Amino acid dipepetide frequency for Streptomyces buecherae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.113AlaAla: 23.113 ± 0.179	1.128AlaCys: 1.128 ± 0.02	9.342AlaAsp: 9.342 ± 0.075	9.157AlaGlu: 9.157 ± 0.091	3.414AlaPhe: 3.414 ± 0.043	14.047AlaGly: 14.047 ± 0.097	3.318AlaHis: 3.318 ± 0.04	3.579AlaIle: 3.579 ± 0.043	2.642AlaLys: 2.642 ± 0.049	15.058AlaLeu: 15.058 ± 0.112	2.5AlaMet: 2.5 ± 0.032	1.858AlaAsn: 1.858 ± 0.033	8.695AlaPro: 8.695 ± 0.087	3.815AlaGln: 3.815 ± 0.04	11.64AlaArg: 11.64 ± 0.087	6.377AlaSer: 6.377 ± 0.061	8.032AlaThr: 8.032 ± 0.069	11.971AlaVal: 11.971 ± 0.096	1.925AlaTrp: 1.925 ± 0.032	2.828AlaTyr: 2.828 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.2CysAla: 1.2 ± 0.027	0.099CysCys: 0.099 ± 0.008	0.484CysAsp: 0.484 ± 0.013	0.4CysGlu: 0.4 ± 0.014	0.202CysPhe: 0.202 ± 0.01	0.928CysGly: 0.928 ± 0.022	0.21CysHis: 0.21 ± 0.01	0.123CysIle: 0.123 ± 0.007	0.111CysLys: 0.111 ± 0.008	0.685CysLeu: 0.685 ± 0.022	0.115CysMet: 0.115 ± 0.007	0.106CysAsn: 0.106 ± 0.007	0.493CysPro: 0.493 ± 0.016	0.211CysGln: 0.211 ± 0.009	0.602CysArg: 0.602 ± 0.016	0.431CysSer: 0.431 ± 0.015	0.45CysThr: 0.45 ± 0.017	0.687CysVal: 0.687 ± 0.018	0.132CysTrp: 0.132 ± 0.007	0.163CysTyr: 0.163 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.8AspAla: 8.8 ± 0.085	0.406AspCys: 0.406 ± 0.016	3.519AspAsp: 3.519 ± 0.045	3.838AspGlu: 3.838 ± 0.043	1.548AspPhe: 1.548 ± 0.03	6.518AspGly: 6.518 ± 0.064	1.468AspHis: 1.468 ± 0.029	1.745AspIle: 1.745 ± 0.031	1.085AspLys: 1.085 ± 0.029	6.113AspLeu: 6.113 ± 0.053	0.734AspMet: 0.734 ± 0.018	0.86AspAsn: 0.86 ± 0.02	4.619AspPro: 4.619 ± 0.052	1.792AspGln: 1.792 ± 0.03	4.855AspArg: 4.855 ± 0.044	2.383AspSer: 2.383 ± 0.033	2.979AspThr: 2.979 ± 0.045	4.616AspVal: 4.616 ± 0.043	1.053AspTrp: 1.053 ± 0.023	1.119AspTyr: 1.119 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.577GluAla: 7.577 ± 0.082	0.386GluCys: 0.386 ± 0.014	2.462GluAsp: 2.462 ± 0.031	3.289GluGlu: 3.289 ± 0.05	1.431GluPhe: 1.431 ± 0.025	4.202GluGly: 4.202 ± 0.055	1.605GluHis: 1.605 ± 0.03	1.935GluIle: 1.935 ± 0.031	1.204GluLys: 1.204 ± 0.026	6.845GluLeu: 6.845 ± 0.071	0.846GluMet: 0.846 ± 0.02	0.891GluAsn: 0.891 ± 0.021	3.723GluPro: 3.723 ± 0.051	2.129GluGln: 2.129 ± 0.031	6.387GluArg: 6.387 ± 0.067	2.47GluSer: 2.47 ± 0.036	2.726GluThr: 2.726 ± 0.033	4.605GluVal: 4.605 ± 0.049	0.743GluTrp: 0.743 ± 0.02	1.045GluTyr: 1.045 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.675PheAla: 3.675 ± 0.045	0.263PheCys: 0.263 ± 0.009	1.959PheAsp: 1.959 ± 0.031	1.311PheGlu: 1.311 ± 0.025	0.792PhePhe: 0.792 ± 0.023	2.795PheGly: 2.795 ± 0.038	0.625PheHis: 0.625 ± 0.017	0.674PheIle: 0.674 ± 0.017	0.422PheLys: 0.422 ± 0.014	2.404PheLeu: 2.404 ± 0.04	0.338PheMet: 0.338 ± 0.014	0.485PheAsn: 0.485 ± 0.016	1.311PhePro: 1.311 ± 0.022	0.659PheGln: 0.659 ± 0.017	1.736PheArg: 1.736 ± 0.026	1.314PheSer: 1.314 ± 0.024	1.825PheThr: 1.825 ± 0.029	2.098PheVal: 2.098 ± 0.033	0.374PheTrp: 0.374 ± 0.013	0.526PheTyr: 0.526 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	12.444GlyAla: 12.444 ± 0.104	0.808GlyCys: 0.808 ± 0.02	5.401GlyAsp: 5.401 ± 0.053	5.229GlyGlu: 5.229 ± 0.051	2.619GlyPhe: 2.619 ± 0.037	9.371GlyGly: 9.371 ± 0.095	2.377GlyHis: 2.377 ± 0.038	2.944GlyIle: 2.944 ± 0.037	2.272GlyLys: 2.272 ± 0.046	9.218GlyLeu: 9.218 ± 0.077	1.903GlyMet: 1.903 ± 0.031	1.509GlyAsn: 1.509 ± 0.033	5.956GlyPro: 5.956 ± 0.069	3.058GlyGln: 3.058 ± 0.052	7.824GlyArg: 7.824 ± 0.071	5.03GlySer: 5.03 ± 0.051	6.002GlyThr: 6.002 ± 0.057	7.546GlyVal: 7.546 ± 0.08	1.678GlyTrp: 1.678 ± 0.028	2.288GlyTyr: 2.288 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	3.091HisAla: 3.091 ± 0.04	0.22HisCys: 0.22 ± 0.01	1.307HisAsp: 1.307 ± 0.024	1.263HisGlu: 1.263 ± 0.026	0.62HisPhe: 0.62 ± 0.017	2.489HisGly: 2.489 ± 0.044	0.736HisHis: 0.736 ± 0.023	0.641HisIle: 0.641 ± 0.017	0.338HisLys: 0.338 ± 0.013	2.612HisLeu: 2.612 ± 0.038	0.299HisMet: 0.299 ± 0.014	0.351HisAsn: 0.351 ± 0.013	2.058HisPro: 2.058 ± 0.034	0.773HisGln: 0.773 ± 0.022	2.193HisArg: 2.193 ± 0.032	1.018HisSer: 1.018 ± 0.022	1.43HisThr: 1.43 ± 0.027	1.748HisVal: 1.748 ± 0.03	0.392HisTrp: 0.392 ± 0.012	0.474HisTyr: 0.474 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.669IleAla: 4.669 ± 0.05	0.237IleCys: 0.237 ± 0.009	2.176IleAsp: 2.176 ± 0.031	1.945IleGlu: 1.945 ± 0.031	0.625IlePhe: 0.625 ± 0.018	3.256IleGly: 3.256 ± 0.045	0.55IleHis: 0.55 ± 0.017	0.8IleIle: 0.8 ± 0.023	0.699IleLys: 0.699 ± 0.021	1.954IleLeu: 1.954 ± 0.028	0.394IleMet: 0.394 ± 0.014	0.656IleAsn: 0.656 ± 0.017	1.48IlePro: 1.48 ± 0.029	0.644IleGln: 0.644 ± 0.017	1.985IleArg: 1.985 ± 0.032	1.613IleSer: 1.613 ± 0.026	1.986IleThr: 1.986 ± 0.034	2.473IleVal: 2.473 ± 0.038	0.311IleTrp: 0.311 ± 0.012	0.487IleTyr: 0.487 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.507LysAla: 2.507 ± 0.04	0.113LysCys: 0.113 ± 0.008	1.135LysAsp: 1.135 ± 0.029	1.029LysGlu: 1.029 ± 0.026	0.372LysPhe: 0.372 ± 0.014	1.62LysGly: 1.62 ± 0.037	0.404LysHis: 0.404 ± 0.012	0.746LysIle: 0.746 ± 0.023	0.75LysLys: 0.75 ± 0.03	1.85LysLeu: 1.85 ± 0.036	0.341LysMet: 0.341 ± 0.013	0.457LysAsn: 0.457 ± 0.021	1.28LysPro: 1.28 ± 0.03	0.582LysGln: 0.582 ± 0.019	1.419LysArg: 1.419 ± 0.032	0.972LysSer: 0.972 ± 0.021	1.167LysThr: 1.167 ± 0.028	1.644LysVal: 1.644 ± 0.032	0.235LysTrp: 0.235 ± 0.011	0.378LysTyr: 0.378 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.912LeuAla: 15.912 ± 0.105	0.806LeuCys: 0.806 ± 0.019	6.485LeuAsp: 6.485 ± 0.063	4.415LeuGlu: 4.415 ± 0.052	2.493LeuPhe: 2.493 ± 0.034	8.873LeuGly: 8.873 ± 0.071	2.32LeuHis: 2.32 ± 0.039	3.066LeuIle: 3.066 ± 0.039	1.581LeuLys: 1.581 ± 0.027	10.891LeuLeu: 10.891 ± 0.097	1.424LeuMet: 1.424 ± 0.027	1.546LeuAsn: 1.546 ± 0.029	6.548LeuPro: 6.548 ± 0.061	1.913LeuGln: 1.913 ± 0.031	9.334LeuArg: 9.334 ± 0.072	5.227LeuSer: 5.227 ± 0.053	6.858LeuThr: 6.858 ± 0.06	8.687LeuVal: 8.687 ± 0.073	1.316LeuTrp: 1.316 ± 0.024	1.696LeuTyr: 1.696 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.27MetAla: 2.27 ± 0.03	0.125MetCys: 0.125 ± 0.008	0.825MetAsp: 0.825 ± 0.019	0.669MetGlu: 0.669 ± 0.02	0.414MetPhe: 0.414 ± 0.012	1.209MetGly: 1.209 ± 0.023	0.304MetHis: 0.304 ± 0.012	0.546MetIle: 0.546 ± 0.016	0.34MetLys: 0.34 ± 0.013	1.522MetLeu: 1.522 ± 0.028	0.258MetMet: 0.258 ± 0.01	0.397MetAsn: 0.397 ± 0.015	1.023MetPro: 1.023 ± 0.022	0.351MetGln: 0.351 ± 0.013	1.359MetArg: 1.359 ± 0.025	1.221MetSer: 1.221 ± 0.025	1.375MetThr: 1.375 ± 0.027	1.245MetVal: 1.245 ± 0.022	0.2MetTrp: 0.2 ± 0.009	0.287MetTyr: 0.287 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.138AsnAla: 2.138 ± 0.036	0.152AsnCys: 0.152 ± 0.008	0.847AsnAsp: 0.847 ± 0.018	0.78AsnGlu: 0.78 ± 0.02	0.413AsnPhe: 0.413 ± 0.015	1.683AsnGly: 1.683 ± 0.035	0.384AsnHis: 0.384 ± 0.014	0.547AsnIle: 0.547 ± 0.017	0.389AsnLys: 0.389 ± 0.015	1.497AsnLeu: 1.497 ± 0.029	0.254AsnMet: 0.254 ± 0.01	0.363AsnAsn: 0.363 ± 0.016	1.266AsnPro: 1.266 ± 0.024	0.481AsnGln: 0.481 ± 0.015	1.201AsnArg: 1.201 ± 0.022	0.786AsnSer: 0.786 ± 0.021	1.008AsnThr: 1.008 ± 0.023	1.256AsnVal: 1.256 ± 0.023	0.281AsnTrp: 0.281 ± 0.013	0.373AsnTyr: 0.373 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	9.907ProAla: 9.907 ± 0.099	0.348ProCys: 0.348 ± 0.013	4.779ProAsp: 4.779 ± 0.053	4.291ProGlu: 4.291 ± 0.047	1.454ProPhe: 1.454 ± 0.022	7.331ProGly: 7.331 ± 0.082	1.671ProHis: 1.671 ± 0.029	1.373ProIle: 1.373 ± 0.027	1.08ProLys: 1.08 ± 0.028	5.48ProLeu: 5.48 ± 0.06	0.942ProMet: 0.942 ± 0.02	0.928ProAsn: 0.928 ± 0.02	4.305ProPro: 4.305 ± 0.071	1.708ProGln: 1.708 ± 0.034	4.791ProArg: 4.791 ± 0.05	3.243ProSer: 3.243 ± 0.043	3.989ProThr: 3.989 ± 0.055	5.22ProVal: 5.22 ± 0.048	0.936ProTrp: 0.936 ± 0.022	1.405ProTyr: 1.405 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.966GlnAla: 3.966 ± 0.052	0.167GlnCys: 0.167 ± 0.009	1.298GlnAsp: 1.298 ± 0.024	1.356GlnGlu: 1.356 ± 0.025	0.616GlnPhe: 0.616 ± 0.017	2.289GlnGly: 2.289 ± 0.041	0.777GlnHis: 0.777 ± 0.022	0.913GlnIle: 0.913 ± 0.019	0.469GlnLys: 0.469 ± 0.016	2.943GlnLeu: 2.943 ± 0.037	0.414GlnMet: 0.414 ± 0.016	0.401GlnAsn: 0.401 ± 0.014	2.126GlnPro: 2.126 ± 0.044	1.243GlnGln: 1.243 ± 0.034	2.813GlnArg: 2.813 ± 0.038	1.229GlnSer: 1.229 ± 0.024	1.226GlnThr: 1.226 ± 0.024	2.37GlnVal: 2.37 ± 0.033	0.46GlnTrp: 0.46 ± 0.014	0.521GlnTyr: 0.521 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	11.652ArgAla: 11.652 ± 0.092	0.684ArgCys: 0.684 ± 0.017	4.613ArgAsp: 4.613 ± 0.052	5.207ArgGlu: 5.207 ± 0.06	2.275ArgPhe: 2.275 ± 0.032	6.584ArgGly: 6.584 ± 0.065	2.262ArgHis: 2.262 ± 0.033	2.63ArgIle: 2.63 ± 0.037	1.559ArgLys: 1.559 ± 0.031	8.965ArgLeu: 8.965 ± 0.076	1.662ArgMet: 1.662 ± 0.031	1.269ArgAsn: 1.269 ± 0.026	5.546ArgPro: 5.546 ± 0.058	2.584ArgGln: 2.584 ± 0.039	8.002ArgArg: 8.002 ± 0.075	4.03ArgSer: 4.03 ± 0.046	5.154ArgThr: 5.154 ± 0.057	6.627ArgVal: 6.627 ± 0.058	1.502ArgTrp: 1.502 ± 0.028	1.892ArgTyr: 1.892 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.957SerAla: 6.957 ± 0.059	0.369SerCys: 0.369 ± 0.013	2.693SerAsp: 2.693 ± 0.036	2.361SerGlu: 2.361 ± 0.033	1.423SerPhe: 1.423 ± 0.024	5.742SerGly: 5.742 ± 0.056	1.059SerHis: 1.059 ± 0.024	1.341SerIle: 1.341 ± 0.021	0.927SerLys: 0.927 ± 0.022	4.674SerLeu: 4.674 ± 0.055	0.934SerMet: 0.934 ± 0.02	0.847SerAsn: 0.847 ± 0.022	3.226SerPro: 3.226 ± 0.042	1.345SerGln: 1.345 ± 0.026	3.682SerArg: 3.682 ± 0.04	2.537SerSer: 2.537 ± 0.046	2.908SerThr: 2.908 ± 0.032	4.04SerVal: 4.04 ± 0.043	0.846SerTrp: 0.846 ± 0.02	1.173SerTyr: 1.173 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.748ThrAla: 8.748 ± 0.071	0.423ThrCys: 0.423 ± 0.014	3.624ThrAsp: 3.624 ± 0.043	3.197ThrGlu: 3.197 ± 0.039	1.531ThrPhe: 1.531 ± 0.025	6.518ThrGly: 6.518 ± 0.056	1.314ThrHis: 1.314 ± 0.028	1.647ThrIle: 1.647 ± 0.027	1.026ThrLys: 1.026 ± 0.027	5.656ThrLeu: 5.656 ± 0.05	0.879ThrMet: 0.879 ± 0.021	0.95ThrAsn: 0.95 ± 0.023	4.424ThrPro: 4.424 ± 0.047	1.32ThrGln: 1.32 ± 0.029	4.004ThrArg: 4.004 ± 0.049	3.119ThrSer: 3.119 ± 0.037	3.798ThrThr: 3.798 ± 0.053	5.708ThrVal: 5.708 ± 0.056	0.912ThrTrp: 0.912 ± 0.022	1.296ThrTyr: 1.296 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.19ValAla: 11.19 ± 0.086	0.749ValCys: 0.749 ± 0.021	4.921ValAsp: 4.921 ± 0.055	4.735ValGlu: 4.735 ± 0.058	2.297ValPhe: 2.297 ± 0.038	6.749ValGly: 6.749 ± 0.062	1.873ValHis: 1.873 ± 0.029	2.856ValIle: 2.856 ± 0.037	1.457ValLys: 1.457 ± 0.027	9.081ValLeu: 9.081 ± 0.078	1.245ValMet: 1.245 ± 0.024	1.547ValAsn: 1.547 ± 0.026	5.124ValPro: 5.124 ± 0.054	1.774ValGln: 1.774 ± 0.028	7.553ValArg: 7.553 ± 0.067	4.281ValSer: 4.281 ± 0.047	5.255ValThr: 5.255 ± 0.049	7.607ValVal: 7.607 ± 0.077	1.133ValTrp: 1.133 ± 0.024	1.403ValTyr: 1.403 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.69TrpAla: 1.69 ± 0.029	0.179TrpCys: 0.179 ± 0.009	0.807TrpAsp: 0.807 ± 0.018	0.78TrpGlu: 0.78 ± 0.018	0.456TrpPhe: 0.456 ± 0.013	1.085TrpGly: 1.085 ± 0.023	0.402TrpHis: 0.402 ± 0.014	0.437TrpIle: 0.437 ± 0.012	0.343TrpLys: 0.343 ± 0.014	1.833TrpLeu: 1.833 ± 0.032	0.256TrpMet: 0.256 ± 0.011	0.341TrpAsn: 0.341 ± 0.013	0.842TrpPro: 0.842 ± 0.019	0.612TrpGln: 0.612 ± 0.015	1.499TrpArg: 1.499 ± 0.028	0.949TrpSer: 0.949 ± 0.021	0.886TrpThr: 0.886 ± 0.019	1.051TrpVal: 1.051 ± 0.023	0.314TrpTrp: 0.314 ± 0.013	0.343TrpTyr: 0.343 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.931TyrAla: 2.931 ± 0.038	0.169TyrCys: 0.169 ± 0.009	1.376TyrAsp: 1.376 ± 0.026	1.246TyrGlu: 1.246 ± 0.024	0.589TyrPhe: 0.589 ± 0.017	2.188TyrGly: 2.188 ± 0.031	0.395TyrHis: 0.395 ± 0.013	0.395TyrIle: 0.395 ± 0.015	0.308TyrLys: 0.308 ± 0.012	2.111TyrLeu: 2.111 ± 0.034	0.203TyrMet: 0.203 ± 0.01	0.335TyrAsn: 0.335 ± 0.013	1.136TyrPro: 1.136 ± 0.025	0.603TyrGln: 0.603 ± 0.019	1.824TyrArg: 1.824 ± 0.029	0.855TyrSer: 0.855 ± 0.021	1.038TyrThr: 1.038 ± 0.021	1.633TyrVal: 1.633 ± 0.03	0.361TyrTrp: 0.361 ± 0.015	0.408TyrTyr: 0.408 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6802 proteins (2354689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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