Amino acid dipepetide frequency for Propionibacteriaceae bacterium NML 150081

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.009AlaAla: 18.009 ± 0.224	0.868AlaCys: 0.868 ± 0.035	8.582AlaAsp: 8.582 ± 0.114	8.74AlaGlu: 8.74 ± 0.12	2.96AlaPhe: 2.96 ± 0.055	11.74AlaGly: 11.74 ± 0.135	2.322AlaHis: 2.322 ± 0.057	5.15AlaIle: 5.15 ± 0.079	2.69AlaLys: 2.69 ± 0.066	11.839AlaLeu: 11.839 ± 0.139	2.997AlaMet: 2.997 ± 0.061	2.423AlaAsn: 2.423 ± 0.058	5.932AlaPro: 5.932 ± 0.09	4.341AlaGln: 4.341 ± 0.073	7.743AlaArg: 7.743 ± 0.103	6.138AlaSer: 6.138 ± 0.08	7.224AlaThr: 7.224 ± 0.101	10.222AlaVal: 10.222 ± 0.123	2.044AlaTrp: 2.044 ± 0.053	2.785AlaTyr: 2.785 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.716CysAla: 0.716 ± 0.036	0.075CysCys: 0.075 ± 0.009	0.424CysAsp: 0.424 ± 0.022	0.364CysGlu: 0.364 ± 0.019	0.211CysPhe: 0.211 ± 0.015	0.77CysGly: 0.77 ± 0.034	0.209CysHis: 0.209 ± 0.016	0.244CysIle: 0.244 ± 0.017	0.078CysLys: 0.078 ± 0.011	0.635CysLeu: 0.635 ± 0.026	0.121CysMet: 0.121 ± 0.013	0.149CysAsn: 0.149 ± 0.013	0.415CysPro: 0.415 ± 0.022	0.241CysGln: 0.241 ± 0.017	0.517CysArg: 0.517 ± 0.024	0.431CysSer: 0.431 ± 0.022	0.408CysThr: 0.408 ± 0.02	0.518CysVal: 0.518 ± 0.023	0.108CysTrp: 0.108 ± 0.01	0.144CysTyr: 0.144 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.068AspAla: 7.068 ± 0.097	0.381AspCys: 0.381 ± 0.02	3.868AspAsp: 3.868 ± 0.088	4.199AspGlu: 4.199 ± 0.08	1.808AspPhe: 1.808 ± 0.039	5.857AspGly: 5.857 ± 0.097	1.712AspHis: 1.712 ± 0.054	2.159AspIle: 2.159 ± 0.05	1.15AspLys: 1.15 ± 0.039	7.215AspLeu: 7.215 ± 0.103	0.972AspMet: 0.972 ± 0.031	1.204AspAsn: 1.204 ± 0.041	4.976AspPro: 4.976 ± 0.073	2.74AspGln: 2.74 ± 0.06	4.849AspArg: 4.849 ± 0.086	2.834AspSer: 2.834 ± 0.054	2.98AspThr: 2.98 ± 0.068	4.497AspVal: 4.497 ± 0.067	1.088AspTrp: 1.088 ± 0.029	1.208AspTyr: 1.208 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.465GluAla: 7.465 ± 0.111	0.321GluCys: 0.321 ± 0.021	3.322GluAsp: 3.322 ± 0.07	3.544GluGlu: 3.544 ± 0.073	1.695GluPhe: 1.695 ± 0.054	4.444GluGly: 4.444 ± 0.076	1.451GluHis: 1.451 ± 0.039	2.613GluIle: 2.613 ± 0.062	1.241GluLys: 1.241 ± 0.04	7.277GluLeu: 7.277 ± 0.097	1.128GluMet: 1.128 ± 0.037	1.101GluAsn: 1.101 ± 0.038	3.688GluPro: 3.688 ± 0.074	2.894GluGln: 2.894 ± 0.064	4.715GluArg: 4.715 ± 0.079	2.872GluSer: 2.872 ± 0.068	2.9GluThr: 2.9 ± 0.066	5.668GluVal: 5.668 ± 0.085	0.842GluTrp: 0.842 ± 0.031	1.057GluTyr: 1.057 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.324PheAla: 3.324 ± 0.066	0.241PheCys: 0.241 ± 0.016	2.077PheAsp: 2.077 ± 0.058	1.612PheGlu: 1.612 ± 0.044	0.875PhePhe: 0.875 ± 0.031	3.148PheGly: 3.148 ± 0.057	0.585PheHis: 0.585 ± 0.023	1.017PheIle: 1.017 ± 0.039	0.458PheLys: 0.458 ± 0.027	2.567PheLeu: 2.567 ± 0.055	0.432PheMet: 0.432 ± 0.023	0.641PheAsn: 0.641 ± 0.027	1.239PhePro: 1.239 ± 0.033	0.828PheGln: 0.828 ± 0.033	1.549PheArg: 1.549 ± 0.041	1.566PheSer: 1.566 ± 0.037	1.901PheThr: 1.901 ± 0.053	2.345PheVal: 2.345 ± 0.045	0.484PheTrp: 0.484 ± 0.026	0.526PheTyr: 0.526 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.547GlyAla: 9.547 ± 0.111	0.754GlyCys: 0.754 ± 0.035	5.172GlyAsp: 5.172 ± 0.084	5.421GlyGlu: 5.421 ± 0.085	2.82GlyPhe: 2.82 ± 0.062	7.856GlyGly: 7.856 ± 0.112	2.067GlyHis: 2.067 ± 0.054	4.174GlyIle: 4.174 ± 0.072	2.229GlyLys: 2.229 ± 0.053	9.161GlyLeu: 9.161 ± 0.117	2.146GlyMet: 2.146 ± 0.052	1.906GlyAsn: 1.906 ± 0.06	4.469GlyPro: 4.469 ± 0.079	3.68GlyGln: 3.68 ± 0.089	6.286GlyArg: 6.286 ± 0.086	5.432GlySer: 5.432 ± 0.095	5.265GlyThr: 5.265 ± 0.096	7.615GlyVal: 7.615 ± 0.103	2.052GlyTrp: 2.052 ± 0.053	2.083GlyTyr: 2.083 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.33HisAla: 2.33 ± 0.053	0.2HisCys: 0.2 ± 0.015	1.54HisAsp: 1.54 ± 0.043	1.222HisGlu: 1.222 ± 0.039	0.568HisPhe: 0.568 ± 0.024	2.171HisGly: 2.171 ± 0.057	0.802HisHis: 0.802 ± 0.03	0.667HisIle: 0.667 ± 0.027	0.29HisLys: 0.29 ± 0.017	2.379HisLeu: 2.379 ± 0.057	0.31HisMet: 0.31 ± 0.02	0.453HisAsn: 0.453 ± 0.021	1.676HisPro: 1.676 ± 0.052	0.923HisGln: 0.923 ± 0.034	1.934HisArg: 1.934 ± 0.051	1.054HisSer: 1.054 ± 0.036	1.148HisThr: 1.148 ± 0.04	1.611HisVal: 1.611 ± 0.045	0.394HisTrp: 0.394 ± 0.022	0.452HisTyr: 0.452 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.655IleAla: 5.655 ± 0.084	0.362IleCys: 0.362 ± 0.021	3.225IleAsp: 3.225 ± 0.066	2.713IleGlu: 2.713 ± 0.057	1.141IlePhe: 1.141 ± 0.038	4.385IleGly: 4.385 ± 0.078	0.904IleHis: 0.904 ± 0.031	1.786IleIle: 1.786 ± 0.054	0.888IleLys: 0.888 ± 0.027	3.299IleLeu: 3.299 ± 0.076	0.709IleMet: 0.709 ± 0.031	1.05IleAsn: 1.05 ± 0.03	2.11IlePro: 2.11 ± 0.055	1.09IleGln: 1.09 ± 0.033	2.567IleArg: 2.567 ± 0.05	2.29IleSer: 2.29 ± 0.049	2.827IleThr: 2.827 ± 0.062	3.557IleVal: 3.557 ± 0.067	0.518IleTrp: 0.518 ± 0.025	0.734IleTyr: 0.734 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.429LysAla: 2.429 ± 0.059	0.071LysCys: 0.071 ± 0.008	1.112LysAsp: 1.112 ± 0.039	1.063LysGlu: 1.063 ± 0.043	0.569LysPhe: 0.569 ± 0.026	1.462LysGly: 1.462 ± 0.044	0.429LysHis: 0.429 ± 0.02	0.877LysIle: 0.877 ± 0.031	0.69LysLys: 0.69 ± 0.033	1.998LysLeu: 1.998 ± 0.054	0.429LysMet: 0.429 ± 0.021	0.452LysAsn: 0.452 ± 0.025	1.302LysPro: 1.302 ± 0.046	0.734LysGln: 0.734 ± 0.028	1.501LysArg: 1.501 ± 0.042	1.019LysSer: 1.019 ± 0.041	1.044LysThr: 1.044 ± 0.036	1.861LysVal: 1.861 ± 0.057	0.258LysTrp: 0.258 ± 0.016	0.454LysTyr: 0.454 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.317LeuAla: 14.317 ± 0.161	0.678LeuCys: 0.678 ± 0.032	6.151LeuAsp: 6.151 ± 0.087	5.242LeuGlu: 5.242 ± 0.073	2.334LeuPhe: 2.334 ± 0.059	8.905LeuGly: 8.905 ± 0.112	1.998LeuHis: 1.998 ± 0.058	4.064LeuIle: 4.064 ± 0.074	1.639LeuLys: 1.639 ± 0.044	9.881LeuLeu: 9.881 ± 0.15	1.835LeuMet: 1.835 ± 0.04	2.001LeuAsn: 2.001 ± 0.044	6.099LeuPro: 6.099 ± 0.097	2.938LeuGln: 2.938 ± 0.061	7.126LeuArg: 7.126 ± 0.124	5.656LeuSer: 5.656 ± 0.081	6.616LeuThr: 6.616 ± 0.084	9.318LeuVal: 9.318 ± 0.121	1.448LeuTrp: 1.448 ± 0.041	1.582LeuTyr: 1.582 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.712MetAla: 2.712 ± 0.056	0.133MetCys: 0.133 ± 0.012	0.987MetAsp: 0.987 ± 0.037	0.867MetGlu: 0.867 ± 0.031	0.539MetPhe: 0.539 ± 0.024	1.529MetGly: 1.529 ± 0.046	0.34MetHis: 0.34 ± 0.02	0.979MetIle: 0.979 ± 0.033	0.463MetLys: 0.463 ± 0.021	2.004MetLeu: 2.004 ± 0.048	0.454MetMet: 0.454 ± 0.024	0.494MetAsn: 0.494 ± 0.023	1.219MetPro: 1.219 ± 0.036	0.546MetGln: 0.546 ± 0.024	1.34MetArg: 1.34 ± 0.039	1.533MetSer: 1.533 ± 0.042	1.612MetThr: 1.612 ± 0.044	1.829MetVal: 1.829 ± 0.048	0.268MetTrp: 0.268 ± 0.017	0.352MetTyr: 0.352 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.298AsnAla: 2.298 ± 0.049	0.147AsnCys: 0.147 ± 0.014	1.232AsnAsp: 1.232 ± 0.042	1.097AsnGlu: 1.097 ± 0.04	0.604AsnPhe: 0.604 ± 0.025	2.018AsnGly: 2.018 ± 0.053	0.484AsnHis: 0.484 ± 0.024	0.798AsnIle: 0.798 ± 0.031	0.417AsnLys: 0.417 ± 0.022	2.033AsnLeu: 2.033 ± 0.045	0.379AsnMet: 0.379 ± 0.02	0.577AsnAsn: 0.577 ± 0.028	1.723AsnPro: 1.723 ± 0.051	0.854AsnGln: 0.854 ± 0.032	1.638AsnArg: 1.638 ± 0.045	1.067AsnSer: 1.067 ± 0.037	1.13AsnThr: 1.13 ± 0.035	1.539AsnVal: 1.539 ± 0.041	0.364AsnTrp: 0.364 ± 0.02	0.501AsnTyr: 0.501 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.346ProAla: 7.346 ± 0.104	0.241ProCys: 0.241 ± 0.017	4.621ProAsp: 4.621 ± 0.077	4.479ProGlu: 4.479 ± 0.075	1.472ProPhe: 1.472 ± 0.038	5.668ProGly: 5.668 ± 0.097	1.205ProHis: 1.205 ± 0.034	2.11ProIle: 2.11 ± 0.05	1.12ProLys: 1.12 ± 0.039	4.635ProLeu: 4.635 ± 0.079	1.107ProMet: 1.107 ± 0.033	1.203ProAsn: 1.203 ± 0.038	2.793ProPro: 2.793 ± 0.068	2.275ProGln: 2.275 ± 0.057	3.535ProArg: 3.535 ± 0.069	3.281ProSer: 3.281 ± 0.068	4.001ProThr: 4.001 ± 0.092	4.916ProVal: 4.916 ± 0.073	1.031ProTrp: 1.031 ± 0.039	1.147ProTyr: 1.147 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.674GlnAla: 4.674 ± 0.089	0.178GlnCys: 0.178 ± 0.016	1.598GlnAsp: 1.598 ± 0.038	1.761GlnGlu: 1.761 ± 0.047	0.885GlnPhe: 0.885 ± 0.03	2.749GlnGly: 2.749 ± 0.074	0.873GlnHis: 0.873 ± 0.032	1.685GlnIle: 1.685 ± 0.043	0.547GlnLys: 0.547 ± 0.026	4.337GlnLeu: 4.337 ± 0.078	0.678GlnMet: 0.678 ± 0.028	0.592GlnAsn: 0.592 ± 0.029	2.497GlnPro: 2.497 ± 0.059	2.15GlnGln: 2.15 ± 0.086	3.126GlnArg: 3.126 ± 0.073	1.637GlnSer: 1.637 ± 0.038	1.852GlnThr: 1.852 ± 0.047	3.43GlnVal: 3.43 ± 0.059	0.689GlnTrp: 0.689 ± 0.035	0.718GlnTyr: 0.718 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.733ArgAla: 7.733 ± 0.116	0.499ArgCys: 0.499 ± 0.025	4.129ArgAsp: 4.129 ± 0.073	4.105ArgGlu: 4.105 ± 0.072	2.112ArgPhe: 2.112 ± 0.052	5.325ArgGly: 5.325 ± 0.082	1.874ArgHis: 1.874 ± 0.053	3.444ArgIle: 3.444 ± 0.063	1.421ArgLys: 1.421 ± 0.042	7.281ArgLeu: 7.281 ± 0.115	1.63ArgMet: 1.63 ± 0.042	1.515ArgAsn: 1.515 ± 0.047	4.085ArgPro: 4.085 ± 0.068	2.764ArgGln: 2.764 ± 0.059	6.522ArgArg: 6.522 ± 0.116	4.071ArgSer: 4.071 ± 0.075	4.31ArgThr: 4.31 ± 0.078	5.43ArgVal: 5.43 ± 0.081	1.508ArgTrp: 1.508 ± 0.047	1.479ArgTyr: 1.479 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.16SerAla: 6.16 ± 0.085	0.34SerCys: 0.34 ± 0.022	3.171SerAsp: 3.171 ± 0.067	3.138SerGlu: 3.138 ± 0.067	1.682SerPhe: 1.682 ± 0.043	5.702SerGly: 5.702 ± 0.078	1.205SerHis: 1.205 ± 0.038	2.158SerIle: 2.158 ± 0.053	1.158SerLys: 1.158 ± 0.044	4.995SerLeu: 4.995 ± 0.077	1.313SerMet: 1.313 ± 0.037	1.229SerAsn: 1.229 ± 0.04	3.315SerPro: 3.315 ± 0.07	1.904SerGln: 1.904 ± 0.044	3.635SerArg: 3.635 ± 0.072	3.35SerSer: 3.35 ± 0.068	3.391SerThr: 3.391 ± 0.067	4.271SerVal: 4.271 ± 0.076	1.082SerTrp: 1.082 ± 0.037	1.208SerTyr: 1.208 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.328ThrAla: 7.328 ± 0.099	0.372ThrCys: 0.372 ± 0.021	4.085ThrAsp: 4.085 ± 0.073	3.659ThrGlu: 3.659 ± 0.067	1.662ThrPhe: 1.662 ± 0.049	5.991ThrGly: 5.991 ± 0.092	1.135ThrHis: 1.135 ± 0.04	2.684ThrIle: 2.684 ± 0.057	1.192ThrLys: 1.192 ± 0.034	5.331ThrLeu: 5.331 ± 0.075	1.161ThrMet: 1.161 ± 0.032	1.288ThrAsn: 1.288 ± 0.042	4.099ThrPro: 4.099 ± 0.089	1.63ThrGln: 1.63 ± 0.044	3.528ThrArg: 3.528 ± 0.068	3.517ThrSer: 3.517 ± 0.073	4.008ThrThr: 4.008 ± 0.098	5.464ThrVal: 5.464 ± 0.091	1.045ThrTrp: 1.045 ± 0.036	1.207ThrTyr: 1.207 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.093ValAla: 11.093 ± 0.129	0.622ValCys: 0.622 ± 0.03	5.286ValAsp: 5.286 ± 0.082	5.165ValGlu: 5.165 ± 0.083	2.187ValPhe: 2.187 ± 0.051	7.243ValGly: 7.243 ± 0.108	1.705ValHis: 1.705 ± 0.047	3.888ValIle: 3.888 ± 0.072	1.465ValLys: 1.465 ± 0.046	8.795ValLeu: 8.795 ± 0.124	1.787ValMet: 1.787 ± 0.047	1.772ValAsn: 1.772 ± 0.044	4.547ValPro: 4.547 ± 0.076	2.358ValGln: 2.358 ± 0.048	6.16ValArg: 6.16 ± 0.101	4.584ValSer: 4.584 ± 0.08	5.611ValThr: 5.611 ± 0.075	8.473ValVal: 8.473 ± 0.125	1.289ValTrp: 1.289 ± 0.039	1.305ValTyr: 1.305 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.721TrpAla: 1.721 ± 0.049	0.144TrpCys: 0.144 ± 0.012	0.918TrpAsp: 0.918 ± 0.03	0.751TrpGlu: 0.751 ± 0.031	0.609TrpPhe: 0.609 ± 0.027	1.286TrpGly: 1.286 ± 0.044	0.444TrpHis: 0.444 ± 0.025	0.705TrpIle: 0.705 ± 0.031	0.322TrpLys: 0.322 ± 0.019	2.127TrpLeu: 2.127 ± 0.061	0.336TrpMet: 0.336 ± 0.019	0.397TrpAsn: 0.397 ± 0.024	0.875TrpPro: 0.875 ± 0.034	1.03TrpGln: 1.03 ± 0.035	1.469TrpArg: 1.469 ± 0.048	1.068TrpSer: 1.068 ± 0.033	1.06TrpThr: 1.06 ± 0.04	1.289TrpVal: 1.289 ± 0.036	0.522TrpTrp: 0.522 ± 0.026	0.331TrpTyr: 0.331 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.825TyrAla: 2.825 ± 0.062	0.152TyrCys: 0.152 ± 0.012	1.266TyrAsp: 1.266 ± 0.05	1.099TyrGlu: 1.099 ± 0.037	0.68TyrPhe: 0.68 ± 0.027	1.888TyrGly: 1.888 ± 0.054	0.377TyrHis: 0.377 ± 0.019	0.61TyrIle: 0.61 ± 0.025	0.295TyrLys: 0.295 ± 0.019	2.039TyrLeu: 2.039 ± 0.051	0.275TyrMet: 0.275 ± 0.019	0.453TyrAsn: 0.453 ± 0.021	1.126TyrPro: 1.126 ± 0.043	0.734TyrGln: 0.734 ± 0.03	1.501TyrArg: 1.501 ± 0.04	1.008TyrSer: 1.008 ± 0.033	1.097TyrThr: 1.097 ± 0.04	1.481TyrVal: 1.481 ± 0.042	0.369TyrTrp: 0.369 ± 0.026	0.417TyrTyr: 0.417 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2661 proteins (906985 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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