Amino acid dipepetide frequency for Oricola cellulosilytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.671AlaAla: 15.671 ± 0.168	0.975AlaCys: 0.975 ± 0.031	6.781AlaAsp: 6.781 ± 0.089	7.838AlaGlu: 7.838 ± 0.1	4.753AlaPhe: 4.753 ± 0.068	10.737AlaGly: 10.737 ± 0.108	2.228AlaHis: 2.228 ± 0.043	6.881AlaIle: 6.881 ± 0.085	3.949AlaLys: 3.949 ± 0.066	12.314AlaLeu: 12.314 ± 0.131	3.681AlaMet: 3.681 ± 0.054	3.012AlaAsn: 3.012 ± 0.059	4.841AlaPro: 4.841 ± 0.074	3.235AlaGln: 3.235 ± 0.057	8.126AlaArg: 8.126 ± 0.093	6.457AlaSer: 6.457 ± 0.081	5.59AlaThr: 5.59 ± 0.078	8.861AlaVal: 8.861 ± 0.091	1.351AlaTrp: 1.351 ± 0.042	2.486AlaTyr: 2.486 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.932CysAla: 0.932 ± 0.031	0.097CysCys: 0.097 ± 0.009	0.553CysAsp: 0.553 ± 0.025	0.473CysGlu: 0.473 ± 0.021	0.333CysPhe: 0.333 ± 0.017	0.973CysGly: 0.973 ± 0.039	0.248CysHis: 0.248 ± 0.016	0.434CysIle: 0.434 ± 0.019	0.182CysLys: 0.182 ± 0.012	0.728CysLeu: 0.728 ± 0.026	0.172CysMet: 0.172 ± 0.015	0.214CysAsn: 0.214 ± 0.014	0.445CysPro: 0.445 ± 0.02	0.207CysGln: 0.207 ± 0.015	0.607CysArg: 0.607 ± 0.024	0.454CysSer: 0.454 ± 0.018	0.413CysThr: 0.413 ± 0.021	0.626CysVal: 0.626 ± 0.024	0.113CysTrp: 0.113 ± 0.01	0.202CysTyr: 0.202 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.096AspAla: 7.096 ± 0.095	0.535AspCys: 0.535 ± 0.026	3.553AspAsp: 3.553 ± 0.063	3.966AspGlu: 3.966 ± 0.057	2.386AspPhe: 2.386 ± 0.047	5.574AspGly: 5.574 ± 0.082	1.375AspHis: 1.375 ± 0.04	3.452AspIle: 3.452 ± 0.057	1.682AspLys: 1.682 ± 0.041	5.777AspLeu: 5.777 ± 0.069	1.427AspMet: 1.427 ± 0.037	1.463AspAsn: 1.463 ± 0.044	3.475AspPro: 3.475 ± 0.054	1.562AspGln: 1.562 ± 0.04	4.436AspArg: 4.436 ± 0.073	2.257AspSer: 2.257 ± 0.05	2.798AspThr: 2.798 ± 0.055	4.273AspVal: 4.273 ± 0.061	0.909AspTrp: 0.909 ± 0.031	1.484AspTyr: 1.484 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.859GluAla: 7.859 ± 0.099	0.395GluCys: 0.395 ± 0.022	3.271GluAsp: 3.271 ± 0.064	3.917GluGlu: 3.917 ± 0.076	2.072GluPhe: 2.072 ± 0.042	4.597GluGly: 4.597 ± 0.069	1.282GluHis: 1.282 ± 0.035	4.174GluIle: 4.174 ± 0.058	2.756GluLys: 2.756 ± 0.058	5.467GluLeu: 5.467 ± 0.072	1.803GluMet: 1.803 ± 0.041	2.091GluAsn: 2.091 ± 0.045	2.862GluPro: 2.862 ± 0.045	2.054GluGln: 2.054 ± 0.047	5.202GluArg: 5.202 ± 0.065	2.713GluSer: 2.713 ± 0.044	4.184GluThr: 4.184 ± 0.067	3.896GluVal: 3.896 ± 0.061	0.763GluTrp: 0.763 ± 0.027	1.153GluTyr: 1.153 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.741PheAla: 4.741 ± 0.076	0.405PheCys: 0.405 ± 0.02	2.859PheAsp: 2.859 ± 0.057	2.526PheGlu: 2.526 ± 0.051	1.599PhePhe: 1.599 ± 0.047	3.824PheGly: 3.824 ± 0.062	0.773PheHis: 0.773 ± 0.025	1.798PheIle: 1.798 ± 0.042	1.003PheLys: 1.003 ± 0.031	3.626PheLeu: 3.626 ± 0.07	0.891PheMet: 0.891 ± 0.035	1.087PheAsn: 1.087 ± 0.032	1.695PhePro: 1.695 ± 0.035	1.028PheGln: 1.028 ± 0.032	2.446PheArg: 2.446 ± 0.049	2.474PheSer: 2.474 ± 0.047	1.96PheThr: 1.96 ± 0.04	2.997PheVal: 2.997 ± 0.057	0.58PheTrp: 0.58 ± 0.025	0.962PheTyr: 0.962 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.131GlyAla: 9.131 ± 0.103	0.826GlyCys: 0.826 ± 0.033	4.813GlyAsp: 4.813 ± 0.073	5.474GlyGlu: 5.474 ± 0.081	3.838GlyPhe: 3.838 ± 0.058	7.486GlyGly: 7.486 ± 0.118	1.914GlyHis: 1.914 ± 0.043	4.877GlyIle: 4.877 ± 0.069	3.554GlyLys: 3.554 ± 0.062	8.39GlyLeu: 8.39 ± 0.096	2.506GlyMet: 2.506 ± 0.043	2.304GlyAsn: 2.304 ± 0.046	3.357GlyPro: 3.357 ± 0.057	2.528GlyGln: 2.528 ± 0.047	6.025GlyArg: 6.025 ± 0.076	4.773GlySer: 4.773 ± 0.065	4.569GlyThr: 4.569 ± 0.075	6.319GlyVal: 6.319 ± 0.076	1.321GlyTrp: 1.321 ± 0.039	2.395GlyTyr: 2.395 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.28HisAla: 2.28 ± 0.046	0.261HisCys: 0.261 ± 0.015	1.291HisAsp: 1.291 ± 0.033	1.141HisGlu: 1.141 ± 0.027	0.871HisPhe: 0.871 ± 0.03	2.005HisGly: 2.005 ± 0.044	0.593HisHis: 0.593 ± 0.023	1.005HisIle: 1.005 ± 0.031	0.484HisLys: 0.484 ± 0.023	1.898HisLeu: 1.898 ± 0.046	0.53HisMet: 0.53 ± 0.021	0.51HisAsn: 0.51 ± 0.022	1.259HisPro: 1.259 ± 0.034	0.547HisGln: 0.547 ± 0.025	1.478HisArg: 1.478 ± 0.04	0.966HisSer: 0.966 ± 0.032	0.862HisThr: 0.862 ± 0.032	1.61HisVal: 1.61 ± 0.037	0.292HisTrp: 0.292 ± 0.017	0.52HisTyr: 0.52 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.78IleAla: 7.78 ± 0.085	0.511IleCys: 0.511 ± 0.023	3.794IleAsp: 3.794 ± 0.061	3.907IleGlu: 3.907 ± 0.064	1.945IlePhe: 1.945 ± 0.045	5.2IleGly: 5.2 ± 0.071	0.956IleHis: 0.956 ± 0.033	2.497IleIle: 2.497 ± 0.063	1.349IleLys: 1.349 ± 0.033	4.798IleLeu: 4.798 ± 0.079	1.063IleMet: 1.063 ± 0.034	1.512IleAsn: 1.512 ± 0.037	2.428IlePro: 2.428 ± 0.054	1.206IleGln: 1.206 ± 0.033	3.598IleArg: 3.598 ± 0.055	3.203IleSer: 3.203 ± 0.06	2.716IleThr: 2.716 ± 0.054	4.606IleVal: 4.606 ± 0.068	0.602IleTrp: 0.602 ± 0.023	1.196IleTyr: 1.196 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.168LysAla: 4.168 ± 0.073	0.19LysCys: 0.19 ± 0.013	1.726LysAsp: 1.726 ± 0.042	1.73LysGlu: 1.73 ± 0.045	0.976LysPhe: 0.976 ± 0.032	2.579LysGly: 2.579 ± 0.053	0.635LysHis: 0.635 ± 0.023	1.853LysIle: 1.853 ± 0.047	1.429LysLys: 1.429 ± 0.048	3.166LysLeu: 3.166 ± 0.056	0.813LysMet: 0.813 ± 0.031	0.96LysAsn: 0.96 ± 0.03	2.073LysPro: 2.073 ± 0.041	0.942LysGln: 0.942 ± 0.033	2.632LysArg: 2.632 ± 0.048	2.144LysSer: 2.144 ± 0.049	2.17LysThr: 2.17 ± 0.05	2.275LysVal: 2.275 ± 0.057	0.38LysTrp: 0.38 ± 0.02	0.653LysTyr: 0.653 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.365LeuAla: 12.365 ± 0.127	0.856LeuCys: 0.856 ± 0.029	5.878LeuAsp: 5.878 ± 0.083	5.684LeuGlu: 5.684 ± 0.075	3.72LeuPhe: 3.72 ± 0.071	7.773LeuGly: 7.773 ± 0.102	1.751LeuHis: 1.751 ± 0.041	4.884LeuIle: 4.884 ± 0.079	3.421LeuLys: 3.421 ± 0.062	8.621LeuLeu: 8.621 ± 0.137	2.293LeuMet: 2.293 ± 0.048	2.597LeuAsn: 2.597 ± 0.045	4.928LeuPro: 4.928 ± 0.07	2.522LeuGln: 2.522 ± 0.046	6.419LeuArg: 6.419 ± 0.086	6.299LeuSer: 6.299 ± 0.08	5.362LeuThr: 5.362 ± 0.081	7.214LeuVal: 7.214 ± 0.1	1.07LeuTrp: 1.07 ± 0.032	2.029LeuTyr: 2.029 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.131MetAla: 3.131 ± 0.054	0.166MetCys: 0.166 ± 0.012	1.273MetAsp: 1.273 ± 0.032	1.396MetGlu: 1.396 ± 0.039	0.829MetPhe: 0.829 ± 0.027	1.886MetGly: 1.886 ± 0.042	0.468MetHis: 0.468 ± 0.02	1.549MetIle: 1.549 ± 0.033	1.119MetLys: 1.119 ± 0.038	2.488MetLeu: 2.488 ± 0.05	0.74MetMet: 0.74 ± 0.028	0.924MetAsn: 0.924 ± 0.029	1.541MetPro: 1.541 ± 0.041	0.807MetGln: 0.807 ± 0.028	1.997MetArg: 1.997 ± 0.04	1.729MetSer: 1.729 ± 0.038	1.889MetThr: 1.889 ± 0.04	1.756MetVal: 1.756 ± 0.039	0.225MetTrp: 0.225 ± 0.014	0.332MetTyr: 0.332 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.387AsnAla: 3.387 ± 0.062	0.246AsnCys: 0.246 ± 0.014	1.567AsnAsp: 1.567 ± 0.035	1.494AsnGlu: 1.494 ± 0.043	1.045AsnPhe: 1.045 ± 0.03	2.661AsnGly: 2.661 ± 0.054	0.558AsnHis: 0.558 ± 0.023	1.498AsnIle: 1.498 ± 0.035	0.677AsnLys: 0.677 ± 0.028	2.508AsnLeu: 2.508 ± 0.053	0.731AsnMet: 0.731 ± 0.026	0.713AsnAsn: 0.713 ± 0.029	1.838AsnPro: 1.838 ± 0.042	0.744AsnGln: 0.744 ± 0.024	2.069AsnArg: 2.069 ± 0.043	1.357AsnSer: 1.357 ± 0.034	1.323AsnThr: 1.323 ± 0.032	2.122AsnVal: 2.122 ± 0.049	0.449AsnTrp: 0.449 ± 0.017	0.695AsnTyr: 0.695 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.509ProAla: 5.509 ± 0.07	0.326ProCys: 0.326 ± 0.019	3.834ProAsp: 3.834 ± 0.063	3.831ProGlu: 3.831 ± 0.066	1.949ProPhe: 1.949 ± 0.041	4.367ProGly: 4.367 ± 0.062	1.032ProHis: 1.032 ± 0.03	2.138ProIle: 2.138 ± 0.045	1.57ProLys: 1.57 ± 0.044	4.49ProLeu: 4.49 ± 0.076	1.117ProMet: 1.117 ± 0.035	1.331ProAsn: 1.331 ± 0.037	2.266ProPro: 2.266 ± 0.049	1.402ProGln: 1.402 ± 0.037	2.686ProArg: 2.686 ± 0.047	2.649ProSer: 2.649 ± 0.058	2.047ProThr: 2.047 ± 0.043	4.445ProVal: 4.445 ± 0.069	0.652ProTrp: 0.652 ± 0.026	1.167ProTyr: 1.167 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.351GlnAla: 3.351 ± 0.057	0.198GlnCys: 0.198 ± 0.013	1.369GlnAsp: 1.369 ± 0.035	1.482GlnGlu: 1.482 ± 0.037	1.048GlnPhe: 1.048 ± 0.032	1.966GlnGly: 1.966 ± 0.041	0.527GlnHis: 0.527 ± 0.021	1.809GlnIle: 1.809 ± 0.045	1.104GlnLys: 1.104 ± 0.033	2.424GlnLeu: 2.424 ± 0.046	0.883GlnMet: 0.883 ± 0.028	0.845GlnAsn: 0.845 ± 0.029	1.48GlnPro: 1.48 ± 0.033	1.015GlnGln: 1.015 ± 0.032	2.124GlnArg: 2.124 ± 0.043	1.702GlnSer: 1.702 ± 0.042	1.66GlnThr: 1.66 ± 0.039	1.974GlnVal: 1.974 ± 0.041	0.323GlnTrp: 0.323 ± 0.017	0.533GlnTyr: 0.533 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.438ArgAla: 7.438 ± 0.094	0.484ArgCys: 0.484 ± 0.022	4.353ArgAsp: 4.353 ± 0.075	4.707ArgGlu: 4.707 ± 0.067	3.113ArgPhe: 3.113 ± 0.054	4.802ArgGly: 4.802 ± 0.062	1.731ArgHis: 1.731 ± 0.038	4.205ArgIle: 4.205 ± 0.069	2.632ArgLys: 2.632 ± 0.056	7.175ArgLeu: 7.175 ± 0.102	2.018ArgMet: 2.018 ± 0.043	2.161ArgAsn: 2.161 ± 0.044	3.277ArgPro: 3.277 ± 0.066	2.346ArgGln: 2.346 ± 0.048	5.538ArgArg: 5.538 ± 0.092	3.994ArgSer: 3.994 ± 0.068	3.565ArgThr: 3.565 ± 0.056	4.514ArgVal: 4.514 ± 0.069	0.908ArgTrp: 0.908 ± 0.028	1.714ArgTyr: 1.714 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.294SerAla: 6.294 ± 0.085	0.427SerCys: 0.427 ± 0.023	3.332SerAsp: 3.332 ± 0.052	3.358SerGlu: 3.358 ± 0.06	2.247SerPhe: 2.247 ± 0.045	6.126SerGly: 6.126 ± 0.078	1.163SerHis: 1.163 ± 0.033	2.896SerIle: 2.896 ± 0.06	1.687SerLys: 1.687 ± 0.045	5.318SerLeu: 5.318 ± 0.078	1.465SerMet: 1.465 ± 0.031	1.503SerAsn: 1.503 ± 0.035	2.632SerPro: 2.632 ± 0.052	1.522SerGln: 1.522 ± 0.038	3.886SerArg: 3.886 ± 0.07	3.231SerSer: 3.231 ± 0.061	2.677SerThr: 2.677 ± 0.055	4.304SerVal: 4.304 ± 0.07	0.71SerTrp: 0.71 ± 0.029	1.245SerTyr: 1.245 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.158ThrAla: 6.158 ± 0.077	0.436ThrCys: 0.436 ± 0.021	2.924ThrAsp: 2.924 ± 0.06	2.858ThrGlu: 2.858 ± 0.056	1.977ThrPhe: 1.977 ± 0.044	5.589ThrGly: 5.589 ± 0.07	0.994ThrHis: 0.994 ± 0.029	3.036ThrIle: 3.036 ± 0.061	1.43ThrLys: 1.43 ± 0.034	5.544ThrLeu: 5.544 ± 0.077	1.265ThrMet: 1.265 ± 0.037	1.306ThrAsn: 1.306 ± 0.037	2.978ThrPro: 2.978 ± 0.044	1.218ThrGln: 1.218 ± 0.032	3.313ThrArg: 3.313 ± 0.05	2.83ThrSer: 2.83 ± 0.053	2.76ThrThr: 2.76 ± 0.059	4.568ThrVal: 4.568 ± 0.07	0.631ThrTrp: 0.631 ± 0.024	1.132ThrTyr: 1.132 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.918ValAla: 8.918 ± 0.099	0.656ValCys: 0.656 ± 0.027	4.214ValAsp: 4.214 ± 0.068	4.795ValGlu: 4.795 ± 0.07	3.077ValPhe: 3.077 ± 0.064	5.293ValGly: 5.293 ± 0.068	1.393ValHis: 1.393 ± 0.036	4.26ValIle: 4.26 ± 0.067	2.344ValLys: 2.344 ± 0.046	7.227ValLeu: 7.227 ± 0.096	2.02ValMet: 2.02 ± 0.042	2.104ValAsn: 2.104 ± 0.042	3.633ValPro: 3.633 ± 0.051	1.817ValGln: 1.817 ± 0.038	5.182ValArg: 5.182 ± 0.075	4.747ValSer: 4.747 ± 0.062	4.591ValThr: 4.591 ± 0.075	5.764ValVal: 5.764 ± 0.08	0.914ValTrp: 0.914 ± 0.034	1.518ValTyr: 1.518 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.154TrpAla: 1.154 ± 0.037	0.133TrpCys: 0.133 ± 0.012	0.616TrpAsp: 0.616 ± 0.021	0.616TrpGlu: 0.616 ± 0.025	0.58TrpPhe: 0.58 ± 0.028	0.807TrpGly: 0.807 ± 0.029	0.298TrpHis: 0.298 ± 0.016	0.71TrpIle: 0.71 ± 0.027	0.486TrpLys: 0.486 ± 0.021	1.506TrpLeu: 1.506 ± 0.039	0.38TrpMet: 0.38 ± 0.019	0.462TrpAsn: 0.462 ± 0.022	0.685TrpPro: 0.685 ± 0.027	0.461TrpGln: 0.461 ± 0.023	1.092TrpArg: 1.092 ± 0.035	0.819TrpSer: 0.819 ± 0.03	0.739TrpThr: 0.739 ± 0.032	0.72TrpVal: 0.72 ± 0.03	0.219TrpTrp: 0.219 ± 0.016	0.28TrpTyr: 0.28 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.405TyrAla: 2.405 ± 0.047	0.281TyrCys: 0.281 ± 0.015	1.475TyrAsp: 1.475 ± 0.043	1.317TyrGlu: 1.317 ± 0.039	0.915TyrPhe: 0.915 ± 0.032	2.154TyrGly: 2.154 ± 0.041	0.487TyrHis: 0.487 ± 0.022	0.912TyrIle: 0.912 ± 0.029	0.632TyrLys: 0.632 ± 0.025	2.22TyrLeu: 2.22 ± 0.052	0.448TyrMet: 0.448 ± 0.02	0.585TyrAsn: 0.585 ± 0.025	1.116TyrPro: 1.116 ± 0.034	0.656TyrGln: 0.656 ± 0.023	1.82TyrArg: 1.82 ± 0.041	1.227TyrSer: 1.227 ± 0.031	1.071TyrThr: 1.071 ± 0.03	1.622TyrVal: 1.622 ± 0.041	0.35TyrTrp: 0.35 ± 0.017	0.595TyrTyr: 0.595 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3475 proteins (1108791 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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