Amino acid dipepetide frequency for Nile crocodilepox virus (isolate Crocodylus niloticus/Zimbabwe/Ume/2001) (CRV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.089AlaAla: 12.089 ± 1.296
1.71AlaCys: 1.71 ± 0.168
4.896AlaAsp: 4.896 ± 0.411
5.315AlaGlu: 5.315 ± 0.451
3.521AlaPhe: 3.521 ± 0.28
5.684AlaGly: 5.684 ± 0.412
1.04AlaHis: 1.04 ± 0.119
3.236AlaIle: 3.236 ± 0.264
2.565AlaLys: 2.565 ± 0.248
7.998AlaLeu: 7.998 ± 0.556
1.693AlaMet: 1.693 ± 0.171
3.219AlaAsn: 3.219 ± 0.321
5.433AlaPro: 5.433 ± 0.648
1.509AlaGln: 1.509 ± 0.169
8.736AlaArg: 8.736 ± 0.665
5.751AlaSer: 5.751 ± 0.562
4.46AlaThr: 4.46 ± 0.268
7.059AlaVal: 7.059 ± 0.397
0.52AlaTrp: 0.52 ± 0.102
2.767AlaTyr: 2.767 ± 0.247
0.0AlaXaa: 0.0 ± 0.0
Cys
1.425CysAla: 1.425 ± 0.161
0.721CysCys: 0.721 ± 0.119
1.358CysAsp: 1.358 ± 0.135
0.973CysGlu: 0.973 ± 0.097
1.123CysPhe: 1.123 ± 0.136
1.224CysGly: 1.224 ± 0.128
0.553CysHis: 0.553 ± 0.11
0.62CysIle: 0.62 ± 0.099
0.738CysLys: 0.738 ± 0.105
2.297CysLeu: 2.297 ± 0.203
0.319CysMet: 0.319 ± 0.077
0.755CysAsn: 0.755 ± 0.113
0.989CysPro: 0.989 ± 0.15
0.57CysGln: 0.57 ± 0.098
1.979CysArg: 1.979 ± 0.212
1.693CysSer: 1.693 ± 0.156
0.788CysThr: 0.788 ± 0.12
2.012CysVal: 2.012 ± 0.241
0.252CysTrp: 0.252 ± 0.068
0.738CysTyr: 0.738 ± 0.097
0.0CysXaa: 0.0 ± 0.0
Asp
6.321AspAla: 6.321 ± 0.591
1.023AspCys: 1.023 ± 0.145
4.292AspAsp: 4.292 ± 0.344
3.706AspGlu: 3.706 ± 0.268
2.834AspPhe: 2.834 ± 0.27
4.41AspGly: 4.41 ± 0.291
1.14AspHis: 1.14 ± 0.146
2.465AspIle: 2.465 ± 0.23
2.23AspLys: 2.23 ± 0.227
6.439AspLeu: 6.439 ± 0.416
0.989AspMet: 0.989 ± 0.12
1.861AspAsn: 1.861 ± 0.201
3.638AspPro: 3.638 ± 0.255
1.492AspGln: 1.492 ± 0.189
4.292AspArg: 4.292 ± 0.29
4.292AspSer: 4.292 ± 0.373
2.23AspThr: 2.23 ± 0.236
5.349AspVal: 5.349 ± 0.348
0.402AspTrp: 0.402 ± 0.092
2.549AspTyr: 2.549 ± 0.258
0.0AspXaa: 0.0 ± 0.0
Glu
4.577GluAla: 4.577 ± 0.361
0.905GluCys: 0.905 ± 0.129
3.974GluAsp: 3.974 ± 0.313
4.158GluGlu: 4.158 ± 0.261
2.347GluPhe: 2.347 ± 0.253
2.331GluGly: 2.331 ± 0.23
1.274GluHis: 1.274 ± 0.126
3.806GluIle: 3.806 ± 0.265
2.314GluLys: 2.314 ± 0.258
5.634GluLeu: 5.634 ± 0.291
1.291GluMet: 1.291 ± 0.165
2.532GluAsn: 2.532 ± 0.204
2.616GluPro: 2.616 ± 0.2
1.241GluGln: 1.241 ± 0.147
4.913GluArg: 4.913 ± 0.33
3.622GluSer: 3.622 ± 0.349
3.253GluThr: 3.253 ± 0.196
3.806GluVal: 3.806 ± 0.268
0.419GluTrp: 0.419 ± 0.076
2.599GluTyr: 2.599 ± 0.228
0.0GluXaa: 0.0 ± 0.0
Phe
3.571PheAla: 3.571 ± 0.248
1.241PheCys: 1.241 ± 0.167
2.716PheAsp: 2.716 ± 0.269
2.331PheGlu: 2.331 ± 0.217
2.197PhePhe: 2.197 ± 0.245
2.599PheGly: 2.599 ± 0.187
0.838PheHis: 0.838 ± 0.118
1.861PheIle: 1.861 ± 0.196
1.626PheLys: 1.626 ± 0.162
4.712PheLeu: 4.712 ± 0.345
0.721PheMet: 0.721 ± 0.11
1.878PheAsn: 1.878 ± 0.202
2.331PhePro: 2.331 ± 0.175
0.838PheGln: 0.838 ± 0.121
3.773PheArg: 3.773 ± 0.33
3.94PheSer: 3.94 ± 0.24
2.029PheThr: 2.029 ± 0.19
4.225PheVal: 4.225 ± 0.285
0.486PheTrp: 0.486 ± 0.09
2.129PheTyr: 2.129 ± 0.219
0.0PheXaa: 0.0 ± 0.0
Gly
5.265GlyAla: 5.265 ± 0.384
1.123GlyCys: 1.123 ± 0.116
4.024GlyAsp: 4.024 ± 0.334
3.203GlyGlu: 3.203 ± 0.223
2.532GlyPhe: 2.532 ± 0.202
4.728GlyGly: 4.728 ± 0.581
1.19GlyHis: 1.19 ± 0.145
2.163GlyIle: 2.163 ± 0.236
2.096GlyLys: 2.096 ± 0.211
4.695GlyLeu: 4.695 ± 0.365
0.939GlyMet: 0.939 ± 0.152
2.414GlyAsn: 2.414 ± 0.236
2.918GlyPro: 2.918 ± 0.315
1.408GlyGln: 1.408 ± 0.168
5.483GlyArg: 5.483 ± 0.405
4.779GlySer: 4.779 ± 0.46
2.565GlyThr: 2.565 ± 0.278
3.823GlyVal: 3.823 ± 0.304
0.268GlyTrp: 0.268 ± 0.082
2.331GlyTyr: 2.331 ± 0.277
0.0GlyXaa: 0.0 ± 0.0
His
1.291HisAla: 1.291 ± 0.167
0.57HisCys: 0.57 ± 0.102
1.174HisAsp: 1.174 ± 0.134
0.922HisGlu: 0.922 ± 0.146
0.805HisPhe: 0.805 ± 0.124
1.325HisGly: 1.325 ± 0.137
0.537HisHis: 0.537 ± 0.103
0.922HisIle: 0.922 ± 0.117
0.486HisLys: 0.486 ± 0.101
1.861HisLeu: 1.861 ± 0.152
0.319HisMet: 0.319 ± 0.082
0.855HisAsn: 0.855 ± 0.124
0.956HisPro: 0.956 ± 0.129
0.637HisGln: 0.637 ± 0.105
1.61HisArg: 1.61 ± 0.157
0.704HisSer: 0.704 ± 0.121
0.755HisThr: 0.755 ± 0.102
1.828HisVal: 1.828 ± 0.187
0.201HisTrp: 0.201 ± 0.051
0.805HisTyr: 0.805 ± 0.107
0.0HisXaa: 0.0 ± 0.0
Ile
3.706IleAla: 3.706 ± 0.203
0.973IleCys: 0.973 ± 0.133
3.203IleAsp: 3.203 ± 0.245
2.716IleGlu: 2.716 ± 0.215
2.364IlePhe: 2.364 ± 0.232
2.096IleGly: 2.096 ± 0.169
0.755IleHis: 0.755 ± 0.112
2.23IleIle: 2.23 ± 0.254
2.297IleLys: 2.297 ± 0.286
4.209IleLeu: 4.209 ± 0.333
0.788IleMet: 0.788 ± 0.1
2.532IleAsn: 2.532 ± 0.264
1.811IlePro: 1.811 ± 0.203
0.973IleGln: 0.973 ± 0.171
2.599IleArg: 2.599 ± 0.218
3.521IleSer: 3.521 ± 0.31
2.297IleThr: 2.297 ± 0.241
3.421IleVal: 3.421 ± 0.252
0.235IleTrp: 0.235 ± 0.065
2.163IleTyr: 2.163 ± 0.203
0.0IleXaa: 0.0 ± 0.0
Lys
2.046LysAla: 2.046 ± 0.218
0.637LysCys: 0.637 ± 0.111
1.811LysAsp: 1.811 ± 0.189
1.979LysGlu: 1.979 ± 0.22
1.744LysPhe: 1.744 ± 0.229
1.123LysGly: 1.123 ± 0.148
1.291LysHis: 1.291 ± 0.148
2.515LysIle: 2.515 ± 0.315
2.565LysLys: 2.565 ± 0.284
3.84LysLeu: 3.84 ± 0.288
1.14LysMet: 1.14 ± 0.163
1.945LysAsn: 1.945 ± 0.189
1.526LysPro: 1.526 ± 0.191
0.822LysGln: 0.822 ± 0.138
2.951LysArg: 2.951 ± 0.2
2.666LysSer: 2.666 ± 0.225
2.431LysThr: 2.431 ± 0.203
2.197LysVal: 2.197 ± 0.236
0.168LysTrp: 0.168 ± 0.05
1.71LysTyr: 1.71 ± 0.201
0.0LysXaa: 0.0 ± 0.0
Leu
9.038LeuAla: 9.038 ± 0.635
1.945LeuCys: 1.945 ± 0.193
6.07LeuAsp: 6.07 ± 0.345
6.237LeuGlu: 6.237 ± 0.413
4.41LeuPhe: 4.41 ± 0.314
5.718LeuGly: 5.718 ± 0.313
1.291LeuHis: 1.291 ± 0.158
4.812LeuIle: 4.812 ± 0.264
3.789LeuLys: 3.789 ± 0.281
9.759LeuLeu: 9.759 ± 0.527
2.079LeuMet: 2.079 ± 0.157
3.706LeuAsn: 3.706 ± 0.277
5.651LeuPro: 5.651 ± 0.417
2.213LeuGln: 2.213 ± 0.174
7.881LeuArg: 7.881 ± 0.466
6.774LeuSer: 6.774 ± 0.357
5.131LeuThr: 5.131 ± 0.297
6.757LeuVal: 6.757 ± 0.426
0.587LeuTrp: 0.587 ± 0.094
3.555LeuTyr: 3.555 ± 0.211
0.0LeuXaa: 0.0 ± 0.0
Met
1.274MetAla: 1.274 ± 0.171
0.285MetCys: 0.285 ± 0.072
1.19MetAsp: 1.19 ± 0.12
1.107MetGlu: 1.107 ± 0.152
0.805MetPhe: 0.805 ± 0.112
0.872MetGly: 0.872 ± 0.118
0.302MetHis: 0.302 ± 0.079
1.224MetIle: 1.224 ± 0.146
0.755MetLys: 0.755 ± 0.107
2.079MetLeu: 2.079 ± 0.163
0.52MetMet: 0.52 ± 0.115
0.788MetAsn: 0.788 ± 0.12
0.922MetPro: 0.922 ± 0.105
0.369MetGln: 0.369 ± 0.088
1.392MetArg: 1.392 ± 0.179
1.828MetSer: 1.828 ± 0.16
1.073MetThr: 1.073 ± 0.139
1.258MetVal: 1.258 ± 0.163
0.117MetTrp: 0.117 ± 0.045
0.637MetTyr: 0.637 ± 0.111
0.0MetXaa: 0.0 ± 0.0
Asn
3.337AsnAla: 3.337 ± 0.249
0.721AsnCys: 0.721 ± 0.129
2.163AsnAsp: 2.163 ± 0.215
2.113AsnGlu: 2.113 ± 0.205
2.113AsnPhe: 2.113 ± 0.21
2.213AsnGly: 2.213 ± 0.188
0.738AsnHis: 0.738 ± 0.117
2.264AsnIle: 2.264 ± 0.318
1.878AsnLys: 1.878 ± 0.238
3.706AsnLeu: 3.706 ± 0.26
0.553AsnMet: 0.553 ± 0.105
2.096AsnAsn: 2.096 ± 0.262
1.995AsnPro: 1.995 ± 0.3
1.157AsnGln: 1.157 ± 0.272
2.599AsnArg: 2.599 ± 0.207
2.549AsnSer: 2.549 ± 0.199
1.626AsnThr: 1.626 ± 0.187
3.437AsnVal: 3.437 ± 0.261
0.268AsnTrp: 0.268 ± 0.064
1.911AsnTyr: 1.911 ± 0.235
0.0AsnXaa: 0.0 ± 0.0
Pro
5.869ProAla: 5.869 ± 0.747
1.107ProCys: 1.107 ± 0.143
3.722ProAsp: 3.722 ± 0.248
3.421ProGlu: 3.421 ± 0.273
1.962ProPhe: 1.962 ± 0.163
3.622ProGly: 3.622 ± 0.39
0.939ProHis: 0.939 ± 0.113
1.777ProIle: 1.777 ± 0.21
1.459ProLys: 1.459 ± 0.175
4.292ProLeu: 4.292 ± 0.259
0.704ProMet: 0.704 ± 0.105
1.794ProAsn: 1.794 ± 0.295
5.433ProPro: 5.433 ± 1.007
1.325ProGln: 1.325 ± 0.178
5.181ProArg: 5.181 ± 0.715
3.974ProSer: 3.974 ± 0.39
2.381ProThr: 2.381 ± 0.182
4.276ProVal: 4.276 ± 0.54
0.587ProTrp: 0.587 ± 0.096
1.258ProTyr: 1.258 ± 0.165
0.0ProXaa: 0.0 ± 0.0
Gln
1.509GlnAla: 1.509 ± 0.201
0.369GlnCys: 0.369 ± 0.097
1.241GlnAsp: 1.241 ± 0.17
1.274GlnGlu: 1.274 ± 0.147
0.939GlnPhe: 0.939 ± 0.142
1.056GlnGly: 1.056 ± 0.207
0.503GlnHis: 0.503 ± 0.114
1.123GlnIle: 1.123 ± 0.139
0.889GlnLys: 0.889 ± 0.121
2.448GlnLeu: 2.448 ± 0.188
0.654GlnMet: 0.654 ± 0.099
0.939GlnAsn: 0.939 ± 0.129
1.593GlnPro: 1.593 ± 0.481
0.788GlnGln: 0.788 ± 0.128
1.962GlnArg: 1.962 ± 0.172
1.442GlnSer: 1.442 ± 0.161
1.341GlnThr: 1.341 ± 0.156
1.526GlnVal: 1.526 ± 0.16
0.101GlnTrp: 0.101 ± 0.04
0.939GlnTyr: 0.939 ± 0.152
0.0GlnXaa: 0.0 ± 0.0
Arg
7.998ArgAla: 7.998 ± 0.673
1.559ArgCys: 1.559 ± 0.167
4.829ArgAsp: 4.829 ± 0.273
4.795ArgGlu: 4.795 ± 0.324
4.46ArgPhe: 4.46 ± 0.298
4.611ArgGly: 4.611 ± 0.337
2.113ArgHis: 2.113 ± 0.206
2.968ArgIle: 2.968 ± 0.241
2.582ArgLys: 2.582 ± 0.225
8.769ArgLeu: 8.769 ± 0.513
1.241ArgMet: 1.241 ± 0.154
2.8ArgAsn: 2.8 ± 0.244
4.309ArgPro: 4.309 ± 0.394
2.23ArgGln: 2.23 ± 0.175
9.608ArgArg: 9.608 ± 0.757
6.338ArgSer: 6.338 ± 0.482
3.488ArgThr: 3.488 ± 0.247
6.958ArgVal: 6.958 ± 0.417
0.604ArgTrp: 0.604 ± 0.101
3.32ArgTyr: 3.32 ± 0.228
0.0ArgXaa: 0.0 ± 0.0
Ser
5.919SerAla: 5.919 ± 0.467
1.408SerCys: 1.408 ± 0.196
5.215SerAsp: 5.215 ± 0.475
3.622SerGlu: 3.622 ± 0.286
3.303SerPhe: 3.303 ± 0.208
4.896SerGly: 4.896 ± 0.552
1.107SerHis: 1.107 ± 0.141
3.186SerIle: 3.186 ± 0.265
2.666SerLys: 2.666 ± 0.255
7.461SerLeu: 7.461 ± 0.336
1.593SerMet: 1.593 ± 0.199
2.767SerAsn: 2.767 ± 0.233
4.125SerPro: 4.125 ± 0.397
1.576SerGln: 1.576 ± 0.153
6.791SerArg: 6.791 ± 0.426
8.35SerSer: 8.35 ± 1.131
3.387SerThr: 3.387 ± 0.242
5.449SerVal: 5.449 ± 0.308
0.419SerTrp: 0.419 ± 0.098
2.431SerTyr: 2.431 ± 0.165
0.0SerXaa: 0.0 ± 0.0
Thr
3.84ThrAla: 3.84 ± 0.26
1.241ThrCys: 1.241 ± 0.179
2.918ThrAsp: 2.918 ± 0.275
2.783ThrGlu: 2.783 ± 0.224
1.979ThrPhe: 1.979 ± 0.199
2.85ThrGly: 2.85 ± 0.29
0.838ThrHis: 0.838 ± 0.129
2.414ThrIle: 2.414 ± 0.211
1.308ThrLys: 1.308 ± 0.164
5.198ThrLeu: 5.198 ± 0.239
0.788ThrMet: 0.788 ± 0.111
1.543ThrAsn: 1.543 ± 0.171
2.565ThrPro: 2.565 ± 0.267
1.04ThrGln: 1.04 ± 0.143
3.722ThrArg: 3.722 ± 0.273
3.437ThrSer: 3.437 ± 0.24
2.448ThrThr: 2.448 ± 0.231
4.074ThrVal: 4.074 ± 0.272
0.436ThrTrp: 0.436 ± 0.079
2.129ThrTyr: 2.129 ± 0.203
0.0ThrXaa: 0.0 ± 0.0
Val
6.657ValAla: 6.657 ± 0.398
2.012ValCys: 2.012 ± 0.182
4.41ValAsp: 4.41 ± 0.331
4.779ValGlu: 4.779 ± 0.281
3.84ValPhe: 3.84 ± 0.306
4.007ValGly: 4.007 ± 0.251
1.14ValHis: 1.14 ± 0.167
3.471ValIle: 3.471 ± 0.283
3.203ValLys: 3.203 ± 0.348
6.556ValLeu: 6.556 ± 0.357
1.643ValMet: 1.643 ± 0.133
3.337ValAsn: 3.337 ± 0.242
4.343ValPro: 4.343 ± 0.451
1.442ValGln: 1.442 ± 0.188
6.355ValArg: 6.355 ± 0.38
6.606ValSer: 6.606 ± 0.289
4.024ValThr: 4.024 ± 0.231
5.952ValVal: 5.952 ± 0.405
0.352ValTrp: 0.352 ± 0.096
3.286ValTyr: 3.286 ± 0.232
0.0ValXaa: 0.0 ± 0.0
Trp
0.319TrpAla: 0.319 ± 0.078
0.218TrpCys: 0.218 ± 0.052
0.285TrpAsp: 0.285 ± 0.087
0.285TrpGlu: 0.285 ± 0.076
0.386TrpPhe: 0.386 ± 0.069
0.335TrpGly: 0.335 ± 0.07
0.084TrpHis: 0.084 ± 0.034
0.386TrpIle: 0.386 ± 0.08
0.268TrpLys: 0.268 ± 0.062
0.905TrpLeu: 0.905 ± 0.111
0.184TrpMet: 0.184 ± 0.044
0.235TrpAsn: 0.235 ± 0.064
0.419TrpPro: 0.419 ± 0.103
0.184TrpGln: 0.184 ± 0.055
0.654TrpArg: 0.654 ± 0.097
0.553TrpSer: 0.553 ± 0.082
0.268TrpThr: 0.268 ± 0.062
0.469TrpVal: 0.469 ± 0.118
0.05TrpTrp: 0.05 ± 0.028
0.268TrpTyr: 0.268 ± 0.056
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.152TyrAla: 3.152 ± 0.248
1.358TyrCys: 1.358 ± 0.135
2.465TyrAsp: 2.465 ± 0.246
1.895TyrGlu: 1.895 ± 0.202
2.381TyrPhe: 2.381 ± 0.187
2.247TyrGly: 2.247 ± 0.187
0.889TyrHis: 0.889 ± 0.118
1.442TyrIle: 1.442 ± 0.223
1.392TyrLys: 1.392 ± 0.171
4.544TyrLeu: 4.544 ± 0.283
0.62TyrMet: 0.62 ± 0.108
1.442TyrAsn: 1.442 ± 0.192
1.509TyrPro: 1.509 ± 0.181
0.822TyrGln: 0.822 ± 0.14
3.119TyrArg: 3.119 ± 0.261
2.85TyrSer: 2.85 ± 0.227
1.576TyrThr: 1.576 ± 0.194
3.538TyrVal: 3.538 ± 0.248
0.285TyrTrp: 0.285 ± 0.081
1.71TyrTyr: 1.71 ± 0.183
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 172 proteins (59641 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski