Amino acid dipepetide frequency for Prauserella rugosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.629AlaAla: 19.629 ± 0.201	0.995AlaCys: 0.995 ± 0.026	9.277AlaAsp: 9.277 ± 0.096	9.542AlaGlu: 9.542 ± 0.094	3.454AlaPhe: 3.454 ± 0.052	13.358AlaGly: 13.358 ± 0.114	2.666AlaHis: 2.666 ± 0.04	4.0AlaIle: 4.0 ± 0.059	2.752AlaLys: 2.752 ± 0.048	12.983AlaLeu: 12.983 ± 0.127	2.726AlaMet: 2.726 ± 0.043	2.064AlaAsn: 2.064 ± 0.04	6.153AlaPro: 6.153 ± 0.076	3.721AlaGln: 3.721 ± 0.063	9.486AlaArg: 9.486 ± 0.1	6.073AlaSer: 6.073 ± 0.075	7.17AlaThr: 7.17 ± 0.078	11.948AlaVal: 11.948 ± 0.107	1.725AlaTrp: 1.725 ± 0.038	2.272AlaTyr: 2.272 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.968CysAla: 0.968 ± 0.029	0.084CysCys: 0.084 ± 0.008	0.475CysAsp: 0.475 ± 0.019	0.38CysGlu: 0.38 ± 0.014	0.206CysPhe: 0.206 ± 0.012	0.908CysGly: 0.908 ± 0.026	0.182CysHis: 0.182 ± 0.012	0.198CysIle: 0.198 ± 0.012	0.096CysLys: 0.096 ± 0.008	0.623CysLeu: 0.623 ± 0.021	0.103CysMet: 0.103 ± 0.007	0.121CysAsn: 0.121 ± 0.009	0.439CysPro: 0.439 ± 0.018	0.155CysGln: 0.155 ± 0.01	0.543CysArg: 0.543 ± 0.019	0.412CysSer: 0.412 ± 0.016	0.482CysThr: 0.482 ± 0.018	0.632CysVal: 0.632 ± 0.016	0.103CysTrp: 0.103 ± 0.009	0.167CysTyr: 0.167 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.25AspAla: 8.25 ± 0.083	0.372AspCys: 0.372 ± 0.015	4.522AspAsp: 4.522 ± 0.058	5.042AspGlu: 5.042 ± 0.064	1.499AspPhe: 1.499 ± 0.033	6.696AspGly: 6.696 ± 0.073	1.455AspHis: 1.455 ± 0.034	2.138AspIle: 2.138 ± 0.041	1.168AspLys: 1.168 ± 0.032	6.087AspLeu: 6.087 ± 0.071	0.933AspMet: 0.933 ± 0.026	1.05AspAsn: 1.05 ± 0.031	4.643AspPro: 4.643 ± 0.054	1.548AspGln: 1.548 ± 0.036	5.015AspArg: 5.015 ± 0.07	2.721AspSer: 2.721 ± 0.048	3.741AspThr: 3.741 ± 0.054	6.454AspVal: 6.454 ± 0.071	0.904AspTrp: 0.904 ± 0.023	1.254AspTyr: 1.254 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.311GluAla: 7.311 ± 0.079	0.369GluCys: 0.369 ± 0.014	2.848GluAsp: 2.848 ± 0.053	3.136GluGlu: 3.136 ± 0.055	1.849GluPhe: 1.849 ± 0.036	4.243GluGly: 4.243 ± 0.057	1.88GluHis: 1.88 ± 0.034	2.369GluIle: 2.369 ± 0.044	1.396GluLys: 1.396 ± 0.037	7.442GluLeu: 7.442 ± 0.073	0.958GluMet: 0.958 ± 0.027	1.184GluAsn: 1.184 ± 0.032	3.864GluPro: 3.864 ± 0.061	2.605GluGln: 2.605 ± 0.042	5.741GluArg: 5.741 ± 0.078	3.094GluSer: 3.094 ± 0.046	3.108GluThr: 3.108 ± 0.048	4.97GluVal: 4.97 ± 0.054	0.863GluTrp: 0.863 ± 0.025	1.189GluTyr: 1.189 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.703PheAla: 3.703 ± 0.054	0.258PheCys: 0.258 ± 0.014	2.202PheAsp: 2.202 ± 0.04	1.417PheGlu: 1.417 ± 0.031	0.809PhePhe: 0.809 ± 0.024	3.32PheGly: 3.32 ± 0.05	0.6PheHis: 0.6 ± 0.019	0.687PheIle: 0.687 ± 0.021	0.353PheLys: 0.353 ± 0.015	2.462PheLeu: 2.462 ± 0.044	0.365PheMet: 0.365 ± 0.016	0.53PheAsn: 0.53 ± 0.02	1.305PhePro: 1.305 ± 0.03	0.573PheGln: 0.573 ± 0.019	1.758PheArg: 1.758 ± 0.031	1.43PheSer: 1.43 ± 0.031	1.924PheThr: 1.924 ± 0.037	2.523PheVal: 2.523 ± 0.044	0.4PheTrp: 0.4 ± 0.018	0.591PheTyr: 0.591 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.249GlyAla: 11.249 ± 0.105	0.765GlyCys: 0.765 ± 0.023	5.833GlyAsp: 5.833 ± 0.066	5.828GlyGlu: 5.828 ± 0.061	2.943GlyPhe: 2.943 ± 0.047	9.585GlyGly: 9.585 ± 0.145	2.134GlyHis: 2.134 ± 0.037	3.742GlyIle: 3.742 ± 0.05	2.341GlyLys: 2.341 ± 0.046	8.871GlyLeu: 8.871 ± 0.094	2.222GlyMet: 2.222 ± 0.044	1.859GlyAsn: 1.859 ± 0.043	4.692GlyPro: 4.692 ± 0.064	2.83GlyGln: 2.83 ± 0.052	7.139GlyArg: 7.139 ± 0.08	5.565GlySer: 5.565 ± 0.077	6.154GlyThr: 6.154 ± 0.065	8.277GlyVal: 8.277 ± 0.084	1.547GlyTrp: 1.547 ± 0.032	2.35GlyTyr: 2.35 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.848HisAla: 2.848 ± 0.047	0.216HisCys: 0.216 ± 0.013	1.448HisAsp: 1.448 ± 0.031	1.274HisGlu: 1.274 ± 0.03	0.59HisPhe: 0.59 ± 0.02	2.433HisGly: 2.433 ± 0.046	0.651HisHis: 0.651 ± 0.024	0.681HisIle: 0.681 ± 0.021	0.314HisLys: 0.314 ± 0.014	2.108HisLeu: 2.108 ± 0.04	0.335HisMet: 0.335 ± 0.015	0.379HisAsn: 0.379 ± 0.016	1.585HisPro: 1.585 ± 0.039	0.557HisGln: 0.557 ± 0.017	1.993HisArg: 1.993 ± 0.035	0.93HisSer: 0.93 ± 0.025	1.181HisThr: 1.181 ± 0.032	1.998HisVal: 1.998 ± 0.037	0.336HisTrp: 0.336 ± 0.015	0.492HisTyr: 0.492 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.259IleAla: 5.259 ± 0.063	0.266IleCys: 0.266 ± 0.013	2.657IleAsp: 2.657 ± 0.045	2.151IleGlu: 2.151 ± 0.042	0.734IlePhe: 0.734 ± 0.026	3.876IleGly: 3.876 ± 0.059	0.608IleHis: 0.608 ± 0.018	1.011IleIle: 1.011 ± 0.031	0.645IleLys: 0.645 ± 0.022	2.305IleLeu: 2.305 ± 0.046	0.483IleMet: 0.483 ± 0.019	0.763IleAsn: 0.763 ± 0.023	1.741IlePro: 1.741 ± 0.035	0.667IleGln: 0.667 ± 0.019	2.159IleArg: 2.159 ± 0.038	1.749IleSer: 1.749 ± 0.033	2.408IleThr: 2.408 ± 0.041	3.26IleVal: 3.26 ± 0.058	0.328IleTrp: 0.328 ± 0.014	0.601IleTyr: 0.601 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.591LysAla: 2.591 ± 0.043	0.093LysCys: 0.093 ± 0.008	1.068LysAsp: 1.068 ± 0.028	1.037LysGlu: 1.037 ± 0.031	0.425LysPhe: 0.425 ± 0.018	1.557LysGly: 1.557 ± 0.034	0.462LysHis: 0.462 ± 0.017	0.82LysIle: 0.82 ± 0.022	0.663LysLys: 0.663 ± 0.029	2.034LysLeu: 2.034 ± 0.04	0.345LysMet: 0.345 ± 0.016	0.474LysAsn: 0.474 ± 0.018	1.334LysPro: 1.334 ± 0.033	0.756LysGln: 0.756 ± 0.025	1.613LysArg: 1.613 ± 0.039	0.988LysSer: 0.988 ± 0.034	1.119LysThr: 1.119 ± 0.029	1.785LysVal: 1.785 ± 0.038	0.215LysTrp: 0.215 ± 0.011	0.404LysTyr: 0.404 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.357LeuAla: 14.357 ± 0.121	0.721LeuCys: 0.721 ± 0.024	6.856LeuAsp: 6.856 ± 0.076	4.933LeuGlu: 4.933 ± 0.063	2.459LeuPhe: 2.459 ± 0.043	9.209LeuGly: 9.209 ± 0.088	2.092LeuHis: 2.092 ± 0.04	3.101LeuIle: 3.101 ± 0.06	1.546LeuLys: 1.546 ± 0.037	10.038LeuLeu: 10.038 ± 0.105	1.456LeuMet: 1.456 ± 0.031	1.601LeuAsn: 1.601 ± 0.034	5.91LeuPro: 5.91 ± 0.066	2.021LeuGln: 2.021 ± 0.037	8.158LeuArg: 8.158 ± 0.092	5.436LeuSer: 5.436 ± 0.056	6.128LeuThr: 6.128 ± 0.063	9.182LeuVal: 9.182 ± 0.095	1.14LeuTrp: 1.14 ± 0.028	1.593LeuTyr: 1.593 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.251MetAla: 2.251 ± 0.042	0.137MetCys: 0.137 ± 0.009	0.865MetAsp: 0.865 ± 0.026	0.673MetGlu: 0.673 ± 0.019	0.509MetPhe: 0.509 ± 0.019	1.326MetGly: 1.326 ± 0.028	0.339MetHis: 0.339 ± 0.015	0.744MetIle: 0.744 ± 0.024	0.37MetLys: 0.37 ± 0.016	1.924MetLeu: 1.924 ± 0.037	0.301MetMet: 0.301 ± 0.016	0.451MetAsn: 0.451 ± 0.017	1.204MetPro: 1.204 ± 0.029	0.502MetGln: 0.502 ± 0.018	1.549MetArg: 1.549 ± 0.03	1.47MetSer: 1.47 ± 0.035	1.748MetThr: 1.748 ± 0.032	1.34MetVal: 1.34 ± 0.031	0.211MetTrp: 0.211 ± 0.011	0.271MetTyr: 0.271 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.346AsnAla: 2.346 ± 0.042	0.137AsnCys: 0.137 ± 0.009	1.039AsnAsp: 1.039 ± 0.027	0.887AsnGlu: 0.887 ± 0.025	0.469AsnPhe: 0.469 ± 0.018	1.909AsnGly: 1.909 ± 0.047	0.403AsnHis: 0.403 ± 0.014	0.67AsnIle: 0.67 ± 0.022	0.387AsnLys: 0.387 ± 0.016	1.735AsnLeu: 1.735 ± 0.035	0.352AsnMet: 0.352 ± 0.017	0.415AsnAsn: 0.415 ± 0.02	1.437AsnPro: 1.437 ± 0.034	0.519AsnGln: 0.519 ± 0.021	1.326AsnArg: 1.326 ± 0.033	0.917AsnSer: 0.917 ± 0.026	1.184AsnThr: 1.184 ± 0.032	1.572AsnVal: 1.572 ± 0.032	0.266AsnTrp: 0.266 ± 0.014	0.418AsnTyr: 0.418 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.561ProAla: 7.561 ± 0.082	0.328ProCys: 0.328 ± 0.015	4.697ProAsp: 4.697 ± 0.063	4.562ProGlu: 4.562 ± 0.063	1.467ProPhe: 1.467 ± 0.028	6.009ProGly: 6.009 ± 0.077	1.352ProHis: 1.352 ± 0.03	1.586ProIle: 1.586 ± 0.033	1.163ProLys: 1.163 ± 0.032	4.668ProLeu: 4.668 ± 0.056	1.076ProMet: 1.076 ± 0.026	1.075ProAsn: 1.075 ± 0.029	3.202ProPro: 3.202 ± 0.067	1.77ProGln: 1.77 ± 0.044	3.702ProArg: 3.702 ± 0.06	3.24ProSer: 3.24 ± 0.056	3.26ProThr: 3.26 ± 0.049	5.239ProVal: 5.239 ± 0.067	0.872ProTrp: 0.872 ± 0.023	1.158ProTyr: 1.158 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.699GlnAla: 3.699 ± 0.056	0.147GlnCys: 0.147 ± 0.01	1.315GlnAsp: 1.315 ± 0.028	1.311GlnGlu: 1.311 ± 0.03	0.663GlnPhe: 0.663 ± 0.02	2.175GlnGly: 2.175 ± 0.046	0.711GlnHis: 0.711 ± 0.02	1.041GlnIle: 1.041 ± 0.029	0.532GlnLys: 0.532 ± 0.019	3.174GlnLeu: 3.174 ± 0.052	0.471GlnMet: 0.471 ± 0.017	0.53GlnAsn: 0.53 ± 0.02	1.89GlnPro: 1.89 ± 0.05	1.451GlnGln: 1.451 ± 0.042	2.623GlnArg: 2.623 ± 0.041	1.256GlnSer: 1.256 ± 0.031	1.255GlnThr: 1.255 ± 0.03	2.366GlnVal: 2.366 ± 0.04	0.409GlnTrp: 0.409 ± 0.017	0.566GlnTyr: 0.566 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.042ArgAla: 9.042 ± 0.104	0.582ArgCys: 0.582 ± 0.023	4.607ArgAsp: 4.607 ± 0.06	4.719ArgGlu: 4.719 ± 0.067	2.392ArgPhe: 2.392 ± 0.045	5.995ArgGly: 5.995 ± 0.06	1.844ArgHis: 1.844 ± 0.038	3.35ArgIle: 3.35 ± 0.044	1.813ArgLys: 1.813 ± 0.039	7.628ArgLeu: 7.628 ± 0.089	1.882ArgMet: 1.882 ± 0.032	1.512ArgAsn: 1.512 ± 0.037	4.461ArgPro: 4.461 ± 0.068	2.154ArgGln: 2.154 ± 0.044	7.584ArgArg: 7.584 ± 0.092	4.21ArgSer: 4.21 ± 0.061	5.112ArgThr: 5.112 ± 0.058	6.034ArgVal: 6.034 ± 0.066	1.341ArgTrp: 1.341 ± 0.031	1.822ArgTyr: 1.822 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.955SerAla: 6.955 ± 0.078	0.353SerCys: 0.353 ± 0.016	3.369SerAsp: 3.369 ± 0.047	3.056SerGlu: 3.056 ± 0.047	1.438SerPhe: 1.438 ± 0.031	6.465SerGly: 6.465 ± 0.081	0.948SerHis: 0.948 ± 0.026	1.65SerIle: 1.65 ± 0.03	0.992SerLys: 0.992 ± 0.03	4.423SerLeu: 4.423 ± 0.053	1.204SerMet: 1.204 ± 0.023	0.97SerAsn: 0.97 ± 0.025	2.936SerPro: 2.936 ± 0.049	1.246SerGln: 1.246 ± 0.031	3.566SerArg: 3.566 ± 0.049	3.048SerSer: 3.048 ± 0.056	3.483SerThr: 3.483 ± 0.054	4.387SerVal: 4.387 ± 0.051	0.868SerTrp: 0.868 ± 0.028	1.064SerTyr: 1.064 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	8.274ThrAla: 8.274 ± 0.095	0.429ThrCys: 0.429 ± 0.018	3.872ThrAsp: 3.872 ± 0.047	3.511ThrGlu: 3.511 ± 0.05	1.706ThrPhe: 1.706 ± 0.035	6.463ThrGly: 6.463 ± 0.06	1.162ThrHis: 1.162 ± 0.034	1.974ThrIle: 1.974 ± 0.039	1.192ThrLys: 1.192 ± 0.032	5.529ThrLeu: 5.529 ± 0.064	1.105ThrMet: 1.105 ± 0.029	1.03ThrAsn: 1.03 ± 0.026	3.982ThrPro: 3.982 ± 0.051	1.35ThrGln: 1.35 ± 0.031	3.878ThrArg: 3.878 ± 0.057	3.457ThrSer: 3.457 ± 0.048	3.994ThrThr: 3.994 ± 0.069	6.152ThrVal: 6.152 ± 0.069	0.925ThrTrp: 0.925 ± 0.026	1.215ThrTyr: 1.215 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.833ValAla: 11.833 ± 0.108	0.716ValCys: 0.716 ± 0.019	6.341ValAsp: 6.341 ± 0.065	5.181ValGlu: 5.181 ± 0.062	2.465ValPhe: 2.465 ± 0.043	7.401ValGly: 7.401 ± 0.085	2.079ValHis: 2.079 ± 0.035	2.849ValIle: 2.849 ± 0.047	1.476ValLys: 1.476 ± 0.035	10.087ValLeu: 10.087 ± 0.093	1.346ValMet: 1.346 ± 0.03	1.657ValAsn: 1.657 ± 0.033	5.297ValPro: 5.297 ± 0.065	2.081ValGln: 2.081 ± 0.038	7.124ValArg: 7.124 ± 0.073	4.644ValSer: 4.644 ± 0.066	5.708ValThr: 5.708 ± 0.064	9.402ValVal: 9.402 ± 0.105	1.045ValTrp: 1.045 ± 0.03	1.527ValTyr: 1.527 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.482TrpAla: 1.482 ± 0.033	0.161TrpCys: 0.161 ± 0.01	0.757TrpAsp: 0.757 ± 0.024	0.649TrpGlu: 0.649 ± 0.018	0.536TrpPhe: 0.536 ± 0.024	0.952TrpGly: 0.952 ± 0.023	0.353TrpHis: 0.353 ± 0.014	0.58TrpIle: 0.58 ± 0.021	0.279TrpLys: 0.279 ± 0.014	1.709TrpLeu: 1.709 ± 0.03	0.302TrpMet: 0.302 ± 0.015	0.348TrpAsn: 0.348 ± 0.014	0.775TrpPro: 0.775 ± 0.024	0.559TrpGln: 0.559 ± 0.018	1.346TrpArg: 1.346 ± 0.033	0.806TrpSer: 0.806 ± 0.023	0.908TrpThr: 0.908 ± 0.029	0.999TrpVal: 0.999 ± 0.03	0.358TrpTrp: 0.358 ± 0.016	0.28TrpTyr: 0.28 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.383TyrAla: 2.383 ± 0.043	0.147TyrCys: 0.147 ± 0.01	1.446TyrAsp: 1.446 ± 0.033	1.129TyrGlu: 1.129 ± 0.028	0.598TyrPhe: 0.598 ± 0.02	2.045TyrGly: 2.045 ± 0.043	0.43TyrHis: 0.43 ± 0.016	0.481TyrIle: 0.481 ± 0.019	0.302TyrLys: 0.302 ± 0.015	2.109TyrLeu: 2.109 ± 0.038	0.216TyrMet: 0.216 ± 0.012	0.376TyrAsn: 0.376 ± 0.016	1.135TyrPro: 1.135 ± 0.034	0.521TyrGln: 0.521 ± 0.02	1.782TyrArg: 1.782 ± 0.038	0.974TyrSer: 0.974 ± 0.026	1.135TyrThr: 1.135 ± 0.031	1.741TyrVal: 1.741 ± 0.033	0.283TyrTrp: 0.283 ± 0.012	0.448TyrTyr: 0.448 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4886 proteins (1566181 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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