Amino acid dipepetide frequency for Lactococcus hodotermopsidis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.008AlaAla: 6.008 ± 0.147
0.489AlaCys: 0.489 ± 0.03
5.356AlaAsp: 5.356 ± 0.125
6.029AlaGlu: 6.029 ± 0.127
3.384AlaPhe: 3.384 ± 0.083
5.068AlaGly: 5.068 ± 0.112
1.499AlaHis: 1.499 ± 0.045
6.452AlaIle: 6.452 ± 0.109
5.923AlaLys: 5.923 ± 0.132
7.49AlaLeu: 7.49 ± 0.108
2.052AlaMet: 2.052 ± 0.058
3.582AlaAsn: 3.582 ± 0.084
2.305AlaPro: 2.305 ± 0.069
3.14AlaGln: 3.14 ± 0.078
3.024AlaArg: 3.024 ± 0.082
4.016AlaSer: 4.016 ± 0.084
5.074AlaThr: 5.074 ± 0.098
5.513AlaVal: 5.513 ± 0.111
0.607AlaTrp: 0.607 ± 0.031
2.797AlaTyr: 2.797 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.377CysAla: 0.377 ± 0.025
0.048CysCys: 0.048 ± 0.009
0.37CysAsp: 0.37 ± 0.023
0.332CysGlu: 0.332 ± 0.023
0.266CysPhe: 0.266 ± 0.022
0.484CysGly: 0.484 ± 0.029
0.17CysHis: 0.17 ± 0.019
0.237CysIle: 0.237 ± 0.022
0.199CysLys: 0.199 ± 0.02
0.563CysLeu: 0.563 ± 0.033
0.104CysMet: 0.104 ± 0.011
0.177CysAsn: 0.177 ± 0.02
0.195CysPro: 0.195 ± 0.021
0.258CysGln: 0.258 ± 0.022
0.174CysArg: 0.174 ± 0.018
0.313CysSer: 0.313 ± 0.02
0.238CysThr: 0.238 ± 0.021
0.338CysVal: 0.338 ± 0.024
0.047CysTrp: 0.047 ± 0.009
0.212CysTyr: 0.212 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.558AspAla: 3.558 ± 0.08
0.299AspCys: 0.299 ± 0.025
3.59AspAsp: 3.59 ± 0.127
5.022AspGlu: 5.022 ± 0.121
3.902AspPhe: 3.902 ± 0.086
4.067AspGly: 4.067 ± 0.147
0.744AspHis: 0.744 ± 0.036
4.257AspIle: 4.257 ± 0.078
4.861AspLys: 4.861 ± 0.089
5.848AspLeu: 5.848 ± 0.12
1.524AspMet: 1.524 ± 0.054
3.113AspAsn: 3.113 ± 0.091
1.346AspPro: 1.346 ± 0.057
1.259AspGln: 1.259 ± 0.044
1.722AspArg: 1.722 ± 0.055
3.801AspSer: 3.801 ± 0.38
2.996AspThr: 2.996 ± 0.064
4.354AspVal: 4.354 ± 0.095
0.663AspTrp: 0.663 ± 0.04
2.894AspTyr: 2.894 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
4.609GluAla: 4.609 ± 0.139
0.241GluCys: 0.241 ± 0.021
2.793GluAsp: 2.793 ± 0.108
4.128GluGlu: 4.128 ± 0.125
2.961GluPhe: 2.961 ± 0.076
2.771GluGly: 2.771 ± 0.069
1.097GluHis: 1.097 ± 0.059
6.419GluIle: 6.419 ± 0.124
6.426GluLys: 6.426 ± 0.117
6.631GluLeu: 6.631 ± 0.106
2.02GluMet: 2.02 ± 0.053
5.193GluAsn: 5.193 ± 0.091
1.529GluPro: 1.529 ± 0.05
2.343GluGln: 2.343 ± 0.072
2.856GluArg: 2.856 ± 0.082
3.561GluSer: 3.561 ± 0.115
4.735GluThr: 4.735 ± 0.118
4.799GluVal: 4.799 ± 0.124
0.525GluTrp: 0.525 ± 0.027
1.792GluTyr: 1.792 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.748PheAla: 3.748 ± 0.087
0.314PheCys: 0.314 ± 0.024
3.965PheAsp: 3.965 ± 0.094
3.529PheGlu: 3.529 ± 0.083
2.15PhePhe: 2.15 ± 0.068
3.474PheGly: 3.474 ± 0.079
0.732PheHis: 0.732 ± 0.034
3.509PheIle: 3.509 ± 0.089
2.694PheLys: 2.694 ± 0.07
4.324PheLeu: 4.324 ± 0.103
1.136PheMet: 1.136 ± 0.042
2.189PheAsn: 2.189 ± 0.063
1.628PhePro: 1.628 ± 0.056
1.493PheGln: 1.493 ± 0.053
1.555PheArg: 1.555 ± 0.051
3.482PheSer: 3.482 ± 0.083
2.666PheThr: 2.666 ± 0.061
3.549PheVal: 3.549 ± 0.071
0.445PheTrp: 0.445 ± 0.031
1.832PheTyr: 1.832 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
4.916GlyAla: 4.916 ± 0.117
0.374GlyCys: 0.374 ± 0.027
3.303GlyAsp: 3.303 ± 0.109
3.798GlyGlu: 3.798 ± 0.082
3.336GlyPhe: 3.336 ± 0.082
4.323GlyGly: 4.323 ± 0.11
1.2GlyHis: 1.2 ± 0.051
5.255GlyIle: 5.255 ± 0.107
4.984GlyLys: 4.984 ± 0.094
5.75GlyLeu: 5.75 ± 0.101
1.711GlyMet: 1.711 ± 0.063
3.015GlyAsn: 3.015 ± 0.083
1.096GlyPro: 1.096 ± 0.046
2.338GlyGln: 2.338 ± 0.066
2.509GlyArg: 2.509 ± 0.072
3.348GlySer: 3.348 ± 0.097
3.758GlyThr: 3.758 ± 0.082
4.801GlyVal: 4.801 ± 0.092
0.641GlyTrp: 0.641 ± 0.031
2.596GlyTyr: 2.596 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.35HisAla: 1.35 ± 0.048
0.125HisCys: 0.125 ± 0.015
1.223HisAsp: 1.223 ± 0.056
1.192HisGlu: 1.192 ± 0.043
1.121HisPhe: 1.121 ± 0.044
1.241HisGly: 1.241 ± 0.045
0.523HisHis: 0.523 ± 0.029
1.192HisIle: 1.192 ± 0.047
0.976HisLys: 0.976 ± 0.051
1.736HisLeu: 1.736 ± 0.06
0.397HisMet: 0.397 ± 0.028
0.742HisAsn: 0.742 ± 0.038
0.753HisPro: 0.753 ± 0.037
0.711HisGln: 0.711 ± 0.04
0.708HisArg: 0.708 ± 0.041
0.872HisSer: 0.872 ± 0.048
0.911HisThr: 0.911 ± 0.043
1.141HisVal: 1.141 ± 0.049
0.17HisTrp: 0.17 ± 0.016
0.778HisTyr: 0.778 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.956IleAla: 6.956 ± 0.095
0.529IleCys: 0.529 ± 0.032
4.83IleAsp: 4.83 ± 0.101
4.797IleGlu: 4.797 ± 0.09
4.081IlePhe: 4.081 ± 0.106
5.141IleGly: 5.141 ± 0.101
1.217IleHis: 1.217 ± 0.046
5.471IleIle: 5.471 ± 0.116
5.031IleLys: 5.031 ± 0.099
7.442IleLeu: 7.442 ± 0.15
1.689IleMet: 1.689 ± 0.06
3.47IleAsn: 3.47 ± 0.088
2.741IlePro: 2.741 ± 0.08
2.329IleGln: 2.329 ± 0.071
2.626IleArg: 2.626 ± 0.071
5.503IleSer: 5.503 ± 0.1
4.284IleThr: 4.284 ± 0.083
5.552IleVal: 5.552 ± 0.104
0.592IleTrp: 0.592 ± 0.028
2.708IleTyr: 2.708 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
5.531LysAla: 5.531 ± 0.119
0.237LysCys: 0.237 ± 0.02
3.342LysAsp: 3.342 ± 0.084
4.687LysGlu: 4.687 ± 0.097
2.993LysPhe: 2.993 ± 0.08
3.454LysGly: 3.454 ± 0.082
1.236LysHis: 1.236 ± 0.055
6.538LysIle: 6.538 ± 0.117
5.853LysLys: 5.853 ± 0.119
6.423LysLeu: 6.423 ± 0.115
2.371LysMet: 2.371 ± 0.062
4.511LysAsn: 4.511 ± 0.087
2.14LysPro: 2.14 ± 0.06
2.47LysGln: 2.47 ± 0.073
2.891LysArg: 2.891 ± 0.077
4.217LysSer: 4.217 ± 0.09
4.729LysThr: 4.729 ± 0.094
4.559LysVal: 4.559 ± 0.108
0.654LysTrp: 0.654 ± 0.034
2.509LysTyr: 2.509 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
9.133LeuAla: 9.133 ± 0.123
0.486LeuCys: 0.486 ± 0.03
5.646LeuAsp: 5.646 ± 0.114
6.001LeuGlu: 6.001 ± 0.125
4.109LeuPhe: 4.109 ± 0.102
5.851LeuGly: 5.851 ± 0.116
1.445LeuHis: 1.445 ± 0.046
6.866LeuIle: 6.866 ± 0.146
6.437LeuLys: 6.437 ± 0.104
8.782LeuLeu: 8.782 ± 0.161
2.274LeuMet: 2.274 ± 0.064
4.265LeuAsn: 4.265 ± 0.088
3.941LeuPro: 3.941 ± 0.088
3.057LeuGln: 3.057 ± 0.08
3.384LeuArg: 3.384 ± 0.081
6.95LeuSer: 6.95 ± 0.114
6.989LeuThr: 6.989 ± 0.1
6.391LeuVal: 6.391 ± 0.115
0.62LeuTrp: 0.62 ± 0.03
2.722LeuTyr: 2.722 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
2.277MetAla: 2.277 ± 0.067
0.111MetCys: 0.111 ± 0.014
1.054MetAsp: 1.054 ± 0.045
0.988MetGlu: 0.988 ± 0.038
0.898MetPhe: 0.898 ± 0.042
1.482MetGly: 1.482 ± 0.045
0.314MetHis: 0.314 ± 0.021
2.125MetIle: 2.125 ± 0.072
1.924MetLys: 1.924 ± 0.052
2.313MetLeu: 2.313 ± 0.068
0.747MetMet: 0.747 ± 0.036
1.309MetAsn: 1.309 ± 0.053
1.101MetPro: 1.101 ± 0.041
0.827MetGln: 0.827 ± 0.037
1.072MetArg: 1.072 ± 0.048
1.712MetSer: 1.712 ± 0.055
2.417MetThr: 2.417 ± 0.068
1.547MetVal: 1.547 ± 0.049
0.177MetTrp: 0.177 ± 0.017
0.573MetTyr: 0.573 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.834AsnAla: 3.834 ± 0.087
0.266AsnCys: 0.266 ± 0.023
2.867AsnAsp: 2.867 ± 0.067
3.0AsnGlu: 3.0 ± 0.081
2.761AsnPhe: 2.761 ± 0.073
3.927AsnGly: 3.927 ± 0.09
1.027AsnHis: 1.027 ± 0.044
3.636AsnIle: 3.636 ± 0.1
2.961AsnLys: 2.961 ± 0.068
5.087AsnLeu: 5.087 ± 0.096
1.152AsnMet: 1.152 ± 0.046
2.189AsnAsn: 2.189 ± 0.059
2.08AsnPro: 2.08 ± 0.06
2.036AsnGln: 2.036 ± 0.057
1.986AsnArg: 1.986 ± 0.056
2.578AsnSer: 2.578 ± 0.062
2.428AsnThr: 2.428 ± 0.066
3.272AsnVal: 3.272 ± 0.072
0.537AsnTrp: 0.537 ± 0.03
2.078AsnTyr: 2.078 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.143ProAla: 2.143 ± 0.064
0.134ProCys: 0.134 ± 0.017
2.212ProAsp: 2.212 ± 0.07
2.916ProGlu: 2.916 ± 0.086
1.672ProPhe: 1.672 ± 0.065
1.437ProGly: 1.437 ± 0.057
0.592ProHis: 0.592 ± 0.029
2.595ProIle: 2.595 ± 0.069
2.316ProLys: 2.316 ± 0.063
2.779ProLeu: 2.779 ± 0.074
0.697ProMet: 0.697 ± 0.03
1.761ProAsn: 1.761 ± 0.079
0.587ProPro: 0.587 ± 0.034
1.104ProGln: 1.104 ± 0.045
0.953ProArg: 0.953 ± 0.04
1.983ProSer: 1.983 ± 0.066
2.189ProThr: 2.189 ± 0.07
2.364ProVal: 2.364 ± 0.071
0.308ProTrp: 0.308 ± 0.023
1.141ProTyr: 1.141 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.207GlnAla: 3.207 ± 0.087
0.1GlnCys: 0.1 ± 0.013
1.639GlnAsp: 1.639 ± 0.064
2.456GlnGlu: 2.456 ± 0.065
1.522GlnPhe: 1.522 ± 0.055
1.859GlnGly: 1.859 ± 0.053
0.585GlnHis: 0.585 ± 0.031
2.982GlnIle: 2.982 ± 0.064
2.942GlnLys: 2.942 ± 0.065
3.498GlnLeu: 3.498 ± 0.083
0.914GlnMet: 0.914 ± 0.036
1.963GlnAsn: 1.963 ± 0.057
1.15GlnPro: 1.15 ± 0.051
1.227GlnGln: 1.227 ± 0.055
1.228GlnArg: 1.228 ± 0.044
1.817GlnSer: 1.817 ± 0.059
2.392GlnThr: 2.392 ± 0.076
2.543GlnVal: 2.543 ± 0.063
0.24GlnTrp: 0.24 ± 0.02
1.174GlnTyr: 1.174 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.727ArgAla: 2.727 ± 0.073
0.176ArgCys: 0.176 ± 0.017
2.375ArgAsp: 2.375 ± 0.07
2.891ArgGlu: 2.891 ± 0.077
1.832ArgPhe: 1.832 ± 0.061
2.15ArgGly: 2.15 ± 0.064
0.808ArgHis: 0.808 ± 0.038
2.623ArgIle: 2.623 ± 0.072
2.721ArgLys: 2.721 ± 0.078
3.758ArgLeu: 3.758 ± 0.088
0.962ArgMet: 0.962 ± 0.043
1.706ArgAsn: 1.706 ± 0.049
1.16ArgPro: 1.16 ± 0.048
1.678ArgGln: 1.678 ± 0.051
1.692ArgArg: 1.692 ± 0.065
1.661ArgSer: 1.661 ± 0.053
1.899ArgThr: 1.899 ± 0.059
2.534ArgVal: 2.534 ± 0.075
0.26ArgTrp: 0.26 ± 0.021
1.415ArgTyr: 1.415 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.464SerAla: 4.464 ± 0.115
0.307SerCys: 0.307 ± 0.024
4.626SerAsp: 4.626 ± 0.242
4.852SerGlu: 4.852 ± 0.253
2.892SerPhe: 2.892 ± 0.081
4.595SerGly: 4.595 ± 0.103
1.211SerHis: 1.211 ± 0.049
3.717SerIle: 3.717 ± 0.088
3.823SerLys: 3.823 ± 0.087
5.791SerLeu: 5.791 ± 0.105
1.203SerMet: 1.203 ± 0.039
2.663SerAsn: 2.663 ± 0.064
1.729SerPro: 1.729 ± 0.058
2.528SerGln: 2.528 ± 0.059
2.215SerArg: 2.215 ± 0.069
3.765SerSer: 3.765 ± 0.114
2.968SerThr: 2.968 ± 0.069
3.927SerVal: 3.927 ± 0.082
0.56SerTrp: 0.56 ± 0.035
2.176SerTyr: 2.176 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
5.176ThrAla: 5.176 ± 0.112
0.276ThrCys: 0.276 ± 0.022
3.669ThrAsp: 3.669 ± 0.095
3.689ThrGlu: 3.689 ± 0.077
3.137ThrPhe: 3.137 ± 0.071
4.432ThrGly: 4.432 ± 0.09
1.261ThrHis: 1.261 ± 0.051
4.939ThrIle: 4.939 ± 0.105
3.793ThrLys: 3.793 ± 0.08
6.058ThrLeu: 6.058 ± 0.103
1.298ThrMet: 1.298 ± 0.046
2.596ThrAsn: 2.596 ± 0.074
2.529ThrPro: 2.529 ± 0.071
2.182ThrGln: 2.182 ± 0.057
1.963ThrArg: 1.963 ± 0.06
3.677ThrSer: 3.677 ± 0.077
3.845ThrThr: 3.845 ± 0.103
4.534ThrVal: 4.534 ± 0.113
0.525ThrTrp: 0.525 ± 0.031
2.33ThrTyr: 2.33 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
6.567ValAla: 6.567 ± 0.124
0.353ValCys: 0.353 ± 0.025
4.077ValAsp: 4.077 ± 0.098
4.167ValGlu: 4.167 ± 0.085
2.897ValPhe: 2.897 ± 0.071
4.447ValGly: 4.447 ± 0.104
1.11ValHis: 1.11 ± 0.046
5.551ValIle: 5.551 ± 0.123
5.089ValLys: 5.089 ± 0.095
6.332ValLeu: 6.332 ± 0.113
1.792ValMet: 1.792 ± 0.06
3.269ValAsn: 3.269 ± 0.073
2.422ValPro: 2.422 ± 0.061
1.911ValGln: 1.911 ± 0.066
2.503ValArg: 2.503 ± 0.058
4.304ValSer: 4.304 ± 0.094
4.933ValThr: 4.933 ± 0.162
5.163ValVal: 5.163 ± 0.106
0.542ValTrp: 0.542 ± 0.034
2.201ValTyr: 2.201 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.573TrpAla: 0.573 ± 0.032
0.068TrpCys: 0.068 ± 0.011
0.473TrpAsp: 0.473 ± 0.028
0.553TrpGlu: 0.553 ± 0.034
0.462TrpPhe: 0.462 ± 0.029
0.629TrpGly: 0.629 ± 0.031
0.251TrpHis: 0.251 ± 0.019
0.431TrpIle: 0.431 ± 0.026
0.358TrpLys: 0.358 ± 0.024
1.01TrpLeu: 1.01 ± 0.04
0.224TrpMet: 0.224 ± 0.019
0.366TrpAsn: 0.366 ± 0.026
0.196TrpPro: 0.196 ± 0.019
0.553TrpGln: 0.553 ± 0.034
0.42TrpArg: 0.42 ± 0.026
0.556TrpSer: 0.556 ± 0.03
0.448TrpThr: 0.448 ± 0.029
0.521TrpVal: 0.521 ± 0.027
0.101TrpTrp: 0.101 ± 0.013
0.344TrpTyr: 0.344 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.656TyrAla: 2.656 ± 0.064
0.171TyrCys: 0.171 ± 0.015
2.411TyrAsp: 2.411 ± 0.07
2.403TyrGlu: 2.403 ± 0.071
2.038TyrPhe: 2.038 ± 0.065
2.22TyrGly: 2.22 ± 0.059
0.841TyrHis: 0.841 ± 0.038
2.196TyrIle: 2.196 ± 0.068
2.033TyrLys: 2.033 ± 0.063
3.734TyrLeu: 3.734 ± 0.082
0.7TyrMet: 0.7 ± 0.034
1.624TyrAsn: 1.624 ± 0.055
1.252TyrPro: 1.252 ± 0.041
1.994TyrGln: 1.994 ± 0.062
1.544TyrArg: 1.544 ± 0.048
1.899TyrSer: 1.899 ± 0.062
2.008TyrThr: 2.008 ± 0.073
2.224TyrVal: 2.224 ± 0.057
0.325TyrTrp: 0.325 ± 0.021
1.446TyrTyr: 1.446 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2078 proteins (642429 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski