Amino acid dipepetide frequency for Nitrosopumilaceae archaeon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.371AlaAla: 16.371 ± 0.337
1.578AlaCys: 1.578 ± 0.064
6.22AlaAsp: 6.22 ± 0.123
7.021AlaGlu: 7.021 ± 0.114
2.932AlaPhe: 2.932 ± 0.074
13.86AlaGly: 13.86 ± 0.217
1.832AlaHis: 1.832 ± 0.066
4.35AlaIle: 4.35 ± 0.098
3.094AlaLys: 3.094 ± 0.1
9.376AlaLeu: 9.376 ± 0.211
2.754AlaMet: 2.754 ± 0.074
1.773AlaAsn: 1.773 ± 0.058
5.235AlaPro: 5.235 ± 0.149
1.927AlaGln: 1.927 ± 0.064
9.44AlaArg: 9.44 ± 0.174
6.984AlaSer: 6.984 ± 0.121
4.096AlaThr: 4.096 ± 0.117
8.266AlaVal: 8.266 ± 0.125
1.105AlaTrp: 1.105 ± 0.046
2.697AlaTyr: 2.697 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
1.247CysAla: 1.247 ± 0.055
0.209CysCys: 0.209 ± 0.023
0.634CysAsp: 0.634 ± 0.033
0.582CysGlu: 0.582 ± 0.034
0.316CysPhe: 0.316 ± 0.029
1.468CysGly: 1.468 ± 0.068
0.299CysHis: 0.299 ± 0.023
0.632CysIle: 0.632 ± 0.042
0.452CysLys: 0.452 ± 0.03
0.844CysLeu: 0.844 ± 0.041
0.376CysMet: 0.376 ± 0.026
0.295CysAsn: 0.295 ± 0.023
0.862CysPro: 0.862 ± 0.122
0.24CysGln: 0.24 ± 0.021
1.141CysArg: 1.141 ± 0.05
0.867CysSer: 0.867 ± 0.041
0.901CysThr: 0.901 ± 0.085
0.799CysVal: 0.799 ± 0.041
0.121CysTrp: 0.121 ± 0.016
0.392CysTyr: 0.392 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
7.016AspAla: 7.016 ± 0.141
0.62AspCys: 0.62 ± 0.035
3.541AspAsp: 3.541 ± 0.099
3.837AspGlu: 3.837 ± 0.084
1.538AspPhe: 1.538 ± 0.062
7.49AspGly: 7.49 ± 0.223
1.395AspHis: 1.395 ± 0.061
3.165AspIle: 3.165 ± 0.069
1.742AspLys: 1.742 ± 0.072
5.467AspLeu: 5.467 ± 0.11
1.592AspMet: 1.592 ± 0.047
1.202AspAsn: 1.202 ± 0.06
5.199AspPro: 5.199 ± 0.119
1.026AspGln: 1.026 ± 0.047
4.46AspArg: 4.46 ± 0.106
3.067AspSer: 3.067 ± 0.105
2.73AspThr: 2.73 ± 0.101
4.874AspVal: 4.874 ± 0.105
0.673AspTrp: 0.673 ± 0.033
1.677AspTyr: 1.677 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
7.539GluAla: 7.539 ± 0.143
0.815GluCys: 0.815 ± 0.043
3.465GluAsp: 3.465 ± 0.104
4.757GluGlu: 4.757 ± 0.107
2.404GluPhe: 2.404 ± 0.066
5.418GluGly: 5.418 ± 0.097
1.26GluHis: 1.26 ± 0.044
4.078GluIle: 4.078 ± 0.091
2.811GluLys: 2.811 ± 0.086
4.581GluLeu: 4.581 ± 0.088
1.984GluMet: 1.984 ± 0.068
1.485GluAsn: 1.485 ± 0.06
3.018GluPro: 3.018 ± 0.107
1.345GluGln: 1.345 ± 0.054
5.033GluArg: 5.033 ± 0.132
3.742GluSer: 3.742 ± 0.083
2.307GluThr: 2.307 ± 0.08
4.396GluVal: 4.396 ± 0.08
0.651GluTrp: 0.651 ± 0.037
2.227GluTyr: 2.227 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.125PheAla: 3.125 ± 0.074
0.406PheCys: 0.406 ± 0.024
2.322PheAsp: 2.322 ± 0.07
2.442PheGlu: 2.442 ± 0.064
1.043PhePhe: 1.043 ± 0.049
2.877PheGly: 2.877 ± 0.081
0.642PheHis: 0.642 ± 0.035
1.312PheIle: 1.312 ± 0.061
1.164PheLys: 1.164 ± 0.048
2.502PheLeu: 2.502 ± 0.077
0.862PheMet: 0.862 ± 0.042
0.777PheAsn: 0.777 ± 0.04
1.285PhePro: 1.285 ± 0.051
0.66PheGln: 0.66 ± 0.038
1.867PheArg: 1.867 ± 0.054
2.036PheSer: 2.036 ± 0.057
1.699PheThr: 1.699 ± 0.064
2.405PheVal: 2.405 ± 0.066
0.414PheTrp: 0.414 ± 0.03
0.939PheTyr: 0.939 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
11.483GlyAla: 11.483 ± 0.186
1.393GlyCys: 1.393 ± 0.086
5.826GlyAsp: 5.826 ± 0.132
5.101GlyGlu: 5.101 ± 0.094
3.206GlyPhe: 3.206 ± 0.075
10.73GlyGly: 10.73 ± 0.191
1.873GlyHis: 1.873 ± 0.059
6.342GlyIle: 6.342 ± 0.117
2.821GlyLys: 2.821 ± 0.079
7.793GlyLeu: 7.793 ± 0.152
3.887GlyMet: 3.887 ± 0.093
2.205GlyAsn: 2.205 ± 0.079
4.949GlyPro: 4.949 ± 0.142
2.195GlyGln: 2.195 ± 0.062
9.663GlyArg: 9.663 ± 0.214
7.313GlySer: 7.313 ± 0.124
5.805GlyThr: 5.805 ± 0.155
6.171GlyVal: 6.171 ± 0.11
1.091GlyTrp: 1.091 ± 0.047
2.668GlyTyr: 2.668 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
2.336HisAla: 2.336 ± 0.062
0.221HisCys: 0.221 ± 0.02
1.342HisAsp: 1.342 ± 0.054
1.393HisGlu: 1.393 ± 0.05
0.596HisPhe: 0.596 ± 0.035
2.24HisGly: 2.24 ± 0.071
0.483HisHis: 0.483 ± 0.034
0.905HisIle: 0.905 ± 0.039
0.639HisLys: 0.639 ± 0.036
1.639HisLeu: 1.639 ± 0.055
0.599HisMet: 0.599 ± 0.035
0.53HisAsn: 0.53 ± 0.03
1.324HisPro: 1.324 ± 0.051
0.383HisGln: 0.383 ± 0.025
1.333HisArg: 1.333 ± 0.048
1.036HisSer: 1.036 ± 0.049
0.955HisThr: 0.955 ± 0.04
1.856HisVal: 1.856 ± 0.057
0.161HisTrp: 0.161 ± 0.017
0.591HisTyr: 0.591 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
4.524IleAla: 4.524 ± 0.103
0.608IleCys: 0.608 ± 0.033
3.251IleAsp: 3.251 ± 0.084
3.105IleGlu: 3.105 ± 0.07
1.575IlePhe: 1.575 ± 0.057
4.002IleGly: 4.002 ± 0.091
1.06IleHis: 1.06 ± 0.042
2.664IleIle: 2.664 ± 0.08
2.044IleLys: 2.044 ± 0.076
4.239IleLeu: 4.239 ± 0.088
1.35IleMet: 1.35 ± 0.049
1.355IleAsn: 1.355 ± 0.047
3.137IlePro: 3.137 ± 0.079
1.193IleGln: 1.193 ± 0.054
4.508IleArg: 4.508 ± 0.103
4.077IleSer: 4.077 ± 0.096
3.645IleThr: 3.645 ± 0.103
3.244IleVal: 3.244 ± 0.082
0.482IleTrp: 0.482 ± 0.03
1.452IleTyr: 1.452 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
3.086LysAla: 3.086 ± 0.096
0.471LysCys: 0.471 ± 0.032
1.804LysAsp: 1.804 ± 0.073
2.229LysGlu: 2.229 ± 0.087
1.16LysPhe: 1.16 ± 0.059
2.65LysGly: 2.65 ± 0.1
0.63LysHis: 0.63 ± 0.04
2.378LysIle: 2.378 ± 0.084
2.763LysLys: 2.763 ± 0.089
2.492LysLeu: 2.492 ± 0.066
1.064LysMet: 1.064 ± 0.049
1.095LysAsn: 1.095 ± 0.056
1.538LysPro: 1.538 ± 0.082
0.755LysGln: 0.755 ± 0.035
2.652LysArg: 2.652 ± 0.08
2.1LysSer: 2.1 ± 0.058
1.725LysThr: 1.725 ± 0.071
2.189LysVal: 2.189 ± 0.069
0.332LysTrp: 0.332 ± 0.026
1.362LysTyr: 1.362 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
10.503LeuAla: 10.503 ± 0.208
0.898LeuCys: 0.898 ± 0.041
6.021LeuAsp: 6.021 ± 0.116
6.458LeuGlu: 6.458 ± 0.111
2.298LeuPhe: 2.298 ± 0.069
8.69LeuGly: 8.69 ± 0.156
1.673LeuHis: 1.673 ± 0.061
2.789LeuIle: 2.789 ± 0.082
2.739LeuLys: 2.739 ± 0.081
7.444LeuLeu: 7.444 ± 0.154
1.78LeuMet: 1.78 ± 0.059
1.806LeuAsn: 1.806 ± 0.062
3.833LeuPro: 3.833 ± 0.082
1.704LeuGln: 1.704 ± 0.066
5.997LeuArg: 5.997 ± 0.118
4.809LeuSer: 4.809 ± 0.096
3.03LeuThr: 3.03 ± 0.09
6.974LeuVal: 6.974 ± 0.129
0.698LeuTrp: 0.698 ± 0.041
2.274LeuTyr: 2.274 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
3.422MetAla: 3.422 ± 0.085
0.269MetCys: 0.269 ± 0.022
1.972MetAsp: 1.972 ± 0.064
1.887MetGlu: 1.887 ± 0.061
0.777MetPhe: 0.777 ± 0.041
2.637MetGly: 2.637 ± 0.077
0.667MetHis: 0.667 ± 0.038
1.72MetIle: 1.72 ± 0.057
0.938MetLys: 0.938 ± 0.042
2.754MetLeu: 2.754 ± 0.079
0.989MetMet: 0.989 ± 0.053
0.632MetAsn: 0.632 ± 0.037
1.482MetPro: 1.482 ± 0.047
0.661MetGln: 0.661 ± 0.037
2.324MetArg: 2.324 ± 0.066
1.813MetSer: 1.813 ± 0.057
1.29MetThr: 1.29 ± 0.051
2.044MetVal: 2.044 ± 0.07
0.204MetTrp: 0.204 ± 0.02
0.872MetTyr: 0.872 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.022AsnAla: 2.022 ± 0.058
0.257AsnCys: 0.257 ± 0.022
1.152AsnAsp: 1.152 ± 0.059
1.214AsnGlu: 1.214 ± 0.049
0.787AsnPhe: 0.787 ± 0.046
1.884AsnGly: 1.884 ± 0.066
0.494AsnHis: 0.494 ± 0.032
1.38AsnIle: 1.38 ± 0.055
0.927AsnLys: 0.927 ± 0.055
1.936AsnLeu: 1.936 ± 0.054
0.839AsnMet: 0.839 ± 0.042
0.742AsnAsn: 0.742 ± 0.044
1.715AsnPro: 1.715 ± 0.06
0.501AsnGln: 0.501 ± 0.03
1.54AsnArg: 1.54 ± 0.055
1.266AsnSer: 1.266 ± 0.052
1.309AsnThr: 1.309 ± 0.051
1.699AsnVal: 1.699 ± 0.058
0.24AsnTrp: 0.24 ± 0.018
0.699AsnTyr: 0.699 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
6.625ProAla: 6.625 ± 0.171
0.527ProCys: 0.527 ± 0.035
4.365ProAsp: 4.365 ± 0.17
3.709ProGlu: 3.709 ± 0.119
1.43ProPhe: 1.43 ± 0.047
7.351ProGly: 7.351 ± 0.151
0.989ProHis: 0.989 ± 0.042
1.513ProIle: 1.513 ± 0.058
1.471ProLys: 1.471 ± 0.068
3.63ProLeu: 3.63 ± 0.087
1.152ProMet: 1.152 ± 0.045
0.9ProAsn: 0.9 ± 0.038
3.391ProPro: 3.391 ± 0.134
0.915ProGln: 0.915 ± 0.041
3.623ProArg: 3.623 ± 0.103
3.037ProSer: 3.037 ± 0.074
1.894ProThr: 1.894 ± 0.073
4.462ProVal: 4.462 ± 0.101
0.535ProTrp: 0.535 ± 0.031
1.4ProTyr: 1.4 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
2.082GlnAla: 2.082 ± 0.064
0.209GlnCys: 0.209 ± 0.021
1.224GlnAsp: 1.224 ± 0.049
1.317GlnGlu: 1.317 ± 0.054
0.725GlnPhe: 0.725 ± 0.034
1.537GlnGly: 1.537 ± 0.074
0.437GlnHis: 0.437 ± 0.03
1.369GlnIle: 1.369 ± 0.055
1.033GlnLys: 1.033 ± 0.04
1.564GlnLeu: 1.564 ± 0.057
0.78GlnMet: 0.78 ± 0.042
0.549GlnAsn: 0.549 ± 0.032
0.73GlnPro: 0.73 ± 0.041
0.535GlnGln: 0.535 ± 0.033
1.426GlnArg: 1.426 ± 0.045
1.229GlnSer: 1.229 ± 0.049
0.967GlnThr: 0.967 ± 0.04
1.875GlnVal: 1.875 ± 0.052
0.162GlnTrp: 0.162 ± 0.018
0.673GlnTyr: 0.673 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
8.083ArgAla: 8.083 ± 0.168
1.005ArgCys: 1.005 ± 0.044
5.168ArgAsp: 5.168 ± 0.124
4.641ArgGlu: 4.641 ± 0.099
2.486ArgPhe: 2.486 ± 0.074
7.673ArgGly: 7.673 ± 0.171
1.92ArgHis: 1.92 ± 0.074
5.373ArgIle: 5.373 ± 0.11
2.419ArgLys: 2.419 ± 0.088
7.05ArgLeu: 7.05 ± 0.116
2.849ArgMet: 2.849 ± 0.085
1.799ArgAsn: 1.799 ± 0.057
3.87ArgPro: 3.87 ± 0.097
1.846ArgGln: 1.846 ± 0.057
7.211ArgArg: 7.211 ± 0.185
4.412ArgSer: 4.412 ± 0.096
3.526ArgThr: 3.526 ± 0.093
5.222ArgVal: 5.222 ± 0.09
0.765ArgTrp: 0.765 ± 0.037
2.461ArgTyr: 2.461 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
5.674SerAla: 5.674 ± 0.124
0.872SerCys: 0.872 ± 0.042
3.586SerAsp: 3.586 ± 0.103
3.633SerGlu: 3.633 ± 0.081
2.025SerPhe: 2.025 ± 0.074
7.376SerGly: 7.376 ± 0.121
1.357SerHis: 1.357 ± 0.05
3.193SerIle: 3.193 ± 0.081
2.36SerLys: 2.36 ± 0.074
5.284SerLeu: 5.284 ± 0.103
2.025SerMet: 2.025 ± 0.058
1.468SerAsn: 1.468 ± 0.057
2.892SerPro: 2.892 ± 0.083
1.252SerGln: 1.252 ± 0.05
5.152SerArg: 5.152 ± 0.102
3.947SerSer: 3.947 ± 0.099
2.887SerThr: 2.887 ± 0.079
4.603SerVal: 4.603 ± 0.108
0.777SerTrp: 0.777 ± 0.038
1.994SerTyr: 1.994 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.738ThrAla: 4.738 ± 0.145
0.834ThrCys: 0.834 ± 0.09
2.946ThrAsp: 2.946 ± 0.108
2.699ThrGlu: 2.699 ± 0.068
1.609ThrPhe: 1.609 ± 0.068
5.368ThrGly: 5.368 ± 0.116
0.974ThrHis: 0.974 ± 0.045
2.53ThrIle: 2.53 ± 0.08
1.466ThrLys: 1.466 ± 0.051
3.44ThrLeu: 3.44 ± 0.086
1.128ThrMet: 1.128 ± 0.047
1.136ThrAsn: 1.136 ± 0.059
2.416ThrPro: 2.416 ± 0.081
0.877ThrGln: 0.877 ± 0.051
3.341ThrArg: 3.341 ± 0.076
2.911ThrSer: 2.911 ± 0.082
2.236ThrThr: 2.236 ± 0.104
4.044ThrVal: 4.044 ± 0.137
0.594ThrTrp: 0.594 ± 0.036
1.915ThrTyr: 1.915 ± 0.098
0.0ThrXaa: 0.0 ± 0.0
Val
7.406ValAla: 7.406 ± 0.127
0.917ValCys: 0.917 ± 0.043
4.724ValAsp: 4.724 ± 0.113
4.479ValGlu: 4.479 ± 0.098
2.576ValPhe: 2.576 ± 0.075
5.617ValGly: 5.617 ± 0.108
1.609ValHis: 1.609 ± 0.047
4.137ValIle: 4.137 ± 0.096
2.077ValLys: 2.077 ± 0.073
6.931ValLeu: 6.931 ± 0.131
2.103ValMet: 2.103 ± 0.057
1.639ValAsn: 1.639 ± 0.057
4.31ValPro: 4.31 ± 0.107
1.535ValGln: 1.535 ± 0.055
6.156ValArg: 6.156 ± 0.129
5.339ValSer: 5.339 ± 0.093
4.142ValThr: 4.142 ± 0.144
5.943ValVal: 5.943 ± 0.129
0.742ValTrp: 0.742 ± 0.04
1.825ValTyr: 1.825 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.889TrpAla: 0.889 ± 0.043
0.143TrpCys: 0.143 ± 0.014
0.741TrpAsp: 0.741 ± 0.039
0.622TrpGlu: 0.622 ± 0.039
0.39TrpPhe: 0.39 ± 0.03
0.784TrpGly: 0.784 ± 0.038
0.299TrpHis: 0.299 ± 0.025
0.604TrpIle: 0.604 ± 0.032
0.432TrpLys: 0.432 ± 0.031
0.912TrpLeu: 0.912 ± 0.041
0.368TrpMet: 0.368 ± 0.028
0.338TrpAsn: 0.338 ± 0.024
0.425TrpPro: 0.425 ± 0.027
0.281TrpGln: 0.281 ± 0.021
0.798TrpArg: 0.798 ± 0.042
0.57TrpSer: 0.57 ± 0.036
0.584TrpThr: 0.584 ± 0.041
0.578TrpVal: 0.578 ± 0.035
0.138TrpTrp: 0.138 ± 0.017
0.352TrpTyr: 0.352 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.74TyrAla: 2.74 ± 0.071
0.425TyrCys: 0.425 ± 0.03
2.006TyrAsp: 2.006 ± 0.066
2.193TyrGlu: 2.193 ± 0.065
0.903TyrPhe: 0.903 ± 0.037
2.861TyrGly: 2.861 ± 0.08
0.667TyrHis: 0.667 ± 0.038
1.084TyrIle: 1.084 ± 0.043
1.083TyrLys: 1.083 ± 0.047
2.543TyrLeu: 2.543 ± 0.073
0.87TyrMet: 0.87 ± 0.038
0.875TyrAsn: 0.875 ± 0.054
1.307TyrPro: 1.307 ± 0.048
0.596TyrGln: 0.596 ± 0.031
2.113TyrArg: 2.113 ± 0.062
1.806TyrSer: 1.806 ± 0.066
1.475TyrThr: 1.475 ± 0.077
2.561TyrVal: 2.561 ± 0.076
0.363TyrTrp: 0.363 ± 0.028
0.951TyrTyr: 0.951 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2237 proteins (579143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski