Amino acid dipepetide frequency for Lipotes vexillifer (Yangtze river dolphin)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.429AlaAla: 7.429 ± 0.046	1.405AlaCys: 1.405 ± 0.011	3.063AlaAsp: 3.063 ± 0.016	4.995AlaGlu: 4.995 ± 0.025	2.698AlaPhe: 2.698 ± 0.016	5.142AlaGly: 5.142 ± 0.029	1.601AlaHis: 1.601 ± 0.013	2.773AlaIle: 2.773 ± 0.016	3.429AlaLys: 3.429 ± 0.02	7.478AlaLeu: 7.478 ± 0.034	1.496AlaMet: 1.496 ± 0.01	2.019AlaAsn: 2.019 ± 0.011	4.532AlaPro: 4.532 ± 0.035	3.374AlaGln: 3.374 ± 0.02	3.982AlaArg: 3.982 ± 0.022	5.892AlaSer: 5.892 ± 0.027	3.602AlaThr: 3.602 ± 0.021	4.947AlaVal: 4.947 ± 0.023	0.83AlaTrp: 0.83 ± 0.009	1.576AlaTyr: 1.576 ± 0.012	0.019AlaXaa: 0.019 ± 0.001
Cys	1.248CysAla: 1.248 ± 0.012	0.589CysCys: 0.589 ± 0.008	1.006CysAsp: 1.006 ± 0.012	1.232CysGlu: 1.232 ± 0.016	0.807CysPhe: 0.807 ± 0.009	1.703CysGly: 1.703 ± 0.02	0.648CysHis: 0.648 ± 0.008	0.907CysIle: 0.907 ± 0.009	1.107CysLys: 1.107 ± 0.011	2.118CysLeu: 2.118 ± 0.015	0.402CysMet: 0.402 ± 0.006	0.787CysAsn: 0.787 ± 0.011	1.372CysPro: 1.372 ± 0.016	1.022CysGln: 1.022 ± 0.013	1.273CysArg: 1.273 ± 0.011	1.93CysSer: 1.93 ± 0.018	1.065CysThr: 1.065 ± 0.011	1.284CysVal: 1.284 ± 0.012	0.286CysTrp: 0.286 ± 0.004	0.569CysTyr: 0.569 ± 0.007	0.005CysXaa: 0.005 ± 0.001
Asp	3.007AspAla: 3.007 ± 0.016	1.056AspCys: 1.056 ± 0.011	2.662AspAsp: 2.662 ± 0.018	3.5AspGlu: 3.5 ± 0.02	2.119AspPhe: 2.119 ± 0.015	3.427AspGly: 3.427 ± 0.022	1.142AspHis: 1.142 ± 0.011	2.535AspIle: 2.535 ± 0.017	2.471AspLys: 2.471 ± 0.014	5.068AspLeu: 5.068 ± 0.02	1.099AspMet: 1.099 ± 0.01	1.636AspAsn: 1.636 ± 0.012	2.993AspPro: 2.993 ± 0.014	1.829AspGln: 1.829 ± 0.013	2.496AspArg: 2.496 ± 0.014	4.153AspSer: 4.153 ± 0.025	2.419AspThr: 2.419 ± 0.014	3.121AspVal: 3.121 ± 0.024	0.64AspTrp: 0.64 ± 0.007	1.477AspTyr: 1.477 ± 0.011	0.007AspXaa: 0.007 ± 0.001
Glu	5.475GluAla: 5.475 ± 0.03	1.411GluCys: 1.411 ± 0.021	4.424GluAsp: 4.424 ± 0.021	7.665GluGlu: 7.665 ± 0.051	2.036GluPhe: 2.036 ± 0.013	4.349GluGly: 4.349 ± 0.02	1.516GluHis: 1.516 ± 0.013	3.095GluIle: 3.095 ± 0.02	5.198GluLys: 5.198 ± 0.036	6.461GluLeu: 6.461 ± 0.033	1.678GluMet: 1.678 ± 0.014	3.016GluAsn: 3.016 ± 0.02	3.331GluPro: 3.331 ± 0.025	3.141GluGln: 3.141 ± 0.019	4.107GluArg: 4.107 ± 0.027	4.328GluSer: 4.328 ± 0.023	3.336GluThr: 3.336 ± 0.018	4.206GluVal: 4.206 ± 0.021	0.694GluTrp: 0.694 ± 0.007	1.593GluTyr: 1.593 ± 0.015	0.014GluXaa: 0.014 ± 0.001
Phe	2.058PheAla: 2.058 ± 0.012	0.882PheCys: 0.882 ± 0.009	1.704PheAsp: 1.704 ± 0.013	2.043PheGlu: 2.043 ± 0.015	1.495PhePhe: 1.495 ± 0.013	2.271PheGly: 2.271 ± 0.018	1.043PheHis: 1.043 ± 0.009	1.802PheIle: 1.802 ± 0.015	1.746PheLys: 1.746 ± 0.012	3.917PheLeu: 3.917 ± 0.022	0.772PheMet: 0.772 ± 0.009	1.315PheAsn: 1.315 ± 0.011	1.976PhePro: 1.976 ± 0.014	1.789PheGln: 1.789 ± 0.011	2.003PheArg: 2.003 ± 0.013	3.345PheSer: 3.345 ± 0.016	2.024PheThr: 2.024 ± 0.014	2.168PheVal: 2.168 ± 0.014	0.485PheTrp: 0.485 ± 0.007	1.125PheTyr: 1.125 ± 0.008	0.011PheXaa: 0.011 ± 0.001
Gly	4.961GlyAla: 4.961 ± 0.032	1.276GlyCys: 1.276 ± 0.013	3.269GlyAsp: 3.269 ± 0.018	4.301GlyGlu: 4.301 ± 0.03	2.437GlyPhe: 2.437 ± 0.017	5.403GlyGly: 5.403 ± 0.043	1.724GlyHis: 1.724 ± 0.013	2.746GlyIle: 2.746 ± 0.016	3.804GlyLys: 3.804 ± 0.022	6.127GlyLeu: 6.127 ± 0.03	1.353GlyMet: 1.353 ± 0.013	2.342GlyAsn: 2.342 ± 0.016	4.611GlyPro: 4.611 ± 0.055	2.854GlyGln: 2.854 ± 0.018	3.997GlyArg: 3.997 ± 0.025	5.909GlySer: 5.909 ± 0.031	3.638GlyThr: 3.638 ± 0.023	3.721GlyVal: 3.721 ± 0.021	0.811GlyTrp: 0.811 ± 0.008	1.747GlyTyr: 1.747 ± 0.015	0.019GlyXaa: 0.019 ± 0.001
His	1.383HisAla: 1.383 ± 0.011	0.7HisCys: 0.7 ± 0.008	0.898HisAsp: 0.898 ± 0.007	1.317HisGlu: 1.317 ± 0.01	1.052HisPhe: 1.052 ± 0.009	1.579HisGly: 1.579 ± 0.013	0.913HisHis: 0.913 ± 0.011	1.206HisIle: 1.206 ± 0.011	1.227HisLys: 1.227 ± 0.01	2.879HisLeu: 2.879 ± 0.017	0.584HisMet: 0.584 ± 0.007	0.841HisAsn: 0.841 ± 0.008	1.656HisPro: 1.656 ± 0.013	1.348HisGln: 1.348 ± 0.016	1.628HisArg: 1.628 ± 0.013	2.234HisSer: 2.234 ± 0.016	1.494HisThr: 1.494 ± 0.017	1.539HisVal: 1.539 ± 0.013	0.352HisTrp: 0.352 ± 0.005	0.807HisTyr: 0.807 ± 0.008	0.005HisXaa: 0.005 ± 0.001
Ile	2.625IleAla: 2.625 ± 0.013	1.015IleCys: 1.015 ± 0.01	2.015IleAsp: 2.015 ± 0.014	2.564IleGlu: 2.564 ± 0.016	1.866IlePhe: 1.866 ± 0.016	2.223IleGly: 2.223 ± 0.014	1.33IleHis: 1.33 ± 0.013	2.254IleIle: 2.254 ± 0.015	2.548IleLys: 2.548 ± 0.017	4.402IleLeu: 4.402 ± 0.02	0.991IleMet: 0.991 ± 0.009	1.736IleAsn: 1.736 ± 0.014	2.557IlePro: 2.557 ± 0.014	2.245IleGln: 2.245 ± 0.016	2.368IleArg: 2.368 ± 0.016	3.553IleSer: 3.553 ± 0.02	2.508IleThr: 2.508 ± 0.018	2.468IleVal: 2.468 ± 0.015	0.498IleTrp: 0.498 ± 0.006	1.34IleTyr: 1.34 ± 0.01	0.007IleXaa: 0.007 ± 0.001
Lys	3.997LysAla: 3.997 ± 0.021	1.115LysCys: 1.115 ± 0.013	3.08LysAsp: 3.08 ± 0.021	4.901LysGlu: 4.901 ± 0.031	1.705LysPhe: 1.705 ± 0.013	3.268LysGly: 3.268 ± 0.027	1.368LysHis: 1.368 ± 0.012	2.686LysIle: 2.686 ± 0.018	4.434LysLys: 4.434 ± 0.031	5.061LysLeu: 5.061 ± 0.025	1.414LysMet: 1.414 ± 0.014	2.274LysAsn: 2.274 ± 0.015	3.061LysPro: 3.061 ± 0.023	2.532LysGln: 2.532 ± 0.018	3.272LysArg: 3.272 ± 0.018	3.754LysSer: 3.754 ± 0.023	3.015LysThr: 3.015 ± 0.016	3.432LysVal: 3.432 ± 0.025	0.586LysTrp: 0.586 ± 0.008	1.517LysTyr: 1.517 ± 0.012	0.013LysXaa: 0.013 ± 0.001
Leu	7.055LeuAla: 7.055 ± 0.034	2.133LeuCys: 2.133 ± 0.016	4.82LeuAsp: 4.82 ± 0.02	7.186LeuGlu: 7.186 ± 0.037	3.349LeuPhe: 3.349 ± 0.02	6.1LeuGly: 6.1 ± 0.028	2.654LeuHis: 2.654 ± 0.016	3.774LeuIle: 3.774 ± 0.023	5.71LeuLys: 5.71 ± 0.031	10.699LeuLeu: 10.699 ± 0.053	2.018LeuMet: 2.018 ± 0.015	3.418LeuAsn: 3.418 ± 0.018	6.054LeuPro: 6.054 ± 0.028	5.701LeuGln: 5.701 ± 0.031	6.077LeuArg: 6.077 ± 0.028	7.817LeuSer: 7.817 ± 0.029	4.973LeuThr: 4.973 ± 0.021	5.615LeuVal: 5.615 ± 0.025	1.143LeuTrp: 1.143 ± 0.01	2.515LeuTyr: 2.515 ± 0.017	0.027LeuXaa: 0.027 ± 0.001
Met	1.972MetAla: 1.972 ± 0.014	0.383MetCys: 0.383 ± 0.006	1.25MetAsp: 1.25 ± 0.01	1.824MetGlu: 1.824 ± 0.011	0.727MetPhe: 0.727 ± 0.007	1.326MetGly: 1.326 ± 0.011	0.461MetHis: 0.461 ± 0.006	0.838MetIle: 0.838 ± 0.009	1.386MetLys: 1.386 ± 0.011	1.972MetLeu: 1.972 ± 0.014	0.553MetMet: 0.553 ± 0.007	0.874MetAsn: 0.874 ± 0.009	1.1MetPro: 1.1 ± 0.014	0.929MetGln: 0.929 ± 0.009	1.077MetArg: 1.077 ± 0.01	1.534MetSer: 1.534 ± 0.013	1.11MetThr: 1.11 ± 0.008	1.382MetVal: 1.382 ± 0.01	0.232MetTrp: 0.232 ± 0.004	0.547MetTyr: 0.547 ± 0.005	0.004MetXaa: 0.004 ± 0.001
Asn	2.029AsnAla: 2.029 ± 0.013	0.813AsnCys: 0.813 ± 0.008	1.473AsnAsp: 1.473 ± 0.013	2.129AsnGlu: 2.129 ± 0.016	1.448AsnPhe: 1.448 ± 0.011	2.425AsnGly: 2.425 ± 0.019	0.916AsnHis: 0.916 ± 0.008	2.034AsnIle: 2.034 ± 0.014	2.09AsnLys: 2.09 ± 0.014	3.625AsnLeu: 3.625 ± 0.021	0.892AsnMet: 0.892 ± 0.008	1.436AsnAsn: 1.436 ± 0.013	2.163AsnPro: 2.163 ± 0.014	1.579AsnGln: 1.579 ± 0.013	1.813AsnArg: 1.813 ± 0.011	2.994AsnSer: 2.994 ± 0.019	1.885AsnThr: 1.885 ± 0.016	2.163AsnVal: 2.163 ± 0.013	0.441AsnTrp: 0.441 ± 0.006	1.089AsnTyr: 1.089 ± 0.01	0.008AsnXaa: 0.008 ± 0.001
Pro	5.236ProAla: 5.236 ± 0.037	1.133ProCys: 1.133 ± 0.013	2.847ProAsp: 2.847 ± 0.019	4.539ProGlu: 4.539 ± 0.03	1.922ProPhe: 1.922 ± 0.014	5.636ProGly: 5.636 ± 0.062	1.463ProHis: 1.463 ± 0.011	1.826ProIle: 1.826 ± 0.014	2.736ProLys: 2.736 ± 0.028	5.277ProLeu: 5.277 ± 0.026	1.039ProMet: 1.039 ± 0.009	1.788ProAsn: 1.788 ± 0.012	6.319ProPro: 6.319 ± 0.062	2.892ProGln: 2.892 ± 0.022	3.559ProArg: 3.559 ± 0.025	5.738ProSer: 5.738 ± 0.034	3.064ProThr: 3.064 ± 0.02	3.865ProVal: 3.865 ± 0.022	0.714ProTrp: 0.714 ± 0.008	1.552ProTyr: 1.552 ± 0.016	0.021ProXaa: 0.021 ± 0.001
Gln	3.647GlnAla: 3.647 ± 0.024	0.901GlnCys: 0.901 ± 0.012	2.329GlnAsp: 2.329 ± 0.015	3.795GlnGlu: 3.795 ± 0.024	1.36GlnPhe: 1.36 ± 0.01	2.943GlnGly: 2.943 ± 0.021	1.287GlnHis: 1.287 ± 0.012	1.949GlnIle: 1.949 ± 0.014	2.856GlnLys: 2.856 ± 0.021	4.763GlnLeu: 4.763 ± 0.025	1.104GlnMet: 1.104 ± 0.01	1.773GlnAsn: 1.773 ± 0.014	2.842GlnPro: 2.842 ± 0.021	3.025GlnGln: 3.025 ± 0.034	3.053GlnArg: 3.053 ± 0.02	3.061GlnSer: 3.061 ± 0.016	2.253GlnThr: 2.253 ± 0.015	2.851GlnVal: 2.851 ± 0.015	0.53GlnTrp: 0.53 ± 0.007	1.141GlnTyr: 1.141 ± 0.009	0.011GlnXaa: 0.011 ± 0.001
Arg	4.188ArgAla: 4.188 ± 0.022	1.216ArgCys: 1.216 ± 0.013	2.817ArgAsp: 2.817 ± 0.016	4.094ArgGlu: 4.094 ± 0.025	1.877ArgPhe: 1.877 ± 0.012	3.905ArgGly: 3.905 ± 0.03	1.564ArgHis: 1.564 ± 0.011	2.466ArgIle: 2.466 ± 0.015	3.647ArgLys: 3.647 ± 0.017	5.542ArgLeu: 5.542 ± 0.029	1.192ArgMet: 1.192 ± 0.01	2.055ArgAsn: 2.055 ± 0.012	3.439ArgPro: 3.439 ± 0.019	2.667ArgGln: 2.667 ± 0.018	4.594ArgArg: 4.594 ± 0.033	4.311ArgSer: 4.311 ± 0.026	2.819ArgThr: 2.819 ± 0.014	3.25ArgVal: 3.25 ± 0.019	0.718ArgTrp: 0.718 ± 0.008	1.442ArgTyr: 1.442 ± 0.011	0.014ArgXaa: 0.014 ± 0.001
Ser	5.437SerAla: 5.437 ± 0.027	1.778SerCys: 1.778 ± 0.016	3.835SerAsp: 3.835 ± 0.023	5.118SerGlu: 5.118 ± 0.03	2.969SerPhe: 2.969 ± 0.016	5.751SerGly: 5.751 ± 0.03	2.054SerHis: 2.054 ± 0.014	3.119SerIle: 3.119 ± 0.016	3.971SerLys: 3.971 ± 0.02	8.057SerLeu: 8.057 ± 0.03	1.566SerMet: 1.566 ± 0.013	2.57SerAsn: 2.57 ± 0.016	6.055SerPro: 6.055 ± 0.039	3.805SerGln: 3.805 ± 0.022	4.563SerArg: 4.563 ± 0.026	9.013SerSer: 9.013 ± 0.052	4.31SerThr: 4.31 ± 0.024	4.819SerVal: 4.819 ± 0.021	1.054SerTrp: 1.054 ± 0.01	2.038SerTyr: 2.038 ± 0.015	0.016SerXaa: 0.016 ± 0.001
Thr	3.829ThrAla: 3.829 ± 0.019	1.227ThrCys: 1.227 ± 0.015	2.424ThrAsp: 2.424 ± 0.015	3.439ThrGlu: 3.439 ± 0.021	2.082ThrPhe: 2.082 ± 0.014	3.607ThrGly: 3.607 ± 0.022	1.289ThrHis: 1.289 ± 0.013	2.286ThrIle: 2.286 ± 0.017	2.562ThrLys: 2.562 ± 0.017	5.237ThrLeu: 5.237 ± 0.024	1.081ThrMet: 1.081 ± 0.009	1.676ThrAsn: 1.676 ± 0.011	3.516ThrPro: 3.516 ± 0.025	2.221ThrGln: 2.221 ± 0.014	2.467ThrArg: 2.467 ± 0.013	4.45ThrSer: 4.45 ± 0.025	2.82ThrThr: 2.82 ± 0.025	3.839ThrVal: 3.839 ± 0.023	0.691ThrTrp: 0.691 ± 0.01	1.421ThrTyr: 1.421 ± 0.012	0.012ThrXaa: 0.012 ± 0.001
Val	4.426ValAla: 4.426 ± 0.019	1.41ValCys: 1.41 ± 0.013	2.986ValAsp: 2.986 ± 0.022	3.912ValGlu: 3.912 ± 0.019	2.391ValPhe: 2.391 ± 0.016	3.544ValGly: 3.544 ± 0.017	1.594ValHis: 1.594 ± 0.01	2.92ValIle: 2.92 ± 0.02	3.355ValLys: 3.355 ± 0.024	6.292ValLeu: 6.292 ± 0.025	1.339ValMet: 1.339 ± 0.009	2.253ValAsn: 2.253 ± 0.016	3.731ValPro: 3.731 ± 0.025	2.734ValGln: 2.734 ± 0.016	3.121ValArg: 3.121 ± 0.016	4.836ValSer: 4.836 ± 0.025	3.747ValThr: 3.747 ± 0.028	4.039ValVal: 4.039 ± 0.021	0.734ValTrp: 0.734 ± 0.007	1.631ValTyr: 1.631 ± 0.011	0.011ValXaa: 0.011 ± 0.001
Trp	0.831TrpAla: 0.831 ± 0.008	0.25TrpCys: 0.25 ± 0.004	0.669TrpAsp: 0.669 ± 0.008	0.79TrpGlu: 0.79 ± 0.008	0.452TrpPhe: 0.452 ± 0.006	0.754TrpGly: 0.754 ± 0.009	0.308TrpHis: 0.308 ± 0.005	0.531TrpIle: 0.531 ± 0.007	0.781TrpLys: 0.781 ± 0.008	1.206TrpLeu: 1.206 ± 0.012	0.315TrpMet: 0.315 ± 0.006	0.548TrpAsn: 0.548 ± 0.006	0.53TrpPro: 0.53 ± 0.006	0.523TrpGln: 0.523 ± 0.006	0.748TrpArg: 0.748 ± 0.008	0.859TrpSer: 0.859 ± 0.01	0.656TrpThr: 0.656 ± 0.008	0.706TrpVal: 0.706 ± 0.009	0.2TrpTrp: 0.2 ± 0.004	0.332TrpTyr: 0.332 ± 0.005	0.002TrpXaa: 0.002 ± 0.0
Tyr	1.428TyrAla: 1.428 ± 0.011	0.66TyrCys: 0.66 ± 0.007	1.277TyrAsp: 1.277 ± 0.011	1.713TyrGlu: 1.713 ± 0.013	1.175TyrPhe: 1.175 ± 0.01	1.673TyrGly: 1.673 ± 0.014	0.76TyrHis: 0.76 ± 0.008	1.357TyrIle: 1.357 ± 0.012	1.413TyrLys: 1.413 ± 0.013	2.63TyrLeu: 2.63 ± 0.016	0.59TyrMet: 0.59 ± 0.007	1.081TyrAsn: 1.081 ± 0.009	1.311TyrPro: 1.311 ± 0.012	1.256TyrGln: 1.256 ± 0.009	1.607TyrArg: 1.607 ± 0.013	2.169TyrSer: 2.169 ± 0.014	1.43TyrThr: 1.43 ± 0.012	1.574TyrVal: 1.574 ± 0.012	0.351TyrTrp: 0.351 ± 0.006	0.946TyrTyr: 0.946 ± 0.009	0.005TyrXaa: 0.005 ± 0.001
Xaa	0.019XaaAla: 0.019 ± 0.001	0.005XaaCys: 0.005 ± 0.001	0.01XaaAsp: 0.01 ± 0.001	0.016XaaGlu: 0.016 ± 0.001	0.009XaaPhe: 0.009 ± 0.001	0.02XaaGly: 0.02 ± 0.001	0.005XaaHis: 0.005 ± 0.001	0.007XaaIle: 0.007 ± 0.001	0.013XaaLys: 0.013 ± 0.001	0.026XaaLeu: 0.026 ± 0.001	0.004XaaMet: 0.004 ± 0.001	0.008XaaAsn: 0.008 ± 0.001	0.019XaaPro: 0.019 ± 0.001	0.009XaaGln: 0.009 ± 0.001	0.015XaaArg: 0.015 ± 0.001	0.017XaaSer: 0.017 ± 0.001	0.008XaaThr: 0.008 ± 0.001	0.015XaaVal: 0.015 ± 0.001	0.002XaaTrp: 0.002 ± 0.0	0.004XaaTyr: 0.004 ± 0.001	0.24XaaXaa: 0.24 ± 0.01

Statistics based on 26003 proteins (15020484 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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