Amino acid dipepetide frequency for Streptococcus phage Javan414

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.002AlaAla: 4.002 ± 1.623
0.651AlaCys: 0.651 ± 0.316
4.746AlaAsp: 4.746 ± 0.829
5.77AlaGlu: 5.77 ± 0.706
2.141AlaPhe: 2.141 ± 0.46
4.188AlaGly: 4.188 ± 0.912
0.279AlaHis: 0.279 ± 0.2
4.095AlaIle: 4.095 ± 0.621
6.701AlaLys: 6.701 ± 0.769
6.422AlaLeu: 6.422 ± 1.17
3.071AlaMet: 3.071 ± 0.723
3.816AlaAsn: 3.816 ± 0.624
1.861AlaPro: 1.861 ± 0.442
2.606AlaGln: 2.606 ± 0.635
3.443AlaArg: 3.443 ± 0.6
4.933AlaSer: 4.933 ± 0.814
5.119AlaThr: 5.119 ± 1.123
5.77AlaVal: 5.77 ± 0.848
0.838AlaTrp: 0.838 ± 0.319
2.699AlaTyr: 2.699 ± 0.607
0.0AlaXaa: 0.0 ± 0.0
Cys
0.651CysAla: 0.651 ± 0.249
0.093CysCys: 0.093 ± 0.096
0.186CysAsp: 0.186 ± 0.142
0.558CysGlu: 0.558 ± 0.235
0.279CysPhe: 0.279 ± 0.151
0.279CysGly: 0.279 ± 0.162
0.093CysHis: 0.093 ± 0.125
0.279CysIle: 0.279 ± 0.211
0.465CysLys: 0.465 ± 0.161
0.558CysLeu: 0.558 ± 0.268
0.093CysMet: 0.093 ± 0.111
0.186CysAsn: 0.186 ± 0.106
0.0CysPro: 0.0 ± 0.0
0.465CysGln: 0.465 ± 0.253
0.372CysArg: 0.372 ± 0.171
0.372CysSer: 0.372 ± 0.182
0.465CysThr: 0.465 ± 0.211
0.372CysVal: 0.372 ± 0.195
0.093CysTrp: 0.093 ± 0.078
0.279CysTyr: 0.279 ± 0.169
0.0CysXaa: 0.0 ± 0.0
Asp
2.606AspAla: 2.606 ± 0.444
0.465AspCys: 0.465 ± 0.339
4.746AspAsp: 4.746 ± 1.008
5.491AspGlu: 5.491 ± 0.862
3.816AspPhe: 3.816 ± 0.737
6.329AspGly: 6.329 ± 1.025
0.558AspHis: 0.558 ± 0.186
3.63AspIle: 3.63 ± 0.591
5.491AspLys: 5.491 ± 0.698
4.653AspLeu: 4.653 ± 0.78
1.675AspMet: 1.675 ± 0.508
4.933AspAsn: 4.933 ± 0.862
1.861AspPro: 1.861 ± 0.322
1.117AspGln: 1.117 ± 0.608
2.42AspArg: 2.42 ± 0.492
4.188AspSer: 4.188 ± 0.568
3.909AspThr: 3.909 ± 0.535
3.257AspVal: 3.257 ± 0.561
1.024AspTrp: 1.024 ± 0.322
3.537AspTyr: 3.537 ± 0.59
0.0AspXaa: 0.0 ± 0.0
Glu
5.863GluAla: 5.863 ± 0.876
0.558GluCys: 0.558 ± 0.337
4.56GluAsp: 4.56 ± 0.704
5.398GluGlu: 5.398 ± 0.972
2.978GluPhe: 2.978 ± 0.674
2.047GluGly: 2.047 ± 0.361
1.117GluHis: 1.117 ± 0.319
6.887GluIle: 6.887 ± 0.989
7.818GluLys: 7.818 ± 1.097
8.097GluLeu: 8.097 ± 0.977
1.861GluMet: 1.861 ± 0.452
3.63GluAsn: 3.63 ± 0.769
0.931GluPro: 0.931 ± 0.308
3.35GluGln: 3.35 ± 0.851
2.327GluArg: 2.327 ± 0.529
3.164GluSer: 3.164 ± 0.708
5.677GluThr: 5.677 ± 0.7
4.839GluVal: 4.839 ± 0.674
1.303GluTrp: 1.303 ± 0.375
2.699GluTyr: 2.699 ± 0.817
0.0GluXaa: 0.0 ± 0.0
Phe
3.071PheAla: 3.071 ± 0.492
0.279PheCys: 0.279 ± 0.158
4.002PheAsp: 4.002 ± 0.662
4.653PheGlu: 4.653 ± 0.627
1.954PhePhe: 1.954 ± 0.582
3.63PheGly: 3.63 ± 0.666
0.372PheHis: 0.372 ± 0.182
1.675PheIle: 1.675 ± 0.312
2.42PheLys: 2.42 ± 0.348
1.954PheLeu: 1.954 ± 0.448
0.745PheMet: 0.745 ± 0.294
1.954PheAsn: 1.954 ± 0.474
1.582PhePro: 1.582 ± 0.416
1.489PheGln: 1.489 ± 0.408
1.303PheArg: 1.303 ± 0.373
2.792PheSer: 2.792 ± 0.481
2.42PheThr: 2.42 ± 0.528
1.954PheVal: 1.954 ± 0.704
0.651PheTrp: 0.651 ± 0.24
1.396PheTyr: 1.396 ± 0.351
0.0PheXaa: 0.0 ± 0.0
Gly
4.374GlyAla: 4.374 ± 0.793
0.186GlyCys: 0.186 ± 0.121
2.885GlyAsp: 2.885 ± 0.459
3.63GlyGlu: 3.63 ± 0.661
3.63GlyPhe: 3.63 ± 0.753
4.002GlyGly: 4.002 ± 0.733
0.838GlyHis: 0.838 ± 0.246
4.467GlyIle: 4.467 ± 0.758
7.073GlyLys: 7.073 ± 0.656
6.701GlyLeu: 6.701 ± 0.817
1.954GlyMet: 1.954 ± 0.371
3.443GlyAsn: 3.443 ± 0.614
0.838GlyPro: 0.838 ± 0.347
2.513GlyGln: 2.513 ± 0.557
2.792GlyArg: 2.792 ± 0.451
3.537GlySer: 3.537 ± 1.102
5.212GlyThr: 5.212 ± 1.418
4.281GlyVal: 4.281 ± 0.602
1.21GlyTrp: 1.21 ± 0.294
2.792GlyTyr: 2.792 ± 0.452
0.0GlyXaa: 0.0 ± 0.0
His
0.372HisAla: 0.372 ± 0.177
0.0HisCys: 0.0 ± 0.0
0.745HisAsp: 0.745 ± 0.294
0.651HisGlu: 0.651 ± 0.319
0.651HisPhe: 0.651 ± 0.299
1.21HisGly: 1.21 ± 0.34
0.372HisHis: 0.372 ± 0.182
0.372HisIle: 0.372 ± 0.208
1.024HisLys: 1.024 ± 0.385
1.024HisLeu: 1.024 ± 0.338
0.093HisMet: 0.093 ± 0.09
0.745HisAsn: 0.745 ± 0.268
0.651HisPro: 0.651 ± 0.222
0.745HisGln: 0.745 ± 0.29
0.186HisArg: 0.186 ± 0.159
0.745HisSer: 0.745 ± 0.348
0.558HisThr: 0.558 ± 0.247
0.651HisVal: 0.651 ± 0.214
0.093HisTrp: 0.093 ± 0.086
0.372HisTyr: 0.372 ± 0.171
0.0HisXaa: 0.0 ± 0.0
Ile
5.398IleAla: 5.398 ± 0.732
0.372IleCys: 0.372 ± 0.235
5.677IleAsp: 5.677 ± 0.641
5.026IleGlu: 5.026 ± 0.974
1.861IlePhe: 1.861 ± 0.367
4.188IleGly: 4.188 ± 0.743
0.838IleHis: 0.838 ± 0.269
3.071IleIle: 3.071 ± 0.808
6.608IleLys: 6.608 ± 0.984
5.305IleLeu: 5.305 ± 0.962
1.303IleMet: 1.303 ± 0.456
3.071IleAsn: 3.071 ± 0.37
1.861IlePro: 1.861 ± 0.378
2.047IleGln: 2.047 ± 0.493
1.768IleArg: 1.768 ± 0.368
4.002IleSer: 4.002 ± 0.626
5.026IleThr: 5.026 ± 0.713
3.257IleVal: 3.257 ± 0.578
0.651IleTrp: 0.651 ± 0.235
3.164IleTyr: 3.164 ± 0.502
0.0IleXaa: 0.0 ± 0.0
Lys
6.515LysAla: 6.515 ± 0.803
0.372LysCys: 0.372 ± 0.158
4.56LysAsp: 4.56 ± 0.595
7.352LysGlu: 7.352 ± 0.941
3.537LysPhe: 3.537 ± 0.648
4.467LysGly: 4.467 ± 0.706
1.117LysHis: 1.117 ± 0.324
5.026LysIle: 5.026 ± 0.877
5.956LysLys: 5.956 ± 0.833
5.491LysLeu: 5.491 ± 0.721
2.327LysMet: 2.327 ± 0.511
5.305LysAsn: 5.305 ± 0.8
2.327LysPro: 2.327 ± 0.489
4.095LysGln: 4.095 ± 0.709
3.257LysArg: 3.257 ± 0.84
3.816LysSer: 3.816 ± 0.621
7.445LysThr: 7.445 ± 0.888
5.026LysVal: 5.026 ± 0.702
0.931LysTrp: 0.931 ± 0.274
3.257LysTyr: 3.257 ± 0.538
0.0LysXaa: 0.0 ± 0.0
Leu
5.119LeuAla: 5.119 ± 0.811
0.372LeuCys: 0.372 ± 0.167
5.026LeuAsp: 5.026 ± 0.811
7.259LeuGlu: 7.259 ± 1.035
2.234LeuPhe: 2.234 ± 0.451
5.956LeuGly: 5.956 ± 0.919
1.117LeuHis: 1.117 ± 0.393
4.56LeuIle: 4.56 ± 0.638
6.422LeuLys: 6.422 ± 0.65
5.956LeuLeu: 5.956 ± 0.835
1.954LeuMet: 1.954 ± 0.464
4.002LeuAsn: 4.002 ± 0.768
3.257LeuPro: 3.257 ± 0.433
3.723LeuGln: 3.723 ± 0.529
3.537LeuArg: 3.537 ± 0.595
4.653LeuSer: 4.653 ± 0.505
7.073LeuThr: 7.073 ± 0.797
3.723LeuVal: 3.723 ± 0.552
1.024LeuTrp: 1.024 ± 0.363
1.582LeuTyr: 1.582 ± 0.522
0.0LeuXaa: 0.0 ± 0.0
Met
1.768MetAla: 1.768 ± 0.416
0.372MetCys: 0.372 ± 0.266
1.21MetAsp: 1.21 ± 0.306
1.675MetGlu: 1.675 ± 0.425
0.931MetPhe: 0.931 ± 0.279
0.931MetGly: 0.931 ± 0.245
0.279MetHis: 0.279 ± 0.194
1.861MetIle: 1.861 ± 0.487
2.047MetLys: 2.047 ± 0.516
1.861MetLeu: 1.861 ± 0.404
0.465MetMet: 0.465 ± 0.196
1.024MetAsn: 1.024 ± 0.429
0.558MetPro: 0.558 ± 0.153
0.931MetGln: 0.931 ± 0.3
1.117MetArg: 1.117 ± 0.348
1.675MetSer: 1.675 ± 0.347
3.257MetThr: 3.257 ± 0.554
1.582MetVal: 1.582 ± 0.496
0.372MetTrp: 0.372 ± 0.191
0.745MetTyr: 0.745 ± 0.315
0.0MetXaa: 0.0 ± 0.0
Asn
4.188AsnAla: 4.188 ± 0.845
0.279AsnCys: 0.279 ± 0.196
3.723AsnAsp: 3.723 ± 0.68
3.257AsnGlu: 3.257 ± 0.569
1.768AsnPhe: 1.768 ± 0.335
4.002AsnGly: 4.002 ± 0.62
0.931AsnHis: 0.931 ± 0.26
3.257AsnIle: 3.257 ± 0.575
3.909AsnLys: 3.909 ± 0.514
3.537AsnLeu: 3.537 ± 0.77
1.396AsnMet: 1.396 ± 0.332
3.63AsnAsn: 3.63 ± 0.567
2.42AsnPro: 2.42 ± 0.735
1.768AsnGln: 1.768 ± 0.405
2.234AsnArg: 2.234 ± 0.524
4.002AsnSer: 4.002 ± 0.787
3.164AsnThr: 3.164 ± 0.667
4.933AsnVal: 4.933 ± 0.691
1.117AsnTrp: 1.117 ± 0.328
3.164AsnTyr: 3.164 ± 0.515
0.0AsnXaa: 0.0 ± 0.0
Pro
1.768ProAla: 1.768 ± 0.48
0.186ProCys: 0.186 ± 0.129
1.954ProAsp: 1.954 ± 0.371
2.513ProGlu: 2.513 ± 0.484
0.931ProPhe: 0.931 ± 0.255
0.931ProGly: 0.931 ± 0.39
0.279ProHis: 0.279 ± 0.132
2.047ProIle: 2.047 ± 0.4
1.582ProLys: 1.582 ± 0.42
2.141ProLeu: 2.141 ± 0.536
0.651ProMet: 0.651 ± 0.303
2.141ProAsn: 2.141 ± 0.659
0.465ProPro: 0.465 ± 0.25
1.117ProGln: 1.117 ± 0.262
1.21ProArg: 1.21 ± 0.326
1.861ProSer: 1.861 ± 0.543
1.768ProThr: 1.768 ± 0.477
2.047ProVal: 2.047 ± 0.472
0.093ProTrp: 0.093 ± 0.088
1.024ProTyr: 1.024 ± 0.253
0.0ProXaa: 0.0 ± 0.0
Gln
2.699GlnAla: 2.699 ± 0.603
0.093GlnCys: 0.093 ± 0.089
1.861GlnAsp: 1.861 ± 0.294
3.071GlnGlu: 3.071 ± 0.68
1.954GlnPhe: 1.954 ± 0.483
2.327GlnGly: 2.327 ± 0.44
0.465GlnHis: 0.465 ± 0.169
3.723GlnIle: 3.723 ± 0.524
3.071GlnLys: 3.071 ± 0.514
3.63GlnLeu: 3.63 ± 0.634
1.117GlnMet: 1.117 ± 0.321
2.234GlnAsn: 2.234 ± 0.387
0.465GlnPro: 0.465 ± 0.207
1.117GlnGln: 1.117 ± 0.371
1.768GlnArg: 1.768 ± 0.342
2.141GlnSer: 2.141 ± 0.61
1.768GlnThr: 1.768 ± 0.301
1.954GlnVal: 1.954 ± 0.41
0.279GlnTrp: 0.279 ± 0.143
1.582GlnTyr: 1.582 ± 0.398
0.0GlnXaa: 0.0 ± 0.0
Arg
2.047ArgAla: 2.047 ± 0.435
0.186ArgCys: 0.186 ± 0.172
2.42ArgAsp: 2.42 ± 0.523
2.141ArgGlu: 2.141 ± 0.472
2.234ArgPhe: 2.234 ± 0.468
2.513ArgGly: 2.513 ± 0.49
0.558ArgHis: 0.558 ± 0.234
3.35ArgIle: 3.35 ± 0.578
4.002ArgLys: 4.002 ± 0.956
2.792ArgLeu: 2.792 ± 0.499
0.931ArgMet: 0.931 ± 0.342
2.513ArgAsn: 2.513 ± 0.582
0.372ArgPro: 0.372 ± 0.217
1.675ArgGln: 1.675 ± 0.42
1.396ArgArg: 1.396 ± 0.582
1.768ArgSer: 1.768 ± 0.368
2.513ArgThr: 2.513 ± 0.519
2.234ArgVal: 2.234 ± 0.358
0.745ArgTrp: 0.745 ± 0.236
1.582ArgTyr: 1.582 ± 0.428
0.0ArgXaa: 0.0 ± 0.0
Ser
5.863SerAla: 5.863 ± 1.517
0.465SerCys: 0.465 ± 0.182
4.095SerAsp: 4.095 ± 0.565
5.119SerGlu: 5.119 ± 0.687
2.978SerPhe: 2.978 ± 0.491
6.794SerGly: 6.794 ± 1.006
0.558SerHis: 0.558 ± 0.264
3.257SerIle: 3.257 ± 0.51
4.002SerLys: 4.002 ± 0.618
4.095SerLeu: 4.095 ± 0.602
1.117SerMet: 1.117 ± 0.441
3.723SerAsn: 3.723 ± 0.719
1.396SerPro: 1.396 ± 0.424
1.954SerGln: 1.954 ± 0.453
2.141SerArg: 2.141 ± 0.568
4.839SerSer: 4.839 ± 1.534
4.188SerThr: 4.188 ± 1.131
3.257SerVal: 3.257 ± 0.483
0.465SerTrp: 0.465 ± 0.221
2.792SerTyr: 2.792 ± 0.59
0.0SerXaa: 0.0 ± 0.0
Thr
7.166ThrAla: 7.166 ± 0.998
0.093ThrCys: 0.093 ± 0.086
4.839ThrAsp: 4.839 ± 0.607
3.63ThrGlu: 3.63 ± 0.604
2.513ThrPhe: 2.513 ± 0.531
5.305ThrGly: 5.305 ± 0.791
0.838ThrHis: 0.838 ± 0.238
5.677ThrIle: 5.677 ± 1.131
4.653ThrLys: 4.653 ± 0.791
5.677ThrLeu: 5.677 ± 0.878
1.768ThrMet: 1.768 ± 0.591
3.537ThrAsn: 3.537 ± 0.683
2.792ThrPro: 2.792 ± 0.424
2.234ThrGln: 2.234 ± 0.486
1.954ThrArg: 1.954 ± 0.417
5.77ThrSer: 5.77 ± 0.802
4.933ThrThr: 4.933 ± 0.796
5.863ThrVal: 5.863 ± 1.032
1.489ThrTrp: 1.489 ± 0.385
3.257ThrTyr: 3.257 ± 0.536
0.0ThrXaa: 0.0 ± 0.0
Val
5.956ValAla: 5.956 ± 1.481
0.558ValCys: 0.558 ± 0.226
4.746ValAsp: 4.746 ± 0.895
3.909ValGlu: 3.909 ± 0.666
1.489ValPhe: 1.489 ± 0.367
3.35ValGly: 3.35 ± 0.433
0.279ValHis: 0.279 ± 0.155
3.63ValIle: 3.63 ± 0.71
4.933ValLys: 4.933 ± 0.507
5.398ValLeu: 5.398 ± 0.529
1.21ValMet: 1.21 ± 0.355
3.909ValAsn: 3.909 ± 0.691
1.954ValPro: 1.954 ± 0.421
1.861ValGln: 1.861 ± 0.367
2.513ValArg: 2.513 ± 0.582
4.933ValSer: 4.933 ± 0.559
5.398ValThr: 5.398 ± 0.911
3.909ValVal: 3.909 ± 0.72
0.745ValTrp: 0.745 ± 0.342
1.675ValTyr: 1.675 ± 0.351
0.0ValXaa: 0.0 ± 0.0
Trp
1.024TrpAla: 1.024 ± 0.284
0.279TrpCys: 0.279 ± 0.163
0.838TrpAsp: 0.838 ± 0.259
1.024TrpGlu: 1.024 ± 0.311
0.465TrpPhe: 0.465 ± 0.168
0.651TrpGly: 0.651 ± 0.185
0.0TrpHis: 0.0 ± 0.0
1.21TrpIle: 1.21 ± 0.388
1.024TrpLys: 1.024 ± 0.302
0.558TrpLeu: 0.558 ± 0.273
0.093TrpMet: 0.093 ± 0.082
1.024TrpAsn: 1.024 ± 0.391
0.0TrpPro: 0.0 ± 0.0
0.838TrpGln: 0.838 ± 0.385
0.838TrpArg: 0.838 ± 0.264
1.117TrpSer: 1.117 ± 0.384
1.303TrpThr: 1.303 ± 0.603
0.838TrpVal: 0.838 ± 0.214
0.0TrpTrp: 0.0 ± 0.0
0.931TrpTyr: 0.931 ± 0.363
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.699TyrAla: 2.699 ± 0.534
0.279TyrCys: 0.279 ± 0.188
2.885TyrAsp: 2.885 ± 0.572
2.978TyrGlu: 2.978 ± 0.485
1.954TyrPhe: 1.954 ± 0.579
3.257TyrGly: 3.257 ± 0.625
0.372TyrHis: 0.372 ± 0.157
2.513TyrIle: 2.513 ± 0.52
2.978TyrLys: 2.978 ± 0.557
2.699TyrLeu: 2.699 ± 0.636
0.745TyrMet: 0.745 ± 0.215
1.861TyrAsn: 1.861 ± 0.42
1.117TyrPro: 1.117 ± 0.334
1.675TyrGln: 1.675 ± 0.292
1.396TyrArg: 1.396 ± 0.503
2.792TyrSer: 2.792 ± 0.721
2.792TyrThr: 2.792 ± 0.611
2.606TyrVal: 2.606 ± 0.634
0.931TyrTrp: 0.931 ± 0.339
1.396TyrTyr: 1.396 ± 0.379
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 45 proteins (10746 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski