Amino acid dipepetide frequency for Acidiplasma cupricumulans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.124AlaAla: 4.124 ± 0.128
0.493AlaCys: 0.493 ± 0.036
2.746AlaAsp: 2.746 ± 0.086
2.949AlaGlu: 2.949 ± 0.083
3.052AlaPhe: 3.052 ± 0.088
4.809AlaGly: 4.809 ± 0.129
0.828AlaHis: 0.828 ± 0.044
5.845AlaIle: 5.845 ± 0.14
3.114AlaLys: 3.114 ± 0.081
5.903AlaLeu: 5.903 ± 0.137
1.918AlaMet: 1.918 ± 0.057
2.27AlaAsn: 2.27 ± 0.072
1.576AlaPro: 1.576 ± 0.06
1.027AlaGln: 1.027 ± 0.049
2.561AlaArg: 2.561 ± 0.084
4.083AlaSer: 4.083 ± 0.107
2.395AlaThr: 2.395 ± 0.068
4.397AlaVal: 4.397 ± 0.102
0.456AlaTrp: 0.456 ± 0.034
2.7AlaTyr: 2.7 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.277CysAla: 0.277 ± 0.03
0.05CysCys: 0.05 ± 0.012
0.408CysAsp: 0.408 ± 0.032
0.294CysGlu: 0.294 ± 0.026
0.173CysPhe: 0.173 ± 0.019
0.684CysGly: 0.684 ± 0.042
0.157CysHis: 0.157 ± 0.019
0.577CysIle: 0.577 ± 0.037
0.348CysLys: 0.348 ± 0.029
0.338CysLeu: 0.338 ± 0.024
0.141CysMet: 0.141 ± 0.017
0.382CysAsn: 0.382 ± 0.033
0.416CysPro: 0.416 ± 0.031
0.117CysGln: 0.117 ± 0.015
0.34CysArg: 0.34 ± 0.024
0.446CysSer: 0.446 ± 0.032
0.334CysThr: 0.334 ± 0.028
0.306CysVal: 0.306 ± 0.027
0.044CysTrp: 0.044 ± 0.01
0.211CysTyr: 0.211 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.195AspAla: 3.195 ± 0.08
0.243AspCys: 0.243 ± 0.023
3.231AspAsp: 3.231 ± 0.095
3.949AspGlu: 3.949 ± 0.101
3.026AspPhe: 3.026 ± 0.084
3.225AspGly: 3.225 ± 0.091
0.732AspHis: 0.732 ± 0.039
6.655AspIle: 6.655 ± 0.145
3.927AspLys: 3.927 ± 0.107
5.022AspLeu: 5.022 ± 0.103
1.564AspMet: 1.564 ± 0.057
3.008AspAsn: 3.008 ± 0.08
1.948AspPro: 1.948 ± 0.061
0.887AspGln: 0.887 ± 0.039
2.053AspArg: 2.053 ± 0.071
3.283AspSer: 3.283 ± 0.094
2.189AspThr: 2.189 ± 0.063
3.617AspVal: 3.617 ± 0.098
0.356AspTrp: 0.356 ± 0.03
3.331AspTyr: 3.331 ± 0.092
0.0AspXaa: 0.0 ± 0.0
Glu
2.962GluAla: 2.962 ± 0.083
0.36GluCys: 0.36 ± 0.025
3.221GluAsp: 3.221 ± 0.084
3.774GluGlu: 3.774 ± 0.103
2.632GluPhe: 2.632 ± 0.072
2.374GluGly: 2.374 ± 0.068
0.895GluHis: 0.895 ± 0.04
6.884GluIle: 6.884 ± 0.161
5.816GluLys: 5.816 ± 0.145
4.95GluLeu: 4.95 ± 0.113
1.691GluMet: 1.691 ± 0.049
5.352GluAsn: 5.352 ± 0.111
1.53GluPro: 1.53 ± 0.062
0.927GluGln: 0.927 ± 0.052
2.575GluArg: 2.575 ± 0.081
3.591GluSer: 3.591 ± 0.087
2.732GluThr: 2.732 ± 0.069
2.771GluVal: 2.771 ± 0.079
0.485GluTrp: 0.485 ± 0.03
3.331GluTyr: 3.331 ± 0.084
0.0GluXaa: 0.0 ± 0.0
Phe
2.664PheAla: 2.664 ± 0.089
0.273PheCys: 0.273 ± 0.025
2.529PheAsp: 2.529 ± 0.076
2.143PheGlu: 2.143 ± 0.07
2.722PhePhe: 2.722 ± 0.08
3.446PheGly: 3.446 ± 0.092
0.734PheHis: 0.734 ± 0.042
5.808PheIle: 5.808 ± 0.145
3.15PheLys: 3.15 ± 0.074
4.755PheLeu: 4.755 ± 0.115
1.436PheMet: 1.436 ± 0.052
3.378PheAsn: 3.378 ± 0.085
1.707PhePro: 1.707 ± 0.058
0.869PheGln: 0.869 ± 0.041
1.751PheArg: 1.751 ± 0.061
4.12PheSer: 4.12 ± 0.112
2.571PheThr: 2.571 ± 0.075
2.535PheVal: 2.535 ± 0.077
0.424PheTrp: 0.424 ± 0.035
2.684PheTyr: 2.684 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
3.82GlyAla: 3.82 ± 0.108
0.392GlyCys: 0.392 ± 0.027
3.287GlyAsp: 3.287 ± 0.095
3.251GlyGlu: 3.251 ± 0.085
3.641GlyPhe: 3.641 ± 0.088
4.367GlyGly: 4.367 ± 0.115
1.245GlyHis: 1.245 ± 0.053
8.802GlyIle: 8.802 ± 0.136
4.803GlyLys: 4.803 ± 0.097
5.766GlyLeu: 5.766 ± 0.111
1.918GlyMet: 1.918 ± 0.07
3.768GlyAsn: 3.768 ± 0.087
1.773GlyPro: 1.773 ± 0.059
1.08GlyGln: 1.08 ± 0.044
2.827GlyArg: 2.827 ± 0.085
4.453GlySer: 4.453 ± 0.109
3.76GlyThr: 3.76 ± 0.088
3.748GlyVal: 3.748 ± 0.082
0.649GlyTrp: 0.649 ± 0.043
3.565GlyTyr: 3.565 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
0.82HisAla: 0.82 ± 0.038
0.101HisCys: 0.101 ± 0.015
0.858HisAsp: 0.858 ± 0.042
0.933HisGlu: 0.933 ± 0.041
0.659HisPhe: 0.659 ± 0.033
1.462HisGly: 1.462 ± 0.067
0.245HisHis: 0.245 ± 0.019
1.546HisIle: 1.546 ± 0.062
0.85HisLys: 0.85 ± 0.044
1.255HisLeu: 1.255 ± 0.053
0.489HisMet: 0.489 ± 0.033
0.824HisAsn: 0.824 ± 0.038
0.726HisPro: 0.726 ± 0.042
0.225HisGln: 0.225 ± 0.019
0.585HisArg: 0.585 ± 0.039
0.943HisSer: 0.943 ± 0.039
0.726HisThr: 0.726 ± 0.039
0.889HisVal: 0.889 ± 0.044
0.121HisTrp: 0.121 ± 0.018
0.682HisTyr: 0.682 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.486IleAla: 6.486 ± 0.131
0.547IleCys: 0.547 ± 0.038
5.931IleAsp: 5.931 ± 0.121
5.859IleGlu: 5.859 ± 0.122
5.595IlePhe: 5.595 ± 0.136
6.643IleGly: 6.643 ± 0.149
1.335IleHis: 1.335 ± 0.055
12.646IleIle: 12.646 ± 0.234
9.693IleLys: 9.693 ± 0.165
9.449IleLeu: 9.449 ± 0.167
3.018IleMet: 3.018 ± 0.072
7.921IleAsn: 7.921 ± 0.144
4.359IlePro: 4.359 ± 0.097
1.608IleGln: 1.608 ± 0.057
3.723IleArg: 3.723 ± 0.1
8.406IleSer: 8.406 ± 0.152
5.414IleThr: 5.414 ± 0.103
5.412IleVal: 5.412 ± 0.108
0.615IleTrp: 0.615 ± 0.04
4.994IleTyr: 4.994 ± 0.117
0.0IleXaa: 0.0 ± 0.0
Lys
3.018LysAla: 3.018 ± 0.087
0.569LysCys: 0.569 ± 0.036
3.766LysAsp: 3.766 ± 0.098
4.272LysGlu: 4.272 ± 0.123
3.297LysPhe: 3.297 ± 0.101
3.161LysGly: 3.161 ± 0.09
0.989LysHis: 0.989 ± 0.05
9.222LysIle: 9.222 ± 0.16
7.292LysLys: 7.292 ± 0.134
5.961LysLeu: 5.961 ± 0.126
2.463LysMet: 2.463 ± 0.074
7.771LysAsn: 7.771 ± 0.141
2.089LysPro: 2.089 ± 0.07
1.15LysGln: 1.15 ± 0.048
2.976LysArg: 2.976 ± 0.07
4.994LysSer: 4.994 ± 0.1
3.957LysThr: 3.957 ± 0.09
3.038LysVal: 3.038 ± 0.086
0.553LysTrp: 0.553 ± 0.032
4.88LysTyr: 4.88 ± 0.096
0.0LysXaa: 0.0 ± 0.0
Leu
5.115LeuAla: 5.115 ± 0.114
0.452LeuCys: 0.452 ± 0.029
4.433LeuAsp: 4.433 ± 0.119
4.777LeuGlu: 4.777 ± 0.106
4.303LeuPhe: 4.303 ± 0.108
6.249LeuGly: 6.249 ± 0.126
1.166LeuHis: 1.166 ± 0.052
9.697LeuIle: 9.697 ± 0.173
7.652LeuLys: 7.652 ± 0.132
7.58LeuLeu: 7.58 ± 0.158
2.626LeuMet: 2.626 ± 0.069
6.231LeuAsn: 6.231 ± 0.115
2.913LeuPro: 2.913 ± 0.079
1.486LeuGln: 1.486 ± 0.061
3.5LeuArg: 3.5 ± 0.087
6.822LeuSer: 6.822 ± 0.137
3.999LeuThr: 3.999 ± 0.094
4.186LeuVal: 4.186 ± 0.107
0.637LeuTrp: 0.637 ± 0.039
4.144LeuTyr: 4.144 ± 0.094
0.0LeuXaa: 0.0 ± 0.0
Met
2.294MetAla: 2.294 ± 0.07
0.151MetCys: 0.151 ± 0.019
2.2MetAsp: 2.2 ± 0.072
2.364MetGlu: 2.364 ± 0.071
1.09MetPhe: 1.09 ± 0.054
2.017MetGly: 2.017 ± 0.064
0.573MetHis: 0.573 ± 0.039
2.481MetIle: 2.481 ± 0.072
1.998MetLys: 1.998 ± 0.066
2.473MetLeu: 2.473 ± 0.067
0.661MetMet: 0.661 ± 0.044
1.629MetAsn: 1.629 ± 0.055
1.371MetPro: 1.371 ± 0.045
0.581MetGln: 0.581 ± 0.033
1.043MetArg: 1.043 ± 0.043
1.61MetSer: 1.61 ± 0.052
1.152MetThr: 1.152 ± 0.048
1.958MetVal: 1.958 ± 0.069
0.199MetTrp: 0.199 ± 0.022
1.037MetTyr: 1.037 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.623AsnAla: 3.623 ± 0.092
0.344AsnCys: 0.344 ± 0.028
3.802AsnAsp: 3.802 ± 0.093
4.039AsnGlu: 4.039 ± 0.097
3.066AsnPhe: 3.066 ± 0.079
4.184AsnGly: 4.184 ± 0.102
0.963AsnHis: 0.963 ± 0.051
8.0AsnIle: 8.0 ± 0.163
5.143AsnLys: 5.143 ± 0.121
5.201AsnLeu: 5.201 ± 0.11
1.785AsnMet: 1.785 ± 0.063
4.664AsnAsn: 4.664 ± 0.133
2.479AsnPro: 2.479 ± 0.067
1.076AsnGln: 1.076 ± 0.052
2.091AsnArg: 2.091 ± 0.067
4.307AsnSer: 4.307 ± 0.101
2.845AsnThr: 2.845 ± 0.077
3.838AsnVal: 3.838 ± 0.101
0.334AsnTrp: 0.334 ± 0.027
3.567AsnTyr: 3.567 ± 0.105
0.0AsnXaa: 0.0 ± 0.0
Pro
2.109ProAla: 2.109 ± 0.071
0.175ProCys: 0.175 ± 0.019
2.762ProAsp: 2.762 ± 0.084
3.498ProGlu: 3.498 ± 0.094
1.745ProPhe: 1.745 ± 0.063
2.561ProGly: 2.561 ± 0.077
0.537ProHis: 0.537 ± 0.036
2.111ProIle: 2.111 ± 0.063
1.769ProLys: 1.769 ± 0.061
3.148ProLeu: 3.148 ± 0.078
0.834ProMet: 0.834 ± 0.041
1.232ProAsn: 1.232 ± 0.053
1.021ProPro: 1.021 ± 0.041
0.7ProGln: 0.7 ± 0.042
1.176ProArg: 1.176 ± 0.054
2.081ProSer: 2.081 ± 0.068
1.355ProThr: 1.355 ± 0.054
3.38ProVal: 3.38 ± 0.095
0.336ProTrp: 0.336 ± 0.029
1.866ProTyr: 1.866 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
1.062GlnAla: 1.062 ± 0.042
0.117GlnCys: 0.117 ± 0.016
0.85GlnAsp: 0.85 ± 0.038
1.076GlnGlu: 1.076 ± 0.053
0.796GlnPhe: 0.796 ± 0.043
1.047GlnGly: 1.047 ± 0.045
0.275GlnHis: 0.275 ± 0.023
1.727GlnIle: 1.727 ± 0.061
1.588GlnLys: 1.588 ± 0.056
1.427GlnLeu: 1.427 ± 0.06
0.541GlnMet: 0.541 ± 0.03
1.214GlnAsn: 1.214 ± 0.051
0.456GlnPro: 0.456 ± 0.031
0.378GlnGln: 0.378 ± 0.029
0.858GlnArg: 0.858 ± 0.042
0.919GlnSer: 0.919 ± 0.042
0.774GlnThr: 0.774 ± 0.041
0.911GlnVal: 0.911 ± 0.044
0.191GlnTrp: 0.191 ± 0.021
0.812GlnTyr: 0.812 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.216ArgAla: 2.216 ± 0.065
0.275ArgCys: 0.275 ± 0.027
2.571ArgAsp: 2.571 ± 0.069
3.078ArgGlu: 3.078 ± 0.083
1.691ArgPhe: 1.691 ± 0.058
2.326ArgGly: 2.326 ± 0.072
0.672ArgHis: 0.672 ± 0.036
4.061ArgIle: 4.061 ± 0.081
3.066ArgLys: 3.066 ± 0.086
3.249ArgLeu: 3.249 ± 0.095
1.084ArgMet: 1.084 ± 0.053
2.421ArgAsn: 2.421 ± 0.063
1.423ArgPro: 1.423 ± 0.056
0.808ArgGln: 0.808 ± 0.041
1.82ArgArg: 1.82 ± 0.071
2.326ArgSer: 2.326 ± 0.077
1.62ArgThr: 1.62 ± 0.054
2.151ArgVal: 2.151 ± 0.07
0.296ArgTrp: 0.296 ± 0.024
2.029ArgTyr: 2.029 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
3.699SerAla: 3.699 ± 0.093
0.408SerCys: 0.408 ± 0.03
3.856SerAsp: 3.856 ± 0.093
4.188SerGlu: 4.188 ± 0.095
3.454SerPhe: 3.454 ± 0.105
6.241SerGly: 6.241 ± 0.105
0.959SerHis: 0.959 ± 0.043
7.157SerIle: 7.157 ± 0.125
4.339SerLys: 4.339 ± 0.096
6.627SerLeu: 6.627 ± 0.13
2.362SerMet: 2.362 ± 0.068
3.293SerAsn: 3.293 ± 0.077
2.238SerPro: 2.238 ± 0.067
1.397SerGln: 1.397 ± 0.052
3.126SerArg: 3.126 ± 0.09
4.936SerSer: 4.936 ± 0.12
2.996SerThr: 2.996 ± 0.074
4.27SerVal: 4.27 ± 0.093
0.579SerTrp: 0.579 ± 0.039
3.48SerTyr: 3.48 ± 0.082
0.0SerXaa: 0.0 ± 0.0
Thr
3.275ThrAla: 3.275 ± 0.104
0.251ThrCys: 0.251 ± 0.02
2.612ThrAsp: 2.612 ± 0.069
2.569ThrGlu: 2.569 ± 0.069
2.338ThrPhe: 2.338 ± 0.08
4.729ThrGly: 4.729 ± 0.098
0.762ThrHis: 0.762 ± 0.041
3.919ThrIle: 3.919 ± 0.086
2.561ThrLys: 2.561 ± 0.083
4.331ThrLeu: 4.331 ± 0.103
1.279ThrMet: 1.279 ± 0.057
2.015ThrAsn: 2.015 ± 0.058
1.946ThrPro: 1.946 ± 0.057
0.828ThrGln: 0.828 ± 0.04
1.697ThrArg: 1.697 ± 0.061
3.179ThrSer: 3.179 ± 0.082
2.123ThrThr: 2.123 ± 0.079
3.685ThrVal: 3.685 ± 0.098
0.386ThrTrp: 0.386 ± 0.029
2.266ThrTyr: 2.266 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
3.203ValAla: 3.203 ± 0.094
0.44ValCys: 0.44 ± 0.031
3.086ValAsp: 3.086 ± 0.08
2.704ValGlu: 2.704 ± 0.074
3.203ValPhe: 3.203 ± 0.083
3.251ValGly: 3.251 ± 0.095
0.959ValHis: 0.959 ± 0.049
6.367ValIle: 6.367 ± 0.127
4.079ValLys: 4.079 ± 0.088
5.334ValLeu: 5.334 ± 0.113
1.554ValMet: 1.554 ± 0.053
3.703ValAsn: 3.703 ± 0.096
2.451ValPro: 2.451 ± 0.074
0.947ValGln: 0.947 ± 0.042
2.133ValArg: 2.133 ± 0.058
4.562ValSer: 4.562 ± 0.088
2.933ValThr: 2.933 ± 0.079
3.094ValVal: 3.094 ± 0.1
0.362ValTrp: 0.362 ± 0.029
2.953ValTyr: 2.953 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.464TrpAla: 0.464 ± 0.03
0.044TrpCys: 0.044 ± 0.009
0.352TrpAsp: 0.352 ± 0.026
0.404TrpGlu: 0.404 ± 0.026
0.491TrpPhe: 0.491 ± 0.036
0.501TrpGly: 0.501 ± 0.042
0.141TrpHis: 0.141 ± 0.016
0.738TrpIle: 0.738 ± 0.04
0.519TrpLys: 0.519 ± 0.035
0.724TrpLeu: 0.724 ± 0.039
0.235TrpMet: 0.235 ± 0.022
0.479TrpAsn: 0.479 ± 0.03
0.215TrpPro: 0.215 ± 0.021
0.157TrpGln: 0.157 ± 0.017
0.37TrpArg: 0.37 ± 0.027
0.466TrpSer: 0.466 ± 0.031
0.32TrpThr: 0.32 ± 0.026
0.422TrpVal: 0.422 ± 0.03
0.103TrpTrp: 0.103 ± 0.015
0.358TrpTyr: 0.358 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.823TyrAla: 2.823 ± 0.086
0.356TyrCys: 0.356 ± 0.029
2.937TyrAsp: 2.937 ± 0.078
2.732TyrGlu: 2.732 ± 0.08
2.726TyrPhe: 2.726 ± 0.091
3.639TyrGly: 3.639 ± 0.098
0.772TyrHis: 0.772 ± 0.04
5.412TyrIle: 5.412 ± 0.111
3.707TyrLys: 3.707 ± 0.092
4.473TyrLeu: 4.473 ± 0.085
1.283TyrMet: 1.283 ± 0.057
3.796TyrAsn: 3.796 ± 0.104
1.759TyrPro: 1.759 ± 0.055
0.774TyrGln: 0.774 ± 0.045
1.976TyrArg: 1.976 ± 0.07
4.079TyrSer: 4.079 ± 0.11
2.555TyrThr: 2.555 ± 0.069
2.712TyrVal: 2.712 ± 0.073
0.376TyrTrp: 0.376 ± 0.028
2.921TyrTyr: 2.921 ± 0.097
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1683 proteins (497383 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski