Amino acid dipepetide frequency for Poseidonocella sedimentorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.308AlaAla: 18.308 ± 0.21	1.033AlaCys: 1.033 ± 0.039	6.966AlaAsp: 6.966 ± 0.116	9.456AlaGlu: 9.456 ± 0.129	4.287AlaPhe: 4.287 ± 0.074	11.582AlaGly: 11.582 ± 0.211	2.372AlaHis: 2.372 ± 0.067	5.943AlaIle: 5.943 ± 0.082	3.264AlaLys: 3.264 ± 0.082	15.686AlaLeu: 15.686 ± 0.19	3.617AlaMet: 3.617 ± 0.066	2.529AlaAsn: 2.529 ± 0.056	7.094AlaPro: 7.094 ± 0.115	4.372AlaGln: 4.372 ± 0.066	10.577AlaArg: 10.577 ± 0.16	5.857AlaSer: 5.857 ± 0.107	5.997AlaThr: 5.997 ± 0.148	8.31AlaVal: 8.31 ± 0.115	1.372AlaTrp: 1.372 ± 0.042	2.47AlaTyr: 2.47 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.116CysAla: 1.116 ± 0.046	0.102CysCys: 0.102 ± 0.01	0.59CysAsp: 0.59 ± 0.03	0.443CysGlu: 0.443 ± 0.021	0.294CysPhe: 0.294 ± 0.017	0.918CysGly: 0.918 ± 0.033	0.24CysHis: 0.24 ± 0.017	0.405CysIle: 0.405 ± 0.02	0.18CysLys: 0.18 ± 0.013	0.858CysLeu: 0.858 ± 0.033	0.152CysMet: 0.152 ± 0.012	0.173CysAsn: 0.173 ± 0.012	0.468CysPro: 0.468 ± 0.023	0.196CysGln: 0.196 ± 0.014	0.563CysArg: 0.563 ± 0.027	0.401CysSer: 0.401 ± 0.02	0.41CysThr: 0.41 ± 0.022	0.595CysVal: 0.595 ± 0.026	0.125CysTrp: 0.125 ± 0.013	0.176CysTyr: 0.176 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.946AspAla: 7.946 ± 0.125	0.526AspCys: 0.526 ± 0.022	3.213AspAsp: 3.213 ± 0.104	3.744AspGlu: 3.744 ± 0.075	2.193AspPhe: 2.193 ± 0.049	6.026AspGly: 6.026 ± 0.179	1.328AspHis: 1.328 ± 0.044	3.063AspIle: 3.063 ± 0.078	1.404AspLys: 1.404 ± 0.039	6.494AspLeu: 6.494 ± 0.127	1.48AspMet: 1.48 ± 0.032	1.193AspAsn: 1.193 ± 0.038	3.847AspPro: 3.847 ± 0.071	1.673AspGln: 1.673 ± 0.042	4.205AspArg: 4.205 ± 0.073	2.168AspSer: 2.168 ± 0.055	2.842AspThr: 2.842 ± 0.059	4.135AspVal: 4.135 ± 0.088	1.181AspTrp: 1.181 ± 0.033	1.505AspTyr: 1.505 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	9.281GluAla: 9.281 ± 0.127	0.306GluCys: 0.306 ± 0.017	3.73GluAsp: 3.73 ± 0.071	3.78GluGlu: 3.78 ± 0.076	1.868GluPhe: 1.868 ± 0.049	5.243GluGly: 5.243 ± 0.08	1.088GluHis: 1.088 ± 0.038	4.02GluIle: 4.02 ± 0.06	1.898GluLys: 1.898 ± 0.055	5.469GluLeu: 5.469 ± 0.076	1.804GluMet: 1.804 ± 0.05	1.577GluAsn: 1.577 ± 0.037	2.675GluPro: 2.675 ± 0.066	1.815GluGln: 1.815 ± 0.047	4.533GluArg: 4.533 ± 0.085	2.485GluSer: 2.485 ± 0.049	4.38GluThr: 4.38 ± 0.069	4.378GluVal: 4.378 ± 0.069	0.632GluTrp: 0.632 ± 0.024	1.005GluTyr: 1.005 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.638PheAla: 4.638 ± 0.08	0.41PheCys: 0.41 ± 0.019	2.949PheAsp: 2.949 ± 0.058	2.333PheGlu: 2.333 ± 0.057	1.48PhePhe: 1.48 ± 0.043	3.732PheGly: 3.732 ± 0.066	0.75PheHis: 0.75 ± 0.034	1.638PheIle: 1.638 ± 0.051	0.823PheLys: 0.823 ± 0.034	3.339PheLeu: 3.339 ± 0.067	0.806PheMet: 0.806 ± 0.028	0.939PheAsn: 0.939 ± 0.032	1.568PhePro: 1.568 ± 0.047	0.963PheGln: 0.963 ± 0.03	2.149PheArg: 2.149 ± 0.048	2.082PheSer: 2.082 ± 0.048	2.13PheThr: 2.13 ± 0.05	2.562PheVal: 2.562 ± 0.06	0.54PheTrp: 0.54 ± 0.026	0.88PheTyr: 0.88 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.993GlyAla: 11.993 ± 0.276	0.811GlyCys: 0.811 ± 0.037	4.903GlyAsp: 4.903 ± 0.16	5.221GlyGlu: 5.221 ± 0.073	3.76GlyPhe: 3.76 ± 0.068	7.87GlyGly: 7.87 ± 0.189	1.858GlyHis: 1.858 ± 0.051	4.58GlyIle: 4.58 ± 0.07	2.801GlyLys: 2.801 ± 0.071	9.724GlyLeu: 9.724 ± 0.122	2.485GlyMet: 2.485 ± 0.059	1.883GlyAsn: 1.883 ± 0.056	3.999GlyPro: 3.999 ± 0.073	2.983GlyGln: 2.983 ± 0.066	6.17GlyArg: 6.17 ± 0.09	4.309GlySer: 4.309 ± 0.134	4.725GlyThr: 4.725 ± 0.174	6.325GlyVal: 6.325 ± 0.073	1.477GlyTrp: 1.477 ± 0.04	2.296GlyTyr: 2.296 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.274HisAla: 2.274 ± 0.062	0.223HisCys: 0.223 ± 0.015	1.261HisAsp: 1.261 ± 0.038	1.064HisGlu: 1.064 ± 0.038	0.749HisPhe: 0.749 ± 0.036	1.903HisGly: 1.903 ± 0.045	0.539HisHis: 0.539 ± 0.025	0.899HisIle: 0.899 ± 0.034	0.473HisLys: 0.473 ± 0.022	2.046HisLeu: 2.046 ± 0.058	0.488HisMet: 0.488 ± 0.025	0.43HisAsn: 0.43 ± 0.019	1.336HisPro: 1.336 ± 0.042	0.516HisGln: 0.516 ± 0.02	1.324HisArg: 1.324 ± 0.041	0.88HisSer: 0.88 ± 0.032	0.755HisThr: 0.755 ± 0.03	1.478HisVal: 1.478 ± 0.038	0.318HisTrp: 0.318 ± 0.017	0.537HisTyr: 0.537 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.268IleAla: 7.268 ± 0.089	0.568IleCys: 0.568 ± 0.027	3.587IleAsp: 3.587 ± 0.082	3.555IleGlu: 3.555 ± 0.061	1.768IlePhe: 1.768 ± 0.054	4.802IleGly: 4.802 ± 0.072	0.853IleHis: 0.853 ± 0.033	2.152IleIle: 2.152 ± 0.059	1.208IleLys: 1.208 ± 0.038	4.786IleLeu: 4.786 ± 0.082	1.047IleMet: 1.047 ± 0.037	1.378IleAsn: 1.378 ± 0.036	2.342IlePro: 2.342 ± 0.063	1.012IleGln: 1.012 ± 0.036	3.204IleArg: 3.204 ± 0.063	3.003IleSer: 3.003 ± 0.069	3.009IleThr: 3.009 ± 0.09	3.609IleVal: 3.609 ± 0.077	0.65IleTrp: 0.65 ± 0.026	1.064IleTyr: 1.064 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.412LysAla: 3.412 ± 0.09	0.146LysCys: 0.146 ± 0.011	1.508LysAsp: 1.508 ± 0.051	1.294LysGlu: 1.294 ± 0.046	0.781LysPhe: 0.781 ± 0.029	2.247LysGly: 2.247 ± 0.06	0.512LysHis: 0.512 ± 0.024	1.496LysIle: 1.496 ± 0.042	0.917LysLys: 0.917 ± 0.042	2.689LysLeu: 2.689 ± 0.065	0.721LysMet: 0.721 ± 0.033	0.59LysAsn: 0.59 ± 0.027	1.571LysPro: 1.571 ± 0.051	0.792LysGln: 0.792 ± 0.028	1.938LysArg: 1.938 ± 0.055	1.696LysSer: 1.696 ± 0.049	1.745LysThr: 1.745 ± 0.048	1.945LysVal: 1.945 ± 0.057	0.3LysTrp: 0.3 ± 0.016	0.563LysTyr: 0.563 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.877LeuAla: 13.877 ± 0.142	1.012LeuCys: 1.012 ± 0.043	6.355LeuAsp: 6.355 ± 0.118	5.699LeuGlu: 5.699 ± 0.084	3.589LeuPhe: 3.589 ± 0.066	9.159LeuGly: 9.159 ± 0.105	1.925LeuHis: 1.925 ± 0.048	5.07LeuIle: 5.07 ± 0.083	2.813LeuLys: 2.813 ± 0.074	9.682LeuLeu: 9.682 ± 0.145	2.497LeuMet: 2.497 ± 0.059	2.329LeuAsn: 2.329 ± 0.045	5.709LeuPro: 5.709 ± 0.095	2.573LeuGln: 2.573 ± 0.05	7.935LeuArg: 7.935 ± 0.096	6.929LeuSer: 6.929 ± 0.167	6.235LeuThr: 6.235 ± 0.186	6.653LeuVal: 6.653 ± 0.091	1.336LeuTrp: 1.336 ± 0.047	1.938LeuTyr: 1.938 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.239MetAla: 3.239 ± 0.063	0.173MetCys: 0.173 ± 0.013	1.295MetAsp: 1.295 ± 0.033	1.313MetGlu: 1.313 ± 0.038	0.696MetPhe: 0.696 ± 0.03	2.156MetGly: 2.156 ± 0.053	0.419MetHis: 0.419 ± 0.02	1.49MetIle: 1.49 ± 0.041	0.872MetLys: 0.872 ± 0.036	2.441MetLeu: 2.441 ± 0.057	0.669MetMet: 0.669 ± 0.03	0.696MetAsn: 0.696 ± 0.028	1.423MetPro: 1.423 ± 0.043	0.81MetGln: 0.81 ± 0.033	1.835MetArg: 1.835 ± 0.051	1.799MetSer: 1.799 ± 0.047	1.971MetThr: 1.971 ± 0.049	1.647MetVal: 1.647 ± 0.042	0.203MetTrp: 0.203 ± 0.014	0.3MetTyr: 0.3 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.863AsnAla: 2.863 ± 0.053	0.225AsnCys: 0.225 ± 0.015	1.286AsnAsp: 1.286 ± 0.042	1.064AsnGlu: 1.064 ± 0.034	0.918AsnPhe: 0.918 ± 0.032	2.072AsnGly: 2.072 ± 0.054	0.459AsnHis: 0.459 ± 0.021	1.23AsnIle: 1.23 ± 0.037	0.523AsnLys: 0.523 ± 0.027	2.305AsnLeu: 2.305 ± 0.043	0.635AsnMet: 0.635 ± 0.026	0.548AsnAsn: 0.548 ± 0.024	1.704AsnPro: 1.704 ± 0.043	0.596AsnGln: 0.596 ± 0.023	1.554AsnArg: 1.554 ± 0.039	1.058AsnSer: 1.058 ± 0.033	1.229AsnThr: 1.229 ± 0.034	1.645AsnVal: 1.645 ± 0.044	0.392AsnTrp: 0.392 ± 0.022	0.537AsnTyr: 0.537 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.355ProAla: 6.355 ± 0.109	0.368ProCys: 0.368 ± 0.02	3.941ProAsp: 3.941 ± 0.072	4.744ProGlu: 4.744 ± 0.092	1.907ProPhe: 1.907 ± 0.045	5.004ProGly: 5.004 ± 0.074	1.003ProHis: 1.003 ± 0.038	2.213ProIle: 2.213 ± 0.056	1.481ProLys: 1.481 ± 0.053	4.853ProLeu: 4.853 ± 0.09	1.255ProMet: 1.255 ± 0.04	1.135ProAsn: 1.135 ± 0.03	2.468ProPro: 2.468 ± 0.064	1.659ProGln: 1.659 ± 0.047	3.076ProArg: 3.076 ± 0.081	2.488ProSer: 2.488 ± 0.057	2.322ProThr: 2.322 ± 0.055	4.281ProVal: 4.281 ± 0.076	0.667ProTrp: 0.667 ± 0.027	1.057ProTyr: 1.057 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.56GlnAla: 3.56 ± 0.055	0.197GlnCys: 0.197 ± 0.015	1.57GlnAsp: 1.57 ± 0.041	1.519GlnGlu: 1.519 ± 0.036	1.04GlnPhe: 1.04 ± 0.032	2.409GlnGly: 2.409 ± 0.053	0.54GlnHis: 0.54 ± 0.024	1.935GlnIle: 1.935 ± 0.046	0.9GlnLys: 0.9 ± 0.038	2.647GlnLeu: 2.647 ± 0.053	0.844GlnMet: 0.844 ± 0.032	0.712GlnAsn: 0.712 ± 0.026	1.48GlnPro: 1.48 ± 0.041	0.94GlnGln: 0.94 ± 0.034	2.108GlnArg: 2.108 ± 0.047	1.821GlnSer: 1.821 ± 0.04	1.873GlnThr: 1.873 ± 0.046	2.066GlnVal: 2.066 ± 0.05	0.368GlnTrp: 0.368 ± 0.018	0.553GlnTyr: 0.553 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.525ArgAla: 9.525 ± 0.145	0.501ArgCys: 0.501 ± 0.027	4.369ArgAsp: 4.369 ± 0.069	4.151ArgGlu: 4.151 ± 0.085	2.889ArgPhe: 2.889 ± 0.056	5.224ArgGly: 5.224 ± 0.08	1.509ArgHis: 1.509 ± 0.047	4.038ArgIle: 4.038 ± 0.055	2.104ArgLys: 2.104 ± 0.069	7.827ArgLeu: 7.827 ± 0.123	1.902ArgMet: 1.902 ± 0.048	1.677ArgAsn: 1.677 ± 0.037	3.54ArgPro: 3.54 ± 0.075	2.186ArgGln: 2.186 ± 0.049	5.599ArgArg: 5.599 ± 0.119	3.39ArgSer: 3.39 ± 0.058	3.054ArgThr: 3.054 ± 0.053	4.715ArgVal: 4.715 ± 0.072	0.932ArgTrp: 0.932 ± 0.033	1.592ArgTyr: 1.592 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.398SerAla: 6.398 ± 0.126	0.412SerCys: 0.412 ± 0.022	3.278SerAsp: 3.278 ± 0.079	2.955SerGlu: 2.955 ± 0.05	2.289SerPhe: 2.289 ± 0.05	5.804SerGly: 5.804 ± 0.197	1.014SerHis: 1.014 ± 0.032	2.412SerIle: 2.412 ± 0.054	1.302SerLys: 1.302 ± 0.045	5.153SerLeu: 5.153 ± 0.124	1.268SerMet: 1.268 ± 0.037	1.239SerAsn: 1.239 ± 0.04	2.607SerPro: 2.607 ± 0.065	1.512SerGln: 1.512 ± 0.041	3.411SerArg: 3.411 ± 0.067	2.648SerSer: 2.648 ± 0.064	2.512SerThr: 2.512 ± 0.064	3.74SerVal: 3.74 ± 0.076	0.701SerTrp: 0.701 ± 0.027	1.338SerTyr: 1.338 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.485ThrAla: 6.485 ± 0.167	0.46ThrCys: 0.46 ± 0.025	3.079ThrAsp: 3.079 ± 0.077	3.119ThrGlu: 3.119 ± 0.054	1.878ThrPhe: 1.878 ± 0.05	5.784ThrGly: 5.784 ± 0.19	1.048ThrHis: 1.048 ± 0.037	2.644ThrIle: 2.644 ± 0.079	1.244ThrLys: 1.244 ± 0.04	6.212ThrLeu: 6.212 ± 0.188	1.156ThrMet: 1.156 ± 0.032	1.135ThrAsn: 1.135 ± 0.031	3.316ThrPro: 3.316 ± 0.06	1.488ThrGln: 1.488 ± 0.041	3.73ThrArg: 3.73 ± 0.059	2.679ThrSer: 2.679 ± 0.078	2.773ThrThr: 2.773 ± 0.097	4.264ThrVal: 4.264 ± 0.131	0.629ThrTrp: 0.629 ± 0.026	1.126ThrTyr: 1.126 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.668ValAla: 8.668 ± 0.097	0.6ValCys: 0.6 ± 0.027	3.999ValAsp: 3.999 ± 0.071	4.547ValGlu: 4.547 ± 0.068	2.896ValPhe: 2.896 ± 0.053	5.268ValGly: 5.268 ± 0.083	1.268ValHis: 1.268 ± 0.037	4.043ValIle: 4.043 ± 0.068	1.784ValLys: 1.784 ± 0.053	7.284ValLeu: 7.284 ± 0.082	1.828ValMet: 1.828 ± 0.048	1.759ValAsn: 1.759 ± 0.039	3.426ValPro: 3.426 ± 0.071	1.822ValGln: 1.822 ± 0.041	4.21ValArg: 4.21 ± 0.071	4.386ValSer: 4.386 ± 0.085	4.463ValThr: 4.463 ± 0.156	5.292ValVal: 5.292 ± 0.093	0.878ValTrp: 0.878 ± 0.032	1.464ValTyr: 1.464 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.375TrpAla: 1.375 ± 0.042	0.12TrpCys: 0.12 ± 0.011	0.758TrpAsp: 0.758 ± 0.036	0.709TrpGlu: 0.709 ± 0.025	0.515TrpPhe: 0.515 ± 0.023	0.968TrpGly: 0.968 ± 0.03	0.284TrpHis: 0.284 ± 0.015	0.685TrpIle: 0.685 ± 0.026	0.39TrpLys: 0.39 ± 0.024	1.579TrpLeu: 1.579 ± 0.043	0.357TrpMet: 0.357 ± 0.017	0.362TrpAsn: 0.362 ± 0.021	0.677TrpPro: 0.677 ± 0.024	0.549TrpGln: 0.549 ± 0.021	1.073TrpArg: 1.073 ± 0.038	0.82TrpSer: 0.82 ± 0.031	0.735TrpThr: 0.735 ± 0.028	0.817TrpVal: 0.817 ± 0.031	0.204TrpTrp: 0.204 ± 0.014	0.263TrpTyr: 0.263 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.513TyrAla: 2.513 ± 0.046	0.212TyrCys: 0.212 ± 0.013	1.529TyrAsp: 1.529 ± 0.042	1.259TyrGlu: 1.259 ± 0.037	0.913TyrPhe: 0.913 ± 0.032	2.004TyrGly: 2.004 ± 0.049	0.484TyrHis: 0.484 ± 0.024	0.91TyrIle: 0.91 ± 0.028	0.479TyrLys: 0.479 ± 0.02	2.241TyrLeu: 2.241 ± 0.053	0.433TyrMet: 0.433 ± 0.024	0.56TyrAsn: 0.56 ± 0.026	1.028TyrPro: 1.028 ± 0.037	0.624TyrGln: 0.624 ± 0.024	1.532TyrArg: 1.532 ± 0.042	1.092TyrSer: 1.092 ± 0.034	1.09TyrThr: 1.09 ± 0.031	1.427TyrVal: 1.427 ± 0.042	0.335TyrTrp: 0.335 ± 0.018	0.539TyrTyr: 0.539 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3242 proteins (1066642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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