Amino acid dipepetide frequency for Photobacterium gaetbulicola Gung47

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.779AlaAla: 8.779 ± 0.105	1.034AlaCys: 1.034 ± 0.03	4.957AlaAsp: 4.957 ± 0.059	6.004AlaGlu: 6.004 ± 0.082	3.627AlaPhe: 3.627 ± 0.052	6.763AlaGly: 6.763 ± 0.071	1.653AlaHis: 1.653 ± 0.03	6.043AlaIle: 6.043 ± 0.069	4.651AlaLys: 4.651 ± 0.062	9.953AlaLeu: 9.953 ± 0.095	3.172AlaMet: 3.172 ± 0.053	3.545AlaAsn: 3.545 ± 0.048	3.16AlaPro: 3.16 ± 0.049	3.705AlaGln: 3.705 ± 0.05	3.939AlaArg: 3.939 ± 0.057	5.587AlaSer: 5.587 ± 0.061	4.525AlaThr: 4.525 ± 0.051	6.458AlaVal: 6.458 ± 0.071	1.022AlaTrp: 1.022 ± 0.025	2.489AlaTyr: 2.489 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.811CysAla: 0.811 ± 0.022	0.199CysCys: 0.199 ± 0.012	0.654CysAsp: 0.654 ± 0.021	0.658CysGlu: 0.658 ± 0.022	0.459CysPhe: 0.459 ± 0.018	0.952CysGly: 0.952 ± 0.025	0.45CysHis: 0.45 ± 0.022	0.588CysIle: 0.588 ± 0.016	0.424CysLys: 0.424 ± 0.016	1.02CysLeu: 1.02 ± 0.027	0.267CysMet: 0.267 ± 0.012	0.381CysAsn: 0.381 ± 0.015	0.473CysPro: 0.473 ± 0.018	0.601CysGln: 0.601 ± 0.021	0.587CysArg: 0.587 ± 0.02	0.779CysSer: 0.779 ± 0.023	0.48CysThr: 0.48 ± 0.018	0.658CysVal: 0.658 ± 0.021	0.16CysTrp: 0.16 ± 0.01	0.41CysTyr: 0.41 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.4AspAla: 4.4 ± 0.061	0.606AspCys: 0.606 ± 0.017	3.024AspAsp: 3.024 ± 0.048	3.746AspGlu: 3.746 ± 0.056	2.461AspPhe: 2.461 ± 0.042	3.997AspGly: 3.997 ± 0.062	1.248AspHis: 1.248 ± 0.029	3.98AspIle: 3.98 ± 0.051	3.081AspLys: 3.081 ± 0.046	4.865AspLeu: 4.865 ± 0.053	1.485AspMet: 1.485 ± 0.028	2.586AspAsn: 2.586 ± 0.04	2.186AspPro: 2.186 ± 0.037	1.993AspGln: 1.993 ± 0.036	2.403AspArg: 2.403 ± 0.039	3.278AspSer: 3.278 ± 0.053	2.706AspThr: 2.706 ± 0.043	3.794AspVal: 3.794 ± 0.048	0.878AspTrp: 0.878 ± 0.028	2.077AspTyr: 2.077 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.587GluAla: 5.587 ± 0.07	0.55GluCys: 0.55 ± 0.016	2.761GluAsp: 2.761 ± 0.04	3.692GluGlu: 3.692 ± 0.055	2.197GluPhe: 2.197 ± 0.034	3.768GluGly: 3.768 ± 0.055	1.62GluHis: 1.62 ± 0.035	3.495GluIle: 3.495 ± 0.046	3.426GluLys: 3.426 ± 0.053	6.977GluLeu: 6.977 ± 0.086	1.804GluMet: 1.804 ± 0.034	2.357GluAsn: 2.357 ± 0.043	2.275GluPro: 2.275 ± 0.038	4.394GluGln: 4.394 ± 0.059	3.518GluArg: 3.518 ± 0.059	3.331GluSer: 3.331 ± 0.054	2.973GluThr: 2.973 ± 0.044	4.244GluVal: 4.244 ± 0.059	0.829GluTrp: 0.829 ± 0.024	1.791GluTyr: 1.791 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.726PheAla: 3.726 ± 0.056	0.545PheCys: 0.545 ± 0.02	2.809PheAsp: 2.809 ± 0.045	2.412PheGlu: 2.412 ± 0.036	1.775PhePhe: 1.775 ± 0.036	3.298PheGly: 3.298 ± 0.053	0.836PheHis: 0.836 ± 0.022	2.719PheIle: 2.719 ± 0.05	1.761PheLys: 1.761 ± 0.031	3.336PheLeu: 3.336 ± 0.049	1.092PheMet: 1.092 ± 0.026	1.959PheAsn: 1.959 ± 0.039	1.412PhePro: 1.412 ± 0.028	1.166PheGln: 1.166 ± 0.024	1.656PheArg: 1.656 ± 0.034	3.262PheSer: 3.262 ± 0.048	2.325PheThr: 2.325 ± 0.041	2.81PheVal: 2.81 ± 0.05	0.543PheTrp: 0.543 ± 0.018	1.313PheTyr: 1.313 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.542GlyAla: 5.542 ± 0.068	1.02GlyCys: 1.02 ± 0.025	3.725GlyAsp: 3.725 ± 0.054	4.487GlyGlu: 4.487 ± 0.054	3.374GlyPhe: 3.374 ± 0.047	5.141GlyGly: 5.141 ± 0.068	1.712GlyHis: 1.712 ± 0.039	5.01GlyIle: 5.01 ± 0.067	3.925GlyLys: 3.925 ± 0.054	7.3GlyLeu: 7.3 ± 0.077	2.299GlyMet: 2.299 ± 0.044	2.776GlyAsn: 2.776 ± 0.043	1.817GlyPro: 1.817 ± 0.037	3.121GlyGln: 3.121 ± 0.039	3.307GlyArg: 3.307 ± 0.048	4.197GlySer: 4.197 ± 0.048	3.554GlyThr: 3.554 ± 0.046	5.281GlyVal: 5.281 ± 0.062	1.143GlyTrp: 1.143 ± 0.029	2.85GlyTyr: 2.85 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.73HisAla: 1.73 ± 0.035	0.351HisCys: 0.351 ± 0.015	1.217HisAsp: 1.217 ± 0.031	1.129HisGlu: 1.129 ± 0.03	1.122HisPhe: 1.122 ± 0.028	1.686HisGly: 1.686 ± 0.033	0.832HisHis: 0.832 ± 0.029	1.388HisIle: 1.388 ± 0.033	0.954HisLys: 0.954 ± 0.022	2.236HisLeu: 2.236 ± 0.042	0.548HisMet: 0.548 ± 0.017	0.945HisAsn: 0.945 ± 0.026	1.204HisPro: 1.204 ± 0.029	1.334HisGln: 1.334 ± 0.035	1.229HisArg: 1.229 ± 0.03	1.471HisSer: 1.471 ± 0.034	1.118HisThr: 1.118 ± 0.026	1.274HisVal: 1.274 ± 0.026	0.387HisTrp: 0.387 ± 0.016	0.93HisTyr: 0.93 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.456IleAla: 6.456 ± 0.07	0.714IleCys: 0.714 ± 0.023	4.004IleAsp: 4.004 ± 0.047	4.287IleGlu: 4.287 ± 0.053	2.166IlePhe: 2.166 ± 0.046	4.789IleGly: 4.789 ± 0.061	1.313IleHis: 1.313 ± 0.031	3.398IleIle: 3.398 ± 0.055	2.916IleLys: 2.916 ± 0.046	4.919IleLeu: 4.919 ± 0.065	1.419IleMet: 1.419 ± 0.03	2.856IleAsn: 2.856 ± 0.04	2.72IlePro: 2.72 ± 0.039	2.034IleGln: 2.034 ± 0.038	2.838IleArg: 2.838 ± 0.039	4.278IleSer: 4.278 ± 0.052	3.642IleThr: 3.642 ± 0.055	3.952IleVal: 3.952 ± 0.049	0.631IleTrp: 0.631 ± 0.02	1.683IleTyr: 1.683 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.71LysAla: 4.71 ± 0.06	0.315LysCys: 0.315 ± 0.014	2.49LysAsp: 2.49 ± 0.042	2.993LysGlu: 2.993 ± 0.044	1.378LysPhe: 1.378 ± 0.031	3.213LysGly: 3.213 ± 0.047	1.201LysHis: 1.201 ± 0.027	2.584LysIle: 2.584 ± 0.043	2.52LysLys: 2.52 ± 0.042	5.015LysLeu: 5.015 ± 0.054	1.376LysMet: 1.376 ± 0.033	1.79LysAsn: 1.79 ± 0.035	2.388LysPro: 2.388 ± 0.036	2.669LysGln: 2.669 ± 0.044	2.5LysArg: 2.5 ± 0.041	2.658LysSer: 2.658 ± 0.041	2.575LysThr: 2.575 ± 0.042	3.542LysVal: 3.542 ± 0.049	0.554LysTrp: 0.554 ± 0.017	1.385LysTyr: 1.385 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.764LeuAla: 10.764 ± 0.085	1.142LeuCys: 1.142 ± 0.029	5.769LeuAsp: 5.769 ± 0.069	6.024LeuGlu: 6.024 ± 0.067	4.213LeuPhe: 4.213 ± 0.065	7.359LeuGly: 7.359 ± 0.081	2.033LeuHis: 2.033 ± 0.042	5.912LeuIle: 5.912 ± 0.086	4.873LeuLys: 4.873 ± 0.049	10.688LeuLeu: 10.688 ± 0.125	2.796LeuMet: 2.796 ± 0.049	4.161LeuAsn: 4.161 ± 0.047	5.058LeuPro: 5.058 ± 0.064	3.641LeuGln: 3.641 ± 0.055	4.552LeuArg: 4.552 ± 0.06	7.707LeuSer: 7.707 ± 0.078	5.924LeuThr: 5.924 ± 0.066	7.111LeuVal: 7.111 ± 0.078	1.116LeuTrp: 1.116 ± 0.029	2.641LeuTyr: 2.641 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.079MetAla: 3.079 ± 0.049	0.219MetCys: 0.219 ± 0.013	1.366MetAsp: 1.366 ± 0.029	1.348MetGlu: 1.348 ± 0.028	1.008MetPhe: 1.008 ± 0.026	1.987MetGly: 1.987 ± 0.037	0.519MetHis: 0.519 ± 0.017	1.653MetIle: 1.653 ± 0.039	1.489MetLys: 1.489 ± 0.032	2.99MetLeu: 2.99 ± 0.047	0.943MetMet: 0.943 ± 0.024	1.097MetAsn: 1.097 ± 0.025	1.372MetPro: 1.372 ± 0.032	1.089MetGln: 1.089 ± 0.025	1.216MetArg: 1.216 ± 0.025	1.883MetSer: 1.883 ± 0.03	1.778MetThr: 1.778 ± 0.036	2.137MetVal: 2.137 ± 0.041	0.259MetTrp: 0.259 ± 0.015	0.621MetTyr: 0.621 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.289AsnAla: 3.289 ± 0.048	0.392AsnCys: 0.392 ± 0.016	2.225AsnAsp: 2.225 ± 0.043	2.234AsnGlu: 2.234 ± 0.039	1.527AsnPhe: 1.527 ± 0.036	3.024AsnGly: 3.024 ± 0.043	1.001AsnHis: 1.001 ± 0.028	2.671AsnIle: 2.671 ± 0.044	2.0AsnLys: 2.0 ± 0.036	3.687AsnLeu: 3.687 ± 0.05	1.016AsnMet: 1.016 ± 0.024	1.848AsnAsn: 1.848 ± 0.042	2.113AsnPro: 2.113 ± 0.044	2.075AsnGln: 2.075 ± 0.038	2.036AsnArg: 2.036 ± 0.039	2.26AsnSer: 2.26 ± 0.038	2.183AsnThr: 2.183 ± 0.038	2.513AsnVal: 2.513 ± 0.042	0.634AsnTrp: 0.634 ± 0.021	1.366AsnTyr: 1.366 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.78ProAla: 3.78 ± 0.054	0.384ProCys: 0.384 ± 0.018	2.49ProAsp: 2.49 ± 0.044	3.427ProGlu: 3.427 ± 0.044	1.802ProPhe: 1.802 ± 0.036	2.591ProGly: 2.591 ± 0.043	0.918ProHis: 0.918 ± 0.028	2.284ProIle: 2.284 ± 0.037	1.795ProLys: 1.795 ± 0.034	4.427ProLeu: 4.427 ± 0.061	1.173ProMet: 1.173 ± 0.028	1.608ProAsn: 1.608 ± 0.035	1.334ProPro: 1.334 ± 0.031	1.864ProGln: 1.864 ± 0.034	1.523ProArg: 1.523 ± 0.031	2.558ProSer: 2.558 ± 0.041	2.192ProThr: 2.192 ± 0.037	3.521ProVal: 3.521 ± 0.046	0.538ProTrp: 0.538 ± 0.015	1.343ProTyr: 1.343 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.696GlnAla: 4.696 ± 0.059	0.455GlnCys: 0.455 ± 0.018	2.052GlnAsp: 2.052 ± 0.031	2.373GlnGlu: 2.373 ± 0.04	1.779GlnPhe: 1.779 ± 0.032	3.072GlnGly: 3.072 ± 0.046	1.24GlnHis: 1.24 ± 0.029	2.445GlnIle: 2.445 ± 0.038	1.725GlnLys: 1.725 ± 0.034	5.576GlnLeu: 5.576 ± 0.078	1.14GlnMet: 1.14 ± 0.027	1.416GlnAsn: 1.416 ± 0.026	2.127GlnPro: 2.127 ± 0.039	3.427GlnGln: 3.427 ± 0.071	2.534GlnArg: 2.534 ± 0.041	2.7GlnSer: 2.7 ± 0.043	2.137GlnThr: 2.137 ± 0.039	3.119GlnVal: 3.119 ± 0.044	0.701GlnTrp: 0.701 ± 0.021	1.501GlnTyr: 1.501 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	3.568ArgAla: 3.568 ± 0.057	0.547ArgCys: 0.547 ± 0.018	2.551ArgAsp: 2.551 ± 0.045	3.158ArgGlu: 3.158 ± 0.056	2.229ArgPhe: 2.229 ± 0.033	2.809ArgGly: 2.809 ± 0.048	1.3ArgHis: 1.3 ± 0.031	2.875ArgIle: 2.875 ± 0.04	2.274ArgLys: 2.274 ± 0.037	5.21ArgLeu: 5.21 ± 0.064	1.244ArgMet: 1.244 ± 0.024	1.911ArgAsn: 1.911 ± 0.031	1.796ArgPro: 1.796 ± 0.032	2.702ArgGln: 2.702 ± 0.043	2.617ArgArg: 2.617 ± 0.055	2.627ArgSer: 2.627 ± 0.038	2.151ArgThr: 2.151 ± 0.04	3.14ArgVal: 3.14 ± 0.046	0.716ArgTrp: 0.716 ± 0.018	1.871ArgTyr: 1.871 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.293SerAla: 5.293 ± 0.055	0.691SerCys: 0.691 ± 0.024	3.415SerAsp: 3.415 ± 0.049	3.826SerGlu: 3.826 ± 0.055	2.708SerPhe: 2.708 ± 0.05	4.994SerGly: 4.994 ± 0.056	1.574SerHis: 1.574 ± 0.031	3.678SerIle: 3.678 ± 0.053	2.787SerLys: 2.787 ± 0.038	6.97SerLeu: 6.97 ± 0.07	1.709SerMet: 1.709 ± 0.032	2.448SerAsn: 2.448 ± 0.042	2.648SerPro: 2.648 ± 0.044	3.072SerGln: 3.072 ± 0.052	3.022SerArg: 3.022 ± 0.048	4.162SerSer: 4.162 ± 0.067	3.149SerThr: 3.149 ± 0.042	4.434SerVal: 4.434 ± 0.054	0.849SerTrp: 0.849 ± 0.023	2.129SerTyr: 2.129 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.803ThrAla: 4.803 ± 0.058	0.495ThrCys: 0.495 ± 0.016	2.805ThrAsp: 2.805 ± 0.036	3.056ThrGlu: 3.056 ± 0.039	2.104ThrPhe: 2.104 ± 0.037	4.18ThrGly: 4.18 ± 0.062	1.161ThrHis: 1.161 ± 0.025	3.229ThrIle: 3.229 ± 0.044	2.095ThrLys: 2.095 ± 0.036	6.112ThrLeu: 6.112 ± 0.066	1.313ThrMet: 1.313 ± 0.026	1.919ThrAsn: 1.919 ± 0.041	2.669ThrPro: 2.669 ± 0.042	2.172ThrGln: 2.172 ± 0.036	2.262ThrArg: 2.262 ± 0.041	3.136ThrSer: 3.136 ± 0.048	2.87ThrThr: 2.87 ± 0.046	4.065ThrVal: 4.065 ± 0.049	0.563ThrTrp: 0.563 ± 0.018	1.455ThrTyr: 1.455 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.776ValAla: 6.776 ± 0.077	0.781ValCys: 0.781 ± 0.021	4.126ValAsp: 4.126 ± 0.053	4.649ValGlu: 4.649 ± 0.063	2.76ValPhe: 2.76 ± 0.045	4.883ValGly: 4.883 ± 0.06	1.239ValHis: 1.239 ± 0.03	4.758ValIle: 4.758 ± 0.058	3.412ValLys: 3.412 ± 0.05	6.882ValLeu: 6.882 ± 0.067	2.2ValMet: 2.2 ± 0.038	2.851ValAsn: 2.851 ± 0.05	2.799ValPro: 2.799 ± 0.04	2.08ValGln: 2.08 ± 0.035	2.937ValArg: 2.937 ± 0.046	4.833ValSer: 4.833 ± 0.063	4.138ValThr: 4.138 ± 0.053	5.607ValVal: 5.607 ± 0.068	0.769ValTrp: 0.769 ± 0.021	1.84ValTyr: 1.84 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.907TrpAla: 0.907 ± 0.028	0.153TrpCys: 0.153 ± 0.01	0.636TrpAsp: 0.636 ± 0.02	0.587TrpGlu: 0.587 ± 0.022	0.609TrpPhe: 0.609 ± 0.023	0.83TrpGly: 0.83 ± 0.024	0.389TrpHis: 0.389 ± 0.016	0.651TrpIle: 0.651 ± 0.019	0.512TrpLys: 0.512 ± 0.018	1.888TrpLeu: 1.888 ± 0.039	0.35TrpMet: 0.35 ± 0.013	0.474TrpAsn: 0.474 ± 0.017	0.511TrpPro: 0.511 ± 0.018	1.034TrpGln: 1.034 ± 0.028	0.719TrpArg: 0.719 ± 0.019	0.734TrpSer: 0.734 ± 0.023	0.527TrpThr: 0.527 ± 0.019	0.869TrpVal: 0.869 ± 0.022	0.24TrpTrp: 0.24 ± 0.013	0.416TrpTyr: 0.416 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.367TyrAla: 2.367 ± 0.037	0.419TyrCys: 0.419 ± 0.015	1.715TyrAsp: 1.715 ± 0.041	1.501TyrGlu: 1.501 ± 0.029	1.458TyrPhe: 1.458 ± 0.033	2.248TyrGly: 2.248 ± 0.043	0.846TyrHis: 0.846 ± 0.025	1.654TyrIle: 1.654 ± 0.03	1.237TyrLys: 1.237 ± 0.033	3.438TyrLeu: 3.438 ± 0.051	0.705TyrMet: 0.705 ± 0.019	1.167TyrAsn: 1.167 ± 0.032	1.489TyrPro: 1.489 ± 0.031	2.043TyrGln: 2.043 ± 0.041	1.902TyrArg: 1.902 ± 0.036	2.115TyrSer: 2.115 ± 0.042	1.516TyrThr: 1.516 ± 0.031	1.791TyrVal: 1.791 ± 0.034	0.502TyrTrp: 0.502 ± 0.018	1.071TyrTyr: 1.071 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4974 proteins (1665140 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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