Amino acid dipepetide frequency for Alicyclobacillaceae bacterium I2511

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.618AlaAla: 9.618 ± 0.132	0.803AlaCys: 0.803 ± 0.031	4.327AlaAsp: 4.327 ± 0.073	4.952AlaGlu: 4.952 ± 0.073	3.266AlaPhe: 3.266 ± 0.063	7.459AlaGly: 7.459 ± 0.092	2.102AlaHis: 2.102 ± 0.048	4.953AlaIle: 4.953 ± 0.083	3.678AlaLys: 3.678 ± 0.069	10.057AlaLeu: 10.057 ± 0.104	2.688AlaMet: 2.688 ± 0.061	3.011AlaAsn: 3.011 ± 0.058	3.043AlaPro: 3.043 ± 0.056	4.696AlaGln: 4.696 ± 0.091	4.641AlaArg: 4.641 ± 0.08	4.955AlaSer: 4.955 ± 0.086	5.277AlaThr: 5.277 ± 0.09	8.3AlaVal: 8.3 ± 0.105	1.329AlaTrp: 1.329 ± 0.039	2.616AlaTyr: 2.616 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.62CysAla: 0.62 ± 0.025	0.095CysCys: 0.095 ± 0.011	0.429CysAsp: 0.429 ± 0.022	0.415CysGlu: 0.415 ± 0.02	0.245CysPhe: 0.245 ± 0.017	0.894CysGly: 0.894 ± 0.033	0.251CysHis: 0.251 ± 0.016	0.409CysIle: 0.409 ± 0.021	0.27CysLys: 0.27 ± 0.016	0.737CysLeu: 0.737 ± 0.03	0.158CysMet: 0.158 ± 0.013	0.279CysAsn: 0.279 ± 0.017	0.499CysPro: 0.499 ± 0.029	0.363CysGln: 0.363 ± 0.02	0.479CysArg: 0.479 ± 0.02	0.489CysSer: 0.489 ± 0.021	0.487CysThr: 0.487 ± 0.024	0.632CysVal: 0.632 ± 0.029	0.087CysTrp: 0.087 ± 0.009	0.215CysTyr: 0.215 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.02AspAla: 4.02 ± 0.064	0.379AspCys: 0.379 ± 0.018	1.722AspAsp: 1.722 ± 0.049	3.028AspGlu: 3.028 ± 0.061	1.935AspPhe: 1.935 ± 0.05	3.591AspGly: 3.591 ± 0.072	0.957AspHis: 0.957 ± 0.035	2.648AspIle: 2.648 ± 0.062	1.823AspLys: 1.823 ± 0.052	5.379AspLeu: 5.379 ± 0.085	1.144AspMet: 1.144 ± 0.039	1.298AspAsn: 1.298 ± 0.038	2.202AspPro: 2.202 ± 0.048	1.408AspGln: 1.408 ± 0.04	2.493AspArg: 2.493 ± 0.05	2.291AspSer: 2.291 ± 0.051	2.377AspThr: 2.377 ± 0.052	4.151AspVal: 4.151 ± 0.069	0.879AspTrp: 0.879 ± 0.034	1.344AspTyr: 1.344 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.809GluAla: 4.809 ± 0.077	0.35GluCys: 0.35 ± 0.02	2.655GluAsp: 2.655 ± 0.057	3.387GluGlu: 3.387 ± 0.072	2.131GluPhe: 2.131 ± 0.051	3.58GluGly: 3.58 ± 0.074	1.396GluHis: 1.396 ± 0.038	3.354GluIle: 3.354 ± 0.056	2.484GluLys: 2.484 ± 0.048	5.848GluLeu: 5.848 ± 0.083	1.618GluMet: 1.618 ± 0.046	1.956GluAsn: 1.956 ± 0.047	1.914GluPro: 1.914 ± 0.043	3.347GluGln: 3.347 ± 0.066	3.628GluArg: 3.628 ± 0.065	3.092GluSer: 3.092 ± 0.06	3.082GluThr: 3.082 ± 0.053	4.778GluVal: 4.778 ± 0.092	0.825GluTrp: 0.825 ± 0.029	1.396GluTyr: 1.396 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.835PheAla: 3.835 ± 0.059	0.347PheCys: 0.347 ± 0.019	1.719PheAsp: 1.719 ± 0.051	1.742PheGlu: 1.742 ± 0.046	1.588PhePhe: 1.588 ± 0.047	3.388PheGly: 3.388 ± 0.063	1.058PheHis: 1.058 ± 0.032	2.078PheIle: 2.078 ± 0.052	0.954PheLys: 0.954 ± 0.033	3.984PheLeu: 3.984 ± 0.079	0.887PheMet: 0.887 ± 0.03	1.187PheAsn: 1.187 ± 0.034	1.822PhePro: 1.822 ± 0.045	1.529PheGln: 1.529 ± 0.037	1.927PheArg: 1.927 ± 0.047	2.6PheSer: 2.6 ± 0.056	2.299PheThr: 2.299 ± 0.049	3.269PheVal: 3.269 ± 0.061	0.537PheTrp: 0.537 ± 0.026	1.166PheTyr: 1.166 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.427GlyAla: 6.427 ± 0.092	0.755GlyCys: 0.755 ± 0.032	3.236GlyAsp: 3.236 ± 0.068	4.061GlyGlu: 4.061 ± 0.08	3.261GlyPhe: 3.261 ± 0.063	6.127GlyGly: 6.127 ± 0.094	1.942GlyHis: 1.942 ± 0.046	5.309GlyIle: 5.309 ± 0.085	3.525GlyLys: 3.525 ± 0.066	8.635GlyLeu: 8.635 ± 0.108	2.441GlyMet: 2.441 ± 0.055	2.714GlyAsn: 2.714 ± 0.063	2.845GlyPro: 2.845 ± 0.055	3.716GlyGln: 3.716 ± 0.07	4.189GlyArg: 4.189 ± 0.074	4.598GlySer: 4.598 ± 0.086	4.844GlyThr: 4.844 ± 0.083	7.29GlyVal: 7.29 ± 0.099	1.399GlyTrp: 1.399 ± 0.045	2.612GlyTyr: 2.612 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.865HisAla: 1.865 ± 0.046	0.251HisCys: 0.251 ± 0.017	0.881HisAsp: 0.881 ± 0.028	1.15HisGlu: 1.15 ± 0.037	1.016HisPhe: 1.016 ± 0.033	1.934HisGly: 1.934 ± 0.038	0.841HisHis: 0.841 ± 0.029	1.325HisIle: 1.325 ± 0.035	0.841HisLys: 0.841 ± 0.032	2.856HisLeu: 2.856 ± 0.054	0.635HisMet: 0.635 ± 0.024	0.726HisAsn: 0.726 ± 0.029	1.909HisPro: 1.909 ± 0.044	1.207HisGln: 1.207 ± 0.033	1.715HisArg: 1.715 ± 0.046	1.546HisSer: 1.546 ± 0.035	1.446HisThr: 1.446 ± 0.044	1.887HisVal: 1.887 ± 0.049	0.554HisTrp: 0.554 ± 0.025	0.731HisTyr: 0.731 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.293IleAla: 5.293 ± 0.078	0.463IleCys: 0.463 ± 0.022	2.397IleAsp: 2.397 ± 0.049	2.892IleGlu: 2.892 ± 0.058	1.849IlePhe: 1.849 ± 0.049	4.608IleGly: 4.608 ± 0.076	1.633IleHis: 1.633 ± 0.042	2.345IleIle: 2.345 ± 0.063	1.471IleLys: 1.471 ± 0.041	5.688IleLeu: 5.688 ± 0.09	0.994IleMet: 0.994 ± 0.034	1.569IleAsn: 1.569 ± 0.041	3.087IlePro: 3.087 ± 0.061	2.41IleGln: 2.41 ± 0.052	3.226IleArg: 3.226 ± 0.06	3.378IleSer: 3.378 ± 0.07	2.943IleThr: 2.943 ± 0.065	4.311IleVal: 4.311 ± 0.066	0.621IleTrp: 0.621 ± 0.025	1.434IleTyr: 1.434 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	2.992LysAla: 2.992 ± 0.06	0.209LysCys: 0.209 ± 0.013	1.765LysAsp: 1.765 ± 0.044	2.265LysGlu: 2.265 ± 0.058	1.186LysPhe: 1.186 ± 0.036	2.58LysGly: 2.58 ± 0.058	0.809LysHis: 0.809 ± 0.027	2.075LysIle: 2.075 ± 0.05	1.63LysLys: 1.63 ± 0.051	3.454LysLeu: 3.454 ± 0.068	1.063LysMet: 1.063 ± 0.036	1.377LysAsn: 1.377 ± 0.038	1.513LysPro: 1.513 ± 0.038	1.853LysGln: 1.853 ± 0.048	2.25LysArg: 2.25 ± 0.049	2.214LysSer: 2.214 ± 0.046	2.238LysThr: 2.238 ± 0.048	2.979LysVal: 2.979 ± 0.059	0.535LysTrp: 0.535 ± 0.025	1.015LysTyr: 1.015 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.151LeuAla: 11.151 ± 0.134	0.904LeuCys: 0.904 ± 0.029	4.896LeuAsp: 4.896 ± 0.081	5.615LeuGlu: 5.615 ± 0.08	3.993LeuPhe: 3.993 ± 0.079	8.38LeuGly: 8.38 ± 0.092	2.84LeuHis: 2.84 ± 0.059	4.947LeuIle: 4.947 ± 0.085	3.54LeuLys: 3.54 ± 0.061	11.474LeuLeu: 11.474 ± 0.139	2.575LeuMet: 2.575 ± 0.053	3.536LeuAsn: 3.536 ± 0.058	5.325LeuPro: 5.325 ± 0.077	5.892LeuGln: 5.892 ± 0.095	6.545LeuArg: 6.545 ± 0.12	7.292LeuSer: 7.292 ± 0.093	6.549LeuThr: 6.549 ± 0.092	8.232LeuVal: 8.232 ± 0.109	1.696LeuTrp: 1.696 ± 0.043	2.905LeuTyr: 2.905 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.738MetAla: 2.738 ± 0.058	0.176MetCys: 0.176 ± 0.013	1.348MetAsp: 1.348 ± 0.036	1.629MetGlu: 1.629 ± 0.039	0.788MetPhe: 0.788 ± 0.031	2.326MetGly: 2.326 ± 0.05	0.517MetHis: 0.517 ± 0.026	1.255MetIle: 1.255 ± 0.038	1.164MetLys: 1.164 ± 0.034	2.295MetLeu: 2.295 ± 0.059	0.778MetMet: 0.778 ± 0.031	1.128MetAsn: 1.128 ± 0.037	1.117MetPro: 1.117 ± 0.038	1.155MetGln: 1.155 ± 0.036	1.333MetArg: 1.333 ± 0.037	1.714MetSer: 1.714 ± 0.05	1.569MetThr: 1.569 ± 0.044	2.086MetVal: 2.086 ± 0.045	0.317MetTrp: 0.317 ± 0.021	0.569MetTyr: 0.569 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.713AsnAla: 2.713 ± 0.065	0.228AsnCys: 0.228 ± 0.017	1.209AsnAsp: 1.209 ± 0.036	1.718AsnGlu: 1.718 ± 0.041	1.319AsnPhe: 1.319 ± 0.037	2.777AsnGly: 2.777 ± 0.073	0.855AsnHis: 0.855 ± 0.028	1.718AsnIle: 1.718 ± 0.041	1.047AsnLys: 1.047 ± 0.035	3.608AsnLeu: 3.608 ± 0.066	0.74AsnMet: 0.74 ± 0.027	1.036AsnAsn: 1.036 ± 0.038	2.432AsnPro: 2.432 ± 0.045	1.762AsnGln: 1.762 ± 0.056	1.986AsnArg: 1.986 ± 0.043	2.025AsnSer: 2.025 ± 0.053	1.914AsnThr: 1.914 ± 0.047	2.447AsnVal: 2.447 ± 0.052	0.58AsnTrp: 0.58 ± 0.026	0.879AsnTyr: 0.879 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.724ProAla: 3.724 ± 0.058	0.287ProCys: 0.287 ± 0.019	2.347ProAsp: 2.347 ± 0.056	3.114ProGlu: 3.114 ± 0.065	1.85ProPhe: 1.85 ± 0.043	3.898ProGly: 3.898 ± 0.065	1.19ProHis: 1.19 ± 0.035	2.333ProIle: 2.333 ± 0.052	1.589ProLys: 1.589 ± 0.05	4.808ProLeu: 4.808 ± 0.065	1.167ProMet: 1.167 ± 0.035	1.68ProAsn: 1.68 ± 0.048	1.713ProPro: 1.713 ± 0.048	2.189ProGln: 2.189 ± 0.055	1.964ProArg: 1.964 ± 0.046	2.729ProSer: 2.729 ± 0.06	2.825ProThr: 2.825 ± 0.06	4.348ProVal: 4.348 ± 0.078	0.82ProTrp: 0.82 ± 0.034	1.481ProTyr: 1.481 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	5.103GlnAla: 5.103 ± 0.085	0.287GlnCys: 0.287 ± 0.017	2.031GlnAsp: 2.031 ± 0.046	2.822GlnGlu: 2.822 ± 0.061	1.588GlnPhe: 1.588 ± 0.04	3.854GlnGly: 3.854 ± 0.062	1.056GlnHis: 1.056 ± 0.036	2.423GlnIle: 2.423 ± 0.049	1.708GlnLys: 1.708 ± 0.044	4.71GlnLeu: 4.71 ± 0.078	1.3GlnMet: 1.3 ± 0.039	1.557GlnAsn: 1.557 ± 0.045	2.181GlnPro: 2.181 ± 0.062	2.971GlnGln: 2.971 ± 0.081	3.079GlnArg: 3.079 ± 0.067	3.134GlnSer: 3.134 ± 0.067	2.956GlnThr: 2.956 ± 0.071	4.575GlnVal: 4.575 ± 0.083	0.925GlnTrp: 0.925 ± 0.032	1.248GlnTyr: 1.248 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	4.242ArgAla: 4.242 ± 0.072	0.444ArgCys: 0.444 ± 0.021	2.731ArgAsp: 2.731 ± 0.059	3.745ArgGlu: 3.745 ± 0.067	2.25ArgPhe: 2.25 ± 0.05	3.868ArgGly: 3.868 ± 0.069	1.48ArgHis: 1.48 ± 0.043	3.252ArgIle: 3.252 ± 0.061	2.434ArgLys: 2.434 ± 0.054	6.237ArgLeu: 6.237 ± 0.09	1.678ArgMet: 1.678 ± 0.04	1.849ArgAsn: 1.849 ± 0.039	2.365ArgPro: 2.365 ± 0.059	3.079ArgGln: 3.079 ± 0.061	3.85ArgArg: 3.85 ± 0.086	2.943ArgSer: 2.943 ± 0.052	2.914ArgThr: 2.914 ± 0.061	4.901ArgVal: 4.901 ± 0.082	0.945ArgTrp: 0.945 ± 0.031	1.761ArgTyr: 1.761 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.091SerAla: 5.091 ± 0.08	0.41SerCys: 0.41 ± 0.024	2.414SerAsp: 2.414 ± 0.061	3.002SerGlu: 3.002 ± 0.059	2.374SerPhe: 2.374 ± 0.053	5.423SerGly: 5.423 ± 0.097	1.472SerHis: 1.472 ± 0.038	3.144SerIle: 3.144 ± 0.065	1.982SerLys: 1.982 ± 0.046	7.045SerLeu: 7.045 ± 0.093	1.582SerMet: 1.582 ± 0.039	1.951SerAsn: 1.951 ± 0.055	2.952SerPro: 2.952 ± 0.061	2.796SerGln: 2.796 ± 0.058	3.139SerArg: 3.139 ± 0.056	3.818SerSer: 3.818 ± 0.082	3.526SerThr: 3.526 ± 0.071	5.115SerVal: 5.115 ± 0.083	0.9SerTrp: 0.9 ± 0.026	1.646SerTyr: 1.646 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.74ThrAla: 5.74 ± 0.079	0.44ThrCys: 0.44 ± 0.022	2.659ThrAsp: 2.659 ± 0.049	2.981ThrGlu: 2.981 ± 0.06	2.207ThrPhe: 2.207 ± 0.048	5.239ThrGly: 5.239 ± 0.089	1.515ThrHis: 1.515 ± 0.043	2.518ThrIle: 2.518 ± 0.049	1.701ThrLys: 1.701 ± 0.04	6.808ThrLeu: 6.808 ± 0.093	1.242ThrMet: 1.242 ± 0.032	1.765ThrAsn: 1.765 ± 0.049	3.08ThrPro: 3.08 ± 0.061	2.62ThrGln: 2.62 ± 0.062	2.876ThrArg: 2.876 ± 0.06	3.445ThrSer: 3.445 ± 0.085	3.341ThrThr: 3.341 ± 0.07	5.44ThrVal: 5.44 ± 0.086	0.881ThrTrp: 0.881 ± 0.034	1.624ThrTyr: 1.624 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	8.175ValAla: 8.175 ± 0.099	0.862ValCys: 0.862 ± 0.031	4.352ValAsp: 4.352 ± 0.07	4.846ValGlu: 4.846 ± 0.083	3.253ValPhe: 3.253 ± 0.067	6.437ValGly: 6.437 ± 0.085	2.165ValHis: 2.165 ± 0.047	4.379ValIle: 4.379 ± 0.076	2.837ValLys: 2.837 ± 0.06	9.405ValLeu: 9.405 ± 0.104	2.173ValMet: 2.173 ± 0.044	2.834ValAsn: 2.834 ± 0.06	3.926ValPro: 3.926 ± 0.063	4.077ValGln: 4.077 ± 0.063	4.83ValArg: 4.83 ± 0.072	5.142ValSer: 5.142 ± 0.071	5.018ValThr: 5.018 ± 0.078	7.432ValVal: 7.432 ± 0.11	1.2ValTrp: 1.2 ± 0.036	2.45ValTyr: 2.45 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	1.152TrpAla: 1.152 ± 0.037	0.104TrpCys: 0.104 ± 0.01	0.615TrpAsp: 0.615 ± 0.026	0.783TrpGlu: 0.783 ± 0.033	0.659TrpPhe: 0.659 ± 0.026	1.049TrpGly: 1.049 ± 0.036	0.383TrpHis: 0.383 ± 0.02	0.837TrpIle: 0.837 ± 0.033	0.51TrpLys: 0.51 ± 0.024	2.125TrpLeu: 2.125 ± 0.049	0.546TrpMet: 0.546 ± 0.022	0.599TrpAsn: 0.599 ± 0.028	0.682TrpPro: 0.682 ± 0.028	0.983TrpGln: 0.983 ± 0.032	0.936TrpArg: 0.936 ± 0.036	0.944TrpSer: 0.944 ± 0.035	0.862TrpThr: 0.862 ± 0.032	1.352TrpVal: 1.352 ± 0.043	0.3TrpTrp: 0.3 ± 0.02	0.398TrpTyr: 0.398 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.463TyrAla: 2.463 ± 0.057	0.258TyrCys: 0.258 ± 0.016	1.338TyrAsp: 1.338 ± 0.038	1.483TyrGlu: 1.483 ± 0.047	1.157TyrPhe: 1.157 ± 0.03	2.514TyrGly: 2.514 ± 0.052	0.851TyrHis: 0.851 ± 0.032	1.312TyrIle: 1.312 ± 0.04	0.815TyrLys: 0.815 ± 0.032	3.136TyrLeu: 3.136 ± 0.064	0.594TyrMet: 0.594 ± 0.024	0.94TyrAsn: 0.94 ± 0.039	1.45TyrPro: 1.45 ± 0.038	1.458TyrGln: 1.458 ± 0.042	1.882TyrArg: 1.882 ± 0.043	1.433TyrSer: 1.433 ± 0.045	1.651TyrThr: 1.651 ± 0.046	2.27TyrVal: 2.27 ± 0.047	0.487TyrTrp: 0.487 ± 0.024	0.878TyrTyr: 0.878 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3312 proteins (970464 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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