MetIle: 1.217 ± 0.607
2.737MetLys: 2.737 ± 1.366
1.825MetLeu: 1.825 ± 0.442
1.217MetMet: 1.217 ± 0.604
2.129MetAsn: 2.129 ± 0.572
0.608MetPro: 0.608 ± 0.353
2.433MetGln: 2.433 ± 0.778
2.129MetArg: 2.129 ± 0.69
2.433MetSer: 2.433 ± 2.123
2.737MetThr: 2.737 ± 1.366
3.65MetVal: 3.65 ± 1.322
0.608MetTrp: 0.608 ± 0.722
1.217MetTyr: 1.217 ± 0.707
0.0MetXaa: 0.0 ± 0.0
Asn
2.737AsnAla: 2.737 ± 1.343
0.608AsnCys: 0.608 ± 0.303
2.129AsnAsp: 2.129 ± 0.572
1.521AsnGlu: 1.521 ± 0.759
3.041AsnPhe: 3.041 ± 0.859
1.217AsnGly: 1.217 ± 0.607
0.912AsnHis: 0.912 ± 0.875
1.825AsnIle: 1.825 ± 0.627
2.433AsnLys: 2.433 ± 0.521
4.258AsnLeu: 4.258 ± 0.79
1.217AsnMet: 1.217 ± 0.604
1.825AsnAsn: 1.825 ± 0.91
2.737AsnPro: 2.737 ± 1.191
0.608AsnGln: 0.608 ± 0.353
3.954AsnArg: 3.954 ± 1.446
3.041AsnSer: 3.041 ± 0.773
1.217AsnThr: 1.217 ± 0.607
3.65AsnVal: 3.65 ± 0.948
0.304AsnTrp: 0.304 ± 0.152
2.433AsnTyr: 2.433 ± 0.877
0.0AsnXaa: 0.0 ± 0.0
Pro
2.737ProAla: 2.737 ± 1.116
0.304ProCys: 0.304 ± 0.152
4.258ProAsp: 4.258 ± 0.79
1.521ProGlu: 1.521 ± 0.759
2.433ProPhe: 2.433 ± 1.476
1.521ProGly: 1.521 ± 0.759
0.608ProHis: 0.608 ± 0.722
2.737ProIle: 2.737 ± 0.813
2.129ProLys: 2.129 ± 0.572
2.129ProLeu: 2.129 ± 1.612
2.129ProMet: 2.129 ± 0.509
1.825ProAsn: 1.825 ± 0.904
1.825ProPro: 1.825 ± 2.652
0.912ProGln: 0.912 ± 0.271
0.912ProArg: 0.912 ± 0.455
2.129ProSer: 2.129 ± 0.753
3.65ProThr: 3.65 ± 1.322
2.737ProVal: 2.737 ± 0.574
0.608ProTrp: 0.608 ± 0.722
2.129ProTyr: 2.129 ± 1.062
0.0ProXaa: 0.0 ± 0.0
Gln
0.608GlnAla: 0.608 ± 0.303
1.217GlnCys: 1.217 ± 0.261
1.217GlnAsp: 1.217 ± 0.604
0.912GlnGlu: 0.912 ± 0.271
0.608GlnPhe: 0.608 ± 0.303
2.129GlnGly: 2.129 ± 0.509
0.608GlnHis: 0.608 ± 0.303
2.129GlnIle: 2.129 ± 0.572
0.608GlnLys: 0.608 ± 0.303
0.912GlnLeu: 0.912 ± 0.455
0.608GlnMet: 0.608 ± 0.303
0.912GlnAsn: 0.912 ± 0.875
0.608GlnPro: 0.608 ± 0.303
0.608GlnGln: 0.608 ± 0.303
1.521GlnArg: 1.521 ± 0.759
0.608GlnSer: 0.608 ± 0.722
3.041GlnThr: 3.041 ± 0.859
0.608GlnVal: 0.608 ± 0.303
0.0GlnTrp: 0.0 ± 0.0
1.217GlnTyr: 1.217 ± 0.261
0.0GlnXaa: 0.0 ± 0.0
Arg
2.129ArgAla: 2.129 ± 1.062
0.912ArgCys: 0.912 ± 0.455
4.562ArgAsp: 4.562 ± 1.463
7.299ArgGlu: 7.299 ± 2.593
2.737ArgPhe: 2.737 ± 0.855
3.65ArgGly: 3.65 ± 0.655
1.217ArgHis: 1.217 ± 0.261
4.562ArgIle: 4.562 ± 1.282
2.737ArgLys: 2.737 ± 0.855
5.474ArgLeu: 5.474 ± 1.148
2.737ArgMet: 2.737 ± 0.884
3.65ArgAsn: 3.65 ± 0.655
1.825ArgPro: 1.825 ± 1.459
0.0ArgGln: 0.0 ± 0.0
3.041ArgArg: 3.041 ± 0.773
3.345ArgSer: 3.345 ± 0.531
3.041ArgThr: 3.041 ± 0.426
5.17ArgVal: 5.17 ± 0.774
0.912ArgTrp: 0.912 ± 0.455
5.779ArgTyr: 5.779 ± 2.533
0.0ArgXaa: 0.0 ± 0.0
Ser
3.65SerAla: 3.65 ± 0.978
0.608SerCys: 0.608 ± 0.303
3.65SerAsp: 3.65 ± 0.883
3.041SerGlu: 3.041 ± 1.001
1.217SerPhe: 1.217 ± 0.738
4.258SerGly: 4.258 ± 1.949
1.521SerHis: 1.521 ± 0.759
4.562SerIle: 4.562 ± 0.187
2.129SerLys: 2.129 ± 0.509
7.603SerLeu: 7.603 ± 2.193
3.041SerMet: 3.041 ± 1.194
1.217SerAsn: 1.217 ± 0.261
1.521SerPro: 1.521 ± 0.611
2.129SerGln: 2.129 ± 1.062
4.258SerArg: 4.258 ± 0.928
2.433SerSer: 2.433 ± 0.778
3.65SerThr: 3.65 ± 0.087
6.387SerVal: 6.387 ± 0.468
0.304SerTrp: 0.304 ± 0.152
2.129SerTyr: 2.129 ± 0.509
0.0SerXaa: 0.0 ± 0.0
Thr
2.129ThrAla: 2.129 ± 0.509
1.217ThrCys: 1.217 ± 0.261
3.041ThrAsp: 3.041 ± 1.001
3.041ThrGlu: 3.041 ± 0.658
3.041ThrPhe: 3.041 ± 0.306
4.562ThrGly: 4.562 ± 0.76
1.825ThrHis: 1.825 ± 0.91
4.258ThrIle: 4.258 ± 1.949
3.345ThrLys: 3.345 ± 3.655
3.345ThrLeu: 3.345 ± 3.257
0.608ThrMet: 0.608 ± 0.353
2.737ThrAsn: 2.737 ± 0.453
1.521ThrPro: 1.521 ± 0.597
1.521ThrGln: 1.521 ± 0.759
5.17ThrArg: 5.17 ± 0.774
3.345ThrSer: 3.345 ± 0.166
2.737ThrThr: 2.737 ± 0.884
4.562ThrVal: 4.562 ± 1.282
0.304ThrTrp: 0.304 ± 0.152
2.129ThrTyr: 2.129 ± 0.572
0.0ThrXaa: 0.0 ± 0.0
Val
6.691ValAla: 6.691 ± 1.116
2.433ValCys: 2.433 ± 0.877
6.083ValAsp: 6.083 ± 0.429
4.866ValGlu: 4.866 ± 1.09
3.954ValPhe: 3.954 ± 0.184
4.866ValGly: 4.866 ± 1.754
1.217ValHis: 1.217 ± 0.738
3.345ValIle: 3.345 ± 1.837
3.954ValLys: 3.954 ± 1.31
6.995ValLeu: 6.995 ± 0.676
2.737ValMet: 2.737 ± 0.525
2.737ValAsn: 2.737 ± 0.884
3.041ValPro: 3.041 ± 0.773
1.521ValGln: 1.521 ± 0.607
3.041ValArg: 3.041 ± 0.658
5.474ValSer: 5.474 ± 0.713
2.737ValThr: 2.737 ± 0.813
6.083ValVal: 6.083 ± 2.429
0.304ValTrp: 0.304 ± 0.152
4.562ValTyr: 4.562 ± 0.473
0.0ValXaa: 0.0 ± 0.0
Trp
0.304TrpAla: 0.304 ± 0.152
0.304TrpCys: 0.304 ± 0.472
0.304TrpAsp: 0.304 ± 0.152
0.304TrpGlu: 0.304 ± 0.472
0.304TrpPhe: 0.304 ± 0.472
0.608TrpGly: 0.608 ± 0.303
0.304TrpHis: 0.304 ± 0.152
0.608TrpIle: 0.608 ± 1.017
0.0TrpLys: 0.0 ± 0.0
1.217TrpLeu: 1.217 ± 0.607
0.912TrpMet: 0.912 ± 0.648
0.0TrpAsn: 0.0 ± 0.0
0.304TrpPro: 0.304 ± 0.817
0.304TrpGln: 0.304 ± 0.472
0.912TrpArg: 0.912 ± 0.455
0.608TrpSer: 0.608 ± 0.303
0.608TrpThr: 0.608 ± 0.303
1.217TrpVal: 1.217 ± 1.443
0.304TrpTrp: 0.304 ± 0.817
0.304TrpTyr: 0.304 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.825TyrAla: 1.825 ± 0.442
0.304TyrCys: 0.304 ± 0.152
4.562TyrAsp: 4.562 ± 1.019
2.737TyrGlu: 2.737 ± 1.366
3.345TyrPhe: 3.345 ± 1.127
3.041TyrGly: 3.041 ± 0.773
2.433TyrHis: 2.433 ± 0.877
5.17TyrIle: 5.17 ± 1.566
1.825TyrLys: 1.825 ± 0.442
4.258TyrLeu: 4.258 ± 1.922
0.304TyrMet: 0.304 ± 0.472
2.129TyrAsn: 2.129 ± 1.062
1.521TyrPro: 1.521 ± 0.611
1.217TyrGln: 1.217 ± 0.261
3.65TyrArg: 3.65 ± 0.782
2.737TyrSer: 2.737 ± 0.855
3.345TyrThr: 3.345 ± 1.127
2.737TyrVal: 2.737 ± 0.453
0.304TyrTrp: 0.304 ± 0.472
1.825TyrTyr: 1.825 ± 1.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.304XaaLys: 0.304 ± 0.152
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski