Amino acid dipepetide frequency for Paraglaciecola hydrolytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.799AlaAla: 7.799 ± 0.104	0.948AlaCys: 0.948 ± 0.023	5.107AlaAsp: 5.107 ± 0.056	5.42AlaGlu: 5.42 ± 0.077	3.528AlaPhe: 3.528 ± 0.055	5.942AlaGly: 5.942 ± 0.078	1.661AlaHis: 1.661 ± 0.037	5.843AlaIle: 5.843 ± 0.07	5.158AlaLys: 5.158 ± 0.071	9.919AlaLeu: 9.919 ± 0.102	2.452AlaMet: 2.452 ± 0.037	4.217AlaAsn: 4.217 ± 0.053	2.825AlaPro: 2.825 ± 0.048	4.49AlaGln: 4.49 ± 0.067	3.343AlaArg: 3.343 ± 0.046	5.543AlaSer: 5.543 ± 0.059	4.608AlaThr: 4.608 ± 0.065	5.518AlaVal: 5.518 ± 0.067	0.993AlaTrp: 0.993 ± 0.026	2.631AlaTyr: 2.631 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.826CysAla: 0.826 ± 0.025	0.161CysCys: 0.161 ± 0.012	0.501CysAsp: 0.501 ± 0.021	0.532CysGlu: 0.532 ± 0.023	0.447CysPhe: 0.447 ± 0.019	0.813CysGly: 0.813 ± 0.029	0.328CysHis: 0.328 ± 0.019	0.655CysIle: 0.655 ± 0.022	0.449CysLys: 0.449 ± 0.019	1.054CysLeu: 1.054 ± 0.03	0.217CysMet: 0.217 ± 0.013	0.337CysAsn: 0.337 ± 0.015	0.374CysPro: 0.374 ± 0.019	0.51CysGln: 0.51 ± 0.02	0.4CysArg: 0.4 ± 0.019	0.729CysSer: 0.729 ± 0.026	0.429CysThr: 0.429 ± 0.017	0.595CysVal: 0.595 ± 0.019	0.139CysTrp: 0.139 ± 0.009	0.322CysTyr: 0.322 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.36AspAla: 4.36 ± 0.057	0.534AspCys: 0.534 ± 0.019	3.075AspAsp: 3.075 ± 0.071	3.556AspGlu: 3.556 ± 0.062	2.773AspPhe: 2.773 ± 0.043	3.847AspGly: 3.847 ± 0.085	0.993AspHis: 0.993 ± 0.029	4.198AspIle: 4.198 ± 0.063	3.551AspLys: 3.551 ± 0.055	5.229AspLeu: 5.229 ± 0.059	1.403AspMet: 1.403 ± 0.032	2.74AspAsn: 2.74 ± 0.048	2.183AspPro: 2.183 ± 0.043	1.891AspGln: 1.891 ± 0.035	1.837AspArg: 1.837 ± 0.039	3.53AspSer: 3.53 ± 0.055	2.592AspThr: 2.592 ± 0.045	3.661AspVal: 3.661 ± 0.054	0.956AspTrp: 0.956 ± 0.027	2.197AspTyr: 2.197 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.383GluAla: 4.383 ± 0.061	0.42GluCys: 0.42 ± 0.018	2.502GluAsp: 2.502 ± 0.046	2.69GluGlu: 2.69 ± 0.052	2.617GluPhe: 2.617 ± 0.041	3.042GluGly: 3.042 ± 0.047	1.518GluHis: 1.518 ± 0.033	3.629GluIle: 3.629 ± 0.053	3.242GluLys: 3.242 ± 0.057	7.12GluLeu: 7.12 ± 0.082	1.34GluMet: 1.34 ± 0.031	2.545GluAsn: 2.545 ± 0.041	1.879GluPro: 1.879 ± 0.041	4.289GluGln: 4.289 ± 0.068	2.666GluArg: 2.666 ± 0.047	3.197GluSer: 3.197 ± 0.047	2.666GluThr: 2.666 ± 0.047	3.692GluVal: 3.692 ± 0.054	0.71GluTrp: 0.71 ± 0.025	1.817GluTyr: 1.817 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.176PheAla: 4.176 ± 0.06	0.531PheCys: 0.531 ± 0.02	2.866PheAsp: 2.866 ± 0.051	2.534PheGlu: 2.534 ± 0.041	1.82PhePhe: 1.82 ± 0.038	3.103PheGly: 3.103 ± 0.05	0.777PheHis: 0.777 ± 0.024	2.894PheIle: 2.894 ± 0.047	2.215PheLys: 2.215 ± 0.037	3.518PheLeu: 3.518 ± 0.056	1.086PheMet: 1.086 ± 0.025	2.304PheAsn: 2.304 ± 0.039	1.463PhePro: 1.463 ± 0.038	1.241PheGln: 1.241 ± 0.028	1.474PheArg: 1.474 ± 0.033	3.756PheSer: 3.756 ± 0.057	2.418PheThr: 2.418 ± 0.044	3.049PheVal: 3.049 ± 0.042	0.592PheTrp: 0.592 ± 0.023	1.512PheTyr: 1.512 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	4.992GlyAla: 4.992 ± 0.07	0.747GlyCys: 0.747 ± 0.025	3.581GlyAsp: 3.581 ± 0.059	3.738GlyGlu: 3.738 ± 0.053	3.406GlyPhe: 3.406 ± 0.049	4.577GlyGly: 4.577 ± 0.074	1.463GlyHis: 1.463 ± 0.034	4.721GlyIle: 4.721 ± 0.063	3.945GlyLys: 3.945 ± 0.062	7.325GlyLeu: 7.325 ± 0.076	1.832GlyMet: 1.832 ± 0.042	2.72GlyAsn: 2.72 ± 0.056	1.687GlyPro: 1.687 ± 0.039	3.037GlyGln: 3.037 ± 0.052	2.713GlyArg: 2.713 ± 0.049	4.258GlySer: 4.258 ± 0.06	3.21GlyThr: 3.21 ± 0.053	4.606GlyVal: 4.606 ± 0.059	1.003GlyTrp: 1.003 ± 0.031	2.376GlyTyr: 2.376 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.634HisAla: 1.634 ± 0.032	0.316HisCys: 0.316 ± 0.017	1.066HisAsp: 1.066 ± 0.027	1.082HisGlu: 1.082 ± 0.03	1.132HisPhe: 1.132 ± 0.029	1.482HisGly: 1.482 ± 0.032	0.655HisHis: 0.655 ± 0.025	1.465HisIle: 1.465 ± 0.029	1.166HisLys: 1.166 ± 0.028	2.201HisLeu: 2.201 ± 0.038	0.529HisMet: 0.529 ± 0.017	1.013HisAsn: 1.013 ± 0.026	1.096HisPro: 1.096 ± 0.027	1.172HisGln: 1.172 ± 0.032	0.939HisArg: 0.939 ± 0.024	1.488HisSer: 1.488 ± 0.034	1.07HisThr: 1.07 ± 0.026	1.276HisVal: 1.276 ± 0.03	0.395HisTrp: 0.395 ± 0.017	0.941HisTyr: 0.941 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.218IleAla: 6.218 ± 0.078	0.681IleCys: 0.681 ± 0.028	4.24IleAsp: 4.24 ± 0.059	4.47IleGlu: 4.47 ± 0.061	2.416IlePhe: 2.416 ± 0.042	4.498IleGly: 4.498 ± 0.064	1.228IleHis: 1.228 ± 0.029	3.752IleIle: 3.752 ± 0.064	3.703IleLys: 3.703 ± 0.053	5.588IleLeu: 5.588 ± 0.073	1.321IleMet: 1.321 ± 0.029	3.511IleAsn: 3.511 ± 0.045	2.522IlePro: 2.522 ± 0.043	2.5IleGln: 2.5 ± 0.042	2.576IleArg: 2.576 ± 0.044	4.788IleSer: 4.788 ± 0.061	3.579IleThr: 3.579 ± 0.044	4.219IleVal: 4.219 ± 0.062	0.697IleTrp: 0.697 ± 0.023	1.849IleTyr: 1.849 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.694LysAla: 4.694 ± 0.06	0.318LysCys: 0.318 ± 0.018	2.734LysAsp: 2.734 ± 0.05	2.592LysGlu: 2.592 ± 0.047	1.786LysPhe: 1.786 ± 0.031	3.175LysGly: 3.175 ± 0.048	1.303LysHis: 1.303 ± 0.034	3.436LysIle: 3.436 ± 0.055	2.792LysLys: 2.792 ± 0.051	5.895LysLeu: 5.895 ± 0.068	1.291LysMet: 1.291 ± 0.029	2.616LysAsn: 2.616 ± 0.046	2.356LysPro: 2.356 ± 0.04	3.451LysGln: 3.451 ± 0.061	2.535LysArg: 2.535 ± 0.043	3.269LysSer: 3.269 ± 0.048	3.037LysThr: 3.037 ± 0.047	3.894LysVal: 3.894 ± 0.048	0.591LysTrp: 0.591 ± 0.02	1.443LysTyr: 1.443 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	10.774LeuAla: 10.774 ± 0.106	1.106LeuCys: 1.106 ± 0.032	5.838LeuAsp: 5.838 ± 0.069	5.392LeuGlu: 5.392 ± 0.062	4.373LeuPhe: 4.373 ± 0.066	6.843LeuGly: 6.843 ± 0.069	2.189LeuHis: 2.189 ± 0.041	6.502LeuIle: 6.502 ± 0.08	5.528LeuLys: 5.528 ± 0.069	11.594LeuLeu: 11.594 ± 0.135	2.539LeuMet: 2.539 ± 0.052	5.199LeuAsn: 5.199 ± 0.066	4.737LeuPro: 4.737 ± 0.058	4.812LeuGln: 4.812 ± 0.071	4.33LeuArg: 4.33 ± 0.05	8.58LeuSer: 8.58 ± 0.083	5.882LeuThr: 5.882 ± 0.064	7.37LeuVal: 7.37 ± 0.074	1.167LeuTrp: 1.167 ± 0.031	2.888LeuTyr: 2.888 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.466MetAla: 2.466 ± 0.042	0.183MetCys: 0.183 ± 0.011	1.223MetAsp: 1.223 ± 0.032	1.068MetGlu: 1.068 ± 0.026	0.933MetPhe: 0.933 ± 0.026	1.632MetGly: 1.632 ± 0.038	0.523MetHis: 0.523 ± 0.019	1.236MetIle: 1.236 ± 0.028	1.126MetLys: 1.126 ± 0.023	2.934MetLeu: 2.934 ± 0.045	0.604MetMet: 0.604 ± 0.02	0.984MetAsn: 0.984 ± 0.027	1.23MetPro: 1.23 ± 0.033	1.545MetGln: 1.545 ± 0.033	1.077MetArg: 1.077 ± 0.028	1.845MetSer: 1.845 ± 0.035	1.428MetThr: 1.428 ± 0.032	1.509MetVal: 1.509 ± 0.03	0.238MetTrp: 0.238 ± 0.011	0.558MetTyr: 0.558 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.651AsnAla: 3.651 ± 0.047	0.444AsnCys: 0.444 ± 0.019	2.458AsnAsp: 2.458 ± 0.055	2.473AsnGlu: 2.473 ± 0.041	1.872AsnPhe: 1.872 ± 0.04	3.099AsnGly: 3.099 ± 0.05	0.986AsnHis: 0.986 ± 0.027	3.31AsnIle: 3.31 ± 0.054	2.71AsnLys: 2.71 ± 0.038	4.626AsnLeu: 4.626 ± 0.057	1.134AsnMet: 1.134 ± 0.026	2.565AsnAsn: 2.565 ± 0.056	2.162AsnPro: 2.162 ± 0.044	2.432AsnGln: 2.432 ± 0.044	1.893AsnArg: 1.893 ± 0.035	2.995AsnSer: 2.995 ± 0.044	2.604AsnThr: 2.604 ± 0.05	2.791AsnVal: 2.791 ± 0.048	0.738AsnTrp: 0.738 ± 0.021	1.612AsnTyr: 1.612 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.271ProAla: 3.271 ± 0.052	0.305ProCys: 0.305 ± 0.014	2.447ProAsp: 2.447 ± 0.049	2.804ProGlu: 2.804 ± 0.043	1.74ProPhe: 1.74 ± 0.033	2.227ProGly: 2.227 ± 0.041	0.826ProHis: 0.826 ± 0.023	2.376ProIle: 2.376 ± 0.042	1.911ProLys: 1.911 ± 0.035	4.12ProLeu: 4.12 ± 0.054	0.936ProMet: 0.936 ± 0.028	1.776ProAsn: 1.776 ± 0.036	1.171ProPro: 1.171 ± 0.031	1.964ProGln: 1.964 ± 0.041	1.281ProArg: 1.281 ± 0.029	2.466ProSer: 2.466 ± 0.04	2.11ProThr: 2.11 ± 0.042	2.758ProVal: 2.758 ± 0.035	0.535ProTrp: 0.535 ± 0.021	1.22ProTyr: 1.22 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.039GlnAla: 5.039 ± 0.069	0.416GlnCys: 0.416 ± 0.018	2.514GlnAsp: 2.514 ± 0.047	2.313GlnGlu: 2.313 ± 0.047	2.066GlnPhe: 2.066 ± 0.034	3.344GlnGly: 3.344 ± 0.05	1.608GlnHis: 1.608 ± 0.04	3.026GlnIle: 3.026 ± 0.045	2.408GlnLys: 2.408 ± 0.048	5.836GlnLeu: 5.836 ± 0.08	1.126GlnMet: 1.126 ± 0.028	2.232GlnAsn: 2.232 ± 0.039	1.694GlnPro: 1.694 ± 0.037	4.535GlnGln: 4.535 ± 0.104	2.387GlnArg: 2.387 ± 0.046	3.101GlnSer: 3.101 ± 0.048	2.744GlnThr: 2.744 ± 0.044	3.378GlnVal: 3.378 ± 0.046	0.766GlnTrp: 0.766 ± 0.025	1.548GlnTyr: 1.548 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.228ArgAla: 3.228 ± 0.052	0.374ArgCys: 0.374 ± 0.016	2.153ArgAsp: 2.153 ± 0.036	2.444ArgGlu: 2.444 ± 0.051	2.136ArgPhe: 2.136 ± 0.038	2.395ArgGly: 2.395 ± 0.045	0.964ArgHis: 0.964 ± 0.023	2.844ArgIle: 2.844 ± 0.042	2.092ArgLys: 2.092 ± 0.043	4.601ArgLeu: 4.601 ± 0.059	1.036ArgMet: 1.036 ± 0.03	1.829ArgAsn: 1.829 ± 0.037	1.485ArgPro: 1.485 ± 0.033	2.205ArgGln: 2.205 ± 0.04	1.893ArgArg: 1.893 ± 0.041	2.489ArgSer: 2.489 ± 0.04	1.927ArgThr: 1.927 ± 0.041	2.664ArgVal: 2.664 ± 0.047	0.595ArgTrp: 0.595 ± 0.023	1.636ArgTyr: 1.636 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	6.076SerAla: 6.076 ± 0.066	0.64SerCys: 0.64 ± 0.021	3.733SerAsp: 3.733 ± 0.055	3.814SerGlu: 3.814 ± 0.055	2.995SerPhe: 2.995 ± 0.044	4.953SerGly: 4.953 ± 0.068	1.58SerHis: 1.58 ± 0.037	4.32SerIle: 4.32 ± 0.053	3.289SerLys: 3.289 ± 0.053	7.517SerLeu: 7.517 ± 0.07	1.64SerMet: 1.64 ± 0.033	2.887SerAsn: 2.887 ± 0.049	2.568SerPro: 2.568 ± 0.041	3.445SerGln: 3.445 ± 0.054	2.796SerArg: 2.796 ± 0.046	4.756SerSer: 4.756 ± 0.066	3.463SerThr: 3.463 ± 0.043	4.549SerVal: 4.549 ± 0.059	0.968SerTrp: 0.968 ± 0.027	2.157SerTyr: 2.157 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.607ThrAla: 4.607 ± 0.065	0.471ThrCys: 0.471 ± 0.02	2.868ThrAsp: 2.868 ± 0.053	2.951ThrGlu: 2.951 ± 0.047	2.123ThrPhe: 2.123 ± 0.042	3.742ThrGly: 3.742 ± 0.049	1.118ThrHis: 1.118 ± 0.027	3.242ThrIle: 3.242 ± 0.052	2.461ThrLys: 2.461 ± 0.039	6.208ThrLeu: 6.208 ± 0.069	1.12ThrMet: 1.12 ± 0.027	2.199ThrAsn: 2.199 ± 0.044	2.464ThrPro: 2.464 ± 0.037	2.747ThrGln: 2.747 ± 0.045	1.999ThrArg: 1.999 ± 0.037	3.475ThrSer: 3.475 ± 0.056	2.953ThrThr: 2.953 ± 0.046	3.537ThrVal: 3.537 ± 0.053	0.601ThrTrp: 0.601 ± 0.021	1.599ThrTyr: 1.599 ± 0.036	0.001ThrXaa: 0.001 ± 0.001
Val	6.212ValAla: 6.212 ± 0.064	0.703ValCys: 0.703 ± 0.023	3.9ValAsp: 3.9 ± 0.055	4.037ValGlu: 4.037 ± 0.048	2.885ValPhe: 2.885 ± 0.046	4.32ValGly: 4.32 ± 0.059	1.188ValHis: 1.188 ± 0.028	4.538ValIle: 4.538 ± 0.06	3.62ValLys: 3.62 ± 0.059	6.884ValLeu: 6.884 ± 0.082	1.756ValMet: 1.756 ± 0.035	3.167ValAsn: 3.167 ± 0.052	2.451ValPro: 2.451 ± 0.041	2.39ValGln: 2.39 ± 0.04	2.512ValArg: 2.512 ± 0.037	4.916ValSer: 4.916 ± 0.061	3.787ValThr: 3.787 ± 0.056	5.004ValVal: 5.004 ± 0.054	0.736ValTrp: 0.736 ± 0.024	1.827ValTyr: 1.827 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.919TrpAla: 0.919 ± 0.027	0.145TrpCys: 0.145 ± 0.009	0.664TrpAsp: 0.664 ± 0.023	0.476TrpGlu: 0.476 ± 0.02	0.591TrpPhe: 0.591 ± 0.021	0.831TrpGly: 0.831 ± 0.023	0.42TrpHis: 0.42 ± 0.016	0.671TrpIle: 0.671 ± 0.023	0.444TrpLys: 0.444 ± 0.017	1.931TrpLeu: 1.931 ± 0.041	0.35TrpMet: 0.35 ± 0.015	0.491TrpAsn: 0.491 ± 0.021	0.499TrpPro: 0.499 ± 0.02	1.297TrpGln: 1.297 ± 0.032	0.7TrpArg: 0.7 ± 0.024	0.766TrpSer: 0.766 ± 0.026	0.546TrpThr: 0.546 ± 0.023	0.795TrpVal: 0.795 ± 0.023	0.219TrpTrp: 0.219 ± 0.012	0.431TrpTyr: 0.431 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.622TyrAla: 2.622 ± 0.04	0.376TyrCys: 0.376 ± 0.015	1.635TyrAsp: 1.635 ± 0.035	1.578TyrGlu: 1.578 ± 0.033	1.689TyrPhe: 1.689 ± 0.041	2.071TyrGly: 2.071 ± 0.038	0.791TyrHis: 0.791 ± 0.02	1.702TyrIle: 1.702 ± 0.032	1.396TyrLys: 1.396 ± 0.031	3.544TyrLeu: 3.544 ± 0.05	0.631TyrMet: 0.631 ± 0.024	1.221TyrAsn: 1.221 ± 0.034	1.395TyrPro: 1.395 ± 0.032	2.129TyrGln: 2.129 ± 0.041	1.639TyrArg: 1.639 ± 0.033	2.198TyrSer: 2.198 ± 0.046	1.43TyrThr: 1.43 ± 0.034	1.969TyrVal: 1.969 ± 0.039	0.546TyrTrp: 0.546 ± 0.022	1.137TyrTyr: 1.137 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 4354 proteins (1486281 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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