Amino acid dipepetide frequency for Oceanobacillus halophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.944AlaAla: 4.944 ± 0.089	0.538AlaCys: 0.538 ± 0.022	3.233AlaAsp: 3.233 ± 0.055	4.44AlaGlu: 4.44 ± 0.072	3.207AlaPhe: 3.207 ± 0.065	4.885AlaGly: 4.885 ± 0.084	1.095AlaHis: 1.095 ± 0.033	6.057AlaIle: 6.057 ± 0.084	4.462AlaLys: 4.462 ± 0.065	6.484AlaLeu: 6.484 ± 0.085	2.002AlaMet: 2.002 ± 0.05	2.937AlaAsn: 2.937 ± 0.056	1.938AlaPro: 1.938 ± 0.051	1.91AlaGln: 1.91 ± 0.044	2.413AlaArg: 2.413 ± 0.053	3.9AlaSer: 3.9 ± 0.062	3.382AlaThr: 3.382 ± 0.059	5.015AlaVal: 5.015 ± 0.073	0.608AlaTrp: 0.608 ± 0.024	2.181AlaTyr: 2.181 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.333CysAla: 0.333 ± 0.018	0.057CysCys: 0.057 ± 0.008	0.33CysAsp: 0.33 ± 0.018	0.369CysGlu: 0.369 ± 0.018	0.234CysPhe: 0.234 ± 0.014	0.575CysGly: 0.575 ± 0.029	0.195CysHis: 0.195 ± 0.015	0.419CysIle: 0.419 ± 0.02	0.333CysLys: 0.333 ± 0.02	0.513CysLeu: 0.513 ± 0.022	0.147CysMet: 0.147 ± 0.012	0.283CysAsn: 0.283 ± 0.016	0.301CysPro: 0.301 ± 0.02	0.194CysGln: 0.194 ± 0.011	0.226CysArg: 0.226 ± 0.015	0.425CysSer: 0.425 ± 0.018	0.334CysThr: 0.334 ± 0.019	0.361CysVal: 0.361 ± 0.018	0.054CysTrp: 0.054 ± 0.007	0.229CysTyr: 0.229 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.24AspAla: 3.24 ± 0.054	0.297AspCys: 0.297 ± 0.018	2.739AspAsp: 2.739 ± 0.061	4.621AspGlu: 4.621 ± 0.077	2.51AspPhe: 2.51 ± 0.052	3.467AspGly: 3.467 ± 0.062	1.027AspHis: 1.027 ± 0.026	4.571AspIle: 4.571 ± 0.074	3.603AspLys: 3.603 ± 0.059	5.014AspLeu: 5.014 ± 0.055	1.495AspMet: 1.495 ± 0.033	2.309AspAsn: 2.309 ± 0.047	1.913AspPro: 1.913 ± 0.042	1.805AspGln: 1.805 ± 0.043	2.281AspArg: 2.281 ± 0.061	2.804AspSer: 2.804 ± 0.057	2.725AspThr: 2.725 ± 0.056	3.84AspVal: 3.84 ± 0.053	0.639AspTrp: 0.639 ± 0.026	2.349AspTyr: 2.349 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.151GluAla: 5.151 ± 0.079	0.282GluCys: 0.282 ± 0.018	4.255GluAsp: 4.255 ± 0.074	7.86GluGlu: 7.86 ± 0.098	2.671GluPhe: 2.671 ± 0.051	4.306GluGly: 4.306 ± 0.067	1.385GluHis: 1.385 ± 0.034	6.014GluIle: 6.014 ± 0.073	7.036GluLys: 7.036 ± 0.09	7.172GluLeu: 7.172 ± 0.075	2.385GluMet: 2.385 ± 0.043	4.35GluAsn: 4.35 ± 0.071	1.95GluPro: 1.95 ± 0.039	3.262GluGln: 3.262 ± 0.066	3.36GluArg: 3.36 ± 0.056	3.963GluSer: 3.963 ± 0.068	4.051GluThr: 4.051 ± 0.074	5.481GluVal: 5.481 ± 0.091	0.812GluTrp: 0.812 ± 0.032	2.388GluTyr: 2.388 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.96PheAla: 2.96 ± 0.059	0.289PheCys: 0.289 ± 0.014	2.454PheAsp: 2.454 ± 0.048	2.765PheGlu: 2.765 ± 0.05	2.279PhePhe: 2.279 ± 0.061	3.217PheGly: 3.217 ± 0.061	1.046PheHis: 1.046 ± 0.032	4.164PheIle: 4.164 ± 0.082	2.314PheLys: 2.314 ± 0.052	4.502PheLeu: 4.502 ± 0.087	1.206PheMet: 1.206 ± 0.033	1.943PheAsn: 1.943 ± 0.043	1.698PhePro: 1.698 ± 0.037	1.673PheGln: 1.673 ± 0.039	1.495PheArg: 1.495 ± 0.04	3.257PheSer: 3.257 ± 0.054	2.614PheThr: 2.614 ± 0.049	3.149PheVal: 3.149 ± 0.061	0.459PheTrp: 0.459 ± 0.018	1.765PheTyr: 1.765 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.595GlyAla: 4.595 ± 0.095	0.505GlyCys: 0.505 ± 0.023	3.217GlyAsp: 3.217 ± 0.068	4.681GlyGlu: 4.681 ± 0.065	3.284GlyPhe: 3.284 ± 0.058	4.739GlyGly: 4.739 ± 0.089	1.301GlyHis: 1.301 ± 0.036	6.217GlyIle: 6.217 ± 0.082	4.908GlyLys: 4.908 ± 0.066	6.399GlyLeu: 6.399 ± 0.08	2.195GlyMet: 2.195 ± 0.046	2.971GlyAsn: 2.971 ± 0.049	1.723GlyPro: 1.723 ± 0.047	2.0GlyGln: 2.0 ± 0.046	2.463GlyArg: 2.463 ± 0.06	3.921GlySer: 3.921 ± 0.063	4.034GlyThr: 4.034 ± 0.062	5.013GlyVal: 5.013 ± 0.072	0.758GlyTrp: 0.758 ± 0.026	2.798GlyTyr: 2.798 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.307HisAla: 1.307 ± 0.036	0.171HisCys: 0.171 ± 0.014	1.027HisAsp: 1.027 ± 0.034	1.297HisGlu: 1.297 ± 0.044	1.03HisPhe: 1.03 ± 0.033	1.371HisGly: 1.371 ± 0.038	0.659HisHis: 0.659 ± 0.032	1.504HisIle: 1.504 ± 0.038	1.014HisLys: 1.014 ± 0.032	2.014HisLeu: 2.014 ± 0.046	0.519HisMet: 0.519 ± 0.02	0.763HisAsn: 0.763 ± 0.028	1.103HisPro: 1.103 ± 0.035	0.8HisGln: 0.8 ± 0.026	0.82HisArg: 0.82 ± 0.028	1.157HisSer: 1.157 ± 0.031	1.058HisThr: 1.058 ± 0.035	1.44HisVal: 1.44 ± 0.039	0.199HisTrp: 0.199 ± 0.012	0.871HisTyr: 0.871 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.098IleAla: 6.098 ± 0.087	0.559IleCys: 0.559 ± 0.021	4.459IleAsp: 4.459 ± 0.061	5.826IleGlu: 5.826 ± 0.089	3.632IlePhe: 3.632 ± 0.076	6.315IleGly: 6.315 ± 0.095	1.776IleHis: 1.776 ± 0.039	6.783IleIle: 6.783 ± 0.099	4.716IleLys: 4.716 ± 0.064	7.653IleLeu: 7.653 ± 0.108	1.961IleMet: 1.961 ± 0.046	3.866IleAsn: 3.866 ± 0.064	3.576IlePro: 3.576 ± 0.065	3.113IleGln: 3.113 ± 0.063	3.06IleArg: 3.06 ± 0.047	5.399IleSer: 5.399 ± 0.079	4.715IleThr: 4.715 ± 0.074	5.676IleVal: 5.676 ± 0.079	0.695IleTrp: 0.695 ± 0.028	2.833IleTyr: 2.833 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.305LysAla: 4.305 ± 0.07	0.268LysCys: 0.268 ± 0.015	4.05LysAsp: 4.05 ± 0.068	7.342LysGlu: 7.342 ± 0.102	1.95LysPhe: 1.95 ± 0.046	4.177LysGly: 4.177 ± 0.066	1.394LysHis: 1.394 ± 0.038	4.663LysIle: 4.663 ± 0.075	5.806LysLys: 5.806 ± 0.082	5.792LysLeu: 5.792 ± 0.083	2.202LysMet: 2.202 ± 0.051	3.573LysAsn: 3.573 ± 0.063	2.147LysPro: 2.147 ± 0.041	3.204LysGln: 3.204 ± 0.056	3.236LysArg: 3.236 ± 0.063	3.623LysSer: 3.623 ± 0.06	3.427LysThr: 3.427 ± 0.057	4.707LysVal: 4.707 ± 0.071	0.773LysTrp: 0.773 ± 0.028	2.297LysTyr: 2.297 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	6.538LeuAla: 6.538 ± 0.085	0.537LeuCys: 0.537 ± 0.023	5.029LeuAsp: 5.029 ± 0.067	6.99LeuGlu: 6.99 ± 0.081	4.861LeuPhe: 4.861 ± 0.081	6.411LeuGly: 6.411 ± 0.094	1.895LeuHis: 1.895 ± 0.042	7.498LeuIle: 7.498 ± 0.127	6.08LeuLys: 6.08 ± 0.073	9.695LeuLeu: 9.695 ± 0.127	2.402LeuMet: 2.402 ± 0.044	4.297LeuAsn: 4.297 ± 0.068	3.781LeuPro: 3.781 ± 0.058	3.404LeuGln: 3.404 ± 0.056	3.461LeuArg: 3.461 ± 0.065	6.58LeuSer: 6.58 ± 0.075	5.554LeuThr: 5.554 ± 0.073	6.172LeuVal: 6.172 ± 0.08	0.747LeuTrp: 0.747 ± 0.029	3.072LeuTyr: 3.072 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.955MetAla: 1.955 ± 0.047	0.118MetCys: 0.118 ± 0.011	1.725MetAsp: 1.725 ± 0.041	2.435MetGlu: 2.435 ± 0.041	1.073MetPhe: 1.073 ± 0.033	1.789MetGly: 1.789 ± 0.051	0.448MetHis: 0.448 ± 0.015	2.266MetIle: 2.266 ± 0.047	2.506MetLys: 2.506 ± 0.04	2.428MetLeu: 2.428 ± 0.053	0.865MetMet: 0.865 ± 0.03	1.674MetAsn: 1.674 ± 0.044	0.914MetPro: 0.914 ± 0.029	0.953MetGln: 0.953 ± 0.032	1.032MetArg: 1.032 ± 0.03	1.683MetSer: 1.683 ± 0.036	1.569MetThr: 1.569 ± 0.038	1.919MetVal: 1.919 ± 0.04	0.178MetTrp: 0.178 ± 0.014	0.774MetTyr: 0.774 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.752AsnAla: 2.752 ± 0.048	0.297AsnCys: 0.297 ± 0.017	2.424AsnAsp: 2.424 ± 0.038	3.809AsnGlu: 3.809 ± 0.066	1.812AsnPhe: 1.812 ± 0.035	3.364AsnGly: 3.364 ± 0.062	1.213AsnHis: 1.213 ± 0.034	3.824AsnIle: 3.824 ± 0.063	3.323AsnLys: 3.323 ± 0.057	4.195AsnLeu: 4.195 ± 0.066	1.415AsnMet: 1.415 ± 0.037	2.541AsnAsn: 2.541 ± 0.064	2.232AsnPro: 2.232 ± 0.046	2.313AsnGln: 2.313 ± 0.053	2.127AsnArg: 2.127 ± 0.043	2.432AsnSer: 2.432 ± 0.051	2.365AsnThr: 2.365 ± 0.046	3.144AsnVal: 3.144 ± 0.059	0.607AsnTrp: 0.607 ± 0.022	1.943AsnTyr: 1.943 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.084ProAla: 2.084 ± 0.047	0.186ProCys: 0.186 ± 0.013	2.026ProAsp: 2.026 ± 0.046	3.059ProGlu: 3.059 ± 0.051	1.877ProPhe: 1.877 ± 0.043	2.257ProGly: 2.257 ± 0.05	0.721ProHis: 0.721 ± 0.028	3.043ProIle: 3.043 ± 0.049	2.223ProLys: 2.223 ± 0.045	3.239ProLeu: 3.239 ± 0.056	0.87ProMet: 0.87 ± 0.028	1.828ProAsn: 1.828 ± 0.043	0.935ProPro: 0.935 ± 0.035	0.969ProGln: 0.969 ± 0.031	1.067ProArg: 1.067 ± 0.027	2.223ProSer: 2.223 ± 0.049	2.019ProThr: 2.019 ± 0.047	2.758ProVal: 2.758 ± 0.051	0.329ProTrp: 0.329 ± 0.018	1.442ProTyr: 1.442 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.593GlnAla: 2.593 ± 0.051	0.167GlnCys: 0.167 ± 0.013	1.701GlnAsp: 1.701 ± 0.044	3.004GlnGlu: 3.004 ± 0.062	1.582GlnPhe: 1.582 ± 0.04	2.144GlnGly: 2.144 ± 0.041	0.696GlnHis: 0.696 ± 0.025	2.66GlnIle: 2.66 ± 0.048	2.607GlnLys: 2.607 ± 0.059	3.857GlnLeu: 3.857 ± 0.072	1.165GlnMet: 1.165 ± 0.036	1.609GlnAsn: 1.609 ± 0.044	1.133GlnPro: 1.133 ± 0.033	1.689GlnGln: 1.689 ± 0.045	1.399GlnArg: 1.399 ± 0.031	2.164GlnSer: 2.164 ± 0.044	1.999GlnThr: 1.999 ± 0.043	2.519GlnVal: 2.519 ± 0.042	0.367GlnTrp: 0.367 ± 0.018	1.197GlnTyr: 1.197 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.175ArgAla: 2.175 ± 0.045	0.205ArgCys: 0.205 ± 0.015	2.03ArgAsp: 2.03 ± 0.044	3.102ArgGlu: 3.102 ± 0.062	1.767ArgPhe: 1.767 ± 0.043	2.25ArgGly: 2.25 ± 0.055	0.679ArgHis: 0.679 ± 0.026	3.073ArgIle: 3.073 ± 0.058	3.383ArgLys: 3.383 ± 0.065	3.769ArgLeu: 3.769 ± 0.07	1.259ArgMet: 1.259 ± 0.037	2.073ArgAsn: 2.073 ± 0.05	1.182ArgPro: 1.182 ± 0.039	1.366ArgGln: 1.366 ± 0.037	1.772ArgArg: 1.772 ± 0.044	2.088ArgSer: 2.088 ± 0.05	2.04ArgThr: 2.04 ± 0.043	2.577ArgVal: 2.577 ± 0.051	0.384ArgTrp: 0.384 ± 0.018	1.507ArgTyr: 1.507 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.549SerAla: 3.549 ± 0.06	0.294SerCys: 0.294 ± 0.013	3.081SerAsp: 3.081 ± 0.059	4.251SerGlu: 4.251 ± 0.061	3.187SerPhe: 3.187 ± 0.064	4.509SerGly: 4.509 ± 0.069	1.167SerHis: 1.167 ± 0.032	5.515SerIle: 5.515 ± 0.078	3.92SerLys: 3.92 ± 0.076	5.855SerLeu: 5.855 ± 0.086	1.712SerMet: 1.712 ± 0.04	2.889SerAsn: 2.889 ± 0.047	1.998SerPro: 1.998 ± 0.039	1.825SerGln: 1.825 ± 0.046	2.254SerArg: 2.254 ± 0.05	3.996SerSer: 3.996 ± 0.074	3.226SerThr: 3.226 ± 0.052	4.059SerVal: 4.059 ± 0.065	0.591SerTrp: 0.591 ± 0.024	2.319SerTyr: 2.319 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.73ThrAla: 3.73 ± 0.061	0.349ThrCys: 0.349 ± 0.019	2.921ThrAsp: 2.921 ± 0.056	3.941ThrGlu: 3.941 ± 0.055	2.688ThrPhe: 2.688 ± 0.052	4.124ThrGly: 4.124 ± 0.068	1.017ThrHis: 1.017 ± 0.032	4.953ThrIle: 4.953 ± 0.072	3.394ThrLys: 3.394 ± 0.05	5.076ThrLeu: 5.076 ± 0.075	1.342ThrMet: 1.342 ± 0.032	2.758ThrAsn: 2.758 ± 0.046	2.196ThrPro: 2.196 ± 0.05	1.377ThrGln: 1.377 ± 0.034	1.737ThrArg: 1.737 ± 0.04	3.369ThrSer: 3.369 ± 0.058	3.058ThrThr: 3.058 ± 0.063	4.094ThrVal: 4.094 ± 0.062	0.594ThrTrp: 0.594 ± 0.021	2.037ThrTyr: 2.037 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.74ValAla: 4.74 ± 0.078	0.481ValCys: 0.481 ± 0.022	4.016ValAsp: 4.016 ± 0.065	5.025ValGlu: 5.025 ± 0.064	3.211ValPhe: 3.211 ± 0.056	4.642ValGly: 4.642 ± 0.072	1.299ValHis: 1.299 ± 0.035	5.918ValIle: 5.918 ± 0.085	4.449ValLys: 4.449 ± 0.073	6.737ValLeu: 6.737 ± 0.089	1.88ValMet: 1.88 ± 0.041	3.25ValAsn: 3.25 ± 0.065	2.735ValPro: 2.735 ± 0.047	2.356ValGln: 2.356 ± 0.047	2.513ValArg: 2.513 ± 0.048	4.484ValSer: 4.484 ± 0.065	4.182ValThr: 4.182 ± 0.059	4.915ValVal: 4.915 ± 0.079	0.564ValTrp: 0.564 ± 0.023	2.303ValTyr: 2.303 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.546TrpAla: 0.546 ± 0.024	0.059TrpCys: 0.059 ± 0.007	0.53TrpAsp: 0.53 ± 0.02	0.689TrpGlu: 0.689 ± 0.023	0.509TrpPhe: 0.509 ± 0.022	0.69TrpGly: 0.69 ± 0.025	0.166TrpHis: 0.166 ± 0.013	0.853TrpIle: 0.853 ± 0.026	0.788TrpLys: 0.788 ± 0.026	1.024TrpLeu: 1.024 ± 0.035	0.352TrpMet: 0.352 ± 0.016	0.584TrpAsn: 0.584 ± 0.022	0.259TrpPro: 0.259 ± 0.014	0.353TrpGln: 0.353 ± 0.02	0.391TrpArg: 0.391 ± 0.022	0.555TrpSer: 0.555 ± 0.023	0.462TrpThr: 0.462 ± 0.021	0.591TrpVal: 0.591 ± 0.025	0.144TrpTrp: 0.144 ± 0.013	0.365TrpTyr: 0.365 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.035TyrAla: 2.035 ± 0.042	0.252TyrCys: 0.252 ± 0.017	2.003TyrAsp: 2.003 ± 0.05	2.628TyrGlu: 2.628 ± 0.057	1.886TyrPhe: 1.886 ± 0.048	2.488TyrGly: 2.488 ± 0.052	0.946TyrHis: 0.946 ± 0.027	2.716TyrIle: 2.716 ± 0.049	2.069TyrLys: 2.069 ± 0.046	3.584TyrLeu: 3.584 ± 0.062	0.931TyrMet: 0.931 ± 0.029	1.634TyrAsn: 1.634 ± 0.039	1.441TyrPro: 1.441 ± 0.039	1.683TyrGln: 1.683 ± 0.046	1.578TyrArg: 1.578 ± 0.038	2.173TyrSer: 2.173 ± 0.046	1.939TyrThr: 1.939 ± 0.038	2.273TyrVal: 2.273 ± 0.041	0.409TyrTrp: 0.409 ± 0.019	1.565TyrTyr: 1.565 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3727 proteins (1103683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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