Amino acid dipepetide frequency for Aspergillus tubingensis (strain CBS 134.48)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.672AlaAla: 8.672 ± 0.057	1.146AlaCys: 1.146 ± 0.014	4.131AlaAsp: 4.131 ± 0.027	4.931AlaGlu: 4.931 ± 0.036	3.145AlaPhe: 3.145 ± 0.026	5.682AlaGly: 5.682 ± 0.039	1.808AlaHis: 1.808 ± 0.018	4.304AlaIle: 4.304 ± 0.028	3.644AlaLys: 3.644 ± 0.03	7.721AlaLeu: 7.721 ± 0.04	1.982AlaMet: 1.982 ± 0.019	2.837AlaAsn: 2.837 ± 0.021	4.561AlaPro: 4.561 ± 0.042	3.274AlaGln: 3.274 ± 0.028	4.803AlaArg: 4.803 ± 0.033	7.136AlaSer: 7.136 ± 0.048	5.223AlaThr: 5.223 ± 0.032	5.416AlaVal: 5.416 ± 0.034	1.198AlaTrp: 1.198 ± 0.016	2.26AlaTyr: 2.26 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.003CysAla: 1.003 ± 0.014	0.274CysCys: 0.274 ± 0.008	0.712CysAsp: 0.712 ± 0.012	0.628CysGlu: 0.628 ± 0.012	0.576CysPhe: 0.576 ± 0.011	0.975CysGly: 0.975 ± 0.014	0.375CysHis: 0.375 ± 0.009	0.787CysIle: 0.787 ± 0.012	0.477CysLys: 0.477 ± 0.01	1.431CysLeu: 1.431 ± 0.017	0.304CysMet: 0.304 ± 0.007	0.452CysAsn: 0.452 ± 0.009	0.687CysPro: 0.687 ± 0.012	0.492CysGln: 0.492 ± 0.01	0.845CysArg: 0.845 ± 0.014	1.017CysSer: 1.017 ± 0.016	0.762CysThr: 0.762 ± 0.011	0.875CysVal: 0.875 ± 0.013	0.224CysTrp: 0.224 ± 0.006	0.391CysTyr: 0.391 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.535AspAla: 4.535 ± 0.03	0.647AspCys: 0.647 ± 0.011	3.948AspAsp: 3.948 ± 0.039	4.207AspGlu: 4.207 ± 0.036	2.12AspPhe: 2.12 ± 0.019	3.922AspGly: 3.922 ± 0.028	1.287AspHis: 1.287 ± 0.015	3.13AspIle: 3.13 ± 0.024	2.18AspLys: 2.18 ± 0.024	5.152AspLeu: 5.152 ± 0.032	1.254AspMet: 1.254 ± 0.016	1.869AspAsn: 1.869 ± 0.019	3.345AspPro: 3.345 ± 0.028	1.896AspGln: 1.896 ± 0.017	3.131AspArg: 3.131 ± 0.028	4.035AspSer: 4.035 ± 0.034	3.042AspThr: 3.042 ± 0.023	3.685AspVal: 3.685 ± 0.029	0.921AspTrp: 0.921 ± 0.013	1.718AspTyr: 1.718 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	5.153GluAla: 5.153 ± 0.037	0.671GluCys: 0.671 ± 0.012	4.022GluAsp: 4.022 ± 0.035	5.431GluGlu: 5.431 ± 0.062	1.925GluPhe: 1.925 ± 0.018	3.817GluGly: 3.817 ± 0.027	1.395GluHis: 1.395 ± 0.016	2.947GluIle: 2.947 ± 0.027	3.428GluLys: 3.428 ± 0.033	5.063GluLeu: 5.063 ± 0.034	1.463GluMet: 1.463 ± 0.017	2.183GluAsn: 2.183 ± 0.02	2.786GluPro: 2.786 ± 0.044	2.487GluGln: 2.487 ± 0.027	3.886GluArg: 3.886 ± 0.033	4.285GluSer: 4.285 ± 0.034	3.496GluThr: 3.496 ± 0.029	3.645GluVal: 3.645 ± 0.026	0.91GluTrp: 0.91 ± 0.015	1.75GluTyr: 1.75 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.008PheAla: 3.008 ± 0.024	0.608PheCys: 0.608 ± 0.009	2.251PheAsp: 2.251 ± 0.019	2.072PheGlu: 2.072 ± 0.019	1.695PhePhe: 1.695 ± 0.021	2.807PheGly: 2.807 ± 0.028	0.99PheHis: 0.99 ± 0.014	1.885PheIle: 1.885 ± 0.018	1.34PheLys: 1.34 ± 0.016	3.686PheLeu: 3.686 ± 0.03	0.783PheMet: 0.783 ± 0.012	1.38PheAsn: 1.38 ± 0.016	2.041PhePro: 2.041 ± 0.021	1.408PheGln: 1.408 ± 0.015	2.061PheArg: 2.061 ± 0.02	3.066PheSer: 3.066 ± 0.025	2.22PheThr: 2.22 ± 0.021	2.402PheVal: 2.402 ± 0.023	0.665PheTrp: 0.665 ± 0.012	1.181PheTyr: 1.181 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.138GlyAla: 5.138 ± 0.036	0.959GlyCys: 0.959 ± 0.014	3.574GlyAsp: 3.574 ± 0.027	3.627GlyGlu: 3.627 ± 0.028	2.785GlyPhe: 2.785 ± 0.028	5.443GlyGly: 5.443 ± 0.048	1.662GlyHis: 1.662 ± 0.018	3.565GlyIle: 3.565 ± 0.026	3.219GlyLys: 3.219 ± 0.027	6.256GlyLeu: 6.256 ± 0.043	1.623GlyMet: 1.623 ± 0.019	2.427GlyAsn: 2.427 ± 0.026	3.334GlyPro: 3.334 ± 0.029	2.538GlyGln: 2.538 ± 0.023	4.075GlyArg: 4.075 ± 0.029	5.692GlySer: 5.692 ± 0.046	3.941GlyThr: 3.941 ± 0.03	4.573GlyVal: 4.573 ± 0.03	1.21GlyTrp: 1.21 ± 0.018	2.264GlyTyr: 2.264 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.881HisAla: 1.881 ± 0.021	0.363HisCys: 0.363 ± 0.008	1.338HisAsp: 1.338 ± 0.015	1.331HisGlu: 1.331 ± 0.016	0.942HisPhe: 0.942 ± 0.014	1.709HisGly: 1.709 ± 0.019	0.946HisHis: 0.946 ± 0.018	1.273HisIle: 1.273 ± 0.014	0.843HisLys: 0.843 ± 0.013	2.415HisLeu: 2.415 ± 0.023	0.518HisMet: 0.518 ± 0.01	0.884HisAsn: 0.884 ± 0.013	1.808HisPro: 1.808 ± 0.018	0.991HisGln: 0.991 ± 0.015	1.587HisArg: 1.587 ± 0.018	1.871HisSer: 1.871 ± 0.022	1.371HisThr: 1.371 ± 0.017	1.459HisVal: 1.459 ± 0.016	0.374HisTrp: 0.374 ± 0.008	0.755HisTyr: 0.755 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.165IleAla: 4.165 ± 0.029	0.832IleCys: 0.832 ± 0.01	2.827IleAsp: 2.827 ± 0.022	2.752IleGlu: 2.752 ± 0.027	2.078IlePhe: 2.078 ± 0.021	3.23IleGly: 3.23 ± 0.025	1.303IleHis: 1.303 ± 0.017	2.661IleIle: 2.661 ± 0.027	1.985IleLys: 1.985 ± 0.019	4.809IleLeu: 4.809 ± 0.038	1.051IleMet: 1.051 ± 0.015	1.787IleAsn: 1.787 ± 0.018	3.224IlePro: 3.224 ± 0.025	1.934IleGln: 1.934 ± 0.018	2.879IleArg: 2.879 ± 0.025	3.947IleSer: 3.947 ± 0.027	2.934IleThr: 2.934 ± 0.023	3.251IleVal: 3.251 ± 0.028	0.759IleTrp: 0.759 ± 0.012	1.544IleTyr: 1.544 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.785LysAla: 3.785 ± 0.032	0.498LysCys: 0.498 ± 0.009	2.518LysAsp: 2.518 ± 0.025	3.159LysGlu: 3.159 ± 0.032	1.306LysPhe: 1.306 ± 0.016	2.77LysGly: 2.77 ± 0.025	1.062LysHis: 1.062 ± 0.012	2.077LysIle: 2.077 ± 0.022	2.811LysLys: 2.811 ± 0.035	3.811LysLeu: 3.811 ± 0.032	0.928LysMet: 0.928 ± 0.014	1.57LysAsn: 1.57 ± 0.019	2.53LysPro: 2.53 ± 0.027	1.738LysGln: 1.738 ± 0.019	3.154LysArg: 3.154 ± 0.025	3.214LysSer: 3.214 ± 0.032	2.532LysThr: 2.532 ± 0.026	2.683LysVal: 2.683 ± 0.025	0.629LysTrp: 0.629 ± 0.01	1.34LysTyr: 1.34 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.838LeuAla: 7.838 ± 0.044	1.32LeuCys: 1.32 ± 0.014	5.249LeuAsp: 5.249 ± 0.033	5.484LeuGlu: 5.484 ± 0.038	3.532LeuPhe: 3.532 ± 0.028	6.124LeuGly: 6.124 ± 0.044	2.37LeuHis: 2.37 ± 0.024	4.146LeuIle: 4.146 ± 0.035	3.902LeuLys: 3.902 ± 0.03	8.906LeuLeu: 8.906 ± 0.057	1.863LeuMet: 1.863 ± 0.018	3.195LeuAsn: 3.195 ± 0.026	5.651LeuPro: 5.651 ± 0.035	3.981LeuGln: 3.981 ± 0.036	5.912LeuArg: 5.912 ± 0.042	7.685LeuSer: 7.685 ± 0.042	5.067LeuThr: 5.067 ± 0.031	5.626LeuVal: 5.626 ± 0.038	1.266LeuTrp: 1.266 ± 0.017	2.584LeuTyr: 2.584 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.151MetAla: 2.151 ± 0.021	0.26MetCys: 0.26 ± 0.007	1.245MetAsp: 1.245 ± 0.016	1.308MetGlu: 1.308 ± 0.017	0.775MetPhe: 0.775 ± 0.013	1.488MetGly: 1.488 ± 0.017	0.518MetHis: 0.518 ± 0.01	1.047MetIle: 1.047 ± 0.013	0.969MetLys: 0.969 ± 0.014	1.917MetLeu: 1.917 ± 0.02	0.594MetMet: 0.594 ± 0.012	0.808MetAsn: 0.808 ± 0.013	1.243MetPro: 1.243 ± 0.015	0.885MetGln: 0.885 ± 0.012	1.288MetArg: 1.288 ± 0.015	1.919MetSer: 1.919 ± 0.017	1.333MetThr: 1.333 ± 0.017	1.396MetVal: 1.396 ± 0.016	0.275MetTrp: 0.275 ± 0.008	0.564MetTyr: 0.564 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.983AsnAla: 2.983 ± 0.023	0.473AsnCys: 0.473 ± 0.01	1.885AsnAsp: 1.885 ± 0.019	1.981AsnGlu: 1.981 ± 0.019	1.321AsnPhe: 1.321 ± 0.017	2.856AsnGly: 2.856 ± 0.028	0.85AsnHis: 0.85 ± 0.012	2.06AsnIle: 2.06 ± 0.02	1.425AsnLys: 1.425 ± 0.017	3.21AsnLeu: 3.21 ± 0.029	0.836AsnMet: 0.836 ± 0.012	1.504AsnAsn: 1.504 ± 0.021	2.444AsnPro: 2.444 ± 0.023	1.306AsnGln: 1.306 ± 0.015	1.929AsnArg: 1.929 ± 0.019	2.648AsnSer: 2.648 ± 0.023	2.192AsnThr: 2.192 ± 0.022	2.305AsnVal: 2.305 ± 0.02	0.572AsnTrp: 0.572 ± 0.01	1.127AsnTyr: 1.127 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.138ProAla: 5.138 ± 0.048	0.595ProCys: 0.595 ± 0.012	3.27ProAsp: 3.27 ± 0.026	3.906ProGlu: 3.906 ± 0.037	2.133ProPhe: 2.133 ± 0.019	3.854ProGly: 3.854 ± 0.029	1.391ProHis: 1.391 ± 0.018	2.585ProIle: 2.585 ± 0.019	2.432ProLys: 2.432 ± 0.025	4.808ProLeu: 4.808 ± 0.033	1.085ProMet: 1.085 ± 0.014	2.159ProAsn: 2.159 ± 0.02	4.762ProPro: 4.762 ± 0.064	2.44ProGln: 2.44 ± 0.028	3.368ProArg: 3.368 ± 0.03	6.115ProSer: 6.115 ± 0.047	4.032ProThr: 4.032 ± 0.03	3.715ProVal: 3.715 ± 0.029	0.82ProTrp: 0.82 ± 0.013	1.623ProTyr: 1.623 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.347GlnAla: 3.347 ± 0.03	0.49GlnCys: 0.49 ± 0.012	2.032GlnAsp: 2.032 ± 0.023	2.421GlnGlu: 2.421 ± 0.021	1.311GlnPhe: 1.311 ± 0.016	2.376GlnGly: 2.376 ± 0.023	1.054GlnHis: 1.054 ± 0.016	1.906GlnIle: 1.906 ± 0.017	1.898GlnLys: 1.898 ± 0.022	3.611GlnLeu: 3.611 ± 0.027	0.882GlnMet: 0.882 ± 0.012	1.489GlnAsn: 1.489 ± 0.017	2.571GlnPro: 2.571 ± 0.027	2.357GlnGln: 2.357 ± 0.039	2.615GlnArg: 2.615 ± 0.024	3.198GlnSer: 3.198 ± 0.028	2.353GlnThr: 2.353 ± 0.02	2.213GlnVal: 2.213 ± 0.022	0.609GlnTrp: 0.609 ± 0.01	1.224GlnTyr: 1.224 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.606ArgAla: 4.606 ± 0.031	0.792ArgCys: 0.792 ± 0.012	3.326ArgAsp: 3.326 ± 0.028	3.802ArgGlu: 3.802 ± 0.03	2.216ArgPhe: 2.216 ± 0.023	3.704ArgGly: 3.704 ± 0.027	1.581ArgHis: 1.581 ± 0.017	2.916ArgIle: 2.916 ± 0.021	3.261ArgLys: 3.261 ± 0.026	5.714ArgLeu: 5.714 ± 0.038	1.354ArgMet: 1.354 ± 0.014	2.188ArgAsn: 2.188 ± 0.018	3.477ArgPro: 3.477 ± 0.03	2.619ArgGln: 2.619 ± 0.021	5.03ArgArg: 5.03 ± 0.042	4.839ArgSer: 4.839 ± 0.038	3.279ArgThr: 3.279 ± 0.028	3.554ArgVal: 3.554 ± 0.027	0.976ArgTrp: 0.976 ± 0.015	1.805ArgTyr: 1.805 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.612SerAla: 6.612 ± 0.041	0.962SerCys: 0.962 ± 0.015	4.276SerAsp: 4.276 ± 0.032	4.173SerGlu: 4.173 ± 0.033	3.107SerPhe: 3.107 ± 0.023	5.571SerGly: 5.571 ± 0.042	2.019SerHis: 2.019 ± 0.021	4.067SerIle: 4.067 ± 0.025	3.365SerLys: 3.365 ± 0.027	7.576SerLeu: 7.576 ± 0.043	1.755SerMet: 1.755 ± 0.016	2.943SerAsn: 2.943 ± 0.024	5.47SerPro: 5.47 ± 0.05	3.325SerGln: 3.325 ± 0.025	5.024SerArg: 5.024 ± 0.04	8.964SerSer: 8.964 ± 0.069	5.762SerThr: 5.762 ± 0.044	4.79SerVal: 4.79 ± 0.034	1.194SerTrp: 1.194 ± 0.015	2.2SerTyr: 2.2 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.201ThrAla: 5.201 ± 0.033	0.8ThrCys: 0.8 ± 0.012	3.005ThrAsp: 3.005 ± 0.024	3.185ThrGlu: 3.185 ± 0.031	2.244ThrPhe: 2.244 ± 0.02	4.293ThrGly: 4.293 ± 0.031	1.366ThrHis: 1.366 ± 0.016	3.192ThrIle: 3.192 ± 0.027	2.408ThrLys: 2.408 ± 0.022	5.446ThrLeu: 5.446 ± 0.034	1.224ThrMet: 1.224 ± 0.013	2.114ThrAsn: 2.114 ± 0.023	4.287ThrPro: 4.287 ± 0.037	2.101ThrGln: 2.101 ± 0.018	3.091ThrArg: 3.091 ± 0.024	5.39ThrSer: 5.39 ± 0.04	4.647ThrThr: 4.647 ± 0.047	3.877ThrVal: 3.877 ± 0.028	0.898ThrTrp: 0.898 ± 0.013	1.778ThrTyr: 1.778 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.224ValAla: 5.224 ± 0.035	0.927ValCys: 0.927 ± 0.013	3.788ValAsp: 3.788 ± 0.026	3.869ValGlu: 3.869 ± 0.029	2.515ValPhe: 2.515 ± 0.026	4.116ValGly: 4.116 ± 0.031	1.465ValHis: 1.465 ± 0.016	3.092ValIle: 3.092 ± 0.025	2.684ValLys: 2.684 ± 0.023	5.794ValLeu: 5.794 ± 0.039	1.409ValMet: 1.409 ± 0.017	2.264ValAsn: 2.264 ± 0.018	3.7ValPro: 3.7 ± 0.026	2.448ValGln: 2.448 ± 0.021	3.602ValArg: 3.602 ± 0.027	4.859ValSer: 4.859 ± 0.036	3.631ValThr: 3.631 ± 0.029	4.453ValVal: 4.453 ± 0.038	0.909ValTrp: 0.909 ± 0.012	1.899ValTyr: 1.899 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.15TrpAla: 1.15 ± 0.014	0.206TrpCys: 0.206 ± 0.006	0.928TrpAsp: 0.928 ± 0.014	0.88TrpGlu: 0.88 ± 0.013	0.571TrpPhe: 0.571 ± 0.009	0.987TrpGly: 0.987 ± 0.013	0.375TrpHis: 0.375 ± 0.009	0.798TrpIle: 0.798 ± 0.011	0.798TrpLys: 0.798 ± 0.012	1.441TrpLeu: 1.441 ± 0.018	0.388TrpMet: 0.388 ± 0.009	0.658TrpAsn: 0.658 ± 0.011	0.643TrpPro: 0.643 ± 0.011	0.573TrpGln: 0.573 ± 0.009	1.006TrpArg: 1.006 ± 0.014	1.1TrpSer: 1.1 ± 0.015	0.974TrpThr: 0.974 ± 0.015	0.962TrpVal: 0.962 ± 0.014	0.297TrpTrp: 0.297 ± 0.008	0.468TrpTyr: 0.468 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.284TyrAla: 2.284 ± 0.022	0.466TyrCys: 0.466 ± 0.009	1.701TyrAsp: 1.701 ± 0.019	1.597TyrGlu: 1.597 ± 0.016	1.25TyrPhe: 1.25 ± 0.014	2.183TyrGly: 2.183 ± 0.023	0.838TyrHis: 0.838 ± 0.013	1.516TyrIle: 1.516 ± 0.018	1.044TyrLys: 1.044 ± 0.014	2.933TyrLeu: 2.933 ± 0.024	0.685TyrMet: 0.685 ± 0.011	1.193TyrAsn: 1.193 ± 0.016	1.665TyrPro: 1.665 ± 0.02	1.166TyrGln: 1.166 ± 0.014	1.752TyrArg: 1.752 ± 0.017	2.175TyrSer: 2.175 ± 0.021	1.759TyrThr: 1.759 ± 0.019	1.765TyrVal: 1.765 ± 0.019	0.499TyrTrp: 0.499 ± 0.01	1.054TyrTyr: 1.054 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12319 proteins (5835640 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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