Amino acid dipepetide frequency for Blautia sp. An46

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.074AlaAla: 7.074 ± 0.108
1.116AlaCys: 1.116 ± 0.035
3.996AlaAsp: 3.996 ± 0.054
5.245AlaGlu: 5.245 ± 0.078
3.019AlaPhe: 3.019 ± 0.053
6.281AlaGly: 6.281 ± 0.075
1.107AlaHis: 1.107 ± 0.034
4.218AlaIle: 4.218 ± 0.063
4.138AlaLys: 4.138 ± 0.066
6.809AlaLeu: 6.809 ± 0.081
2.295AlaMet: 2.295 ± 0.051
2.089AlaAsn: 2.089 ± 0.048
2.075AlaPro: 2.075 ± 0.053
2.638AlaGln: 2.638 ± 0.057
3.279AlaArg: 3.279 ± 0.058
3.737AlaSer: 3.737 ± 0.065
2.59AlaThr: 2.59 ± 0.054
6.163AlaVal: 6.163 ± 0.084
0.628AlaTrp: 0.628 ± 0.024
2.678AlaTyr: 2.678 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.932CysAla: 0.932 ± 0.032
0.333CysCys: 0.333 ± 0.021
0.73CysAsp: 0.73 ± 0.027
0.834CysGlu: 0.834 ± 0.026
0.673CysPhe: 0.673 ± 0.024
1.481CysGly: 1.481 ± 0.037
0.319CysHis: 0.319 ± 0.018
1.123CysIle: 1.123 ± 0.036
0.713CysLys: 0.713 ± 0.026
1.286CysLeu: 1.286 ± 0.034
0.458CysMet: 0.458 ± 0.02
0.485CysAsn: 0.485 ± 0.021
0.7CysPro: 0.7 ± 0.028
0.59CysGln: 0.59 ± 0.025
0.917CysArg: 0.917 ± 0.033
0.935CysSer: 0.935 ± 0.031
0.757CysThr: 0.757 ± 0.027
0.97CysVal: 0.97 ± 0.035
0.117CysTrp: 0.117 ± 0.01
0.544CysTyr: 0.544 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.203AspAla: 3.203 ± 0.064
0.801AspCys: 0.801 ± 0.027
2.193AspAsp: 2.193 ± 0.061
3.954AspGlu: 3.954 ± 0.072
2.849AspPhe: 2.849 ± 0.052
3.761AspGly: 3.761 ± 0.073
0.865AspHis: 0.865 ± 0.037
4.296AspIle: 4.296 ± 0.065
3.261AspLys: 3.261 ± 0.058
4.666AspLeu: 4.666 ± 0.068
1.895AspMet: 1.895 ± 0.042
2.005AspAsn: 2.005 ± 0.049
1.854AspPro: 1.854 ± 0.043
1.807AspGln: 1.807 ± 0.04
2.603AspArg: 2.603 ± 0.05
3.017AspSer: 3.017 ± 0.06
3.107AspThr: 3.107 ± 0.055
3.277AspVal: 3.277 ± 0.061
0.586AspTrp: 0.586 ± 0.025
2.851AspTyr: 2.851 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.862GluAla: 5.862 ± 0.085
0.792GluCys: 0.792 ± 0.027
4.799GluAsp: 4.799 ± 0.073
9.323GluGlu: 9.323 ± 0.135
2.704GluPhe: 2.704 ± 0.053
5.173GluGly: 5.173 ± 0.075
1.348GluHis: 1.348 ± 0.037
6.157GluIle: 6.157 ± 0.07
8.138GluLys: 8.138 ± 0.106
7.043GluLeu: 7.043 ± 0.089
2.467GluMet: 2.467 ± 0.043
4.604GluAsn: 4.604 ± 0.069
2.032GluPro: 2.032 ± 0.044
2.974GluGln: 2.974 ± 0.059
3.667GluArg: 3.667 ± 0.061
3.415GluSer: 3.415 ± 0.062
4.018GluThr: 4.018 ± 0.061
4.403GluVal: 4.403 ± 0.07
0.67GluTrp: 0.67 ± 0.026
3.333GluTyr: 3.333 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
2.806PheAla: 2.806 ± 0.051
0.791PheCys: 0.791 ± 0.027
2.324PheAsp: 2.324 ± 0.042
2.506PheGlu: 2.506 ± 0.048
2.112PhePhe: 2.112 ± 0.05
2.952PheGly: 2.952 ± 0.061
0.927PheHis: 0.927 ± 0.03
2.784PheIle: 2.784 ± 0.067
1.851PheLys: 1.851 ± 0.038
4.624PheLeu: 4.624 ± 0.083
1.16PheMet: 1.16 ± 0.037
1.37PheAsn: 1.37 ± 0.041
1.619PhePro: 1.619 ± 0.04
1.862PheGln: 1.862 ± 0.045
1.894PheArg: 1.894 ± 0.044
3.204PheSer: 3.204 ± 0.054
2.354PheThr: 2.354 ± 0.05
2.624PheVal: 2.624 ± 0.051
0.518PheTrp: 0.518 ± 0.025
1.826PheTyr: 1.826 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.973GlyAla: 4.973 ± 0.074
1.26GlyCys: 1.26 ± 0.033
3.433GlyAsp: 3.433 ± 0.068
5.472GlyGlu: 5.472 ± 0.079
3.172GlyPhe: 3.172 ± 0.056
4.86GlyGly: 4.86 ± 0.085
1.22GlyHis: 1.22 ± 0.034
6.512GlyIle: 6.512 ± 0.084
5.884GlyLys: 5.884 ± 0.079
6.043GlyLeu: 6.043 ± 0.087
2.333GlyMet: 2.333 ± 0.047
3.044GlyAsn: 3.044 ± 0.058
1.435GlyPro: 1.435 ± 0.039
2.34GlyGln: 2.34 ± 0.051
3.363GlyArg: 3.363 ± 0.054
4.034GlySer: 4.034 ± 0.067
4.199GlyThr: 4.199 ± 0.074
4.759GlyVal: 4.759 ± 0.075
0.743GlyTrp: 0.743 ± 0.029
3.319GlyTyr: 3.319 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
0.923HisAla: 0.923 ± 0.029
0.344HisCys: 0.344 ± 0.019
0.844HisAsp: 0.844 ± 0.032
1.075HisGlu: 1.075 ± 0.033
0.842HisPhe: 0.842 ± 0.029
1.299HisGly: 1.299 ± 0.038
0.417HisHis: 0.417 ± 0.027
1.422HisIle: 1.422 ± 0.037
0.916HisLys: 0.916 ± 0.03
1.588HisLeu: 1.588 ± 0.038
0.574HisMet: 0.574 ± 0.022
0.659HisAsn: 0.659 ± 0.027
0.878HisPro: 0.878 ± 0.03
0.595HisGln: 0.595 ± 0.024
0.914HisArg: 0.914 ± 0.023
0.976HisSer: 0.976 ± 0.029
0.954HisThr: 0.954 ± 0.029
1.032HisVal: 1.032 ± 0.032
0.188HisTrp: 0.188 ± 0.013
0.791HisTyr: 0.791 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.004IleAla: 5.004 ± 0.075
1.285IleCys: 1.285 ± 0.039
3.614IleAsp: 3.614 ± 0.066
4.749IleGlu: 4.749 ± 0.061
3.272IlePhe: 3.272 ± 0.067
4.725IleGly: 4.725 ± 0.073
1.423IleHis: 1.423 ± 0.039
4.596IleIle: 4.596 ± 0.076
3.691IleLys: 3.691 ± 0.055
7.923IleLeu: 7.923 ± 0.105
1.911IleMet: 1.911 ± 0.044
2.442IleAsn: 2.442 ± 0.052
3.38IlePro: 3.38 ± 0.046
2.977IleGln: 2.977 ± 0.052
3.995IleArg: 3.995 ± 0.065
4.845IleSer: 4.845 ± 0.072
3.927IleThr: 3.927 ± 0.062
4.215IleVal: 4.215 ± 0.081
0.658IleTrp: 0.658 ± 0.028
2.855IleTyr: 2.855 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
5.03LysAla: 5.03 ± 0.074
0.675LysCys: 0.675 ± 0.026
3.913LysAsp: 3.913 ± 0.065
7.394LysGlu: 7.394 ± 0.087
1.86LysPhe: 1.86 ± 0.041
4.539LysGly: 4.539 ± 0.07
0.914LysHis: 0.914 ± 0.03
5.065LysIle: 5.065 ± 0.067
6.491LysLys: 6.491 ± 0.104
5.142LysLeu: 5.142 ± 0.072
2.121LysMet: 2.121 ± 0.047
3.587LysAsn: 3.587 ± 0.06
1.921LysPro: 1.921 ± 0.042
2.134LysGln: 2.134 ± 0.046
3.269LysArg: 3.269 ± 0.053
3.078LysSer: 3.078 ± 0.056
3.667LysThr: 3.667 ± 0.06
4.04LysVal: 4.04 ± 0.061
0.628LysTrp: 0.628 ± 0.023
2.851LysTyr: 2.851 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
7.102LeuAla: 7.102 ± 0.093
1.518LeuCys: 1.518 ± 0.044
5.101LeuAsp: 5.101 ± 0.069
7.774LeuGlu: 7.774 ± 0.099
3.93LeuPhe: 3.93 ± 0.071
6.495LeuGly: 6.495 ± 0.088
1.597LeuHis: 1.597 ± 0.042
5.955LeuIle: 5.955 ± 0.078
6.323LeuLys: 6.323 ± 0.069
9.53LeuLeu: 9.53 ± 0.141
2.687LeuMet: 2.687 ± 0.053
3.567LeuAsn: 3.567 ± 0.052
3.856LeuPro: 3.856 ± 0.062
2.919LeuGln: 2.919 ± 0.057
3.977LeuArg: 3.977 ± 0.063
6.291LeuSer: 6.291 ± 0.083
5.014LeuThr: 5.014 ± 0.073
5.573LeuVal: 5.573 ± 0.08
0.89LeuTrp: 0.89 ± 0.032
3.581LeuTyr: 3.581 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.479MetAla: 2.479 ± 0.052
0.35MetCys: 0.35 ± 0.017
1.768MetAsp: 1.768 ± 0.047
3.06MetGlu: 3.06 ± 0.055
0.959MetPhe: 0.959 ± 0.03
2.243MetGly: 2.243 ± 0.044
0.402MetHis: 0.402 ± 0.02
2.009MetIle: 2.009 ± 0.044
2.681MetLys: 2.681 ± 0.04
2.621MetLeu: 2.621 ± 0.054
0.86MetMet: 0.86 ± 0.032
1.38MetAsn: 1.38 ± 0.035
1.101MetPro: 1.101 ± 0.03
0.806MetGln: 0.806 ± 0.026
1.202MetArg: 1.202 ± 0.033
1.685MetSer: 1.685 ± 0.038
1.666MetThr: 1.666 ± 0.037
1.839MetVal: 1.839 ± 0.041
0.221MetTrp: 0.221 ± 0.016
0.89MetTyr: 0.89 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.597AsnAla: 2.597 ± 0.047
0.63AsnCys: 0.63 ± 0.024
1.633AsnAsp: 1.633 ± 0.043
2.339AsnGlu: 2.339 ± 0.054
1.658AsnPhe: 1.658 ± 0.036
3.014AsnGly: 3.014 ± 0.053
0.777AsnHis: 0.777 ± 0.029
3.225AsnIle: 3.225 ± 0.06
2.25AsnLys: 2.25 ± 0.052
3.94AsnLeu: 3.94 ± 0.062
1.273AsnMet: 1.273 ± 0.031
1.493AsnAsn: 1.493 ± 0.04
2.096AsnPro: 2.096 ± 0.04
1.59AsnGln: 1.59 ± 0.042
2.122AsnArg: 2.122 ± 0.047
2.194AsnSer: 2.194 ± 0.043
2.193AsnThr: 2.193 ± 0.049
2.44AsnVal: 2.44 ± 0.05
0.44AsnTrp: 0.44 ± 0.02
1.762AsnTyr: 1.762 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.437ProAla: 2.437 ± 0.054
0.5ProCys: 0.5 ± 0.021
2.355ProAsp: 2.355 ± 0.053
3.835ProGlu: 3.835 ± 0.06
1.638ProPhe: 1.638 ± 0.043
2.692ProGly: 2.692 ± 0.048
0.559ProHis: 0.559 ± 0.023
1.923ProIle: 1.923 ± 0.042
1.871ProLys: 1.871 ± 0.045
3.122ProLeu: 3.122 ± 0.054
0.919ProMet: 0.919 ± 0.031
1.124ProAsn: 1.124 ± 0.03
0.848ProPro: 0.848 ± 0.032
1.324ProGln: 1.324 ± 0.04
1.269ProArg: 1.269 ± 0.038
1.845ProSer: 1.845 ± 0.045
1.429ProThr: 1.429 ± 0.039
3.122ProVal: 3.122 ± 0.055
0.386ProTrp: 0.386 ± 0.024
1.575ProTyr: 1.575 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
2.794GlnAla: 2.794 ± 0.061
0.384GlnCys: 0.384 ± 0.02
1.857GlnAsp: 1.857 ± 0.038
4.018GlnGlu: 4.018 ± 0.071
1.108GlnPhe: 1.108 ± 0.033
2.743GlnGly: 2.743 ± 0.06
0.446GlnHis: 0.446 ± 0.023
2.801GlnIle: 2.801 ± 0.048
2.908GlnLys: 2.908 ± 0.054
2.837GlnLeu: 2.837 ± 0.051
1.22GlnMet: 1.22 ± 0.036
1.566GlnAsn: 1.566 ± 0.038
1.025GlnPro: 1.025 ± 0.032
1.234GlnGln: 1.234 ± 0.044
1.698GlnArg: 1.698 ± 0.042
1.654GlnSer: 1.654 ± 0.043
1.767GlnThr: 1.767 ± 0.044
2.399GlnVal: 2.399 ± 0.048
0.402GlnTrp: 0.402 ± 0.019
1.437GlnTyr: 1.437 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.732ArgAla: 2.732 ± 0.053
0.607ArgCys: 0.607 ± 0.027
2.349ArgAsp: 2.349 ± 0.049
5.066ArgGlu: 5.066 ± 0.088
1.947ArgPhe: 1.947 ± 0.046
2.822ArgGly: 2.822 ± 0.058
0.856ArgHis: 0.856 ± 0.027
3.763ArgIle: 3.763 ± 0.056
4.221ArgLys: 4.221 ± 0.062
4.388ArgLeu: 4.388 ± 0.065
1.547ArgMet: 1.547 ± 0.036
2.117ArgAsn: 2.117 ± 0.049
1.449ArgPro: 1.449 ± 0.041
2.117ArgGln: 2.117 ± 0.046
2.628ArgArg: 2.628 ± 0.056
2.192ArgSer: 2.192 ± 0.047
2.243ArgThr: 2.243 ± 0.046
2.491ArgVal: 2.491 ± 0.053
0.404ArgTrp: 0.404 ± 0.022
1.912ArgTyr: 1.912 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
3.85SerAla: 3.85 ± 0.061
0.893SerCys: 0.893 ± 0.025
2.784SerAsp: 2.784 ± 0.051
3.532SerGlu: 3.532 ± 0.06
2.787SerPhe: 2.787 ± 0.049
4.796SerGly: 4.796 ± 0.067
1.067SerHis: 1.067 ± 0.034
3.876SerIle: 3.876 ± 0.072
2.908SerLys: 2.908 ± 0.055
5.59SerLeu: 5.59 ± 0.084
1.776SerMet: 1.776 ± 0.038
1.816SerAsn: 1.816 ± 0.038
2.04SerPro: 2.04 ± 0.046
2.434SerGln: 2.434 ± 0.056
3.197SerArg: 3.197 ± 0.059
3.704SerSer: 3.704 ± 0.081
2.518SerThr: 2.518 ± 0.051
4.014SerVal: 4.014 ± 0.061
0.624SerTrp: 0.624 ± 0.024
2.463SerTyr: 2.463 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.237ThrAla: 4.237 ± 0.066
0.653ThrCys: 0.653 ± 0.021
2.982ThrAsp: 2.982 ± 0.054
4.085ThrGlu: 4.085 ± 0.072
2.085ThrPhe: 2.085 ± 0.048
4.755ThrGly: 4.755 ± 0.077
0.831ThrHis: 0.831 ± 0.028
3.45ThrIle: 3.45 ± 0.058
2.601ThrLys: 2.601 ± 0.054
4.779ThrLeu: 4.779 ± 0.062
1.39ThrMet: 1.39 ± 0.036
1.634ThrAsn: 1.634 ± 0.043
2.122ThrPro: 2.122 ± 0.038
1.703ThrGln: 1.703 ± 0.042
2.201ThrArg: 2.201 ± 0.043
2.727ThrSer: 2.727 ± 0.052
2.445ThrThr: 2.445 ± 0.055
4.256ThrVal: 4.256 ± 0.063
0.49ThrTrp: 0.49 ± 0.022
1.901ThrTyr: 1.901 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
4.028ValAla: 4.028 ± 0.076
1.184ValCys: 1.184 ± 0.033
3.24ValAsp: 3.24 ± 0.059
4.689ValGlu: 4.689 ± 0.077
3.116ValPhe: 3.116 ± 0.054
3.845ValGly: 3.845 ± 0.082
1.067ValHis: 1.067 ± 0.035
4.76ValIle: 4.76 ± 0.08
4.402ValLys: 4.402 ± 0.071
6.78ValLeu: 6.78 ± 0.09
1.938ValMet: 1.938 ± 0.044
2.568ValAsn: 2.568 ± 0.045
2.488ValPro: 2.488 ± 0.053
2.088ValGln: 2.088 ± 0.052
2.991ValArg: 2.991 ± 0.051
4.363ValSer: 4.363 ± 0.061
3.776ValThr: 3.776 ± 0.068
4.195ValVal: 4.195 ± 0.077
0.671ValTrp: 0.671 ± 0.025
2.66ValTyr: 2.66 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.575TrpAla: 0.575 ± 0.023
0.137TrpCys: 0.137 ± 0.011
0.568TrpAsp: 0.568 ± 0.02
0.823TrpGlu: 0.823 ± 0.027
0.446TrpPhe: 0.446 ± 0.019
0.734TrpGly: 0.734 ± 0.025
0.182TrpHis: 0.182 ± 0.014
0.708TrpIle: 0.708 ± 0.029
0.869TrpLys: 0.869 ± 0.032
0.932TrpLeu: 0.932 ± 0.027
0.295TrpMet: 0.295 ± 0.016
0.521TrpAsn: 0.521 ± 0.022
0.214TrpPro: 0.214 ± 0.015
0.398TrpGln: 0.398 ± 0.019
0.418TrpArg: 0.418 ± 0.019
0.483TrpSer: 0.483 ± 0.023
0.439TrpThr: 0.439 ± 0.02
0.517TrpVal: 0.517 ± 0.021
0.111TrpTrp: 0.111 ± 0.01
0.362TrpTyr: 0.362 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.538TyrAla: 2.538 ± 0.051
0.647TyrCys: 0.647 ± 0.022
2.371TyrAsp: 2.371 ± 0.048
3.148TyrGlu: 3.148 ± 0.054
1.93TyrPhe: 1.93 ± 0.044
3.186TyrGly: 3.186 ± 0.054
0.904TyrHis: 0.904 ± 0.028
2.844TyrIle: 2.844 ± 0.054
2.203TyrLys: 2.203 ± 0.049
4.037TyrLeu: 4.037 ± 0.072
1.105TyrMet: 1.105 ± 0.037
1.594TyrAsn: 1.594 ± 0.042
1.639TyrPro: 1.639 ± 0.04
1.767TyrGln: 1.767 ± 0.043
2.244TyrArg: 2.244 ± 0.043
2.29TyrSer: 2.29 ± 0.05
2.265TyrThr: 2.265 ± 0.055
2.52TyrVal: 2.52 ± 0.044
0.357TyrTrp: 0.357 ± 0.019
1.949TyrTyr: 1.949 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3536 proteins (1118543 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski