Amino acid dipepetide frequency for Mesorhizobium albiziae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.95AlaAla: 16.95 ± 0.14	1.019AlaCys: 1.019 ± 0.027	6.884AlaAsp: 6.884 ± 0.067	7.781AlaGlu: 7.781 ± 0.085	4.543AlaPhe: 4.543 ± 0.062	10.959AlaGly: 10.959 ± 0.084	2.137AlaHis: 2.137 ± 0.032	6.758AlaIle: 6.758 ± 0.068	4.57AlaLys: 4.57 ± 0.063	12.396AlaLeu: 12.396 ± 0.105	3.538AlaMet: 3.538 ± 0.043	3.08AlaAsn: 3.08 ± 0.043	5.136AlaPro: 5.136 ± 0.068	3.434AlaGln: 3.434 ± 0.051	8.206AlaArg: 8.206 ± 0.081	6.464AlaSer: 6.464 ± 0.067	6.031AlaThr: 6.031 ± 0.06	8.897AlaVal: 8.897 ± 0.077	1.491AlaTrp: 1.491 ± 0.028	2.587AlaTyr: 2.587 ± 0.037	0.001AlaXaa: 0.001 ± 0.001
Cys	0.88CysAla: 0.88 ± 0.021	0.127CysCys: 0.127 ± 0.009	0.49CysAsp: 0.49 ± 0.017	0.424CysGlu: 0.424 ± 0.016	0.337CysPhe: 0.337 ± 0.013	0.895CysGly: 0.895 ± 0.026	0.235CysHis: 0.235 ± 0.015	0.378CysIle: 0.378 ± 0.016	0.199CysLys: 0.199 ± 0.011	0.791CysLeu: 0.791 ± 0.023	0.166CysMet: 0.166 ± 0.01	0.188CysAsn: 0.188 ± 0.011	0.411CysPro: 0.411 ± 0.018	0.245CysGln: 0.245 ± 0.011	0.617CysArg: 0.617 ± 0.021	0.477CysSer: 0.477 ± 0.017	0.411CysThr: 0.411 ± 0.015	0.595CysVal: 0.595 ± 0.018	0.116CysTrp: 0.116 ± 0.007	0.205CysTyr: 0.205 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.622AspAla: 6.622 ± 0.066	0.494AspCys: 0.494 ± 0.017	3.117AspAsp: 3.117 ± 0.052	3.537AspGlu: 3.537 ± 0.049	2.361AspPhe: 2.361 ± 0.037	5.222AspGly: 5.222 ± 0.069	1.21AspHis: 1.21 ± 0.03	3.322AspIle: 3.322 ± 0.04	1.887AspLys: 1.887 ± 0.035	5.6AspLeu: 5.6 ± 0.059	1.376AspMet: 1.376 ± 0.031	1.447AspAsn: 1.447 ± 0.028	3.354AspPro: 3.354 ± 0.053	1.636AspGln: 1.636 ± 0.033	4.39AspArg: 4.39 ± 0.056	2.175AspSer: 2.175 ± 0.038	2.62AspThr: 2.62 ± 0.045	4.125AspVal: 4.125 ± 0.051	0.95AspTrp: 0.95 ± 0.027	1.426AspTyr: 1.426 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.612GluAla: 7.612 ± 0.073	0.372GluCys: 0.372 ± 0.013	2.646GluAsp: 2.646 ± 0.044	3.261GluGlu: 3.261 ± 0.051	1.997GluPhe: 1.997 ± 0.039	4.149GluGly: 4.149 ± 0.051	1.166GluHis: 1.166 ± 0.024	3.803GluIle: 3.803 ± 0.052	2.839GluLys: 2.839 ± 0.048	5.53GluLeu: 5.53 ± 0.059	1.573GluMet: 1.573 ± 0.029	1.774GluAsn: 1.774 ± 0.037	2.876GluPro: 2.876 ± 0.046	2.078GluGln: 2.078 ± 0.038	4.99GluArg: 4.99 ± 0.062	2.323GluSer: 2.323 ± 0.035	3.585GluThr: 3.585 ± 0.048	3.759GluVal: 3.759 ± 0.052	0.734GluTrp: 0.734 ± 0.022	1.029GluTyr: 1.029 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.762PheAla: 4.762 ± 0.064	0.387PheCys: 0.387 ± 0.015	2.718PheAsp: 2.718 ± 0.038	2.309PheGlu: 2.309 ± 0.038	1.617PhePhe: 1.617 ± 0.032	3.821PheGly: 3.821 ± 0.047	0.808PheHis: 0.808 ± 0.019	1.834PheIle: 1.834 ± 0.032	1.079PheLys: 1.079 ± 0.024	3.553PheLeu: 3.553 ± 0.051	0.855PheMet: 0.855 ± 0.021	1.122PheAsn: 1.122 ± 0.024	1.693PhePro: 1.693 ± 0.035	1.101PheGln: 1.101 ± 0.025	2.427PheArg: 2.427 ± 0.037	2.494PheSer: 2.494 ± 0.035	1.947PheThr: 1.947 ± 0.035	3.01PheVal: 3.01 ± 0.047	0.585PheTrp: 0.585 ± 0.018	0.963PheTyr: 0.963 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.879GlyAla: 8.879 ± 0.078	0.824GlyCys: 0.824 ± 0.024	4.577GlyAsp: 4.577 ± 0.054	4.926GlyGlu: 4.926 ± 0.063	3.725GlyPhe: 3.725 ± 0.049	7.207GlyGly: 7.207 ± 0.09	1.857GlyHis: 1.857 ± 0.034	4.893GlyIle: 4.893 ± 0.057	3.804GlyLys: 3.804 ± 0.052	8.456GlyLeu: 8.456 ± 0.073	2.404GlyMet: 2.404 ± 0.035	2.448GlyAsn: 2.448 ± 0.046	3.235GlyPro: 3.235 ± 0.043	2.714GlyGln: 2.714 ± 0.035	5.88GlyArg: 5.88 ± 0.066	4.849GlySer: 4.849 ± 0.062	4.475GlyThr: 4.475 ± 0.068	6.049GlyVal: 6.049 ± 0.058	1.369GlyTrp: 1.369 ± 0.028	2.335GlyTyr: 2.335 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.228HisAla: 2.228 ± 0.034	0.22HisCys: 0.22 ± 0.013	1.234HisAsp: 1.234 ± 0.025	1.083HisGlu: 1.083 ± 0.025	0.887HisPhe: 0.887 ± 0.023	1.911HisGly: 1.911 ± 0.036	0.574HisHis: 0.574 ± 0.019	0.932HisIle: 0.932 ± 0.023	0.542HisLys: 0.542 ± 0.018	1.945HisLeu: 1.945 ± 0.036	0.499HisMet: 0.499 ± 0.017	0.486HisAsn: 0.486 ± 0.016	1.3HisPro: 1.3 ± 0.024	0.597HisGln: 0.597 ± 0.019	1.453HisArg: 1.453 ± 0.032	0.987HisSer: 0.987 ± 0.025	0.829HisThr: 0.829 ± 0.022	1.527HisVal: 1.527 ± 0.029	0.319HisTrp: 0.319 ± 0.014	0.566HisTyr: 0.566 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.665IleAla: 7.665 ± 0.077	0.525IleCys: 0.525 ± 0.018	3.766IleAsp: 3.766 ± 0.05	3.636IleGlu: 3.636 ± 0.044	1.839IlePhe: 1.839 ± 0.032	5.102IleGly: 5.102 ± 0.057	0.97IleHis: 0.97 ± 0.023	2.404IleIle: 2.404 ± 0.044	1.55IleLys: 1.55 ± 0.033	4.514IleLeu: 4.514 ± 0.062	1.049IleMet: 1.049 ± 0.024	1.464IleAsn: 1.464 ± 0.032	2.409IlePro: 2.409 ± 0.037	1.229IleGln: 1.229 ± 0.031	3.381IleArg: 3.381 ± 0.05	3.127IleSer: 3.127 ± 0.044	2.603IleThr: 2.603 ± 0.039	4.695IleVal: 4.695 ± 0.055	0.618IleTrp: 0.618 ± 0.021	1.163IleTyr: 1.163 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.793LysAla: 4.793 ± 0.067	0.178LysCys: 0.178 ± 0.01	1.872LysAsp: 1.872 ± 0.036	1.85LysGlu: 1.85 ± 0.039	1.08LysPhe: 1.08 ± 0.028	2.764LysGly: 2.764 ± 0.04	0.684LysHis: 0.684 ± 0.021	2.04LysIle: 2.04 ± 0.034	1.704LysLys: 1.704 ± 0.045	3.732LysLeu: 3.732 ± 0.05	0.892LysMet: 0.892 ± 0.026	1.097LysAsn: 1.097 ± 0.027	2.415LysPro: 2.415 ± 0.045	1.2LysGln: 1.2 ± 0.027	2.695LysArg: 2.695 ± 0.047	2.156LysSer: 2.156 ± 0.038	2.224LysThr: 2.224 ± 0.033	2.692LysVal: 2.692 ± 0.044	0.442LysTrp: 0.442 ± 0.016	0.715LysTyr: 0.715 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.025LeuAla: 13.025 ± 0.101	0.814LeuCys: 0.814 ± 0.022	5.874LeuAsp: 5.874 ± 0.059	5.24LeuGlu: 5.24 ± 0.056	3.781LeuPhe: 3.781 ± 0.052	8.01LeuGly: 8.01 ± 0.079	1.815LeuHis: 1.815 ± 0.032	4.997LeuIle: 4.997 ± 0.07	3.994LeuLys: 3.994 ± 0.054	9.108LeuLeu: 9.108 ± 0.099	2.279LeuMet: 2.279 ± 0.035	2.52LeuAsn: 2.52 ± 0.039	5.296LeuPro: 5.296 ± 0.062	2.679LeuGln: 2.679 ± 0.04	6.427LeuArg: 6.427 ± 0.064	6.383LeuSer: 6.383 ± 0.061	5.193LeuThr: 5.193 ± 0.057	7.337LeuVal: 7.337 ± 0.069	1.142LeuTrp: 1.142 ± 0.027	2.06LeuTyr: 2.06 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.154MetAla: 3.154 ± 0.039	0.148MetCys: 0.148 ± 0.009	1.128MetAsp: 1.128 ± 0.026	1.157MetGlu: 1.157 ± 0.023	0.744MetPhe: 0.744 ± 0.021	1.707MetGly: 1.707 ± 0.033	0.476MetHis: 0.476 ± 0.017	1.403MetIle: 1.403 ± 0.028	1.126MetLys: 1.126 ± 0.027	2.633MetLeu: 2.633 ± 0.04	0.697MetMet: 0.697 ± 0.02	0.863MetAsn: 0.863 ± 0.024	1.518MetPro: 1.518 ± 0.027	0.843MetGln: 0.843 ± 0.019	1.886MetArg: 1.886 ± 0.034	1.666MetSer: 1.666 ± 0.028	1.77MetThr: 1.77 ± 0.033	1.715MetVal: 1.715 ± 0.032	0.218MetTrp: 0.218 ± 0.011	0.305MetTyr: 0.305 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.285AsnAla: 3.285 ± 0.046	0.251AsnCys: 0.251 ± 0.014	1.537AsnAsp: 1.537 ± 0.035	1.35AsnGlu: 1.35 ± 0.032	1.079AsnPhe: 1.079 ± 0.026	2.577AsnGly: 2.577 ± 0.045	0.538AsnHis: 0.538 ± 0.019	1.472AsnIle: 1.472 ± 0.029	0.819AsnLys: 0.819 ± 0.024	2.683AsnLeu: 2.683 ± 0.043	0.625AsnMet: 0.625 ± 0.018	0.726AsnAsn: 0.726 ± 0.024	1.97AsnPro: 1.97 ± 0.036	0.796AsnGln: 0.796 ± 0.021	1.912AsnArg: 1.912 ± 0.033	1.356AsnSer: 1.356 ± 0.033	1.291AsnThr: 1.291 ± 0.028	2.036AsnVal: 2.036 ± 0.033	0.479AsnTrp: 0.479 ± 0.017	0.734AsnTyr: 0.734 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.114ProAla: 6.114 ± 0.071	0.311ProCys: 0.311 ± 0.013	3.553ProAsp: 3.553 ± 0.046	3.624ProGlu: 3.624 ± 0.047	2.026ProPhe: 2.026 ± 0.033	4.37ProGly: 4.37 ± 0.057	1.03ProHis: 1.03 ± 0.024	2.274ProIle: 2.274 ± 0.037	1.856ProLys: 1.856 ± 0.035	4.665ProLeu: 4.665 ± 0.05	1.118ProMet: 1.118 ± 0.027	1.381ProAsn: 1.381 ± 0.03	2.422ProPro: 2.422 ± 0.063	1.678ProGln: 1.678 ± 0.032	2.842ProArg: 2.842 ± 0.043	2.786ProSer: 2.786 ± 0.044	2.452ProThr: 2.452 ± 0.04	4.202ProVal: 4.202 ± 0.053	0.682ProTrp: 0.682 ± 0.02	1.233ProTyr: 1.233 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.815GlnAla: 3.815 ± 0.052	0.201GlnCys: 0.201 ± 0.011	1.354GlnAsp: 1.354 ± 0.028	1.48GlnGlu: 1.48 ± 0.029	1.078GlnPhe: 1.078 ± 0.027	2.146GlnGly: 2.146 ± 0.037	0.604GlnHis: 0.604 ± 0.015	1.766GlnIle: 1.766 ± 0.034	1.293GlnLys: 1.293 ± 0.028	2.858GlnLeu: 2.858 ± 0.041	0.85GlnMet: 0.85 ± 0.024	0.897GlnAsn: 0.897 ± 0.021	1.748GlnPro: 1.748 ± 0.033	1.123GlnGln: 1.123 ± 0.029	2.312GlnArg: 2.312 ± 0.041	1.734GlnSer: 1.734 ± 0.032	1.724GlnThr: 1.724 ± 0.032	2.052GlnVal: 2.052 ± 0.031	0.42GlnTrp: 0.42 ± 0.017	0.604GlnTyr: 0.604 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.428ArgAla: 7.428 ± 0.076	0.507ArgCys: 0.507 ± 0.018	4.052ArgAsp: 4.052 ± 0.054	4.191ArgGlu: 4.191 ± 0.054	2.967ArgPhe: 2.967 ± 0.043	4.701ArgGly: 4.701 ± 0.053	1.74ArgHis: 1.74 ± 0.035	3.989ArgIle: 3.989 ± 0.045	2.762ArgLys: 2.762 ± 0.041	7.597ArgLeu: 7.597 ± 0.088	1.898ArgMet: 1.898 ± 0.033	2.036ArgAsn: 2.036 ± 0.035	3.392ArgPro: 3.392 ± 0.047	2.613ArgGln: 2.613 ± 0.035	5.646ArgArg: 5.646 ± 0.067	3.88ArgSer: 3.88 ± 0.056	3.361ArgThr: 3.361 ± 0.053	4.521ArgVal: 4.521 ± 0.061	0.987ArgTrp: 0.987 ± 0.025	1.706ArgTyr: 1.706 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.37SerAla: 6.37 ± 0.068	0.415SerCys: 0.415 ± 0.016	3.017SerAsp: 3.017 ± 0.039	2.987SerGlu: 2.987 ± 0.037	2.409SerPhe: 2.409 ± 0.038	5.659SerGly: 5.659 ± 0.068	1.16SerHis: 1.16 ± 0.025	2.911SerIle: 2.911 ± 0.043	1.816SerLys: 1.816 ± 0.03	5.338SerLeu: 5.338 ± 0.056	1.412SerMet: 1.412 ± 0.027	1.458SerAsn: 1.458 ± 0.03	2.848SerPro: 2.848 ± 0.047	1.567SerGln: 1.567 ± 0.031	3.847SerArg: 3.847 ± 0.049	3.02SerSer: 3.02 ± 0.039	2.745SerThr: 2.745 ± 0.043	4.092SerVal: 4.092 ± 0.045	0.765SerTrp: 0.765 ± 0.019	1.304SerTyr: 1.304 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.26ThrAla: 6.26 ± 0.051	0.396ThrCys: 0.396 ± 0.017	2.723ThrAsp: 2.723 ± 0.042	2.724ThrGlu: 2.724 ± 0.037	2.087ThrPhe: 2.087 ± 0.032	5.043ThrGly: 5.043 ± 0.066	0.957ThrHis: 0.957 ± 0.024	3.054ThrIle: 3.054 ± 0.043	1.58ThrLys: 1.58 ± 0.029	5.424ThrLeu: 5.424 ± 0.06	1.269ThrMet: 1.269 ± 0.026	1.341ThrAsn: 1.341 ± 0.027	3.033ThrPro: 3.033 ± 0.044	1.288ThrGln: 1.288 ± 0.025	3.194ThrArg: 3.194 ± 0.042	2.732ThrSer: 2.732 ± 0.04	2.778ThrThr: 2.778 ± 0.041	4.484ThrVal: 4.484 ± 0.056	0.669ThrTrp: 0.669 ± 0.018	1.199ThrTyr: 1.199 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.271ValAla: 9.271 ± 0.071	0.597ValCys: 0.597 ± 0.018	4.29ValAsp: 4.29 ± 0.053	4.651ValGlu: 4.651 ± 0.054	2.98ValPhe: 2.98 ± 0.044	5.669ValGly: 5.669 ± 0.061	1.379ValHis: 1.379 ± 0.034	3.922ValIle: 3.922 ± 0.046	2.619ValLys: 2.619 ± 0.035	7.263ValLeu: 7.263 ± 0.067	1.82ValMet: 1.82 ± 0.031	2.056ValAsn: 2.056 ± 0.042	3.699ValPro: 3.699 ± 0.044	1.97ValGln: 1.97 ± 0.034	4.901ValArg: 4.901 ± 0.054	4.444ValSer: 4.444 ± 0.054	4.308ValThr: 4.308 ± 0.058	6.048ValVal: 6.048 ± 0.07	0.902ValTrp: 0.902 ± 0.025	1.493ValTyr: 1.493 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.287TrpAla: 1.287 ± 0.029	0.135TrpCys: 0.135 ± 0.008	0.606TrpAsp: 0.606 ± 0.019	0.614TrpGlu: 0.614 ± 0.018	0.573TrpPhe: 0.573 ± 0.02	0.879TrpGly: 0.879 ± 0.023	0.322TrpHis: 0.322 ± 0.012	0.668TrpIle: 0.668 ± 0.018	0.519TrpLys: 0.519 ± 0.018	1.644TrpLeu: 1.644 ± 0.03	0.393TrpMet: 0.393 ± 0.015	0.504TrpAsn: 0.504 ± 0.018	0.743TrpPro: 0.743 ± 0.022	0.545TrpGln: 0.545 ± 0.017	1.12TrpArg: 1.12 ± 0.027	0.842TrpSer: 0.842 ± 0.023	0.783TrpThr: 0.783 ± 0.019	0.764TrpVal: 0.764 ± 0.024	0.241TrpTrp: 0.241 ± 0.011	0.29TrpTyr: 0.29 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.041	0.264TyrCys: 0.264 ± 0.011	1.43TyrAsp: 1.43 ± 0.03	1.268TyrGlu: 1.268 ± 0.03	0.976TyrPhe: 0.976 ± 0.024	2.113TyrGly: 2.113 ± 0.038	0.457TyrHis: 0.457 ± 0.014	0.89TyrIle: 0.89 ± 0.022	0.669TyrLys: 0.669 ± 0.019	2.245TyrLeu: 2.245 ± 0.039	0.441TyrMet: 0.441 ± 0.016	0.627TyrAsn: 0.627 ± 0.019	1.119TyrPro: 1.119 ± 0.024	0.722TyrGln: 0.722 ± 0.021	1.851TyrArg: 1.851 ± 0.033	1.247TyrSer: 1.247 ± 0.03	1.106TyrThr: 1.106 ± 0.028	1.686TyrVal: 1.686 ± 0.031	0.345TyrTrp: 0.345 ± 0.016	0.593TyrTyr: 0.593 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 6112 proteins (1794598 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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