Amino acid dipepetide frequency for Exophiala mesophila (Black yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.447AlaAla: 8.447 ± 0.064	0.99AlaCys: 0.99 ± 0.016	4.243AlaAsp: 4.243 ± 0.026	4.897AlaGlu: 4.897 ± 0.033	3.059AlaPhe: 3.059 ± 0.026	5.5AlaGly: 5.5 ± 0.043	1.748AlaHis: 1.748 ± 0.019	4.325AlaIle: 4.325 ± 0.032	3.999AlaLys: 3.999 ± 0.032	7.514AlaLeu: 7.514 ± 0.049	1.881AlaMet: 1.881 ± 0.02	3.029AlaAsn: 3.029 ± 0.023	4.521AlaPro: 4.521 ± 0.042	3.573AlaGln: 3.573 ± 0.031	4.979AlaArg: 4.979 ± 0.04	7.288AlaSer: 7.288 ± 0.037	5.447AlaThr: 5.447 ± 0.034	5.102AlaVal: 5.102 ± 0.036	1.082AlaTrp: 1.082 ± 0.017	2.088AlaTyr: 2.088 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.839CysAla: 0.839 ± 0.013	0.215CysCys: 0.215 ± 0.008	0.62CysAsp: 0.62 ± 0.012	0.512CysGlu: 0.512 ± 0.011	0.504CysPhe: 0.504 ± 0.01	0.823CysGly: 0.823 ± 0.015	0.331CysHis: 0.331 ± 0.009	0.644CysIle: 0.644 ± 0.011	0.455CysLys: 0.455 ± 0.011	1.163CysLeu: 1.163 ± 0.016	0.232CysMet: 0.232 ± 0.008	0.377CysAsn: 0.377 ± 0.009	0.612CysPro: 0.612 ± 0.012	0.44CysGln: 0.44 ± 0.011	0.71CysArg: 0.71 ± 0.014	0.808CysSer: 0.808 ± 0.014	0.612CysThr: 0.612 ± 0.013	0.703CysVal: 0.703 ± 0.012	0.184CysTrp: 0.184 ± 0.006	0.321CysTyr: 0.321 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.626AspAla: 4.626 ± 0.03	0.56AspCys: 0.56 ± 0.01	4.634AspAsp: 4.634 ± 0.047	4.427AspGlu: 4.427 ± 0.034	2.249AspPhe: 2.249 ± 0.023	3.908AspGly: 3.908 ± 0.032	1.476AspHis: 1.476 ± 0.02	3.018AspIle: 3.018 ± 0.025	2.5AspLys: 2.5 ± 0.028	5.474AspLeu: 5.474 ± 0.036	1.268AspMet: 1.268 ± 0.016	1.994AspAsn: 1.994 ± 0.02	3.555AspPro: 3.555 ± 0.026	2.312AspGln: 2.312 ± 0.021	3.246AspArg: 3.246 ± 0.036	4.424AspSer: 4.424 ± 0.034	3.061AspThr: 3.061 ± 0.022	3.714AspVal: 3.714 ± 0.032	0.873AspTrp: 0.873 ± 0.014	1.563AspTyr: 1.563 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.124GluAla: 5.124 ± 0.037	0.524GluCys: 0.524 ± 0.01	4.11GluAsp: 4.11 ± 0.037	4.719GluGlu: 4.719 ± 0.044	1.873GluPhe: 1.873 ± 0.018	3.359GluGly: 3.359 ± 0.028	1.36GluHis: 1.36 ± 0.017	3.04GluIle: 3.04 ± 0.026	3.429GluLys: 3.429 ± 0.032	4.92GluLeu: 4.92 ± 0.04	1.36GluMet: 1.36 ± 0.018	2.157GluAsn: 2.157 ± 0.022	2.734GluPro: 2.734 ± 0.031	2.526GluGln: 2.526 ± 0.026	3.635GluArg: 3.635 ± 0.037	4.35GluSer: 4.35 ± 0.026	3.393GluThr: 3.393 ± 0.027	3.439GluVal: 3.439 ± 0.026	0.823GluTrp: 0.823 ± 0.012	1.575GluTyr: 1.575 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	3.025PheAla: 3.025 ± 0.022	0.52PheCys: 0.52 ± 0.011	2.373PheAsp: 2.373 ± 0.024	2.125PheGlu: 2.125 ± 0.021	1.594PhePhe: 1.594 ± 0.022	2.816PheGly: 2.816 ± 0.031	0.891PheHis: 0.891 ± 0.014	1.783PheIle: 1.783 ± 0.021	1.443PheLys: 1.443 ± 0.017	3.372PheLeu: 3.372 ± 0.03	0.75PheMet: 0.75 ± 0.012	1.431PheAsn: 1.431 ± 0.018	1.943PhePro: 1.943 ± 0.021	1.453PheGln: 1.453 ± 0.015	1.918PheArg: 1.918 ± 0.02	3.031PheSer: 3.031 ± 0.023	2.094PheThr: 2.094 ± 0.021	2.354PheVal: 2.354 ± 0.023	0.616PheTrp: 0.616 ± 0.012	1.055PheTyr: 1.055 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.979GlyAla: 4.979 ± 0.039	0.726GlyCys: 0.726 ± 0.014	3.57GlyAsp: 3.57 ± 0.03	3.317GlyGlu: 3.317 ± 0.027	2.789GlyPhe: 2.789 ± 0.023	5.501GlyGly: 5.501 ± 0.061	1.736GlyHis: 1.736 ± 0.022	3.488GlyIle: 3.488 ± 0.027	3.233GlyLys: 3.233 ± 0.025	6.035GlyLeu: 6.035 ± 0.038	1.531GlyMet: 1.531 ± 0.02	2.407GlyAsn: 2.407 ± 0.023	3.38GlyPro: 3.38 ± 0.032	2.759GlyGln: 2.759 ± 0.024	4.034GlyArg: 4.034 ± 0.033	5.593GlySer: 5.593 ± 0.044	3.841GlyThr: 3.841 ± 0.032	4.203GlyVal: 4.203 ± 0.029	1.092GlyTrp: 1.092 ± 0.013	2.051GlyTyr: 2.051 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.894HisAla: 1.894 ± 0.019	0.303HisCys: 0.303 ± 0.008	1.537HisAsp: 1.537 ± 0.021	1.344HisGlu: 1.344 ± 0.017	0.946HisPhe: 0.946 ± 0.016	1.773HisGly: 1.773 ± 0.019	0.975HisHis: 0.975 ± 0.017	1.223HisIle: 1.223 ± 0.015	0.991HisLys: 0.991 ± 0.016	2.383HisLeu: 2.383 ± 0.024	0.483HisMet: 0.483 ± 0.011	0.891HisAsn: 0.891 ± 0.014	1.746HisPro: 1.746 ± 0.019	1.167HisGln: 1.167 ± 0.017	1.602HisArg: 1.602 ± 0.021	2.044HisSer: 2.044 ± 0.023	1.307HisThr: 1.307 ± 0.017	1.545HisVal: 1.545 ± 0.018	0.331HisTrp: 0.331 ± 0.007	0.687HisTyr: 0.687 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.175IleAla: 4.175 ± 0.034	0.715IleCys: 0.715 ± 0.011	3.005IleAsp: 3.005 ± 0.025	2.832IleGlu: 2.832 ± 0.026	1.964IlePhe: 1.964 ± 0.024	3.199IleGly: 3.199 ± 0.03	1.264IleHis: 1.264 ± 0.016	2.516IleIle: 2.516 ± 0.027	2.21IleLys: 2.21 ± 0.023	4.708IleLeu: 4.708 ± 0.035	1.003IleMet: 1.003 ± 0.014	1.863IleAsn: 1.863 ± 0.019	3.147IlePro: 3.147 ± 0.024	1.993IleGln: 1.993 ± 0.021	2.773IleArg: 2.773 ± 0.024	4.029IleSer: 4.029 ± 0.028	2.863IleThr: 2.863 ± 0.023	3.182IleVal: 3.182 ± 0.024	0.711IleTrp: 0.711 ± 0.013	1.389IleTyr: 1.389 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.25LysAla: 4.25 ± 0.035	0.471LysCys: 0.471 ± 0.01	2.867LysAsp: 2.867 ± 0.028	3.064LysGlu: 3.064 ± 0.035	1.451LysPhe: 1.451 ± 0.017	2.792LysGly: 2.792 ± 0.026	1.161LysHis: 1.161 ± 0.015	2.34LysIle: 2.34 ± 0.024	3.156LysLys: 3.156 ± 0.037	3.953LysLeu: 3.953 ± 0.033	0.975LysMet: 0.975 ± 0.014	1.657LysAsn: 1.657 ± 0.018	2.754LysPro: 2.754 ± 0.027	1.929LysGln: 1.929 ± 0.02	3.345LysArg: 3.345 ± 0.036	3.803LysSer: 3.803 ± 0.031	2.926LysThr: 2.926 ± 0.026	2.798LysVal: 2.798 ± 0.027	0.64LysTrp: 0.64 ± 0.011	1.36LysTyr: 1.36 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.783LeuAla: 7.783 ± 0.046	1.133LeuCys: 1.133 ± 0.018	5.469LeuAsp: 5.469 ± 0.039	5.363LeuGlu: 5.363 ± 0.044	3.279LeuPhe: 3.279 ± 0.027	5.799LeuGly: 5.799 ± 0.038	2.296LeuHis: 2.296 ± 0.023	4.03LeuIle: 4.03 ± 0.03	4.237LeuLys: 4.237 ± 0.032	8.193LeuLeu: 8.193 ± 0.06	1.75LeuMet: 1.75 ± 0.018	3.266LeuAsn: 3.266 ± 0.028	5.52LeuPro: 5.52 ± 0.032	4.0LeuGln: 4.0 ± 0.035	5.588LeuArg: 5.588 ± 0.041	7.487LeuSer: 7.487 ± 0.041	5.122LeuThr: 5.122 ± 0.036	5.333LeuVal: 5.333 ± 0.043	1.186LeuTrp: 1.186 ± 0.017	2.272LeuTyr: 2.272 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.169MetAla: 2.169 ± 0.02	0.213MetCys: 0.213 ± 0.006	1.21MetAsp: 1.21 ± 0.017	1.107MetGlu: 1.107 ± 0.016	0.725MetPhe: 0.725 ± 0.012	1.372MetGly: 1.372 ± 0.016	0.477MetHis: 0.477 ± 0.009	1.013MetIle: 1.013 ± 0.014	0.929MetLys: 0.929 ± 0.013	1.76MetLeu: 1.76 ± 0.018	0.55MetMet: 0.55 ± 0.012	0.785MetAsn: 0.785 ± 0.013	1.256MetPro: 1.256 ± 0.018	0.853MetGln: 0.853 ± 0.014	1.155MetArg: 1.155 ± 0.015	2.017MetSer: 2.017 ± 0.021	1.378MetThr: 1.378 ± 0.016	1.237MetVal: 1.237 ± 0.016	0.245MetTrp: 0.245 ± 0.007	0.514MetTyr: 0.514 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.064AsnAla: 3.064 ± 0.024	0.402AsnCys: 0.402 ± 0.009	2.141AsnAsp: 2.141 ± 0.024	1.955AsnGlu: 1.955 ± 0.02	1.35AsnPhe: 1.35 ± 0.015	2.916AsnGly: 2.916 ± 0.03	0.959AsnHis: 0.959 ± 0.014	2.064AsnIle: 2.064 ± 0.021	1.581AsnLys: 1.581 ± 0.02	3.449AsnLeu: 3.449 ± 0.025	0.824AsnMet: 0.824 ± 0.013	1.525AsnAsn: 1.525 ± 0.023	2.558AsnPro: 2.558 ± 0.025	1.488AsnGln: 1.488 ± 0.017	1.937AsnArg: 1.937 ± 0.021	2.919AsnSer: 2.919 ± 0.027	2.26AsnThr: 2.26 ± 0.023	2.352AsnVal: 2.352 ± 0.023	0.511AsnTrp: 0.511 ± 0.01	1.042AsnTyr: 1.042 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.024ProAla: 5.024 ± 0.041	0.473ProCys: 0.473 ± 0.011	3.362ProAsp: 3.362 ± 0.025	3.636ProGlu: 3.636 ± 0.033	2.054ProPhe: 2.054 ± 0.021	3.907ProGly: 3.907 ± 0.032	1.432ProHis: 1.432 ± 0.018	2.628ProIle: 2.628 ± 0.021	2.669ProLys: 2.669 ± 0.025	4.844ProLeu: 4.844 ± 0.037	1.059ProMet: 1.059 ± 0.017	2.361ProAsn: 2.361 ± 0.023	5.497ProPro: 5.497 ± 0.068	2.771ProGln: 2.771 ± 0.033	3.501ProArg: 3.501 ± 0.028	6.516ProSer: 6.516 ± 0.053	4.369ProThr: 4.369 ± 0.035	3.599ProVal: 3.599 ± 0.032	0.695ProTrp: 0.695 ± 0.012	1.526ProTyr: 1.526 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.694GlnAla: 3.694 ± 0.029	0.429GlnCys: 0.429 ± 0.01	2.465GlnAsp: 2.465 ± 0.021	2.463GlnGlu: 2.463 ± 0.023	1.33GlnPhe: 1.33 ± 0.017	2.578GlnGly: 2.578 ± 0.024	1.232GlnHis: 1.232 ± 0.018	2.055GlnIle: 2.055 ± 0.021	2.064GlnLys: 2.064 ± 0.021	3.532GlnLeu: 3.532 ± 0.03	0.888GlnMet: 0.888 ± 0.015	1.717GlnAsn: 1.717 ± 0.019	2.768GlnPro: 2.768 ± 0.031	2.629GlnGln: 2.629 ± 0.042	2.831GlnArg: 2.831 ± 0.026	3.67GlnSer: 3.67 ± 0.033	2.562GlnThr: 2.562 ± 0.024	2.386GlnVal: 2.386 ± 0.022	0.556GlnTrp: 0.556 ± 0.011	1.225GlnTyr: 1.225 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.573ArgAla: 4.573 ± 0.032	0.662ArgCys: 0.662 ± 0.013	3.45ArgAsp: 3.45 ± 0.037	3.543ArgGlu: 3.543 ± 0.03	2.075ArgPhe: 2.075 ± 0.021	3.653ArgGly: 3.653 ± 0.034	1.708ArgHis: 1.708 ± 0.02	2.821ArgIle: 2.821 ± 0.022	3.501ArgLys: 3.501 ± 0.029	5.5ArgLeu: 5.5 ± 0.037	1.256ArgMet: 1.256 ± 0.016	2.262ArgAsn: 2.262 ± 0.02	3.812ArgPro: 3.812 ± 0.032	2.891ArgGln: 2.891 ± 0.027	5.147ArgArg: 5.147 ± 0.047	5.082ArgSer: 5.082 ± 0.043	3.345ArgThr: 3.345 ± 0.029	3.194ArgVal: 3.194 ± 0.025	0.874ArgTrp: 0.874 ± 0.015	1.622ArgTyr: 1.622 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.646SerAla: 6.646 ± 0.045	0.803SerCys: 0.803 ± 0.014	4.535SerAsp: 4.535 ± 0.032	4.201SerGlu: 4.201 ± 0.032	3.038SerPhe: 3.038 ± 0.027	5.526SerGly: 5.526 ± 0.042	2.243SerHis: 2.243 ± 0.019	4.23SerIle: 4.23 ± 0.031	3.897SerLys: 3.897 ± 0.036	7.503SerLeu: 7.503 ± 0.049	1.759SerMet: 1.759 ± 0.021	3.313SerAsn: 3.313 ± 0.028	6.078SerPro: 6.078 ± 0.055	3.766SerGln: 3.766 ± 0.037	5.425SerArg: 5.425 ± 0.04	9.806SerSer: 9.806 ± 0.076	6.412SerThr: 6.412 ± 0.05	4.545SerVal: 4.545 ± 0.027	1.095SerTrp: 1.095 ± 0.018	2.024SerTyr: 2.024 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.212ThrAla: 5.212 ± 0.033	0.693ThrCys: 0.693 ± 0.015	3.004ThrAsp: 3.004 ± 0.026	3.062ThrGlu: 3.062 ± 0.026	2.268ThrPhe: 2.268 ± 0.02	4.086ThrGly: 4.086 ± 0.031	1.347ThrHis: 1.347 ± 0.017	3.245ThrIle: 3.245 ± 0.027	2.735ThrLys: 2.735 ± 0.026	5.34ThrLeu: 5.34 ± 0.039	1.235ThrMet: 1.235 ± 0.016	2.355ThrAsn: 2.355 ± 0.02	4.475ThrPro: 4.475 ± 0.036	2.287ThrGln: 2.287 ± 0.022	3.304ThrArg: 3.304 ± 0.027	6.262ThrSer: 6.262 ± 0.05	4.935ThrThr: 4.935 ± 0.083	3.676ThrVal: 3.676 ± 0.03	0.839ThrTrp: 0.839 ± 0.015	1.552ThrTyr: 1.552 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.04ValAla: 5.04 ± 0.037	0.719ValCys: 0.719 ± 0.013	3.817ValAsp: 3.817 ± 0.03	3.693ValGlu: 3.693 ± 0.026	2.343ValPhe: 2.343 ± 0.024	3.907ValGly: 3.907 ± 0.03	1.4ValHis: 1.4 ± 0.016	2.97ValIle: 2.97 ± 0.026	2.87ValLys: 2.87 ± 0.025	5.491ValLeu: 5.491 ± 0.036	1.266ValMet: 1.266 ± 0.014	2.239ValAsn: 2.239 ± 0.024	3.492ValPro: 3.492 ± 0.028	2.505ValGln: 2.505 ± 0.026	3.364ValArg: 3.364 ± 0.029	4.638ValSer: 4.638 ± 0.03	3.529ValThr: 3.529 ± 0.03	4.218ValVal: 4.218 ± 0.039	0.816ValTrp: 0.816 ± 0.014	1.606ValTyr: 1.606 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.05TrpAla: 1.05 ± 0.015	0.173TrpCys: 0.173 ± 0.006	0.827TrpAsp: 0.827 ± 0.012	0.743TrpGlu: 0.743 ± 0.014	0.521TrpPhe: 0.521 ± 0.011	0.844TrpGly: 0.844 ± 0.015	0.352TrpHis: 0.352 ± 0.009	0.748TrpIle: 0.748 ± 0.012	0.758TrpLys: 0.758 ± 0.012	1.319TrpLeu: 1.319 ± 0.016	0.337TrpMet: 0.337 ± 0.009	0.59TrpAsn: 0.59 ± 0.012	0.596TrpPro: 0.596 ± 0.011	0.584TrpGln: 0.584 ± 0.013	0.928TrpArg: 0.928 ± 0.016	1.069TrpSer: 1.069 ± 0.016	0.916TrpThr: 0.916 ± 0.015	0.778TrpVal: 0.778 ± 0.014	0.27TrpTrp: 0.27 ± 0.008	0.427TrpTyr: 0.427 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.098TyrAla: 2.098 ± 0.023	0.383TyrCys: 0.383 ± 0.009	1.642TyrAsp: 1.642 ± 0.02	1.447TyrGlu: 1.447 ± 0.016	1.176TyrPhe: 1.176 ± 0.015	2.006TyrGly: 2.006 ± 0.021	0.782TyrHis: 0.782 ± 0.014	1.363TyrIle: 1.363 ± 0.017	1.037TyrLys: 1.037 ± 0.017	2.653TyrLeu: 2.653 ± 0.023	0.557TyrMet: 0.557 ± 0.009	1.077TyrAsn: 1.077 ± 0.015	1.479TyrPro: 1.479 ± 0.022	1.145TyrGln: 1.145 ± 0.016	1.549TyrArg: 1.549 ± 0.018	2.008TyrSer: 2.008 ± 0.023	1.542TyrThr: 1.542 ± 0.019	1.568TyrVal: 1.568 ± 0.019	0.387TyrTrp: 0.387 ± 0.01	0.854TyrTyr: 0.854 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10000 proteins (5129384 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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