Amino acid dipepetide frequency for Lachancea lanzarotensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.533AlaAla: 5.533 ± 0.065	0.828AlaCys: 0.828 ± 0.022	3.251AlaAsp: 3.251 ± 0.039	4.056AlaGlu: 4.056 ± 0.05	2.781AlaPhe: 2.781 ± 0.04	3.885AlaGly: 3.885 ± 0.055	1.475AlaHis: 1.475 ± 0.029	3.704AlaIle: 3.704 ± 0.038	4.321AlaLys: 4.321 ± 0.05	6.865AlaLeu: 6.865 ± 0.075	1.46AlaMet: 1.46 ± 0.027	2.998AlaAsn: 2.998 ± 0.04	2.944AlaPro: 2.944 ± 0.047	2.957AlaGln: 2.957 ± 0.043	3.255AlaArg: 3.255 ± 0.041	6.023AlaSer: 6.023 ± 0.061	4.07AlaThr: 4.07 ± 0.046	4.363AlaVal: 4.363 ± 0.043	0.639AlaTrp: 0.639 ± 0.017	1.796AlaTyr: 1.796 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	0.767CysAla: 0.767 ± 0.017	0.273CysCys: 0.273 ± 0.011	0.705CysAsp: 0.705 ± 0.019	0.655CysGlu: 0.655 ± 0.019	0.63CysPhe: 0.63 ± 0.017	0.929CysGly: 0.929 ± 0.02	0.337CysHis: 0.337 ± 0.013	0.83CysIle: 0.83 ± 0.021	0.653CysLys: 0.653 ± 0.017	1.28CysLeu: 1.28 ± 0.023	0.256CysMet: 0.256 ± 0.011	0.509CysAsn: 0.509 ± 0.016	0.51CysPro: 0.51 ± 0.019	0.463CysGln: 0.463 ± 0.015	0.61CysArg: 0.61 ± 0.016	1.063CysSer: 1.063 ± 0.023	0.62CysThr: 0.62 ± 0.016	0.905CysVal: 0.905 ± 0.019	0.167CysTrp: 0.167 ± 0.008	0.456CysTyr: 0.456 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.911AspAla: 3.911 ± 0.04	0.641AspCys: 0.641 ± 0.017	4.357AspAsp: 4.357 ± 0.067	4.812AspGlu: 4.812 ± 0.061	2.81AspPhe: 2.81 ± 0.037	3.146AspGly: 3.146 ± 0.038	1.2AspHis: 1.2 ± 0.023	3.308AspIle: 3.308 ± 0.041	3.034AspLys: 3.034 ± 0.04	5.928AspLeu: 5.928 ± 0.053	1.088AspMet: 1.088 ± 0.02	2.488AspAsn: 2.488 ± 0.036	2.577AspPro: 2.577 ± 0.04	2.147AspGln: 2.147 ± 0.032	2.509AspArg: 2.509 ± 0.034	4.79AspSer: 4.79 ± 0.054	2.897AspThr: 2.897 ± 0.04	3.996AspVal: 3.996 ± 0.038	0.64AspTrp: 0.64 ± 0.016	2.002AspTyr: 2.002 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	4.098GluAla: 4.098 ± 0.047	0.665GluCys: 0.665 ± 0.018	4.283GluAsp: 4.283 ± 0.057	5.547GluGlu: 5.547 ± 0.079	2.696GluPhe: 2.696 ± 0.035	2.907GluGly: 2.907 ± 0.034	1.464GluHis: 1.464 ± 0.024	3.725GluIle: 3.725 ± 0.042	4.661GluLys: 4.661 ± 0.057	6.875GluLeu: 6.875 ± 0.069	1.329GluMet: 1.329 ± 0.026	3.721GluAsn: 3.721 ± 0.044	2.297GluPro: 2.297 ± 0.037	2.867GluGln: 2.867 ± 0.041	3.312GluArg: 3.312 ± 0.046	5.087GluSer: 5.087 ± 0.055	3.718GluThr: 3.718 ± 0.04	3.721GluVal: 3.721 ± 0.038	0.674GluTrp: 0.674 ± 0.015	1.979GluTyr: 1.979 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	2.818PheAla: 2.818 ± 0.035	0.589PheCys: 0.589 ± 0.016	2.835PheAsp: 2.835 ± 0.04	2.984PheGlu: 2.984 ± 0.034	1.998PhePhe: 1.998 ± 0.035	2.752PheGly: 2.752 ± 0.051	0.993PheHis: 0.993 ± 0.02	2.232PheIle: 2.232 ± 0.03	2.716PheLys: 2.716 ± 0.031	4.269PheLeu: 4.269 ± 0.053	0.889PheMet: 0.889 ± 0.019	2.061PheAsn: 2.061 ± 0.029	1.839PhePro: 1.839 ± 0.025	1.956PheGln: 1.956 ± 0.03	1.882PheArg: 1.882 ± 0.031	3.661PheSer: 3.661 ± 0.046	2.384PheThr: 2.384 ± 0.036	2.903PheVal: 2.903 ± 0.039	0.548PheTrp: 0.548 ± 0.016	1.512PheTyr: 1.512 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	3.646GlyAla: 3.646 ± 0.044	0.784GlyCys: 0.784 ± 0.02	3.007GlyAsp: 3.007 ± 0.034	3.116GlyGlu: 3.116 ± 0.037	2.67GlyPhe: 2.67 ± 0.039	3.768GlyGly: 3.768 ± 0.074	1.294GlyHis: 1.294 ± 0.024	3.277GlyIle: 3.277 ± 0.049	3.579GlyLys: 3.579 ± 0.043	5.346GlyLeu: 5.346 ± 0.058	1.055GlyMet: 1.055 ± 0.021	2.656GlyAsn: 2.656 ± 0.04	2.092GlyPro: 2.092 ± 0.036	2.113GlyGln: 2.113 ± 0.037	2.63GlyArg: 2.63 ± 0.036	5.571GlySer: 5.571 ± 0.062	3.23GlyThr: 3.23 ± 0.044	3.648GlyVal: 3.648 ± 0.048	0.657GlyTrp: 0.657 ± 0.018	1.77GlyTyr: 1.77 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	1.313HisAla: 1.313 ± 0.024	0.317HisCys: 0.317 ± 0.011	1.304HisAsp: 1.304 ± 0.026	1.404HisGlu: 1.404 ± 0.025	1.07HisPhe: 1.07 ± 0.021	1.329HisGly: 1.329 ± 0.025	0.738HisHis: 0.738 ± 0.023	1.236HisIle: 1.236 ± 0.022	1.254HisLys: 1.254 ± 0.022	2.249HisLeu: 2.249 ± 0.03	0.426HisMet: 0.426 ± 0.015	1.067HisAsn: 1.067 ± 0.023	1.097HisPro: 1.097 ± 0.022	1.014HisGln: 1.014 ± 0.023	1.249HisArg: 1.249 ± 0.021	1.948HisSer: 1.948 ± 0.03	1.173HisThr: 1.173 ± 0.025	1.375HisVal: 1.375 ± 0.025	0.26HisTrp: 0.26 ± 0.01	0.773HisTyr: 0.773 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.74IleAla: 3.74 ± 0.044	0.775IleCys: 0.775 ± 0.018	3.427IleAsp: 3.427 ± 0.039	3.471IleGlu: 3.471 ± 0.041	2.361IlePhe: 2.361 ± 0.039	2.9IleGly: 2.9 ± 0.041	1.182IleHis: 1.182 ± 0.02	2.751IleIle: 2.751 ± 0.042	3.262IleLys: 3.262 ± 0.038	5.248IleLeu: 5.248 ± 0.05	1.097IleMet: 1.097 ± 0.02	2.504IleAsn: 2.504 ± 0.033	2.798IlePro: 2.798 ± 0.041	2.121IleGln: 2.121 ± 0.03	2.55IleArg: 2.55 ± 0.032	4.841IleSer: 4.841 ± 0.048	2.922IleThr: 2.922 ± 0.032	3.592IleVal: 3.592 ± 0.046	0.619IleTrp: 0.619 ± 0.018	1.63IleTyr: 1.63 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.004LysAla: 4.004 ± 0.05	0.72LysCys: 0.72 ± 0.019	3.497LysAsp: 3.497 ± 0.043	4.014LysGlu: 4.014 ± 0.05	2.734LysPhe: 2.734 ± 0.032	2.777LysGly: 2.777 ± 0.035	1.439LysHis: 1.439 ± 0.025	3.715LysIle: 3.715 ± 0.042	4.97LysLys: 4.97 ± 0.065	6.608LysLeu: 6.608 ± 0.06	1.315LysMet: 1.315 ± 0.023	3.327LysAsn: 3.327 ± 0.035	2.853LysPro: 2.853 ± 0.039	2.546LysGln: 2.546 ± 0.036	3.82LysArg: 3.82 ± 0.048	5.25LysSer: 5.25 ± 0.05	3.829LysThr: 3.829 ± 0.04	3.855LysVal: 3.855 ± 0.041	0.761LysTrp: 0.761 ± 0.019	2.047LysTyr: 2.047 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	6.711LeuAla: 6.711 ± 0.061	1.369LeuCys: 1.369 ± 0.023	5.673LeuAsp: 5.673 ± 0.05	6.696LeuGlu: 6.696 ± 0.066	4.037LeuPhe: 4.037 ± 0.052	5.237LeuGly: 5.237 ± 0.053	2.261LeuHis: 2.261 ± 0.032	4.911LeuIle: 4.911 ± 0.054	6.836LeuLys: 6.836 ± 0.064	9.711LeuLeu: 9.711 ± 0.091	1.996LeuMet: 1.996 ± 0.028	4.787LeuAsn: 4.787 ± 0.044	4.7LeuPro: 4.7 ± 0.045	4.845LeuGln: 4.845 ± 0.053	5.388LeuArg: 5.388 ± 0.054	8.46LeuSer: 8.46 ± 0.071	5.269LeuThr: 5.269 ± 0.043	5.993LeuVal: 5.993 ± 0.061	1.014LeuTrp: 1.014 ± 0.021	2.886LeuTyr: 2.886 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	1.558MetAla: 1.558 ± 0.024	0.29MetCys: 0.29 ± 0.011	1.211MetAsp: 1.211 ± 0.026	1.141MetGlu: 1.141 ± 0.024	0.793MetPhe: 0.793 ± 0.018	1.277MetGly: 1.277 ± 0.025	0.398MetHis: 0.398 ± 0.014	1.043MetIle: 1.043 ± 0.02	1.211MetLys: 1.211 ± 0.023	1.894MetLeu: 1.894 ± 0.03	0.449MetMet: 0.449 ± 0.014	0.997MetAsn: 0.997 ± 0.022	0.824MetPro: 0.824 ± 0.02	0.739MetGln: 0.739 ± 0.019	0.974MetArg: 0.974 ± 0.021	2.015MetSer: 2.015 ± 0.03	1.083MetThr: 1.083 ± 0.022	1.295MetVal: 1.295 ± 0.024	0.185MetTrp: 0.185 ± 0.009	0.538MetTyr: 0.538 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.397AsnAla: 3.397 ± 0.04	0.632AsnCys: 0.632 ± 0.016	2.958AsnAsp: 2.958 ± 0.038	3.171AsnGlu: 3.171 ± 0.039	2.142AsnPhe: 2.142 ± 0.028	3.185AsnGly: 3.185 ± 0.04	0.982AsnHis: 0.982 ± 0.018	2.506AsnIle: 2.506 ± 0.031	2.801AsnLys: 2.801 ± 0.037	4.575AsnLeu: 4.575 ± 0.042	0.951AsnMet: 0.951 ± 0.022	2.413AsnAsn: 2.413 ± 0.042	2.218AsnPro: 2.218 ± 0.035	1.721AsnGln: 1.721 ± 0.029	2.192AsnArg: 2.192 ± 0.03	4.477AsnSer: 4.477 ± 0.054	2.628AsnThr: 2.628 ± 0.037	3.22AsnVal: 3.22 ± 0.038	0.582AsnTrp: 0.582 ± 0.015	1.603AsnTyr: 1.603 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	3.087ProAla: 3.087 ± 0.043	0.365ProCys: 0.365 ± 0.013	2.376ProAsp: 2.376 ± 0.034	3.193ProGlu: 3.193 ± 0.041	1.959ProPhe: 1.959 ± 0.031	2.331ProGly: 2.331 ± 0.034	1.052ProHis: 1.052 ± 0.024	2.322ProIle: 2.322 ± 0.034	2.637ProLys: 2.637 ± 0.036	4.234ProLeu: 4.234 ± 0.046	0.786ProMet: 0.786 ± 0.019	2.086ProAsn: 2.086 ± 0.032	2.441ProPro: 2.441 ± 0.054	2.199ProGln: 2.199 ± 0.037	2.043ProArg: 2.043 ± 0.029	4.215ProSer: 4.215 ± 0.056	2.613ProThr: 2.613 ± 0.037	3.04ProVal: 3.04 ± 0.042	0.455ProTrp: 0.455 ± 0.014	1.248ProTyr: 1.248 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	2.593GlnAla: 2.593 ± 0.04	0.466GlnCys: 0.466 ± 0.013	2.521GlnAsp: 2.521 ± 0.036	3.061GlnGlu: 3.061 ± 0.044	1.762GlnPhe: 1.762 ± 0.025	2.048GlnGly: 2.048 ± 0.033	1.092GlnHis: 1.092 ± 0.023	2.384GlnIle: 2.384 ± 0.035	2.754GlnLys: 2.754 ± 0.034	4.447GlnLeu: 4.447 ± 0.053	0.859GlnMet: 0.859 ± 0.022	2.217GlnAsn: 2.217 ± 0.032	1.758GlnPro: 1.758 ± 0.037	3.296GlnGln: 3.296 ± 0.191	2.364GlnArg: 2.364 ± 0.037	3.244GlnSer: 3.244 ± 0.046	2.268GlnThr: 2.268 ± 0.032	2.524GlnVal: 2.524 ± 0.032	0.467GlnTrp: 0.467 ± 0.015	1.3GlnTyr: 1.3 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	3.125ArgAla: 3.125 ± 0.043	0.656ArgCys: 0.656 ± 0.016	2.858ArgAsp: 2.858 ± 0.037	3.227ArgGlu: 3.227 ± 0.045	2.233ArgPhe: 2.233 ± 0.031	2.607ArgGly: 2.607 ± 0.038	1.129ArgHis: 1.129 ± 0.022	2.829ArgIle: 2.829 ± 0.034	3.749ArgLys: 3.749 ± 0.047	4.875ArgLeu: 4.875 ± 0.043	0.996ArgMet: 0.996 ± 0.02	2.623ArgAsn: 2.623 ± 0.033	2.092ArgPro: 2.092 ± 0.03	2.166ArgGln: 2.166 ± 0.032	3.261ArgArg: 3.261 ± 0.046	4.327ArgSer: 4.327 ± 0.045	2.642ArgThr: 2.642 ± 0.035	2.818ArgVal: 2.818 ± 0.037	0.538ArgTrp: 0.538 ± 0.015	1.626ArgTyr: 1.626 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	5.777SerAla: 5.777 ± 0.061	0.978SerCys: 0.978 ± 0.02	4.801SerAsp: 4.801 ± 0.056	5.154SerGlu: 5.154 ± 0.052	3.858SerPhe: 3.858 ± 0.046	5.353SerGly: 5.353 ± 0.062	2.025SerHis: 2.025 ± 0.031	4.626SerIle: 4.626 ± 0.044	5.727SerLys: 5.727 ± 0.055	8.36SerLeu: 8.36 ± 0.064	1.741SerMet: 1.741 ± 0.026	4.339SerAsn: 4.339 ± 0.051	4.02SerPro: 4.02 ± 0.053	3.908SerGln: 3.908 ± 0.046	4.511SerArg: 4.511 ± 0.049	10.494SerSer: 10.494 ± 0.171	5.467SerThr: 5.467 ± 0.07	5.284SerVal: 5.284 ± 0.047	0.89SerTrp: 0.89 ± 0.02	2.37SerTyr: 2.37 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.025ThrAla: 4.025 ± 0.044	0.679ThrCys: 0.679 ± 0.019	2.849ThrAsp: 2.849 ± 0.033	3.203ThrGlu: 3.203 ± 0.038	2.453ThrPhe: 2.453 ± 0.034	3.494ThrGly: 3.494 ± 0.048	1.221ThrHis: 1.221 ± 0.021	3.043ThrIle: 3.043 ± 0.037	3.404ThrLys: 3.404 ± 0.039	5.51ThrLeu: 5.51 ± 0.055	1.069ThrMet: 1.069 ± 0.02	2.627ThrAsn: 2.627 ± 0.034	2.95ThrPro: 2.95 ± 0.043	2.185ThrGln: 2.185 ± 0.034	2.642ThrArg: 2.642 ± 0.034	5.327ThrSer: 5.327 ± 0.063	3.747ThrThr: 3.747 ± 0.061	3.667ThrVal: 3.667 ± 0.049	0.593ThrTrp: 0.593 ± 0.017	1.542ThrTyr: 1.542 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	4.504ValAla: 4.504 ± 0.042	0.863ValCys: 0.863 ± 0.021	3.786ValAsp: 3.786 ± 0.043	4.214ValGlu: 4.214 ± 0.042	2.854ValPhe: 2.854 ± 0.042	3.454ValGly: 3.454 ± 0.045	1.306ValHis: 1.306 ± 0.022	3.272ValIle: 3.272 ± 0.041	3.983ValLys: 3.983 ± 0.046	6.363ValLeu: 6.363 ± 0.061	1.268ValMet: 1.268 ± 0.024	2.836ValAsn: 2.836 ± 0.033	3.092ValPro: 3.092 ± 0.041	2.405ValGln: 2.405 ± 0.034	2.999ValArg: 2.999 ± 0.039	5.543ValSer: 5.543 ± 0.046	3.486ValThr: 3.486 ± 0.044	4.466ValVal: 4.466 ± 0.051	0.695ValTrp: 0.695 ± 0.016	1.866ValTyr: 1.866 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.65TrpAla: 0.65 ± 0.017	0.255TrpCys: 0.255 ± 0.011	0.725TrpAsp: 0.725 ± 0.02	0.632TrpGlu: 0.632 ± 0.015	0.527TrpPhe: 0.527 ± 0.016	0.582TrpGly: 0.582 ± 0.016	0.244TrpHis: 0.244 ± 0.01	0.595TrpIle: 0.595 ± 0.016	0.757TrpLys: 0.757 ± 0.019	1.032TrpLeu: 1.032 ± 0.021	0.238TrpMet: 0.238 ± 0.01	0.603TrpAsn: 0.603 ± 0.018	0.357TrpPro: 0.357 ± 0.012	0.44TrpGln: 0.44 ± 0.013	0.624TrpArg: 0.624 ± 0.018	0.922TrpSer: 0.922 ± 0.023	0.591TrpThr: 0.591 ± 0.017	0.597TrpVal: 0.597 ± 0.016	0.173TrpTrp: 0.173 ± 0.009	0.365TrpTyr: 0.365 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.947TyrAla: 1.947 ± 0.034	0.471TyrCys: 0.471 ± 0.014	1.858TyrAsp: 1.858 ± 0.028	1.876TyrGlu: 1.876 ± 0.028	1.455TyrPhe: 1.455 ± 0.024	1.949TyrGly: 1.949 ± 0.042	0.765TyrHis: 0.765 ± 0.017	1.481TyrIle: 1.481 ± 0.028	1.771TyrLys: 1.771 ± 0.025	3.114TyrLeu: 3.114 ± 0.039	0.645TyrMet: 0.645 ± 0.017	1.495TyrAsn: 1.495 ± 0.024	1.222TyrPro: 1.222 ± 0.025	1.338TyrGln: 1.338 ± 0.027	1.563TyrArg: 1.563 ± 0.024	2.427TyrSer: 2.427 ± 0.033	1.591TyrThr: 1.591 ± 0.027	1.989TyrVal: 1.989 ± 0.03	0.351TyrTrp: 0.351 ± 0.012	1.159TyrTyr: 1.159 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5055 proteins (2472229 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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