Amino acid dipepetide frequency for Anaerotruncus sp. 22A2-44

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.523AlaAla: 14.523 ± 0.235	1.719AlaCys: 1.719 ± 0.045	6.152AlaAsp: 6.152 ± 0.094	6.858AlaGlu: 6.858 ± 0.108	3.87AlaPhe: 3.87 ± 0.077	9.87AlaGly: 9.87 ± 0.136	1.468AlaHis: 1.468 ± 0.043	4.85AlaIle: 4.85 ± 0.082	4.301AlaLys: 4.301 ± 0.08	10.801AlaLeu: 10.801 ± 0.171	2.617AlaMet: 2.617 ± 0.057	2.46AlaAsn: 2.46 ± 0.063	4.43AlaPro: 4.43 ± 0.098	3.068AlaGln: 3.068 ± 0.063	6.369AlaArg: 6.369 ± 0.122	4.946AlaSer: 4.946 ± 0.086	3.658AlaThr: 3.658 ± 0.077	9.324AlaVal: 9.324 ± 0.125	0.758AlaTrp: 0.758 ± 0.034	2.813AlaTyr: 2.813 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.816CysAla: 1.816 ± 0.058	0.31CysCys: 0.31 ± 0.02	1.004CysAsp: 1.004 ± 0.041	1.041CysGlu: 1.041 ± 0.034	0.593CysPhe: 0.593 ± 0.026	2.073CysGly: 2.073 ± 0.056	0.29CysHis: 0.29 ± 0.017	0.786CysIle: 0.786 ± 0.031	0.615CysLys: 0.615 ± 0.026	1.127CysLeu: 1.127 ± 0.038	0.358CysMet: 0.358 ± 0.024	0.427CysAsn: 0.427 ± 0.022	0.832CysPro: 0.832 ± 0.039	0.295CysGln: 0.295 ± 0.017	1.062CysArg: 1.062 ± 0.04	0.748CysSer: 0.748 ± 0.034	0.742CysThr: 0.742 ± 0.031	1.209CysVal: 1.209 ± 0.04	0.141CysTrp: 0.141 ± 0.014	0.436CysTyr: 0.436 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	6.016AspAla: 6.016 ± 0.093	0.863AspCys: 0.863 ± 0.032	2.983AspAsp: 2.983 ± 0.075	4.077AspGlu: 4.077 ± 0.081	2.334AspPhe: 2.334 ± 0.059	5.671AspGly: 5.671 ± 0.115	0.805AspHis: 0.805 ± 0.035	3.329AspIle: 3.329 ± 0.073	2.059AspLys: 2.059 ± 0.06	5.008AspLeu: 5.008 ± 0.085	1.491AspMet: 1.491 ± 0.046	1.562AspAsn: 1.562 ± 0.039	2.848AspPro: 2.848 ± 0.069	1.131AspGln: 1.131 ± 0.041	3.707AspArg: 3.707 ± 0.08	2.606AspSer: 2.606 ± 0.051	2.743AspThr: 2.743 ± 0.061	3.933AspVal: 3.933 ± 0.071	0.529AspTrp: 0.529 ± 0.03	2.361AspTyr: 2.361 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	6.748GluAla: 6.748 ± 0.092	0.675GluCys: 0.675 ± 0.031	3.25GluAsp: 3.25 ± 0.069	5.316GluGlu: 5.316 ± 0.093	2.028GluPhe: 2.028 ± 0.049	5.128GluGly: 5.128 ± 0.08	1.149GluHis: 1.149 ± 0.037	4.572GluIle: 4.572 ± 0.093	3.806GluLys: 3.806 ± 0.073	6.777GluLeu: 6.777 ± 0.113	1.999GluMet: 1.999 ± 0.051	2.764GluAsn: 2.764 ± 0.062	2.704GluPro: 2.704 ± 0.066	2.411GluGln: 2.411 ± 0.062	4.952GluArg: 4.952 ± 0.092	2.995GluSer: 2.995 ± 0.07	3.563GluThr: 3.563 ± 0.065	4.199GluVal: 4.199 ± 0.067	0.555GluTrp: 0.555 ± 0.027	2.12GluTyr: 2.12 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.72PheAla: 3.72 ± 0.069	0.744PheCys: 0.744 ± 0.033	2.606PheAsp: 2.606 ± 0.058	2.264PheGlu: 2.264 ± 0.051	1.693PhePhe: 1.693 ± 0.05	3.558PheGly: 3.558 ± 0.079	0.7PheHis: 0.7 ± 0.029	1.985PheIle: 1.985 ± 0.046	1.296PheLys: 1.296 ± 0.037	3.733PheLeu: 3.733 ± 0.083	0.815PheMet: 0.815 ± 0.031	1.117PheAsn: 1.117 ± 0.041	1.656PhePro: 1.656 ± 0.045	0.999PheGln: 0.999 ± 0.034	1.894PheArg: 1.894 ± 0.048	2.884PheSer: 2.884 ± 0.072	2.476PheThr: 2.476 ± 0.063	2.677PheVal: 2.677 ± 0.057	0.391PheTrp: 0.391 ± 0.024	1.318PheTyr: 1.318 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	8.455GlyAla: 8.455 ± 0.121	1.609GlyCys: 1.609 ± 0.05	4.369GlyAsp: 4.369 ± 0.086	6.325GlyGlu: 6.325 ± 0.085	3.372GlyPhe: 3.372 ± 0.064	7.987GlyGly: 7.987 ± 0.223	1.294GlyHis: 1.294 ± 0.041	5.266GlyIle: 5.266 ± 0.086	4.323GlyLys: 4.323 ± 0.087	7.628GlyLeu: 7.628 ± 0.114	2.731GlyMet: 2.731 ± 0.062	2.641GlyAsn: 2.641 ± 0.083	2.389GlyPro: 2.389 ± 0.063	2.196GlyGln: 2.196 ± 0.052	5.684GlyArg: 5.684 ± 0.091	4.636GlySer: 4.636 ± 0.119	4.614GlyThr: 4.614 ± 0.128	7.412GlyVal: 7.412 ± 0.107	0.99GlyTrp: 0.99 ± 0.036	3.057GlyTyr: 3.057 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.439HisAla: 1.439 ± 0.041	0.328HisCys: 0.328 ± 0.021	0.8HisAsp: 0.8 ± 0.032	0.91HisGlu: 0.91 ± 0.039	0.733HisPhe: 0.733 ± 0.028	1.419HisGly: 1.419 ± 0.043	0.292HisHis: 0.292 ± 0.019	1.042HisIle: 1.042 ± 0.039	0.647HisLys: 0.647 ± 0.027	1.497HisLeu: 1.497 ± 0.04	0.405HisMet: 0.405 ± 0.02	0.583HisAsn: 0.583 ± 0.025	1.026HisPro: 1.026 ± 0.035	0.424HisGln: 0.424 ± 0.021	0.943HisArg: 0.943 ± 0.036	0.811HisSer: 0.811 ± 0.032	0.853HisThr: 0.853 ± 0.031	1.024HisVal: 1.024 ± 0.034	0.126HisTrp: 0.126 ± 0.012	0.576HisTyr: 0.576 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.779IleAla: 5.779 ± 0.087	0.93IleCys: 0.93 ± 0.036	3.598IleAsp: 3.598 ± 0.074	3.464IleGlu: 3.464 ± 0.065	2.019IlePhe: 2.019 ± 0.054	4.789IleGly: 4.789 ± 0.078	0.917IleHis: 0.917 ± 0.036	2.983IleIle: 2.983 ± 0.079	2.197IleLys: 2.197 ± 0.062	5.27IleLeu: 5.27 ± 0.087	1.336IleMet: 1.336 ± 0.044	1.768IleAsn: 1.768 ± 0.049	2.925IlePro: 2.925 ± 0.054	1.287IleGln: 1.287 ± 0.041	3.48IleArg: 3.48 ± 0.066	3.64IleSer: 3.64 ± 0.078	3.41IleThr: 3.41 ± 0.077	4.322IleVal: 4.322 ± 0.08	0.412IleTrp: 0.412 ± 0.021	1.665IleTyr: 1.665 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.072LysAla: 4.072 ± 0.08	0.52LysCys: 0.52 ± 0.024	2.097LysAsp: 2.097 ± 0.058	3.138LysGlu: 3.138 ± 0.075	1.301LysPhe: 1.301 ± 0.041	3.062LysGly: 3.062 ± 0.065	0.622LysHis: 0.622 ± 0.026	2.703LysIle: 2.703 ± 0.06	3.018LysLys: 3.018 ± 0.08	4.249LysLeu: 4.249 ± 0.067	1.366LysMet: 1.366 ± 0.047	1.831LysAsn: 1.831 ± 0.049	1.889LysPro: 1.889 ± 0.054	1.415LysGln: 1.415 ± 0.052	2.691LysArg: 2.691 ± 0.055	2.343LysSer: 2.343 ± 0.046	2.52LysThr: 2.52 ± 0.061	2.966LysVal: 2.966 ± 0.064	0.399LysTrp: 0.399 ± 0.022	1.482LysTyr: 1.482 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	10.35LeuAla: 10.35 ± 0.141	1.934LeuCys: 1.934 ± 0.054	5.468LeuAsp: 5.468 ± 0.079	5.997LeuGlu: 5.997 ± 0.087	3.889LeuPhe: 3.889 ± 0.09	7.71LeuGly: 7.71 ± 0.109	1.584LeuHis: 1.584 ± 0.048	4.843LeuIle: 4.843 ± 0.09	3.798LeuLys: 3.798 ± 0.074	10.57LeuLeu: 10.57 ± 0.174	2.543LeuMet: 2.543 ± 0.06	2.674LeuAsn: 2.674 ± 0.059	4.835LeuPro: 4.835 ± 0.091	2.254LeuGln: 2.254 ± 0.046	6.39LeuArg: 6.39 ± 0.104	6.739LeuSer: 6.739 ± 0.096	5.469LeuThr: 5.469 ± 0.085	6.373LeuVal: 6.373 ± 0.1	0.838LeuTrp: 0.838 ± 0.036	2.898LeuTyr: 2.898 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.547MetAla: 2.547 ± 0.05	0.325MetCys: 0.325 ± 0.021	1.579MetAsp: 1.579 ± 0.047	1.957MetGlu: 1.957 ± 0.052	0.837MetPhe: 0.837 ± 0.036	2.184MetGly: 2.184 ± 0.055	0.344MetHis: 0.344 ± 0.024	1.554MetIle: 1.554 ± 0.042	1.713MetLys: 1.713 ± 0.049	2.697MetLeu: 2.697 ± 0.063	0.744MetMet: 0.744 ± 0.031	1.059MetAsn: 1.059 ± 0.038	1.232MetPro: 1.232 ± 0.038	0.879MetGln: 0.879 ± 0.031	1.568MetArg: 1.568 ± 0.043	1.517MetSer: 1.517 ± 0.042	1.64MetThr: 1.64 ± 0.043	1.771MetVal: 1.771 ± 0.053	0.168MetTrp: 0.168 ± 0.013	0.637MetTyr: 0.637 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.037AsnAla: 3.037 ± 0.068	0.484AsnCys: 0.484 ± 0.023	1.586AsnAsp: 1.586 ± 0.046	1.669AsnGlu: 1.669 ± 0.047	1.186AsnPhe: 1.186 ± 0.042	2.864AsnGly: 2.864 ± 0.092	0.5AsnHis: 0.5 ± 0.024	2.056AsnIle: 2.056 ± 0.051	1.107AsnLys: 1.107 ± 0.043	2.92AsnLeu: 2.92 ± 0.065	0.875AsnMet: 0.875 ± 0.036	0.981AsnAsn: 0.981 ± 0.048	2.064AsnPro: 2.064 ± 0.046	0.845AsnGln: 0.845 ± 0.033	1.901AsnArg: 1.901 ± 0.048	1.454AsnSer: 1.454 ± 0.044	1.661AsnThr: 1.661 ± 0.053	2.189AsnVal: 2.189 ± 0.058	0.309AsnTrp: 0.309 ± 0.021	1.106AsnTyr: 1.106 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	5.42ProAla: 5.42 ± 0.106	0.592ProCys: 0.592 ± 0.028	3.146ProAsp: 3.146 ± 0.071	3.93ProGlu: 3.93 ± 0.069	1.781ProPhe: 1.781 ± 0.045	3.842ProGly: 3.842 ± 0.078	0.721ProHis: 0.721 ± 0.027	1.974ProIle: 1.974 ± 0.052	1.614ProLys: 1.614 ± 0.049	3.86ProLeu: 3.86 ± 0.072	1.022ProMet: 1.022 ± 0.036	1.25ProAsn: 1.25 ± 0.034	1.865ProPro: 1.865 ± 0.054	1.365ProGln: 1.365 ± 0.04	2.314ProArg: 2.314 ± 0.061	2.253ProSer: 2.253 ± 0.061	1.962ProThr: 1.962 ± 0.056	4.072ProVal: 4.072 ± 0.078	0.353ProTrp: 0.353 ± 0.019	1.343ProTyr: 1.343 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.715GlnAla: 2.715 ± 0.062	0.278GlnCys: 0.278 ± 0.02	1.209GlnAsp: 1.209 ± 0.04	1.755GlnGlu: 1.755 ± 0.047	1.011GlnPhe: 1.011 ± 0.034	1.884GlnGly: 1.884 ± 0.049	0.355GlnHis: 0.355 ± 0.021	1.74GlnIle: 1.74 ± 0.045	1.751GlnLys: 1.751 ± 0.047	2.594GlnLeu: 2.594 ± 0.058	0.982GlnMet: 0.982 ± 0.033	1.305GlnAsn: 1.305 ± 0.041	1.114GlnPro: 1.114 ± 0.037	1.129GlnGln: 1.129 ± 0.044	1.586GlnArg: 1.586 ± 0.044	1.451GlnSer: 1.451 ± 0.042	1.349GlnThr: 1.349 ± 0.034	1.992GlnVal: 1.992 ± 0.054	0.232GlnTrp: 0.232 ± 0.019	0.994GlnTyr: 0.994 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.402ArgAla: 6.402 ± 0.123	0.959ArgCys: 0.959 ± 0.04	3.235ArgAsp: 3.235 ± 0.071	5.56ArgGlu: 5.56 ± 0.107	2.593ArgPhe: 2.593 ± 0.067	4.659ArgGly: 4.659 ± 0.084	1.029ArgHis: 1.029 ± 0.033	3.523ArgIle: 3.523 ± 0.07	2.48ArgLys: 2.48 ± 0.062	6.371ArgLeu: 6.371 ± 0.092	2.011ArgMet: 2.011 ± 0.052	1.605ArgAsn: 1.605 ± 0.043	2.553ArgPro: 2.553 ± 0.057	2.037ArgGln: 2.037 ± 0.048	4.897ArgArg: 4.897 ± 0.1	2.728ArgSer: 2.728 ± 0.049	3.081ArgThr: 3.081 ± 0.06	4.522ArgVal: 4.522 ± 0.077	0.613ArgTrp: 0.613 ± 0.028	2.31ArgTyr: 2.31 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.649SerAla: 5.649 ± 0.092	0.864SerCys: 0.864 ± 0.032	3.01SerAsp: 3.01 ± 0.062	3.197SerGlu: 3.197 ± 0.072	2.356SerPhe: 2.356 ± 0.049	5.786SerGly: 5.786 ± 0.166	0.998SerHis: 0.998 ± 0.033	3.135SerIle: 3.135 ± 0.065	1.966SerLys: 1.966 ± 0.047	5.284SerLeu: 5.284 ± 0.083	1.444SerMet: 1.444 ± 0.042	1.43SerAsn: 1.43 ± 0.047	2.497SerPro: 2.497 ± 0.049	1.381SerGln: 1.381 ± 0.043	3.245SerArg: 3.245 ± 0.064	3.047SerSer: 3.047 ± 0.079	2.549SerThr: 2.549 ± 0.067	4.258SerVal: 4.258 ± 0.073	0.469SerTrp: 0.469 ± 0.023	1.968SerTyr: 1.968 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.708ThrAla: 5.708 ± 0.085	0.649ThrCys: 0.649 ± 0.029	2.935ThrAsp: 2.935 ± 0.07	2.88ThrGlu: 2.88 ± 0.059	2.003ThrPhe: 2.003 ± 0.056	5.327ThrGly: 5.327 ± 0.105	0.872ThrHis: 0.872 ± 0.028	3.109ThrIle: 3.109 ± 0.091	1.792ThrLys: 1.792 ± 0.048	5.309ThrLeu: 5.309 ± 0.097	1.238ThrMet: 1.238 ± 0.045	1.432ThrAsn: 1.432 ± 0.043	2.78ThrPro: 2.78 ± 0.057	1.251ThrGln: 1.251 ± 0.039	2.692ThrArg: 2.692 ± 0.058	2.386ThrSer: 2.386 ± 0.063	2.577ThrThr: 2.577 ± 0.073	5.147ThrVal: 5.147 ± 0.117	0.422ThrTrp: 0.422 ± 0.028	1.446ThrTyr: 1.446 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	6.757ValAla: 6.757 ± 0.094	1.469ValCys: 1.469 ± 0.046	4.274ValAsp: 4.274 ± 0.072	4.709ValGlu: 4.709 ± 0.073	3.131ValPhe: 3.131 ± 0.067	5.651ValGly: 5.651 ± 0.107	1.156ValHis: 1.156 ± 0.044	4.521ValIle: 4.521 ± 0.08	3.528ValLys: 3.528 ± 0.069	7.279ValLeu: 7.279 ± 0.119	2.044ValMet: 2.044 ± 0.056	2.458ValAsn: 2.458 ± 0.056	3.39ValPro: 3.39 ± 0.072	1.73ValGln: 1.73 ± 0.051	4.858ValArg: 4.858 ± 0.083	5.098ValSer: 5.098 ± 0.09	4.713ValThr: 4.713 ± 0.115	6.145ValVal: 6.145 ± 0.097	0.721ValTrp: 0.721 ± 0.03	2.528ValTyr: 2.528 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.69TrpAla: 0.69 ± 0.026	0.15TrpCys: 0.15 ± 0.014	0.548TrpAsp: 0.548 ± 0.028	0.624TrpGlu: 0.624 ± 0.029	0.403TrpPhe: 0.403 ± 0.021	0.703TrpGly: 0.703 ± 0.027	0.163TrpHis: 0.163 ± 0.013	0.44TrpIle: 0.44 ± 0.024	0.465TrpLys: 0.465 ± 0.026	0.946TrpLeu: 0.946 ± 0.035	0.277TrpMet: 0.277 ± 0.017	0.333TrpAsn: 0.333 ± 0.022	0.263TrpPro: 0.263 ± 0.02	0.333TrpGln: 0.333 ± 0.022	0.579TrpArg: 0.579 ± 0.026	0.469TrpSer: 0.469 ± 0.024	0.439TrpThr: 0.439 ± 0.021	0.547TrpVal: 0.547 ± 0.029	0.106TrpTrp: 0.106 ± 0.01	0.306TrpTyr: 0.306 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.013TyrAla: 3.013 ± 0.057	0.502TyrCys: 0.502 ± 0.024	2.21TyrAsp: 2.21 ± 0.07	2.038TyrGlu: 2.038 ± 0.052	1.394TyrPhe: 1.394 ± 0.04	2.811TyrGly: 2.811 ± 0.054	0.615TyrHis: 0.615 ± 0.025	1.781TyrIle: 1.781 ± 0.054	1.208TyrLys: 1.208 ± 0.041	3.235TyrLeu: 3.235 ± 0.064	0.654TyrMet: 0.654 ± 0.026	1.11TyrAsn: 1.11 ± 0.039	1.387TyrPro: 1.387 ± 0.041	0.996TyrGln: 0.996 ± 0.036	2.358TyrArg: 2.358 ± 0.055	1.784TyrSer: 1.784 ± 0.05	1.938TyrThr: 1.938 ± 0.057	2.078TyrVal: 2.078 ± 0.056	0.252TyrTrp: 0.252 ± 0.017	1.243TyrTyr: 1.243 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2733 proteins (866568 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---