Amino acid dipepetide frequency for Costertonia aggregata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.232AlaAla: 4.232 ± 0.074
0.571AlaCys: 0.571 ± 0.025
3.585AlaAsp: 3.585 ± 0.072
3.991AlaGlu: 3.991 ± 0.067
3.319AlaPhe: 3.319 ± 0.071
4.109AlaGly: 4.109 ± 0.12
1.194AlaHis: 1.194 ± 0.034
5.385AlaIle: 5.385 ± 0.074
4.886AlaLys: 4.886 ± 0.081
6.378AlaLeu: 6.378 ± 0.09
1.641AlaMet: 1.641 ± 0.041
3.381AlaAsn: 3.381 ± 0.06
2.006AlaPro: 2.006 ± 0.045
2.386AlaGln: 2.386 ± 0.046
2.007AlaArg: 2.007 ± 0.047
4.093AlaSer: 4.093 ± 0.06
3.71AlaThr: 3.71 ± 0.094
4.117AlaVal: 4.117 ± 0.059
0.656AlaTrp: 0.656 ± 0.025
2.464AlaTyr: 2.464 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.453CysAla: 0.453 ± 0.021
0.098CysCys: 0.098 ± 0.011
0.43CysAsp: 0.43 ± 0.019
0.477CysGlu: 0.477 ± 0.021
0.424CysPhe: 0.424 ± 0.021
0.599CysGly: 0.599 ± 0.021
0.172CysHis: 0.172 ± 0.014
0.612CysIle: 0.612 ± 0.019
0.468CysLys: 0.468 ± 0.02
0.609CysLeu: 0.609 ± 0.023
0.139CysMet: 0.139 ± 0.011
0.401CysAsn: 0.401 ± 0.019
0.322CysPro: 0.322 ± 0.019
0.198CysGln: 0.198 ± 0.013
0.205CysArg: 0.205 ± 0.013
0.544CysSer: 0.544 ± 0.021
0.491CysThr: 0.491 ± 0.037
0.383CysVal: 0.383 ± 0.023
0.063CysTrp: 0.063 ± 0.007
0.288CysTyr: 0.288 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.964AspAla: 3.964 ± 0.073
0.435AspCys: 0.435 ± 0.02
3.312AspAsp: 3.312 ± 0.083
3.965AspGlu: 3.965 ± 0.065
4.02AspPhe: 4.02 ± 0.072
4.33AspGly: 4.33 ± 0.169
0.863AspHis: 0.863 ± 0.027
4.677AspIle: 4.677 ± 0.063
4.151AspLys: 4.151 ± 0.061
4.976AspLeu: 4.976 ± 0.068
1.281AspMet: 1.281 ± 0.034
3.284AspAsn: 3.284 ± 0.068
1.653AspPro: 1.653 ± 0.055
1.311AspGln: 1.311 ± 0.031
2.002AspArg: 2.002 ± 0.042
3.48AspSer: 3.48 ± 0.085
3.457AspThr: 3.457 ± 0.077
3.785AspVal: 3.785 ± 0.066
0.809AspTrp: 0.809 ± 0.026
2.845AspTyr: 2.845 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
4.169GluAla: 4.169 ± 0.066
0.331GluCys: 0.331 ± 0.021
3.511GluAsp: 3.511 ± 0.06
4.731GluGlu: 4.731 ± 0.08
2.752GluPhe: 2.752 ± 0.055
3.899GluGly: 3.899 ± 0.068
1.19GluHis: 1.19 ± 0.036
5.477GluIle: 5.477 ± 0.079
6.073GluLys: 6.073 ± 0.092
6.023GluLeu: 6.023 ± 0.079
1.586GluMet: 1.586 ± 0.04
4.778GluAsn: 4.778 ± 0.071
1.753GluPro: 1.753 ± 0.043
2.371GluGln: 2.371 ± 0.047
2.786GluArg: 2.786 ± 0.055
3.286GluSer: 3.286 ± 0.055
3.711GluThr: 3.711 ± 0.064
4.151GluVal: 4.151 ± 0.073
0.668GluTrp: 0.668 ± 0.024
2.502GluTyr: 2.502 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
2.982PheAla: 2.982 ± 0.056
0.424PheCys: 0.424 ± 0.023
3.453PheAsp: 3.453 ± 0.059
3.546PheGlu: 3.546 ± 0.054
2.98PhePhe: 2.98 ± 0.064
3.79PheGly: 3.79 ± 0.067
0.799PheHis: 0.799 ± 0.03
3.638PheIle: 3.638 ± 0.068
3.568PheLys: 3.568 ± 0.061
4.974PheLeu: 4.974 ± 0.079
1.177PheMet: 1.177 ± 0.034
2.994PheAsn: 2.994 ± 0.062
1.727PhePro: 1.727 ± 0.038
1.555PheGln: 1.555 ± 0.036
1.783PheArg: 1.783 ± 0.036
3.949PheSer: 3.949 ± 0.069
3.167PheThr: 3.167 ± 0.061
3.023PheVal: 3.023 ± 0.052
0.606PheTrp: 0.606 ± 0.025
2.234PheTyr: 2.234 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.316GlyAla: 4.316 ± 0.12
0.632GlyCys: 0.632 ± 0.035
3.647GlyAsp: 3.647 ± 0.079
3.888GlyGlu: 3.888 ± 0.068
3.853GlyPhe: 3.853 ± 0.062
4.592GlyGly: 4.592 ± 0.09
1.226GlyHis: 1.226 ± 0.036
5.674GlyIle: 5.674 ± 0.08
5.249GlyLys: 5.249 ± 0.084
6.058GlyLeu: 6.058 ± 0.087
1.716GlyMet: 1.716 ± 0.038
3.879GlyAsn: 3.879 ± 0.075
1.553GlyPro: 1.553 ± 0.124
2.056GlyGln: 2.056 ± 0.051
2.307GlyArg: 2.307 ± 0.052
4.003GlySer: 4.003 ± 0.073
4.169GlyThr: 4.169 ± 0.132
4.307GlyVal: 4.307 ± 0.076
0.834GlyTrp: 0.834 ± 0.029
2.885GlyTyr: 2.885 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
0.97HisAla: 0.97 ± 0.03
0.179HisCys: 0.179 ± 0.012
0.856HisAsp: 0.856 ± 0.028
0.987HisGlu: 0.987 ± 0.03
1.11HisPhe: 1.11 ± 0.032
1.114HisGly: 1.114 ± 0.034
0.485HisHis: 0.485 ± 0.026
1.449HisIle: 1.449 ± 0.037
1.273HisLys: 1.273 ± 0.036
1.739HisLeu: 1.739 ± 0.041
0.39HisMet: 0.39 ± 0.021
0.848HisAsn: 0.848 ± 0.03
0.861HisPro: 0.861 ± 0.03
0.733HisGln: 0.733 ± 0.025
0.721HisArg: 0.721 ± 0.025
1.048HisSer: 1.048 ± 0.032
1.047HisThr: 1.047 ± 0.033
0.992HisVal: 0.992 ± 0.029
0.218HisTrp: 0.218 ± 0.015
0.811HisTyr: 0.811 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.505IleAla: 5.505 ± 0.082
0.62IleCys: 0.62 ± 0.023
4.985IleAsp: 4.985 ± 0.07
4.842IleGlu: 4.842 ± 0.067
3.598IlePhe: 3.598 ± 0.068
5.139IleGly: 5.139 ± 0.073
1.338IleHis: 1.338 ± 0.037
5.357IleIle: 5.357 ± 0.09
5.488IleLys: 5.488 ± 0.083
6.953IleLeu: 6.953 ± 0.094
1.461IleMet: 1.461 ± 0.042
4.172IleAsn: 4.172 ± 0.056
3.195IlePro: 3.195 ± 0.057
2.52IleGln: 2.52 ± 0.048
2.778IleArg: 2.778 ± 0.054
5.363IleSer: 5.363 ± 0.08
4.626IleThr: 4.626 ± 0.085
4.802IleVal: 4.802 ± 0.07
0.754IleTrp: 0.754 ± 0.033
2.706IleTyr: 2.706 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
5.035LysAla: 5.035 ± 0.088
0.32LysCys: 0.32 ± 0.019
4.393LysAsp: 4.393 ± 0.071
5.993LysGlu: 5.993 ± 0.088
2.798LysPhe: 2.798 ± 0.048
4.723LysGly: 4.723 ± 0.074
1.353LysHis: 1.353 ± 0.038
6.019LysIle: 6.019 ± 0.084
7.396LysLys: 7.396 ± 0.122
6.441LysLeu: 6.441 ± 0.089
1.961LysMet: 1.961 ± 0.047
5.273LysAsn: 5.273 ± 0.077
2.4LysPro: 2.4 ± 0.042
2.546LysGln: 2.546 ± 0.05
3.117LysArg: 3.117 ± 0.056
4.679LysSer: 4.679 ± 0.071
4.714LysThr: 4.714 ± 0.074
4.701LysVal: 4.701 ± 0.083
0.824LysTrp: 0.824 ± 0.025
2.89LysTyr: 2.89 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
6.004LeuAla: 6.004 ± 0.076
0.705LeuCys: 0.705 ± 0.027
5.447LeuAsp: 5.447 ± 0.078
6.306LeuGlu: 6.306 ± 0.094
4.903LeuPhe: 4.903 ± 0.086
6.209LeuGly: 6.209 ± 0.076
1.595LeuHis: 1.595 ± 0.039
6.212LeuIle: 6.212 ± 0.088
7.584LeuLys: 7.584 ± 0.1
8.784LeuLeu: 8.784 ± 0.129
2.09LeuMet: 2.09 ± 0.045
5.437LeuAsn: 5.437 ± 0.08
3.61LeuPro: 3.61 ± 0.059
3.219LeuGln: 3.219 ± 0.057
3.455LeuArg: 3.455 ± 0.059
6.414LeuSer: 6.414 ± 0.085
4.983LeuThr: 4.983 ± 0.072
5.639LeuVal: 5.639 ± 0.076
0.855LeuTrp: 0.855 ± 0.028
3.16LeuTyr: 3.16 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
1.857MetAla: 1.857 ± 0.042
0.134MetCys: 0.134 ± 0.012
1.345MetAsp: 1.345 ± 0.036
1.456MetGlu: 1.456 ± 0.045
0.874MetPhe: 0.874 ± 0.037
1.682MetGly: 1.682 ± 0.041
0.457MetHis: 0.457 ± 0.018
1.409MetIle: 1.409 ± 0.036
2.104MetLys: 2.104 ± 0.041
2.011MetLeu: 2.011 ± 0.045
0.566MetMet: 0.566 ± 0.027
1.287MetAsn: 1.287 ± 0.033
0.882MetPro: 0.882 ± 0.028
0.932MetGln: 0.932 ± 0.03
0.952MetArg: 0.952 ± 0.032
1.317MetSer: 1.317 ± 0.039
1.104MetThr: 1.104 ± 0.031
1.57MetVal: 1.57 ± 0.033
0.17MetTrp: 0.17 ± 0.013
0.73MetTyr: 0.73 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.783AsnAla: 3.783 ± 0.056
0.43AsnCys: 0.43 ± 0.025
3.404AsnAsp: 3.404 ± 0.091
3.61AsnGlu: 3.61 ± 0.059
2.93AsnPhe: 2.93 ± 0.054
4.427AsnGly: 4.427 ± 0.092
1.033AsnHis: 1.033 ± 0.034
4.628AsnIle: 4.628 ± 0.068
3.788AsnLys: 3.788 ± 0.072
5.104AsnLeu: 5.104 ± 0.075
1.288AsnMet: 1.288 ± 0.042
3.379AsnAsn: 3.379 ± 0.068
2.733AsnPro: 2.733 ± 0.051
1.944AsnGln: 1.944 ± 0.054
2.311AsnArg: 2.311 ± 0.045
3.482AsnSer: 3.482 ± 0.058
3.905AsnThr: 3.905 ± 0.08
3.467AsnVal: 3.467 ± 0.061
0.7AsnTrp: 0.7 ± 0.027
2.451AsnTyr: 2.451 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
1.859ProAla: 1.859 ± 0.082
0.203ProCys: 0.203 ± 0.013
2.259ProAsp: 2.259 ± 0.078
2.828ProGlu: 2.828 ± 0.053
1.958ProPhe: 1.958 ± 0.042
1.963ProGly: 1.963 ± 0.048
0.6ProHis: 0.6 ± 0.027
2.681ProIle: 2.681 ± 0.054
2.849ProLys: 2.849 ± 0.055
3.056ProLeu: 3.056 ± 0.05
0.816ProMet: 0.816 ± 0.027
2.311ProAsn: 2.311 ± 0.053
0.904ProPro: 0.904 ± 0.029
1.142ProGln: 1.142 ± 0.032
0.994ProArg: 0.994 ± 0.028
2.169ProSer: 2.169 ± 0.046
2.024ProThr: 2.024 ± 0.053
2.345ProVal: 2.345 ± 0.047
0.377ProTrp: 0.377 ± 0.02
1.404ProTyr: 1.404 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
1.848GlnAla: 1.848 ± 0.051
0.163GlnCys: 0.163 ± 0.013
1.696GlnAsp: 1.696 ± 0.041
2.332GlnGlu: 2.332 ± 0.046
1.543GlnPhe: 1.543 ± 0.038
1.92GlnGly: 1.92 ± 0.046
0.597GlnHis: 0.597 ± 0.025
2.536GlnIle: 2.536 ± 0.05
3.011GlnLys: 3.011 ± 0.063
3.425GlnLeu: 3.425 ± 0.058
0.887GlnMet: 0.887 ± 0.027
2.203GlnAsn: 2.203 ± 0.044
1.08GlnPro: 1.08 ± 0.034
1.291GlnGln: 1.291 ± 0.034
1.411GlnArg: 1.411 ± 0.034
1.764GlnSer: 1.764 ± 0.037
1.734GlnThr: 1.734 ± 0.043
1.863GlnVal: 1.863 ± 0.037
0.404GlnTrp: 0.404 ± 0.018
1.253GlnTyr: 1.253 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.138ArgAla: 2.138 ± 0.042
0.194ArgCys: 0.194 ± 0.013
1.921ArgAsp: 1.921 ± 0.041
2.375ArgGlu: 2.375 ± 0.047
2.104ArgPhe: 2.104 ± 0.046
2.015ArgGly: 2.015 ± 0.041
0.656ArgHis: 0.656 ± 0.024
3.04ArgIle: 3.04 ± 0.053
3.094ArgLys: 3.094 ± 0.058
3.62ArgLeu: 3.62 ± 0.056
0.962ArgMet: 0.962 ± 0.033
2.229ArgAsn: 2.229 ± 0.045
1.31ArgPro: 1.31 ± 0.038
1.216ArgGln: 1.216 ± 0.034
1.461ArgArg: 1.461 ± 0.041
2.045ArgSer: 2.045 ± 0.056
1.999ArgThr: 1.999 ± 0.039
2.123ArgVal: 2.123 ± 0.043
0.396ArgTrp: 0.396 ± 0.018
1.701ArgTyr: 1.701 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
3.729SerAla: 3.729 ± 0.067
0.626SerCys: 0.626 ± 0.024
3.737SerAsp: 3.737 ± 0.073
4.034SerGlu: 4.034 ± 0.062
3.66SerPhe: 3.66 ± 0.057
4.649SerGly: 4.649 ± 0.072
1.065SerHis: 1.065 ± 0.034
4.985SerIle: 4.985 ± 0.069
4.95SerLys: 4.95 ± 0.074
5.858SerLeu: 5.858 ± 0.077
1.244SerMet: 1.244 ± 0.035
3.443SerAsn: 3.443 ± 0.063
2.104SerPro: 2.104 ± 0.046
1.979SerGln: 1.979 ± 0.037
2.125SerArg: 2.125 ± 0.051
4.014SerSer: 4.014 ± 0.077
3.469SerThr: 3.469 ± 0.061
4.035SerVal: 4.035 ± 0.067
0.687SerTrp: 0.687 ± 0.025
2.602SerTyr: 2.602 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
3.87ThrAla: 3.87 ± 0.07
0.363ThrCys: 0.363 ± 0.026
3.735ThrAsp: 3.735 ± 0.092
3.326ThrGlu: 3.326 ± 0.057
3.158ThrPhe: 3.158 ± 0.059
4.192ThrGly: 4.192 ± 0.121
0.988ThrHis: 0.988 ± 0.034
4.768ThrIle: 4.768 ± 0.074
3.952ThrLys: 3.952 ± 0.069
5.496ThrLeu: 5.496 ± 0.076
1.129ThrMet: 1.129 ± 0.034
3.155ThrAsn: 3.155 ± 0.081
2.416ThrPro: 2.416 ± 0.058
1.79ThrGln: 1.79 ± 0.043
1.723ThrArg: 1.723 ± 0.036
3.676ThrSer: 3.676 ± 0.066
3.32ThrThr: 3.32 ± 0.076
4.241ThrVal: 4.241 ± 0.085
0.584ThrTrp: 0.584 ± 0.025
2.359ThrTyr: 2.359 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
4.284ValAla: 4.284 ± 0.061
0.528ValCys: 0.528 ± 0.024
3.736ValAsp: 3.736 ± 0.071
3.894ValGlu: 3.894 ± 0.07
3.506ValPhe: 3.506 ± 0.066
3.971ValGly: 3.971 ± 0.072
1.132ValHis: 1.132 ± 0.034
4.358ValIle: 4.358 ± 0.067
4.138ValLys: 4.138 ± 0.061
6.361ValLeu: 6.361 ± 0.085
1.389ValMet: 1.389 ± 0.034
3.439ValAsn: 3.439 ± 0.061
2.495ValPro: 2.495 ± 0.046
1.927ValGln: 1.927 ± 0.042
2.222ValArg: 2.222 ± 0.042
4.513ValSer: 4.513 ± 0.065
3.682ValThr: 3.682 ± 0.092
4.326ValVal: 4.326 ± 0.075
0.633ValTrp: 0.633 ± 0.025
2.339ValTyr: 2.339 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.65TrpAla: 0.65 ± 0.026
0.087TrpCys: 0.087 ± 0.008
0.68TrpAsp: 0.68 ± 0.029
0.741TrpGlu: 0.741 ± 0.026
0.561TrpPhe: 0.561 ± 0.024
0.751TrpGly: 0.751 ± 0.031
0.236TrpHis: 0.236 ± 0.016
0.684TrpIle: 0.684 ± 0.024
0.835TrpLys: 0.835 ± 0.032
1.023TrpLeu: 1.023 ± 0.036
0.339TrpMet: 0.339 ± 0.017
0.69TrpAsn: 0.69 ± 0.028
0.288TrpPro: 0.288 ± 0.017
0.412TrpGln: 0.412 ± 0.02
0.431TrpArg: 0.431 ± 0.018
0.674TrpSer: 0.674 ± 0.026
0.533TrpThr: 0.533 ± 0.024
0.689TrpVal: 0.689 ± 0.027
0.17TrpTrp: 0.17 ± 0.014
0.432TrpTyr: 0.432 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.463TyrAla: 2.463 ± 0.052
0.331TyrCys: 0.331 ± 0.015
2.464TyrAsp: 2.464 ± 0.051
2.43TyrGlu: 2.43 ± 0.045
2.316TyrPhe: 2.316 ± 0.047
2.774TyrGly: 2.774 ± 0.054
0.852TyrHis: 0.852 ± 0.028
2.615TyrIle: 2.615 ± 0.047
2.72TyrLys: 2.72 ± 0.052
3.722TyrLeu: 3.722 ± 0.067
0.776TyrMet: 0.776 ± 0.027
2.213TyrAsn: 2.213 ± 0.052
1.45TyrPro: 1.45 ± 0.044
1.433TyrGln: 1.433 ± 0.045
1.811TyrArg: 1.811 ± 0.043
2.481TyrSer: 2.481 ± 0.052
2.394TyrThr: 2.394 ± 0.049
2.316TyrVal: 2.316 ± 0.044
0.498TyrTrp: 0.498 ± 0.022
1.722TyrTyr: 1.722 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3525 proteins (1168523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski