Amino acid dipepetide frequency for Candidatus Nitrosocosmicus franklandus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.21AlaAla: 3.21 ± 0.1	0.603AlaCys: 0.603 ± 0.034	2.399AlaAsp: 2.399 ± 0.059	2.901AlaGlu: 2.901 ± 0.061	2.347AlaPhe: 2.347 ± 0.06	3.349AlaGly: 3.349 ± 0.099	0.83AlaHis: 0.83 ± 0.04	5.031AlaIle: 5.031 ± 0.094	3.457AlaLys: 3.457 ± 0.066	5.019AlaLeu: 5.019 ± 0.103	1.159AlaMet: 1.159 ± 0.048	2.718AlaAsn: 2.718 ± 0.074	1.404AlaPro: 1.404 ± 0.051	1.707AlaGln: 1.707 ± 0.063	2.033AlaArg: 2.033 ± 0.06	3.951AlaSer: 3.951 ± 0.085	2.822AlaThr: 2.822 ± 0.067	3.191AlaVal: 3.191 ± 0.08	0.414AlaTrp: 0.414 ± 0.028	1.682AlaTyr: 1.682 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.452CysAla: 0.452 ± 0.026	0.183CysCys: 0.183 ± 0.017	0.526CysAsp: 0.526 ± 0.029	0.542CysGlu: 0.542 ± 0.029	0.444CysPhe: 0.444 ± 0.024	0.845CysGly: 0.845 ± 0.039	0.222CysHis: 0.222 ± 0.015	0.94CysIle: 0.94 ± 0.041	0.739CysLys: 0.739 ± 0.034	0.786CysLeu: 0.786 ± 0.033	0.307CysMet: 0.307 ± 0.021	0.755CysAsn: 0.755 ± 0.037	0.506CysPro: 0.506 ± 0.026	0.305CysGln: 0.305 ± 0.021	0.484CysArg: 0.484 ± 0.03	0.774CysSer: 0.774 ± 0.037	0.491CysThr: 0.491 ± 0.029	0.542CysVal: 0.542 ± 0.034	0.088CysTrp: 0.088 ± 0.012	0.418CysTyr: 0.418 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.505AspAla: 2.505 ± 0.069	0.53AspCys: 0.53 ± 0.034	3.428AspAsp: 3.428 ± 0.132	3.752AspGlu: 3.752 ± 0.093	2.651AspPhe: 2.651 ± 0.075	3.329AspGly: 3.329 ± 0.086	1.068AspHis: 1.068 ± 0.043	5.108AspIle: 5.108 ± 0.092	4.397AspLys: 4.397 ± 0.096	5.399AspLeu: 5.399 ± 0.1	1.271AspMet: 1.271 ± 0.047	3.738AspAsn: 3.738 ± 0.089	2.326AspPro: 2.326 ± 0.065	1.642AspGln: 1.642 ± 0.049	2.204AspArg: 2.204 ± 0.052	4.27AspSer: 4.27 ± 0.078	2.835AspThr: 2.835 ± 0.067	3.305AspVal: 3.305 ± 0.071	0.527AspTrp: 0.527 ± 0.028	2.319AspTyr: 2.319 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	2.83GluAla: 2.83 ± 0.069	0.527GluCys: 0.527 ± 0.028	3.178GluAsp: 3.178 ± 0.089	4.049GluGlu: 4.049 ± 0.105	2.768GluPhe: 2.768 ± 0.059	3.237GluGly: 3.237 ± 0.078	1.001GluHis: 1.001 ± 0.04	6.556GluIle: 6.556 ± 0.1	5.664GluLys: 5.664 ± 0.102	5.544GluLeu: 5.544 ± 0.09	1.563GluMet: 1.563 ± 0.05	4.354GluAsn: 4.354 ± 0.085	1.828GluPro: 1.828 ± 0.062	1.919GluGln: 1.919 ± 0.062	2.785GluArg: 2.785 ± 0.062	4.439GluSer: 4.439 ± 0.085	2.946GluThr: 2.946 ± 0.057	3.394GluVal: 3.394 ± 0.079	0.601GluTrp: 0.601 ± 0.026	2.363GluTyr: 2.363 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	2.521PheAla: 2.521 ± 0.063	0.501PheCys: 0.501 ± 0.026	3.203PheAsp: 3.203 ± 0.065	2.841PheGlu: 2.841 ± 0.065	2.027PhePhe: 2.027 ± 0.071	3.016PheGly: 3.016 ± 0.071	0.814PheHis: 0.814 ± 0.038	3.682PheIle: 3.682 ± 0.086	2.632PheLys: 2.632 ± 0.07	4.27PheLeu: 4.27 ± 0.097	0.978PheMet: 0.978 ± 0.042	2.427PheAsn: 2.427 ± 0.05	1.669PhePro: 1.669 ± 0.049	1.254PheGln: 1.254 ± 0.048	1.651PheArg: 1.651 ± 0.054	3.843PheSer: 3.843 ± 0.085	2.396PheThr: 2.396 ± 0.061	3.276PheVal: 3.276 ± 0.073	0.457PheTrp: 0.457 ± 0.029	1.746PheTyr: 1.746 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	3.105GlyAla: 3.105 ± 0.095	0.658GlyCys: 0.658 ± 0.036	2.955GlyAsp: 2.955 ± 0.09	3.12GlyGlu: 3.12 ± 0.087	2.936GlyPhe: 2.936 ± 0.074	4.313GlyGly: 4.313 ± 0.149	1.168GlyHis: 1.168 ± 0.04	6.185GlyIle: 6.185 ± 0.116	4.441GlyLys: 4.441 ± 0.088	5.466GlyLeu: 5.466 ± 0.099	1.596GlyMet: 1.596 ± 0.05	3.755GlyAsn: 3.755 ± 0.109	1.873GlyPro: 1.873 ± 0.069	1.81GlyGln: 1.81 ± 0.064	2.246GlyArg: 2.246 ± 0.069	4.701GlySer: 4.701 ± 0.107	3.476GlyThr: 3.476 ± 0.079	3.51GlyVal: 3.51 ± 0.075	0.636GlyTrp: 0.636 ± 0.042	2.309GlyTyr: 2.309 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.837HisAla: 0.837 ± 0.038	0.254HisCys: 0.254 ± 0.021	1.016HisAsp: 1.016 ± 0.038	1.092HisGlu: 1.092 ± 0.041	0.829HisPhe: 0.829 ± 0.035	1.16HisGly: 1.16 ± 0.042	0.523HisHis: 0.523 ± 0.033	1.606HisIle: 1.606 ± 0.05	1.105HisLys: 1.105 ± 0.042	1.653HisLeu: 1.653 ± 0.045	0.435HisMet: 0.435 ± 0.025	1.112HisAsn: 1.112 ± 0.035	0.957HisPro: 0.957 ± 0.038	0.527HisGln: 0.527 ± 0.026	0.761HisArg: 0.761 ± 0.032	1.355HisSer: 1.355 ± 0.046	0.95HisThr: 0.95 ± 0.042	1.219HisVal: 1.219 ± 0.042	0.168HisTrp: 0.168 ± 0.014	0.706HisTyr: 0.706 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.167IleAla: 5.167 ± 0.089	1.035IleCys: 1.035 ± 0.037	5.732IleAsp: 5.732 ± 0.097	6.049IleGlu: 6.049 ± 0.106	4.043IlePhe: 4.043 ± 0.091	5.764IleGly: 5.764 ± 0.113	1.841IleHis: 1.841 ± 0.05	8.361IleIle: 8.361 ± 0.132	6.594IleLys: 6.594 ± 0.096	9.007IleLeu: 9.007 ± 0.154	2.071IleMet: 2.071 ± 0.054	5.347IleAsn: 5.347 ± 0.09	3.974IlePro: 3.974 ± 0.074	2.813IleGln: 2.813 ± 0.077	3.827IleArg: 3.827 ± 0.075	7.736IleSer: 7.736 ± 0.12	5.257IleThr: 5.257 ± 0.083	6.039IleVal: 6.039 ± 0.105	0.697IleTrp: 0.697 ± 0.031	2.997IleTyr: 2.997 ± 0.074	0.0IleXaa: 0.0 ± 0.0
Lys	3.188LysAla: 3.188 ± 0.071	0.688LysCys: 0.688 ± 0.034	4.245LysAsp: 4.245 ± 0.083	5.373LysGlu: 5.373 ± 0.109	2.927LysPhe: 2.927 ± 0.072	3.767LysGly: 3.767 ± 0.095	1.279LysHis: 1.279 ± 0.051	7.85LysIle: 7.85 ± 0.116	6.467LysLys: 6.467 ± 0.112	6.295LysLeu: 6.295 ± 0.1	2.068LysMet: 2.068 ± 0.057	5.274LysAsn: 5.274 ± 0.09	2.353LysPro: 2.353 ± 0.055	2.092LysGln: 2.092 ± 0.051	3.24LysArg: 3.24 ± 0.081	5.368LysSer: 5.368 ± 0.104	3.814LysThr: 3.814 ± 0.078	4.27LysVal: 4.27 ± 0.095	0.639LysTrp: 0.639 ± 0.031	3.077LysTyr: 3.077 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.162LeuAla: 5.162 ± 0.106	0.866LeuCys: 0.866 ± 0.032	5.515LeuAsp: 5.515 ± 0.102	5.827LeuGlu: 5.827 ± 0.099	4.204LeuPhe: 4.204 ± 0.092	5.43LeuGly: 5.43 ± 0.101	1.615LeuHis: 1.615 ± 0.049	8.104LeuIle: 8.104 ± 0.119	6.897LeuLys: 6.897 ± 0.113	8.713LeuLeu: 8.713 ± 0.14	2.101LeuMet: 2.101 ± 0.06	5.336LeuAsn: 5.336 ± 0.093	3.416LeuPro: 3.416 ± 0.075	2.656LeuGln: 2.656 ± 0.066	3.85LeuArg: 3.85 ± 0.079	8.064LeuSer: 8.064 ± 0.127	4.743LeuThr: 4.743 ± 0.082	5.943LeuVal: 5.943 ± 0.095	0.729LeuTrp: 0.729 ± 0.029	3.052LeuTyr: 3.052 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	1.401MetAla: 1.401 ± 0.05	0.191MetCys: 0.191 ± 0.017	1.368MetAsp: 1.368 ± 0.042	1.249MetGlu: 1.249 ± 0.041	0.951MetPhe: 0.951 ± 0.034	1.458MetGly: 1.458 ± 0.055	0.377MetHis: 0.377 ± 0.02	2.339MetIle: 2.339 ± 0.062	1.878MetLys: 1.878 ± 0.058	2.277MetLeu: 2.277 ± 0.063	0.723MetMet: 0.723 ± 0.039	1.61MetAsn: 1.61 ± 0.051	0.919MetPro: 0.919 ± 0.038	0.732MetGln: 0.732 ± 0.036	0.897MetArg: 0.897 ± 0.039	1.913MetSer: 1.913 ± 0.054	1.531MetThr: 1.531 ± 0.054	1.568MetVal: 1.568 ± 0.049	0.188MetTrp: 0.188 ± 0.018	0.736MetTyr: 0.736 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	2.915AsnAla: 2.915 ± 0.08	0.675AsnCys: 0.675 ± 0.032	3.437AsnAsp: 3.437 ± 0.087	3.855AsnGlu: 3.855 ± 0.091	2.599AsnPhe: 2.599 ± 0.064	3.465AsnGly: 3.465 ± 0.092	1.222AsnHis: 1.222 ± 0.046	5.519AsnIle: 5.519 ± 0.101	4.746AsnLys: 4.746 ± 0.093	5.836AsnLeu: 5.836 ± 0.103	1.571AsnMet: 1.571 ± 0.047	5.206AsnAsn: 5.206 ± 0.118	2.658AsnPro: 2.658 ± 0.072	2.478AsnGln: 2.478 ± 0.082	2.423AsnArg: 2.423 ± 0.072	5.442AsnSer: 5.442 ± 0.109	3.64AsnThr: 3.64 ± 0.1	3.495AsnVal: 3.495 ± 0.075	0.595AsnTrp: 0.595 ± 0.027	2.332AsnTyr: 2.332 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.682ProAla: 1.682 ± 0.059	0.348ProCys: 0.348 ± 0.022	2.183ProAsp: 2.183 ± 0.072	2.329ProGlu: 2.329 ± 0.069	1.819ProPhe: 1.819 ± 0.05	2.09ProGly: 2.09 ± 0.061	0.754ProHis: 0.754 ± 0.034	3.317ProIle: 3.317 ± 0.07	2.241ProLys: 2.241 ± 0.059	3.31ProLeu: 3.31 ± 0.077	0.769ProMet: 0.769 ± 0.034	2.201ProAsn: 2.201 ± 0.064	1.412ProPro: 1.412 ± 0.06	1.26ProGln: 1.26 ± 0.065	1.289ProArg: 1.289 ± 0.041	2.931ProSer: 2.931 ± 0.069	2.1ProThr: 2.1 ± 0.055	2.535ProVal: 2.535 ± 0.058	0.359ProTrp: 0.359 ± 0.025	1.398ProTyr: 1.398 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	1.495GlnAla: 1.495 ± 0.053	0.27GlnCys: 0.27 ± 0.023	1.61GlnAsp: 1.61 ± 0.051	1.856GlnGlu: 1.856 ± 0.067	1.28GlnPhe: 1.28 ± 0.044	1.66GlnGly: 1.66 ± 0.063	0.466GlnHis: 0.466 ± 0.027	3.139GlnIle: 3.139 ± 0.068	2.481GlnLys: 2.481 ± 0.061	2.569GlnLeu: 2.569 ± 0.068	0.869GlnMet: 0.869 ± 0.033	2.135GlnAsn: 2.135 ± 0.064	0.959GlnPro: 0.959 ± 0.054	1.318GlnGln: 1.318 ± 0.091	1.227GlnArg: 1.227 ± 0.04	2.598GlnSer: 2.598 ± 0.078	1.724GlnThr: 1.724 ± 0.058	1.808GlnVal: 1.808 ± 0.055	0.253GlnTrp: 0.253 ± 0.019	1.115GlnTyr: 1.115 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.71ArgAla: 1.71 ± 0.057	0.416ArgCys: 0.416 ± 0.023	2.22ArgAsp: 2.22 ± 0.054	2.754ArgGlu: 2.754 ± 0.062	1.904ArgPhe: 1.904 ± 0.052	2.11ArgGly: 2.11 ± 0.06	0.696ArgHis: 0.696 ± 0.031	4.154ArgIle: 4.154 ± 0.078	3.435ArgLys: 3.435 ± 0.07	3.728ArgLeu: 3.728 ± 0.085	1.106ArgMet: 1.106 ± 0.039	2.671ArgAsn: 2.671 ± 0.063	1.26ArgPro: 1.26 ± 0.051	1.245ArgGln: 1.245 ± 0.042	1.85ArgArg: 1.85 ± 0.058	2.518ArgSer: 2.518 ± 0.065	1.949ArgThr: 1.949 ± 0.055	2.241ArgVal: 2.241 ± 0.061	0.373ArgTrp: 0.373 ± 0.026	1.641ArgTyr: 1.641 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.571SerAla: 3.571 ± 0.08	0.805SerCys: 0.805 ± 0.042	4.262SerAsp: 4.262 ± 0.081	4.622SerGlu: 4.622 ± 0.09	3.757SerPhe: 3.757 ± 0.075	4.965SerGly: 4.965 ± 0.114	1.4SerHis: 1.4 ± 0.042	7.613SerIle: 7.613 ± 0.11	6.26SerLys: 6.26 ± 0.091	7.259SerLeu: 7.259 ± 0.117	2.043SerMet: 2.043 ± 0.058	5.668SerAsn: 5.668 ± 0.107	2.661SerPro: 2.661 ± 0.059	2.522SerGln: 2.522 ± 0.073	3.01SerArg: 3.01 ± 0.073	7.522SerSer: 7.522 ± 0.177	4.715SerThr: 4.715 ± 0.106	4.341SerVal: 4.341 ± 0.089	0.644SerTrp: 0.644 ± 0.03	2.642SerTyr: 2.642 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	2.833ThrAla: 2.833 ± 0.066	0.504ThrCys: 0.504 ± 0.028	2.86ThrAsp: 2.86 ± 0.07	3.127ThrGlu: 3.127 ± 0.068	2.516ThrPhe: 2.516 ± 0.054	3.782ThrGly: 3.782 ± 0.087	0.983ThrHis: 0.983 ± 0.036	5.433ThrIle: 5.433 ± 0.103	3.758ThrLys: 3.758 ± 0.073	4.927ThrLeu: 4.927 ± 0.08	1.33ThrMet: 1.33 ± 0.045	3.583ThrAsn: 3.583 ± 0.087	2.176ThrPro: 2.176 ± 0.064	1.549ThrGln: 1.549 ± 0.05	2.056ThrArg: 2.056 ± 0.057	4.474ThrSer: 4.474 ± 0.095	3.517ThrThr: 3.517 ± 0.106	3.145ThrVal: 3.145 ± 0.074	0.519ThrTrp: 0.519 ± 0.03	1.751ThrTyr: 1.751 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	3.526ValAla: 3.526 ± 0.079	0.681ValCys: 0.681 ± 0.03	3.673ValAsp: 3.673 ± 0.08	3.58ValGlu: 3.58 ± 0.082	2.772ValPhe: 2.772 ± 0.061	3.64ValGly: 3.64 ± 0.094	0.982ValHis: 0.982 ± 0.035	5.738ValIle: 5.738 ± 0.103	4.053ValLys: 4.053 ± 0.088	5.563ValLeu: 5.563 ± 0.11	1.397ValMet: 1.397 ± 0.043	3.427ValAsn: 3.427 ± 0.087	2.158ValPro: 2.158 ± 0.059	1.629ValGln: 1.629 ± 0.058	2.32ValArg: 2.32 ± 0.058	4.844ValSer: 4.844 ± 0.092	3.777ValThr: 3.777 ± 0.075	4.112ValVal: 4.112 ± 0.102	0.538ValTrp: 0.538 ± 0.032	2.249ValTyr: 2.249 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.378TrpAla: 0.378 ± 0.025	0.094TrpCys: 0.094 ± 0.011	0.446TrpAsp: 0.446 ± 0.027	0.4TrpGlu: 0.4 ± 0.021	0.478TrpPhe: 0.478 ± 0.034	0.501TrpGly: 0.501 ± 0.029	0.206TrpHis: 0.206 ± 0.019	1.023TrpIle: 1.023 ± 0.039	0.716TrpLys: 0.716 ± 0.036	0.9TrpLeu: 0.9 ± 0.036	0.251TrpMet: 0.251 ± 0.019	0.643TrpAsn: 0.643 ± 0.03	0.26TrpPro: 0.26 ± 0.022	0.256TrpGln: 0.256 ± 0.022	0.319TrpArg: 0.319 ± 0.02	0.561TrpSer: 0.561 ± 0.031	0.444TrpThr: 0.444 ± 0.026	0.504TrpVal: 0.504 ± 0.03	0.117TrpTrp: 0.117 ± 0.013	0.383TrpTyr: 0.383 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.737TyrAla: 1.737 ± 0.063	0.517TyrCys: 0.517 ± 0.03	2.35TyrAsp: 2.35 ± 0.064	2.228TyrGlu: 2.228 ± 0.052	1.952TyrPhe: 1.952 ± 0.056	2.377TyrGly: 2.377 ± 0.061	0.818TyrHis: 0.818 ± 0.032	2.654TyrIle: 2.654 ± 0.063	2.312TyrLys: 2.312 ± 0.065	3.706TyrLeu: 3.706 ± 0.089	0.7TyrMet: 0.7 ± 0.029	2.148TyrAsn: 2.148 ± 0.055	1.558TyrPro: 1.558 ± 0.052	1.116TyrGln: 1.116 ± 0.039	1.509TyrArg: 1.509 ± 0.041	2.979TyrSer: 2.979 ± 0.061	1.694TyrThr: 1.694 ± 0.044	2.221TyrVal: 2.221 ± 0.064	0.339TyrTrp: 0.339 ± 0.022	1.588TyrTyr: 1.588 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3135 proteins (684365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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