Amino acid dipepetide frequency for Porphyromonas crevioricanis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.853AlaAla: 5.853 ± 0.131
0.827AlaCys: 0.827 ± 0.039
4.291AlaAsp: 4.291 ± 0.098
5.449AlaGlu: 5.449 ± 0.106
3.112AlaPhe: 3.112 ± 0.089
5.066AlaGly: 5.066 ± 0.099
1.514AlaHis: 1.514 ± 0.054
5.325AlaIle: 5.325 ± 0.105
4.594AlaLys: 4.594 ± 0.106
7.536AlaLeu: 7.536 ± 0.129
2.134AlaMet: 2.134 ± 0.061
2.841AlaAsn: 2.841 ± 0.08
2.55AlaPro: 2.55 ± 0.068
3.011AlaGln: 3.011 ± 0.072
3.585AlaArg: 3.585 ± 0.096
4.607AlaSer: 4.607 ± 0.093
3.771AlaThr: 3.771 ± 0.083
4.965AlaVal: 4.965 ± 0.095
0.626AlaTrp: 0.626 ± 0.036
2.958AlaTyr: 2.958 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.734CysAla: 0.734 ± 0.034
0.227CysCys: 0.227 ± 0.021
0.549CysAsp: 0.549 ± 0.032
0.626CysGlu: 0.626 ± 0.034
0.553CysPhe: 0.553 ± 0.032
0.973CysGly: 0.973 ± 0.045
0.332CysHis: 0.332 ± 0.025
0.831CysIle: 0.831 ± 0.041
0.605CysLys: 0.605 ± 0.03
1.21CysLeu: 1.21 ± 0.048
0.306CysMet: 0.306 ± 0.023
0.543CysAsn: 0.543 ± 0.029
0.628CysPro: 0.628 ± 0.035
0.368CysGln: 0.368 ± 0.025
0.808CysArg: 0.808 ± 0.034
1.055CysSer: 1.055 ± 0.054
0.621CysThr: 0.621 ± 0.034
0.644CysVal: 0.644 ± 0.036
0.139CysTrp: 0.139 ± 0.015
0.54CysTyr: 0.54 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.57AspAla: 3.57 ± 0.09
0.765AspCys: 0.765 ± 0.037
2.123AspAsp: 2.123 ± 0.064
3.683AspGlu: 3.683 ± 0.088
2.689AspPhe: 2.689 ± 0.068
3.528AspGly: 3.528 ± 0.092
0.945AspHis: 0.945 ± 0.041
3.945AspIle: 3.945 ± 0.086
3.694AspLys: 3.694 ± 0.077
5.825AspLeu: 5.825 ± 0.117
1.454AspMet: 1.454 ± 0.044
2.198AspAsn: 2.198 ± 0.06
2.226AspPro: 2.226 ± 0.064
1.482AspGln: 1.482 ± 0.048
3.21AspArg: 3.21 ± 0.074
3.231AspSer: 3.231 ± 0.083
2.615AspThr: 2.615 ± 0.069
3.325AspVal: 3.325 ± 0.081
0.731AspTrp: 0.731 ± 0.033
2.505AspTyr: 2.505 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
5.531GluAla: 5.531 ± 0.113
0.553GluCys: 0.553 ± 0.029
3.457GluAsp: 3.457 ± 0.074
5.735GluGlu: 5.735 ± 0.112
2.046GluPhe: 2.046 ± 0.065
4.718GluGly: 4.718 ± 0.1
1.393GluHis: 1.393 ± 0.051
4.746GluIle: 4.746 ± 0.097
4.818GluLys: 4.818 ± 0.1
6.944GluLeu: 6.944 ± 0.115
1.941GluMet: 1.941 ± 0.068
2.844GluAsn: 2.844 ± 0.088
1.976GluPro: 1.976 ± 0.055
3.295GluGln: 3.295 ± 0.073
4.07GluArg: 4.07 ± 0.094
3.5GluSer: 3.5 ± 0.081
3.174GluThr: 3.174 ± 0.074
4.589GluVal: 4.589 ± 0.099
0.666GluTrp: 0.666 ± 0.031
2.44GluTyr: 2.44 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.236PheAla: 3.236 ± 0.068
0.584PheCys: 0.584 ± 0.028
2.762PheAsp: 2.762 ± 0.073
2.435PheGlu: 2.435 ± 0.068
2.196PhePhe: 2.196 ± 0.081
3.05PheGly: 3.05 ± 0.077
0.754PheHis: 0.754 ± 0.03
2.311PheIle: 2.311 ± 0.072
1.858PheLys: 1.858 ± 0.068
4.123PheLeu: 4.123 ± 0.102
0.939PheMet: 0.939 ± 0.043
1.635PheAsn: 1.635 ± 0.058
1.699PhePro: 1.699 ± 0.057
0.968PheGln: 0.968 ± 0.044
2.214PheArg: 2.214 ± 0.061
3.704PheSer: 3.704 ± 0.078
2.002PheThr: 2.002 ± 0.061
3.356PheVal: 3.356 ± 0.076
0.482PheTrp: 0.482 ± 0.029
1.55PheTyr: 1.55 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.723GlyAla: 4.723 ± 0.112
1.063GlyCys: 1.063 ± 0.051
3.344GlyAsp: 3.344 ± 0.068
4.581GlyGlu: 4.581 ± 0.096
3.058GlyPhe: 3.058 ± 0.079
4.945GlyGly: 4.945 ± 0.118
1.402GlyHis: 1.402 ± 0.05
4.873GlyIle: 4.873 ± 0.086
5.122GlyLys: 5.122 ± 0.106
6.543GlyLeu: 6.543 ± 0.12
1.9GlyMet: 1.9 ± 0.065
2.657GlyAsn: 2.657 ± 0.074
1.437GlyPro: 1.437 ± 0.049
2.373GlyGln: 2.373 ± 0.062
3.866GlyArg: 3.866 ± 0.092
4.288GlySer: 4.288 ± 0.079
3.464GlyThr: 3.464 ± 0.082
4.448GlyVal: 4.448 ± 0.082
0.78GlyTrp: 0.78 ± 0.042
3.055GlyTyr: 3.055 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
1.141HisAla: 1.141 ± 0.043
0.379HisCys: 0.379 ± 0.026
0.757HisAsp: 0.757 ± 0.037
1.019HisGlu: 1.019 ± 0.041
1.027HisPhe: 1.027 ± 0.038
1.297HisGly: 1.297 ± 0.049
0.504HisHis: 0.504 ± 0.039
1.68HisIle: 1.68 ± 0.055
1.23HisLys: 1.23 ± 0.049
2.134HisLeu: 2.134 ± 0.057
0.437HisMet: 0.437 ± 0.026
0.881HisAsn: 0.881 ± 0.045
1.127HisPro: 1.127 ± 0.042
0.675HisGln: 0.675 ± 0.027
1.346HisArg: 1.346 ± 0.051
1.454HisSer: 1.454 ± 0.056
1.12HisThr: 1.12 ± 0.04
1.014HisVal: 1.014 ± 0.042
0.249HisTrp: 0.249 ± 0.021
0.965HisTyr: 0.965 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.743IleAla: 5.743 ± 0.102
0.926IleCys: 0.926 ± 0.039
4.561IleAsp: 4.561 ± 0.091
5.034IleGlu: 5.034 ± 0.106
2.523IlePhe: 2.523 ± 0.076
4.602IleGly: 4.602 ± 0.11
1.321IleHis: 1.321 ± 0.045
3.681IleIle: 3.681 ± 0.091
3.59IleLys: 3.59 ± 0.089
5.878IleLeu: 5.878 ± 0.113
1.22IleMet: 1.22 ± 0.043
2.734IleAsn: 2.734 ± 0.077
3.192IlePro: 3.192 ± 0.071
2.033IleGln: 2.033 ± 0.055
4.018IleArg: 4.018 ± 0.089
5.068IleSer: 5.068 ± 0.105
3.415IleThr: 3.415 ± 0.082
4.574IleVal: 4.574 ± 0.094
0.541IleTrp: 0.541 ± 0.031
2.509IleTyr: 2.509 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
4.694LysAla: 4.694 ± 0.097
0.424LysCys: 0.424 ± 0.026
3.24LysAsp: 3.24 ± 0.074
4.983LysGlu: 4.983 ± 0.098
1.743LysPhe: 1.743 ± 0.052
4.326LysGly: 4.326 ± 0.096
1.12LysHis: 1.12 ± 0.043
3.644LysIle: 3.644 ± 0.08
4.062LysLys: 4.062 ± 0.092
5.652LysLeu: 5.652 ± 0.102
1.789LysMet: 1.789 ± 0.054
2.554LysAsn: 2.554 ± 0.081
2.543LysPro: 2.543 ± 0.082
2.6LysGln: 2.6 ± 0.064
3.544LysArg: 3.544 ± 0.075
3.411LysSer: 3.411 ± 0.079
3.153LysThr: 3.153 ± 0.065
3.833LysVal: 3.833 ± 0.095
0.623LysTrp: 0.623 ± 0.035
2.25LysTyr: 2.25 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
7.263LeuAla: 7.263 ± 0.137
1.487LeuCys: 1.487 ± 0.054
5.212LeuAsp: 5.212 ± 0.117
5.655LeuGlu: 5.655 ± 0.095
4.819LeuPhe: 4.819 ± 0.108
6.528LeuGly: 6.528 ± 0.139
2.159LeuHis: 2.159 ± 0.067
6.196LeuIle: 6.196 ± 0.119
5.49LeuLys: 5.49 ± 0.1
11.215LeuLeu: 11.215 ± 0.204
2.469LeuMet: 2.469 ± 0.064
3.892LeuAsn: 3.892 ± 0.097
5.135LeuPro: 5.135 ± 0.102
3.634LeuGln: 3.634 ± 0.071
5.804LeuArg: 5.804 ± 0.107
9.137LeuSer: 9.137 ± 0.16
4.869LeuThr: 4.869 ± 0.089
5.622LeuVal: 5.622 ± 0.101
1.02LeuTrp: 1.02 ± 0.048
3.735LeuTyr: 3.735 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
2.17MetAla: 2.17 ± 0.062
0.229MetCys: 0.229 ± 0.021
1.424MetAsp: 1.424 ± 0.052
1.612MetGlu: 1.612 ± 0.057
0.661MetPhe: 0.661 ± 0.036
1.941MetGly: 1.941 ± 0.064
0.507MetHis: 0.507 ± 0.03
1.55MetIle: 1.55 ± 0.057
1.855MetLys: 1.855 ± 0.059
2.599MetLeu: 2.599 ± 0.08
0.677MetMet: 0.677 ± 0.035
1.174MetAsn: 1.174 ± 0.05
1.261MetPro: 1.261 ± 0.049
1.261MetGln: 1.261 ± 0.044
1.58MetArg: 1.58 ± 0.05
1.691MetSer: 1.691 ± 0.052
1.236MetThr: 1.236 ± 0.041
1.307MetVal: 1.307 ± 0.046
0.175MetTrp: 0.175 ± 0.015
0.644MetTyr: 0.644 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.883AsnAla: 2.883 ± 0.075
0.514AsnCys: 0.514 ± 0.03
1.869AsnAsp: 1.869 ± 0.062
2.499AsnGlu: 2.499 ± 0.074
1.581AsnPhe: 1.581 ± 0.053
2.836AsnGly: 2.836 ± 0.091
0.754AsnHis: 0.754 ± 0.034
2.867AsnIle: 2.867 ± 0.087
2.674AsnLys: 2.674 ± 0.068
3.83AsnLeu: 3.83 ± 0.104
1.063AsnMet: 1.063 ± 0.042
1.792AsnAsn: 1.792 ± 0.056
2.329AsnPro: 2.329 ± 0.072
1.217AsnGln: 1.217 ± 0.046
2.376AsnArg: 2.376 ± 0.06
2.419AsnSer: 2.419 ± 0.064
2.239AsnThr: 2.239 ± 0.063
2.46AsnVal: 2.46 ± 0.08
0.474AsnTrp: 0.474 ± 0.026
1.591AsnTyr: 1.591 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.872ProAla: 2.872 ± 0.082
0.433ProCys: 0.433 ± 0.025
2.515ProAsp: 2.515 ± 0.069
3.539ProGlu: 3.539 ± 0.084
1.815ProPhe: 1.815 ± 0.05
2.576ProGly: 2.576 ± 0.069
0.993ProHis: 0.993 ± 0.042
2.875ProIle: 2.875 ± 0.065
2.214ProLys: 2.214 ± 0.065
4.021ProLeu: 4.021 ± 0.096
1.048ProMet: 1.048 ± 0.042
1.778ProAsn: 1.778 ± 0.055
1.209ProPro: 1.209 ± 0.053
1.776ProGln: 1.776 ± 0.054
1.562ProArg: 1.562 ± 0.045
2.919ProSer: 2.919 ± 0.087
2.24ProThr: 2.24 ± 0.066
2.623ProVal: 2.623 ± 0.065
0.414ProTrp: 0.414 ± 0.033
1.675ProTyr: 1.675 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.025GlnAla: 3.025 ± 0.077
0.317GlnCys: 0.317 ± 0.025
1.869GlnAsp: 1.869 ± 0.054
2.77GlnGlu: 2.77 ± 0.074
1.177GlnPhe: 1.177 ± 0.043
2.296GlnGly: 2.296 ± 0.053
0.729GlnHis: 0.729 ± 0.035
2.682GlnIle: 2.682 ± 0.067
2.342GlnLys: 2.342 ± 0.062
3.802GlnLeu: 3.802 ± 0.079
1.176GlnMet: 1.176 ± 0.045
1.349GlnAsn: 1.349 ± 0.049
1.362GlnPro: 1.362 ± 0.048
1.751GlnGln: 1.751 ± 0.065
1.904GlnArg: 1.904 ± 0.051
2.222GlnSer: 2.222 ± 0.057
2.044GlnThr: 2.044 ± 0.057
2.304GlnVal: 2.304 ± 0.069
0.389GlnTrp: 0.389 ± 0.025
1.303GlnTyr: 1.303 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
3.616ArgAla: 3.616 ± 0.077
0.602ArgCys: 0.602 ± 0.034
2.514ArgAsp: 2.514 ± 0.067
3.874ArgGlu: 3.874 ± 0.09
2.308ArgPhe: 2.308 ± 0.057
3.032ArgGly: 3.032 ± 0.078
1.248ArgHis: 1.248 ± 0.046
4.595ArgIle: 4.595 ± 0.095
3.67ArgLys: 3.67 ± 0.079
5.977ArgLeu: 5.977 ± 0.114
1.76ArgMet: 1.76 ± 0.054
2.308ArgAsn: 2.308 ± 0.065
2.142ArgPro: 2.142 ± 0.074
2.357ArgGln: 2.357 ± 0.072
3.2ArgArg: 3.2 ± 0.078
3.665ArgSer: 3.665 ± 0.079
2.595ArgThr: 2.595 ± 0.065
3.225ArgVal: 3.225 ± 0.084
0.563ArgTrp: 0.563 ± 0.03
2.44ArgTyr: 2.44 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
4.885SerAla: 4.885 ± 0.107
0.955SerCys: 0.955 ± 0.041
3.716SerAsp: 3.716 ± 0.078
4.191SerGlu: 4.191 ± 0.096
3.549SerPhe: 3.549 ± 0.086
4.869SerGly: 4.869 ± 0.105
1.328SerHis: 1.328 ± 0.05
4.608SerIle: 4.608 ± 0.106
3.702SerLys: 3.702 ± 0.091
7.622SerLeu: 7.622 ± 0.124
1.609SerMet: 1.609 ± 0.053
2.626SerAsn: 2.626 ± 0.07
2.999SerPro: 2.999 ± 0.07
2.309SerGln: 2.309 ± 0.067
3.622SerArg: 3.622 ± 0.084
4.957SerSer: 4.957 ± 0.11
3.321SerThr: 3.321 ± 0.081
4.51SerVal: 4.51 ± 0.096
0.728SerTrp: 0.728 ± 0.036
2.703SerTyr: 2.703 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
4.136ThrAla: 4.136 ± 0.08
0.464ThrCys: 0.464 ± 0.028
3.024ThrAsp: 3.024 ± 0.075
3.356ThrGlu: 3.356 ± 0.073
2.133ThrPhe: 2.133 ± 0.064
3.374ThrGly: 3.374 ± 0.067
1.101ThrHis: 1.101 ± 0.048
3.642ThrIle: 3.642 ± 0.084
2.554ThrLys: 2.554 ± 0.066
5.338ThrLeu: 5.338 ± 0.093
1.002ThrMet: 1.002 ± 0.04
1.886ThrAsn: 1.886 ± 0.057
2.695ThrPro: 2.695 ± 0.073
1.644ThrGln: 1.644 ± 0.047
2.159ThrArg: 2.159 ± 0.064
3.223ThrSer: 3.223 ± 0.074
2.8ThrThr: 2.8 ± 0.068
3.364ThrVal: 3.364 ± 0.096
0.435ThrTrp: 0.435 ± 0.028
2.077ThrTyr: 2.077 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
5.003ValAla: 5.003 ± 0.102
0.903ValCys: 0.903 ± 0.038
3.763ValAsp: 3.763 ± 0.08
4.566ValGlu: 4.566 ± 0.091
2.716ValPhe: 2.716 ± 0.081
4.515ValGly: 4.515 ± 0.102
1.11ValHis: 1.11 ± 0.042
3.923ValIle: 3.923 ± 0.089
3.454ValLys: 3.454 ± 0.104
6.17ValLeu: 6.17 ± 0.115
1.449ValMet: 1.449 ± 0.056
2.394ValAsn: 2.394 ± 0.064
2.376ValPro: 2.376 ± 0.062
2.061ValGln: 2.061 ± 0.059
3.568ValArg: 3.568 ± 0.08
4.962ValSer: 4.962 ± 0.093
2.942ValThr: 2.942 ± 0.084
4.677ValVal: 4.677 ± 0.086
0.623ValTrp: 0.623 ± 0.03
2.482ValTyr: 2.482 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.674TrpAla: 0.674 ± 0.033
0.123TrpCys: 0.123 ± 0.013
0.549TrpAsp: 0.549 ± 0.033
0.584TrpGlu: 0.584 ± 0.031
0.378TrpPhe: 0.378 ± 0.03
0.854TrpGly: 0.854 ± 0.037
0.276TrpHis: 0.276 ± 0.019
0.757TrpIle: 0.757 ± 0.037
0.53TrpLys: 0.53 ± 0.03
1.078TrpLeu: 1.078 ± 0.054
0.324TrpMet: 0.324 ± 0.024
0.419TrpAsn: 0.419 ± 0.029
0.301TrpPro: 0.301 ± 0.025
0.595TrpGln: 0.595 ± 0.031
0.576TrpArg: 0.576 ± 0.031
0.617TrpSer: 0.617 ± 0.034
0.456TrpThr: 0.456 ± 0.025
0.618TrpVal: 0.618 ± 0.036
0.147TrpTrp: 0.147 ± 0.016
0.37TrpTyr: 0.37 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.864TyrAla: 2.864 ± 0.074
0.518TyrCys: 0.518 ± 0.026
2.203TyrAsp: 2.203 ± 0.058
2.244TyrGlu: 2.244 ± 0.06
1.776TyrPhe: 1.776 ± 0.062
2.599TyrGly: 2.599 ± 0.069
0.945TyrHis: 0.945 ± 0.04
2.432TyrIle: 2.432 ± 0.062
2.131TyrLys: 2.131 ± 0.055
3.845TyrLeu: 3.845 ± 0.093
0.855TyrMet: 0.855 ± 0.039
1.76TyrAsn: 1.76 ± 0.058
1.91TyrPro: 1.91 ± 0.063
1.408TyrGln: 1.408 ± 0.055
2.677TyrArg: 2.677 ± 0.077
2.682TyrSer: 2.682 ± 0.069
2.327TyrThr: 2.327 ± 0.065
2.2TyrVal: 2.2 ± 0.064
0.419TyrTrp: 0.419 ± 0.026
1.683TyrTyr: 1.683 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1804 proteins (611482 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski