Amino acid dipepetide frequency for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.164AlaAla: 8.164 ± 0.098	0.938AlaCys: 0.938 ± 0.017	3.933AlaAsp: 3.933 ± 0.041	4.849AlaGlu: 4.849 ± 0.052	2.812AlaPhe: 2.812 ± 0.037	4.884AlaGly: 4.884 ± 0.062	1.667AlaHis: 1.667 ± 0.025	3.908AlaIle: 3.908 ± 0.044	4.571AlaLys: 4.571 ± 0.052	7.03AlaLeu: 7.03 ± 0.057	1.709AlaMet: 1.709 ± 0.024	2.865AlaAsn: 2.865 ± 0.032	4.514AlaPro: 4.514 ± 0.078	3.271AlaGln: 3.271 ± 0.043	3.685AlaArg: 3.685 ± 0.037	6.501AlaSer: 6.501 ± 0.064	4.948AlaThr: 4.948 ± 0.048	5.229AlaVal: 5.229 ± 0.047	0.767AlaTrp: 0.767 ± 0.019	2.009AlaTyr: 2.009 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.815CysAla: 0.815 ± 0.017	0.229CysCys: 0.229 ± 0.01	0.739CysAsp: 0.739 ± 0.016	0.664CysGlu: 0.664 ± 0.017	0.532CysPhe: 0.532 ± 0.013	0.937CysGly: 0.937 ± 0.022	0.309CysHis: 0.309 ± 0.011	0.731CysIle: 0.731 ± 0.016	0.588CysLys: 0.588 ± 0.015	1.229CysLeu: 1.229 ± 0.025	0.297CysMet: 0.297 ± 0.01	0.43CysAsn: 0.43 ± 0.011	0.579CysPro: 0.579 ± 0.015	0.427CysGln: 0.427 ± 0.012	0.592CysArg: 0.592 ± 0.014	0.877CysSer: 0.877 ± 0.02	0.648CysThr: 0.648 ± 0.016	0.913CysVal: 0.913 ± 0.019	0.152CysTrp: 0.152 ± 0.008	0.382CysTyr: 0.382 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.189AspAla: 4.189 ± 0.047	0.628AspCys: 0.628 ± 0.018	4.701AspAsp: 4.701 ± 0.061	4.759AspGlu: 4.759 ± 0.057	2.477AspPhe: 2.477 ± 0.032	3.718AspGly: 3.718 ± 0.052	1.355AspHis: 1.355 ± 0.031	3.272AspIle: 3.272 ± 0.037	3.52AspLys: 3.52 ± 0.037	5.15AspLeu: 5.15 ± 0.043	1.403AspMet: 1.403 ± 0.023	2.301AspAsn: 2.301 ± 0.031	2.975AspPro: 2.975 ± 0.033	1.921AspGln: 1.921 ± 0.025	2.672AspArg: 2.672 ± 0.041	4.698AspSer: 4.698 ± 0.051	3.446AspThr: 3.446 ± 0.037	3.959AspVal: 3.959 ± 0.047	0.704AspTrp: 0.704 ± 0.017	1.948AspTyr: 1.948 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	5.056GluAla: 5.056 ± 0.056	0.675GluCys: 0.675 ± 0.015	4.409GluAsp: 4.409 ± 0.058	6.357GluGlu: 6.357 ± 0.092	2.267GluPhe: 2.267 ± 0.032	3.611GluGly: 3.611 ± 0.039	1.394GluHis: 1.394 ± 0.025	3.333GluIle: 3.333 ± 0.034	4.486GluLys: 4.486 ± 0.053	5.526GluLeu: 5.526 ± 0.059	1.603GluMet: 1.603 ± 0.024	2.512GluAsn: 2.512 ± 0.032	2.704GluPro: 2.704 ± 0.046	2.679GluGln: 2.679 ± 0.034	3.354GluArg: 3.354 ± 0.043	4.628GluSer: 4.628 ± 0.054	3.902GluThr: 3.902 ± 0.062	3.971GluVal: 3.971 ± 0.044	0.774GluTrp: 0.774 ± 0.016	1.953GluTyr: 1.953 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	2.881PheAla: 2.881 ± 0.034	0.591PheCys: 0.591 ± 0.016	2.567PheAsp: 2.567 ± 0.027	2.367PheGlu: 2.367 ± 0.026	1.853PhePhe: 1.853 ± 0.032	2.893PheGly: 2.893 ± 0.038	0.873PheHis: 0.873 ± 0.016	1.843PheIle: 1.843 ± 0.027	1.988PheLys: 1.988 ± 0.028	3.483PheLeu: 3.483 ± 0.039	0.893PheMet: 0.893 ± 0.018	1.681PheAsn: 1.681 ± 0.026	1.776PhePro: 1.776 ± 0.026	1.424PheGln: 1.424 ± 0.025	1.695PheArg: 1.695 ± 0.023	3.271PheSer: 3.271 ± 0.032	2.153PheThr: 2.153 ± 0.032	2.84PheVal: 2.84 ± 0.031	0.557PheTrp: 0.557 ± 0.014	1.257PheTyr: 1.257 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	4.862GlyAla: 4.862 ± 0.062	0.757GlyCys: 0.757 ± 0.016	3.693GlyAsp: 3.693 ± 0.037	3.532GlyGlu: 3.532 ± 0.035	2.674GlyPhe: 2.674 ± 0.031	5.355GlyGly: 5.355 ± 0.079	1.685GlyHis: 1.685 ± 0.03	3.331GlyIle: 3.331 ± 0.042	3.597GlyLys: 3.597 ± 0.04	5.434GlyLeu: 5.434 ± 0.051	1.448GlyMet: 1.448 ± 0.027	2.653GlyAsn: 2.653 ± 0.042	2.758GlyPro: 2.758 ± 0.053	2.453GlyGln: 2.453 ± 0.046	2.991GlyArg: 2.991 ± 0.036	5.531GlySer: 5.531 ± 0.095	3.597GlyThr: 3.597 ± 0.065	4.439GlyVal: 4.439 ± 0.054	0.913GlyTrp: 0.913 ± 0.02	2.151GlyTyr: 2.151 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	1.544HisAla: 1.544 ± 0.024	0.296HisCys: 0.296 ± 0.01	1.293HisAsp: 1.293 ± 0.028	1.27HisGlu: 1.27 ± 0.022	0.944HisPhe: 0.944 ± 0.019	1.444HisGly: 1.444 ± 0.028	0.883HisHis: 0.883 ± 0.021	1.213HisIle: 1.213 ± 0.019	1.302HisLys: 1.302 ± 0.022	2.108HisLeu: 2.108 ± 0.028	0.619HisMet: 0.619 ± 0.015	1.024HisAsn: 1.024 ± 0.021	1.392HisPro: 1.392 ± 0.028	1.072HisGln: 1.072 ± 0.025	1.213HisArg: 1.213 ± 0.024	1.882HisSer: 1.882 ± 0.031	1.406HisThr: 1.406 ± 0.023	1.907HisVal: 1.907 ± 0.033	0.269HisTrp: 0.269 ± 0.009	0.77HisTyr: 0.77 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.76IleAla: 3.76 ± 0.035	0.756IleCys: 0.756 ± 0.018	3.109IleAsp: 3.109 ± 0.037	3.042IleGlu: 3.042 ± 0.038	2.034IlePhe: 2.034 ± 0.028	3.039IleGly: 3.039 ± 0.041	1.154IleHis: 1.154 ± 0.02	2.554IleIle: 2.554 ± 0.033	2.791IleLys: 2.791 ± 0.034	4.251IleLeu: 4.251 ± 0.048	1.164IleMet: 1.164 ± 0.021	2.102IleAsn: 2.102 ± 0.029	2.841IlePro: 2.841 ± 0.03	1.891IleGln: 1.891 ± 0.03	2.427IleArg: 2.427 ± 0.029	3.927IleSer: 3.927 ± 0.037	2.929IleThr: 2.929 ± 0.033	3.527IleVal: 3.527 ± 0.041	0.596IleTrp: 0.596 ± 0.014	1.517IleTyr: 1.517 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	4.345LysAla: 4.345 ± 0.046	0.625LysCys: 0.625 ± 0.015	3.493LysAsp: 3.493 ± 0.037	4.475LysGlu: 4.475 ± 0.056	2.007LysPhe: 2.007 ± 0.025	3.066LysGly: 3.066 ± 0.033	1.375LysHis: 1.375 ± 0.02	2.766LysIle: 2.766 ± 0.031	4.93LysLys: 4.93 ± 0.068	5.061LysLeu: 5.061 ± 0.041	1.408LysMet: 1.408 ± 0.022	2.445LysAsn: 2.445 ± 0.027	3.033LysPro: 3.033 ± 0.047	2.457LysGln: 2.457 ± 0.03	3.636LysArg: 3.636 ± 0.036	4.158LysSer: 4.158 ± 0.042	3.7LysThr: 3.7 ± 0.042	3.43LysVal: 3.43 ± 0.04	0.733LysTrp: 0.733 ± 0.017	1.867LysTyr: 1.867 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	7.148LeuAla: 7.148 ± 0.056	1.214LeuCys: 1.214 ± 0.021	5.251LeuAsp: 5.251 ± 0.045	5.67LeuGlu: 5.67 ± 0.05	3.519LeuPhe: 3.519 ± 0.041	5.407LeuGly: 5.407 ± 0.052	1.967LeuHis: 1.967 ± 0.025	3.917LeuIle: 3.917 ± 0.047	5.251LeuLys: 5.251 ± 0.055	8.029LeuLeu: 8.029 ± 0.073	1.919LeuMet: 1.919 ± 0.026	3.526LeuAsn: 3.526 ± 0.041	4.508LeuPro: 4.508 ± 0.046	3.705LeuGln: 3.705 ± 0.04	4.602LeuArg: 4.602 ± 0.046	7.009LeuSer: 7.009 ± 0.057	5.024LeuThr: 5.024 ± 0.054	5.861LeuVal: 5.861 ± 0.057	1.059LeuTrp: 1.059 ± 0.02	2.579LeuTyr: 2.579 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	1.98MetAla: 1.98 ± 0.027	0.28MetCys: 0.28 ± 0.011	1.433MetAsp: 1.433 ± 0.024	1.399MetGlu: 1.399 ± 0.027	0.899MetPhe: 0.899 ± 0.02	1.511MetGly: 1.511 ± 0.029	0.472MetHis: 0.472 ± 0.012	1.035MetIle: 1.035 ± 0.017	1.231MetLys: 1.231 ± 0.021	1.931MetLeu: 1.931 ± 0.028	0.594MetMet: 0.594 ± 0.015	0.894MetAsn: 0.894 ± 0.018	1.117MetPro: 1.117 ± 0.021	0.759MetGln: 0.759 ± 0.021	1.106MetArg: 1.106 ± 0.017	2.185MetSer: 2.185 ± 0.03	1.425MetThr: 1.425 ± 0.024	1.457MetVal: 1.457 ± 0.023	0.289MetTrp: 0.289 ± 0.009	0.656MetTyr: 0.656 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.83AsnAla: 2.83 ± 0.033	0.466AsnCys: 0.466 ± 0.014	2.337AsnAsp: 2.337 ± 0.032	2.262AsnGlu: 2.262 ± 0.026	1.503AsnPhe: 1.503 ± 0.022	2.887AsnGly: 2.887 ± 0.051	0.995AsnHis: 0.995 ± 0.019	2.142AsnIle: 2.142 ± 0.031	2.306AsnLys: 2.306 ± 0.032	3.464AsnLeu: 3.464 ± 0.035	1.062AsnMet: 1.062 ± 0.019	2.073AsnAsn: 2.073 ± 0.043	2.385AsnPro: 2.385 ± 0.035	1.525AsnGln: 1.525 ± 0.029	1.849AsnArg: 1.849 ± 0.024	3.23AsnSer: 3.23 ± 0.046	2.5AsnThr: 2.5 ± 0.036	2.757AsnVal: 2.757 ± 0.033	0.533AsnTrp: 0.533 ± 0.014	1.312AsnTyr: 1.312 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	4.286ProAla: 4.286 ± 0.063	0.448ProCys: 0.448 ± 0.014	2.808ProAsp: 2.808 ± 0.035	3.719ProGlu: 3.719 ± 0.049	1.916ProPhe: 1.916 ± 0.031	3.35ProGly: 3.35 ± 0.059	1.337ProHis: 1.337 ± 0.026	2.397ProIle: 2.397 ± 0.029	3.054ProLys: 3.054 ± 0.041	4.182ProLeu: 4.182 ± 0.041	0.995ProMet: 0.995 ± 0.023	2.03ProAsn: 2.03 ± 0.033	4.054ProPro: 4.054 ± 0.096	2.603ProGln: 2.603 ± 0.047	2.512ProArg: 2.512 ± 0.035	4.874ProSer: 4.874 ± 0.062	3.623ProThr: 3.623 ± 0.061	3.963ProVal: 3.963 ± 0.055	0.557ProTrp: 0.557 ± 0.013	1.434ProTyr: 1.434 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.067GlnAla: 3.067 ± 0.046	0.445GlnCys: 0.445 ± 0.013	1.881GlnAsp: 1.881 ± 0.028	2.431GlnGlu: 2.431 ± 0.036	1.594GlnPhe: 1.594 ± 0.023	2.424GlnGly: 2.424 ± 0.05	1.152GlnHis: 1.152 ± 0.029	2.03GlnIle: 2.03 ± 0.026	2.475GlnLys: 2.475 ± 0.031	3.907GlnLeu: 3.907 ± 0.039	1.083GlnMet: 1.083 ± 0.023	1.619GlnAsn: 1.619 ± 0.027	2.173GlnPro: 2.173 ± 0.04	3.691GlnGln: 3.691 ± 0.134	2.21GlnArg: 2.21 ± 0.028	2.932GlnSer: 2.932 ± 0.04	2.488GlnThr: 2.488 ± 0.041	2.503GlnVal: 2.503 ± 0.033	0.524GlnTrp: 0.524 ± 0.013	1.29GlnTyr: 1.29 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	3.67ArgAla: 3.67 ± 0.037	0.503ArgCys: 0.503 ± 0.017	3.362ArgAsp: 3.362 ± 0.052	3.427ArgGlu: 3.427 ± 0.046	1.992ArgPhe: 1.992 ± 0.026	3.023ArgGly: 3.023 ± 0.038	1.352ArgHis: 1.352 ± 0.02	2.385ArgIle: 2.385 ± 0.032	3.245ArgLys: 3.245 ± 0.041	4.609ArgLeu: 4.609 ± 0.044	1.104ArgMet: 1.104 ± 0.021	2.028ArgAsn: 2.028 ± 0.024	2.378ArgPro: 2.378 ± 0.031	2.39ArgGln: 2.39 ± 0.033	3.471ArgArg: 3.471 ± 0.039	3.607ArgSer: 3.607 ± 0.043	2.485ArgThr: 2.485 ± 0.03	3.27ArgVal: 3.27 ± 0.037	0.582ArgTrp: 0.582 ± 0.014	1.565ArgTyr: 1.565 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.305SerAla: 6.305 ± 0.067	0.837SerCys: 0.837 ± 0.02	4.761SerAsp: 4.761 ± 0.056	4.698SerGlu: 4.698 ± 0.054	3.026SerPhe: 3.026 ± 0.037	5.469SerGly: 5.469 ± 0.083	2.0SerHis: 2.0 ± 0.033	3.902SerIle: 3.902 ± 0.041	4.315SerLys: 4.315 ± 0.048	6.966SerLeu: 6.966 ± 0.059	1.697SerMet: 1.697 ± 0.024	3.237SerAsn: 3.237 ± 0.041	4.913SerPro: 4.913 ± 0.065	3.202SerGln: 3.202 ± 0.041	4.378SerArg: 4.378 ± 0.054	8.835SerSer: 8.835 ± 0.153	5.594SerThr: 5.594 ± 0.082	5.26SerVal: 5.26 ± 0.052	0.869SerTrp: 0.869 ± 0.019	2.149SerTyr: 2.149 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	4.808ThrAla: 4.808 ± 0.053	0.788ThrCys: 0.788 ± 0.017	3.147ThrAsp: 3.147 ± 0.036	3.45ThrGlu: 3.45 ± 0.045	2.214ThrPhe: 2.214 ± 0.029	3.947ThrGly: 3.947 ± 0.091	1.434ThrHis: 1.434 ± 0.029	2.979ThrIle: 2.979 ± 0.032	3.335ThrLys: 3.335 ± 0.039	5.306ThrLeu: 5.306 ± 0.051	1.191ThrMet: 1.191 ± 0.021	2.49ThrAsn: 2.49 ± 0.036	4.433ThrPro: 4.433 ± 0.067	2.433ThrGln: 2.433 ± 0.037	2.811ThrArg: 2.811 ± 0.033	5.382ThrSer: 5.382 ± 0.089	4.412ThrThr: 4.412 ± 0.081	4.27ThrVal: 4.27 ± 0.056	0.69ThrTrp: 0.69 ± 0.016	1.626ThrTyr: 1.626 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	5.652ValAla: 5.652 ± 0.045	0.976ValCys: 0.976 ± 0.019	4.209ValAsp: 4.209 ± 0.045	4.44ValGlu: 4.44 ± 0.05	2.786ValPhe: 2.786 ± 0.03	4.022ValGly: 4.022 ± 0.039	1.428ValHis: 1.428 ± 0.021	3.375ValIle: 3.375 ± 0.045	3.652ValLys: 3.652 ± 0.041	5.629ValLeu: 5.629 ± 0.051	1.42ValMet: 1.42 ± 0.021	2.509ValAsn: 2.509 ± 0.026	3.77ValPro: 3.77 ± 0.061	2.444ValGln: 2.444 ± 0.03	3.06ValArg: 3.06 ± 0.036	5.699ValSer: 5.699 ± 0.05	4.316ValThr: 4.316 ± 0.089	5.061ValVal: 5.061 ± 0.07	0.79ValTrp: 0.79 ± 0.017	2.069ValTyr: 2.069 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.852TrpAla: 0.852 ± 0.017	0.19TrpCys: 0.19 ± 0.007	0.716TrpAsp: 0.716 ± 0.017	0.638TrpGlu: 0.638 ± 0.014	0.519TrpPhe: 0.519 ± 0.016	0.787TrpGly: 0.787 ± 0.019	0.259TrpHis: 0.259 ± 0.01	0.711TrpIle: 0.711 ± 0.015	0.795TrpLys: 0.795 ± 0.016	1.081TrpLeu: 1.081 ± 0.023	0.343TrpMet: 0.343 ± 0.01	0.627TrpAsn: 0.627 ± 0.015	0.388TrpPro: 0.388 ± 0.01	0.416TrpGln: 0.416 ± 0.012	0.68TrpArg: 0.68 ± 0.016	0.875TrpSer: 0.875 ± 0.02	0.751TrpThr: 0.751 ± 0.017	0.751TrpVal: 0.751 ± 0.016	0.252TrpTrp: 0.252 ± 0.009	0.377TrpTyr: 0.377 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.042TyrAla: 2.042 ± 0.028	0.428TyrCys: 0.428 ± 0.013	1.952TyrAsp: 1.952 ± 0.029	1.746TyrGlu: 1.746 ± 0.027	1.317TyrPhe: 1.317 ± 0.024	2.081TyrGly: 2.081 ± 0.03	0.76TyrHis: 0.76 ± 0.016	1.588TyrIle: 1.588 ± 0.025	1.58TyrLys: 1.58 ± 0.024	2.786TyrLeu: 2.786 ± 0.035	0.702TyrMet: 0.702 ± 0.016	1.373TyrAsn: 1.373 ± 0.022	1.449TyrPro: 1.449 ± 0.028	1.153TyrGln: 1.153 ± 0.019	1.504TyrArg: 1.504 ± 0.025	2.314TyrSer: 2.314 ± 0.03	1.799TyrThr: 1.799 ± 0.026	1.939TyrVal: 1.939 ± 0.027	0.398TyrTrp: 0.398 ± 0.012	1.141TyrTyr: 1.141 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6454 proteins (3123758 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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