Amino acid dipepetide frequency for Lactobacillus virus c5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.602AlaAla: 1.602 ± 0.818
0.601AlaCys: 0.601 ± 0.23
4.707AlaAsp: 4.707 ± 0.616
4.106AlaGlu: 4.106 ± 0.572
3.305AlaPhe: 3.305 ± 0.6
5.608AlaGly: 5.608 ± 1.588
0.601AlaHis: 0.601 ± 0.261
4.907AlaIle: 4.907 ± 0.548
5.808AlaLys: 5.808 ± 0.719
4.606AlaLeu: 4.606 ± 0.855
1.803AlaMet: 1.803 ± 0.523
4.707AlaAsn: 4.707 ± 0.974
1.302AlaPro: 1.302 ± 0.321
2.403AlaGln: 2.403 ± 0.779
3.004AlaArg: 3.004 ± 0.684
4.406AlaSer: 4.406 ± 1.065
3.705AlaThr: 3.705 ± 0.596
4.406AlaVal: 4.406 ± 0.918
0.901AlaTrp: 0.901 ± 0.286
3.605AlaTyr: 3.605 ± 0.617
0.0AlaXaa: 0.0 ± 0.0
Cys
0.701CysAla: 0.701 ± 0.335
0.2CysCys: 0.2 ± 0.141
0.1CysAsp: 0.1 ± 0.092
0.601CysGlu: 0.601 ± 0.228
0.1CysPhe: 0.1 ± 0.106
0.801CysGly: 0.801 ± 0.267
0.1CysHis: 0.1 ± 0.096
0.401CysIle: 0.401 ± 0.172
1.302CysLys: 1.302 ± 0.347
1.102CysLeu: 1.102 ± 0.366
0.401CysMet: 0.401 ± 0.161
0.801CysAsn: 0.801 ± 0.264
0.2CysPro: 0.2 ± 0.154
0.501CysGln: 0.501 ± 0.177
0.401CysArg: 0.401 ± 0.183
0.2CysSer: 0.2 ± 0.136
0.601CysThr: 0.601 ± 0.22
0.601CysVal: 0.601 ± 0.27
0.3CysTrp: 0.3 ± 0.172
0.2CysTyr: 0.2 ± 0.126
0.0CysXaa: 0.0 ± 0.0
Asp
3.305AspAla: 3.305 ± 0.44
0.401AspCys: 0.401 ± 0.16
5.307AspAsp: 5.307 ± 0.883
6.008AspGlu: 6.008 ± 0.807
2.904AspPhe: 2.904 ± 0.455
4.707AspGly: 4.707 ± 0.907
0.901AspHis: 0.901 ± 0.306
4.506AspIle: 4.506 ± 0.667
4.406AspLys: 4.406 ± 0.54
5.908AspLeu: 5.908 ± 0.803
2.103AspMet: 2.103 ± 0.465
4.707AspAsn: 4.707 ± 0.699
1.202AspPro: 1.202 ± 0.423
2.203AspGln: 2.203 ± 0.33
1.602AspArg: 1.602 ± 0.332
4.306AspSer: 4.306 ± 0.632
3.305AspThr: 3.305 ± 0.782
4.206AspVal: 4.206 ± 0.568
0.701AspTrp: 0.701 ± 0.278
3.204AspTyr: 3.204 ± 0.581
0.0AspXaa: 0.0 ± 0.0
Glu
5.107GluAla: 5.107 ± 0.823
0.501GluCys: 0.501 ± 0.208
5.207GluAsp: 5.207 ± 0.553
6.109GluGlu: 6.109 ± 0.878
2.504GluPhe: 2.504 ± 0.401
3.305GluGly: 3.305 ± 0.455
0.801GluHis: 0.801 ± 0.237
6.409GluIle: 6.409 ± 0.98
6.008GluLys: 6.008 ± 0.79
5.908GluLeu: 5.908 ± 0.972
2.403GluMet: 2.403 ± 0.505
3.805GluAsn: 3.805 ± 0.457
1.202GluPro: 1.202 ± 0.335
2.303GluGln: 2.303 ± 0.461
2.403GluArg: 2.403 ± 0.468
3.204GluSer: 3.204 ± 0.487
3.705GluThr: 3.705 ± 0.648
5.007GluVal: 5.007 ± 0.733
0.501GluTrp: 0.501 ± 0.236
2.904GluTyr: 2.904 ± 0.531
0.0GluXaa: 0.0 ± 0.0
Phe
2.604PheAla: 2.604 ± 0.545
0.501PheCys: 0.501 ± 0.223
2.203PheAsp: 2.203 ± 0.457
2.604PheGlu: 2.604 ± 0.451
1.502PhePhe: 1.502 ± 0.462
3.405PheGly: 3.405 ± 0.57
0.401PheHis: 0.401 ± 0.247
2.904PheIle: 2.904 ± 0.575
3.905PheLys: 3.905 ± 0.469
2.904PheLeu: 2.904 ± 0.607
0.701PheMet: 0.701 ± 0.304
2.403PheAsn: 2.403 ± 0.545
0.501PhePro: 0.501 ± 0.206
1.402PheGln: 1.402 ± 0.402
1.903PheArg: 1.903 ± 0.436
1.903PheSer: 1.903 ± 0.421
3.104PheThr: 3.104 ± 0.63
2.403PheVal: 2.403 ± 0.437
0.1PheTrp: 0.1 ± 0.122
0.701PheTyr: 0.701 ± 0.263
0.0PheXaa: 0.0 ± 0.0
Gly
4.807GlyAla: 4.807 ± 0.802
0.3GlyCys: 0.3 ± 0.182
4.807GlyAsp: 4.807 ± 0.713
3.305GlyGlu: 3.305 ± 0.599
3.405GlyPhe: 3.405 ± 0.586
4.006GlyGly: 4.006 ± 0.92
1.001GlyHis: 1.001 ± 0.266
5.307GlyIle: 5.307 ± 0.906
5.708GlyLys: 5.708 ± 0.606
5.708GlyLeu: 5.708 ± 0.841
1.903GlyMet: 1.903 ± 0.581
3.805GlyAsn: 3.805 ± 0.773
0.0GlyPro: 0.0 ± 0.0
1.702GlyGln: 1.702 ± 0.455
2.704GlyArg: 2.704 ± 0.569
4.006GlySer: 4.006 ± 0.828
3.705GlyThr: 3.705 ± 0.719
5.107GlyVal: 5.107 ± 0.594
0.701GlyTrp: 0.701 ± 0.199
4.006GlyTyr: 4.006 ± 0.848
0.0GlyXaa: 0.0 ± 0.0
His
1.001HisAla: 1.001 ± 0.43
0.2HisCys: 0.2 ± 0.129
0.401HisAsp: 0.401 ± 0.238
0.901HisGlu: 0.901 ± 0.403
0.3HisPhe: 0.3 ± 0.18
0.701HisGly: 0.701 ± 0.341
0.601HisHis: 0.601 ± 0.319
1.001HisIle: 1.001 ± 0.271
1.402HisLys: 1.402 ± 0.323
1.001HisLeu: 1.001 ± 0.348
0.401HisMet: 0.401 ± 0.18
0.501HisAsn: 0.501 ± 0.205
0.2HisPro: 0.2 ± 0.117
0.401HisGln: 0.401 ± 0.181
0.601HisArg: 0.601 ± 0.208
0.901HisSer: 0.901 ± 0.223
0.701HisThr: 0.701 ± 0.228
1.602HisVal: 1.602 ± 0.462
0.1HisTrp: 0.1 ± 0.108
0.801HisTyr: 0.801 ± 0.278
0.0HisXaa: 0.0 ± 0.0
Ile
3.605IleAla: 3.605 ± 0.664
0.501IleCys: 0.501 ± 0.24
5.107IleAsp: 5.107 ± 0.806
5.608IleGlu: 5.608 ± 0.776
1.502IlePhe: 1.502 ± 0.37
3.505IleGly: 3.505 ± 0.655
0.601IleHis: 0.601 ± 0.22
3.405IleIle: 3.405 ± 0.555
6.609IleLys: 6.609 ± 0.796
5.107IleLeu: 5.107 ± 0.958
1.702IleMet: 1.702 ± 0.386
6.109IleAsn: 6.109 ± 0.793
2.804IlePro: 2.804 ± 0.561
1.903IleGln: 1.903 ± 0.426
2.604IleArg: 2.604 ± 0.578
5.307IleSer: 5.307 ± 0.58
4.907IleThr: 4.907 ± 0.637
4.606IleVal: 4.606 ± 0.712
0.701IleTrp: 0.701 ± 0.303
3.004IleTyr: 3.004 ± 0.562
0.0IleXaa: 0.0 ± 0.0
Lys
6.209LysAla: 6.209 ± 0.924
0.401LysCys: 0.401 ± 0.196
4.006LysAsp: 4.006 ± 0.577
6.609LysGlu: 6.609 ± 0.846
3.004LysPhe: 3.004 ± 0.506
6.409LysGly: 6.409 ± 0.632
0.801LysHis: 0.801 ± 0.291
5.708LysIle: 5.708 ± 0.734
6.91LysLys: 6.91 ± 1.206
7.611LysLeu: 7.611 ± 0.836
2.003LysMet: 2.003 ± 0.478
6.609LysAsn: 6.609 ± 0.931
1.702LysPro: 1.702 ± 0.352
2.904LysGln: 2.904 ± 0.548
4.306LysArg: 4.306 ± 0.796
4.106LysSer: 4.106 ± 0.655
5.207LysThr: 5.207 ± 0.669
5.908LysVal: 5.908 ± 0.861
0.401LysTrp: 0.401 ± 0.17
3.505LysTyr: 3.505 ± 0.577
0.0LysXaa: 0.0 ± 0.0
Leu
5.307LeuAla: 5.307 ± 0.882
1.102LeuCys: 1.102 ± 0.368
4.707LeuAsp: 4.707 ± 0.81
4.907LeuGlu: 4.907 ± 0.667
2.303LeuPhe: 2.303 ± 0.502
5.608LeuGly: 5.608 ± 1.038
1.402LeuHis: 1.402 ± 0.409
5.708LeuIle: 5.708 ± 0.745
6.709LeuLys: 6.709 ± 0.943
5.808LeuLeu: 5.808 ± 0.995
1.602LeuMet: 1.602 ± 0.377
5.107LeuAsn: 5.107 ± 0.676
2.904LeuPro: 2.904 ± 0.624
1.602LeuGln: 1.602 ± 0.296
4.006LeuArg: 4.006 ± 0.608
5.207LeuSer: 5.207 ± 0.695
4.707LeuThr: 4.707 ± 0.642
4.807LeuVal: 4.807 ± 0.825
0.3LeuTrp: 0.3 ± 0.158
3.204LeuTyr: 3.204 ± 0.717
0.0LeuXaa: 0.0 ± 0.0
Met
2.504MetAla: 2.504 ± 0.496
0.3MetCys: 0.3 ± 0.169
1.803MetAsp: 1.803 ± 0.45
1.502MetGlu: 1.502 ± 0.321
0.501MetPhe: 0.501 ± 0.243
1.001MetGly: 1.001 ± 0.263
0.2MetHis: 0.2 ± 0.124
1.302MetIle: 1.302 ± 0.359
3.305MetLys: 3.305 ± 0.71
1.001MetLeu: 1.001 ± 0.278
1.102MetMet: 1.102 ± 0.339
1.702MetAsn: 1.702 ± 0.39
0.701MetPro: 0.701 ± 0.236
0.901MetGln: 0.901 ± 0.266
1.602MetArg: 1.602 ± 0.459
1.602MetSer: 1.602 ± 0.537
1.803MetThr: 1.803 ± 0.427
2.403MetVal: 2.403 ± 0.446
0.3MetTrp: 0.3 ± 0.144
0.1MetTyr: 0.1 ± 0.097
0.0MetXaa: 0.0 ± 0.0
Asn
5.007AsnAla: 5.007 ± 1.167
0.701AsnCys: 0.701 ± 0.274
3.305AsnAsp: 3.305 ± 0.609
5.908AsnGlu: 5.908 ± 0.945
3.104AsnPhe: 3.104 ± 0.526
6.91AsnGly: 6.91 ± 0.731
1.001AsnHis: 1.001 ± 0.369
3.305AsnIle: 3.305 ± 0.636
5.207AsnLys: 5.207 ± 0.683
5.307AsnLeu: 5.307 ± 1.237
1.502AsnMet: 1.502 ± 0.304
3.705AsnAsn: 3.705 ± 0.72
1.903AsnPro: 1.903 ± 0.38
2.504AsnGln: 2.504 ± 0.499
2.604AsnArg: 2.604 ± 0.546
4.807AsnSer: 4.807 ± 0.836
3.305AsnThr: 3.305 ± 0.705
3.805AsnVal: 3.805 ± 0.595
0.801AsnTrp: 0.801 ± 0.309
2.203AsnTyr: 2.203 ± 0.451
0.0AsnXaa: 0.0 ± 0.0
Pro
1.803ProAla: 1.803 ± 0.494
0.2ProCys: 0.2 ± 0.119
0.701ProAsp: 0.701 ± 0.226
1.202ProGlu: 1.202 ± 0.323
0.901ProPhe: 0.901 ± 0.249
1.402ProGly: 1.402 ± 0.559
0.401ProHis: 0.401 ± 0.213
2.003ProIle: 2.003 ± 0.435
2.403ProLys: 2.403 ± 0.523
1.502ProLeu: 1.502 ± 0.319
0.501ProMet: 0.501 ± 0.239
1.602ProAsn: 1.602 ± 0.415
0.501ProPro: 0.501 ± 0.193
0.701ProGln: 0.701 ± 0.213
0.801ProArg: 0.801 ± 0.271
2.203ProSer: 2.203 ± 0.484
1.302ProThr: 1.302 ± 0.328
2.403ProVal: 2.403 ± 0.479
0.601ProTrp: 0.601 ± 0.244
1.302ProTyr: 1.302 ± 0.346
0.0ProXaa: 0.0 ± 0.0
Gln
3.004GlnAla: 3.004 ± 0.457
0.401GlnCys: 0.401 ± 0.217
2.303GlnAsp: 2.303 ± 0.377
1.803GlnGlu: 1.803 ± 0.379
1.001GlnPhe: 1.001 ± 0.245
1.702GlnGly: 1.702 ± 0.382
0.401GlnHis: 0.401 ± 0.194
3.104GlnIle: 3.104 ± 0.588
2.804GlnLys: 2.804 ± 0.666
2.904GlnLeu: 2.904 ± 0.971
0.701GlnMet: 0.701 ± 0.349
2.103GlnAsn: 2.103 ± 0.483
1.202GlnPro: 1.202 ± 0.346
1.502GlnGln: 1.502 ± 0.45
0.701GlnArg: 0.701 ± 0.225
1.803GlnSer: 1.803 ± 0.506
1.702GlnThr: 1.702 ± 0.47
2.203GlnVal: 2.203 ± 0.365
0.2GlnTrp: 0.2 ± 0.133
1.702GlnTyr: 1.702 ± 0.328
0.0GlnXaa: 0.0 ± 0.0
Arg
2.403ArgAla: 2.403 ± 0.469
0.501ArgCys: 0.501 ± 0.245
2.704ArgAsp: 2.704 ± 0.545
3.104ArgGlu: 3.104 ± 0.632
1.702ArgPhe: 1.702 ± 0.281
2.203ArgGly: 2.203 ± 0.437
0.501ArgHis: 0.501 ± 0.269
3.104ArgIle: 3.104 ± 0.533
3.505ArgLys: 3.505 ± 0.639
3.405ArgLeu: 3.405 ± 0.529
1.001ArgMet: 1.001 ± 0.281
2.604ArgAsn: 2.604 ± 0.663
0.801ArgPro: 0.801 ± 0.29
1.102ArgGln: 1.102 ± 0.265
2.003ArgArg: 2.003 ± 0.473
2.303ArgSer: 2.303 ± 0.528
2.403ArgThr: 2.403 ± 0.439
2.604ArgVal: 2.604 ± 0.553
0.801ArgTrp: 0.801 ± 0.29
2.403ArgTyr: 2.403 ± 0.436
0.0ArgXaa: 0.0 ± 0.0
Ser
4.106SerAla: 4.106 ± 0.635
0.801SerCys: 0.801 ± 0.291
4.006SerAsp: 4.006 ± 0.602
3.405SerGlu: 3.405 ± 0.591
3.505SerPhe: 3.505 ± 0.629
3.605SerGly: 3.605 ± 0.557
1.001SerHis: 1.001 ± 0.238
3.405SerIle: 3.405 ± 0.534
5.608SerLys: 5.608 ± 0.622
3.805SerLeu: 3.805 ± 0.563
2.003SerMet: 2.003 ± 0.627
5.107SerAsn: 5.107 ± 0.695
1.702SerPro: 1.702 ± 0.411
2.003SerGln: 2.003 ± 0.495
2.103SerArg: 2.103 ± 0.545
4.606SerSer: 4.606 ± 0.771
3.805SerThr: 3.805 ± 0.672
5.608SerVal: 5.608 ± 0.624
1.102SerTrp: 1.102 ± 0.286
2.804SerTyr: 2.804 ± 0.615
0.0SerXaa: 0.0 ± 0.0
Thr
4.707ThrAla: 4.707 ± 0.812
0.3ThrCys: 0.3 ± 0.178
3.805ThrAsp: 3.805 ± 0.632
4.206ThrGlu: 4.206 ± 0.528
2.203ThrPhe: 2.203 ± 0.482
3.705ThrGly: 3.705 ± 0.546
0.901ThrHis: 0.901 ± 0.277
3.305ThrIle: 3.305 ± 0.61
4.406ThrLys: 4.406 ± 0.736
4.506ThrLeu: 4.506 ± 0.667
1.001ThrMet: 1.001 ± 0.301
3.805ThrAsn: 3.805 ± 1.129
2.003ThrPro: 2.003 ± 0.482
2.003ThrGln: 2.003 ± 0.533
1.903ThrArg: 1.903 ± 0.389
3.605ThrSer: 3.605 ± 0.659
3.004ThrThr: 3.004 ± 0.605
5.808ThrVal: 5.808 ± 0.987
0.801ThrTrp: 0.801 ± 0.24
2.904ThrTyr: 2.904 ± 0.646
0.0ThrXaa: 0.0 ± 0.0
Val
5.808ValAla: 5.808 ± 1.039
0.901ValCys: 0.901 ± 0.368
5.708ValAsp: 5.708 ± 0.71
4.406ValGlu: 4.406 ± 0.7
2.103ValPhe: 2.103 ± 0.487
4.006ValGly: 4.006 ± 0.564
1.402ValHis: 1.402 ± 0.343
5.307ValIle: 5.307 ± 0.501
5.608ValLys: 5.608 ± 0.939
4.707ValLeu: 4.707 ± 0.626
1.402ValMet: 1.402 ± 0.438
5.007ValAsn: 5.007 ± 0.727
1.903ValPro: 1.903 ± 0.394
2.103ValGln: 2.103 ± 0.43
2.604ValArg: 2.604 ± 0.395
5.708ValSer: 5.708 ± 0.569
4.707ValThr: 4.707 ± 0.689
4.306ValVal: 4.306 ± 0.675
0.601ValTrp: 0.601 ± 0.296
3.505ValTyr: 3.505 ± 0.555
0.0ValXaa: 0.0 ± 0.0
Trp
0.701TrpAla: 0.701 ± 0.321
0.1TrpCys: 0.1 ± 0.105
0.401TrpAsp: 0.401 ± 0.205
0.701TrpGlu: 0.701 ± 0.258
0.801TrpPhe: 0.801 ± 0.31
0.901TrpGly: 0.901 ± 0.295
0.401TrpHis: 0.401 ± 0.188
0.601TrpIle: 0.601 ± 0.235
0.601TrpLys: 0.601 ± 0.22
1.102TrpLeu: 1.102 ± 0.335
0.0TrpMet: 0.0 ± 0.0
0.801TrpAsn: 0.801 ± 0.397
0.0TrpPro: 0.0 ± 0.0
0.501TrpGln: 0.501 ± 0.175
0.401TrpArg: 0.401 ± 0.211
0.501TrpSer: 0.501 ± 0.284
0.501TrpThr: 0.501 ± 0.227
0.701TrpVal: 0.701 ± 0.254
0.0TrpTrp: 0.0 ± 0.0
0.401TrpTyr: 0.401 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.803TyrAla: 1.803 ± 0.432
0.701TyrCys: 0.701 ± 0.273
4.606TyrAsp: 4.606 ± 0.555
2.303TyrGlu: 2.303 ± 0.46
1.402TyrPhe: 1.402 ± 0.334
2.504TyrGly: 2.504 ± 0.554
0.3TyrHis: 0.3 ± 0.171
3.505TyrIle: 3.505 ± 0.519
2.103TyrLys: 2.103 ± 0.424
3.104TyrLeu: 3.104 ± 0.623
1.302TyrMet: 1.302 ± 0.332
1.903TyrAsn: 1.903 ± 0.435
1.702TyrPro: 1.702 ± 0.499
2.604TyrGln: 2.604 ± 0.502
2.904TyrArg: 2.904 ± 0.781
3.505TyrSer: 3.505 ± 0.587
2.704TyrThr: 2.704 ± 0.585
3.305TyrVal: 3.305 ± 0.492
0.2TyrTrp: 0.2 ± 0.177
2.103TyrTyr: 2.103 ± 0.463
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 50 proteins (9987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski