Amino acid dipepetide frequency for Aeromonas phage AhyVDH1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.987AlaAla: 13.987 ± 1.538
0.869AlaCys: 0.869 ± 0.254
4.778AlaAsp: 4.778 ± 0.63
6.776AlaGlu: 6.776 ± 0.815
2.954AlaPhe: 2.954 ± 0.507
8.34AlaGly: 8.34 ± 0.867
2.085AlaHis: 2.085 ± 0.515
5.299AlaIle: 5.299 ± 0.614
6.863AlaLys: 6.863 ± 0.938
11.294AlaLeu: 11.294 ± 1.002
5.126AlaMet: 5.126 ± 0.708
3.388AlaAsn: 3.388 ± 0.443
4.952AlaPro: 4.952 ± 0.496
4.344AlaGln: 4.344 ± 0.465
5.299AlaArg: 5.299 ± 0.721
5.647AlaSer: 5.647 ± 0.881
6.429AlaThr: 6.429 ± 0.817
7.297AlaVal: 7.297 ± 0.869
0.695AlaTrp: 0.695 ± 0.293
3.041AlaTyr: 3.041 ± 0.486
0.0AlaXaa: 0.0 ± 0.0
Cys
0.782CysAla: 0.782 ± 0.308
0.174CysCys: 0.174 ± 0.115
0.434CysAsp: 0.434 ± 0.193
0.521CysGlu: 0.521 ± 0.251
0.261CysPhe: 0.261 ± 0.12
1.303CysGly: 1.303 ± 0.373
0.434CysHis: 0.434 ± 0.196
0.695CysIle: 0.695 ± 0.259
0.782CysLys: 0.782 ± 0.221
1.042CysLeu: 1.042 ± 0.302
0.347CysMet: 0.347 ± 0.151
0.521CysAsn: 0.521 ± 0.275
0.608CysPro: 0.608 ± 0.256
0.261CysGln: 0.261 ± 0.173
0.695CysArg: 0.695 ± 0.218
0.521CysSer: 0.521 ± 0.197
0.782CysThr: 0.782 ± 0.287
0.956CysVal: 0.956 ± 0.288
0.347CysTrp: 0.347 ± 0.212
0.261CysTyr: 0.261 ± 0.19
0.0CysXaa: 0.0 ± 0.0
Asp
5.212AspAla: 5.212 ± 0.508
0.869AspCys: 0.869 ± 0.259
2.606AspAsp: 2.606 ± 0.513
3.301AspGlu: 3.301 ± 0.592
1.824AspPhe: 1.824 ± 0.386
5.212AspGly: 5.212 ± 0.729
1.303AspHis: 1.303 ± 0.336
3.041AspIle: 3.041 ± 0.487
3.736AspLys: 3.736 ± 0.635
5.299AspLeu: 5.299 ± 0.673
1.216AspMet: 1.216 ± 0.332
1.477AspAsn: 1.477 ± 0.356
2.346AspPro: 2.346 ± 0.407
1.737AspGln: 1.737 ± 0.362
3.996AspArg: 3.996 ± 0.743
2.085AspSer: 2.085 ± 0.436
2.085AspThr: 2.085 ± 0.418
3.388AspVal: 3.388 ± 0.436
1.042AspTrp: 1.042 ± 0.305
1.216AspTyr: 1.216 ± 0.322
0.0AspXaa: 0.0 ± 0.0
Glu
8.253GluAla: 8.253 ± 0.97
0.695GluCys: 0.695 ± 0.209
2.432GluAsp: 2.432 ± 0.402
3.127GluGlu: 3.127 ± 0.649
1.824GluPhe: 1.824 ± 0.462
5.212GluGly: 5.212 ± 0.696
1.042GluHis: 1.042 ± 0.293
3.736GluIle: 3.736 ± 0.643
3.736GluLys: 3.736 ± 0.61
5.212GluLeu: 5.212 ± 0.815
2.519GluMet: 2.519 ± 0.526
2.085GluAsn: 2.085 ± 0.402
2.259GluPro: 2.259 ± 0.504
2.867GluGln: 2.867 ± 0.598
3.909GluArg: 3.909 ± 0.549
3.996GluSer: 3.996 ± 0.522
3.127GluThr: 3.127 ± 0.439
3.909GluVal: 3.909 ± 0.67
1.303GluTrp: 1.303 ± 0.315
1.216GluTyr: 1.216 ± 0.307
0.0GluXaa: 0.0 ± 0.0
Phe
2.085PheAla: 2.085 ± 0.361
0.521PheCys: 0.521 ± 0.169
1.651PheAsp: 1.651 ± 0.449
1.737PheGlu: 1.737 ± 0.375
0.434PhePhe: 0.434 ± 0.171
3.388PheGly: 3.388 ± 0.584
0.782PheHis: 0.782 ± 0.295
1.651PheIle: 1.651 ± 0.352
1.477PheLys: 1.477 ± 0.289
2.519PheLeu: 2.519 ± 0.444
0.695PheMet: 0.695 ± 0.251
1.042PheAsn: 1.042 ± 0.337
1.216PhePro: 1.216 ± 0.301
1.477PheGln: 1.477 ± 0.323
1.737PheArg: 1.737 ± 0.342
1.477PheSer: 1.477 ± 0.313
2.693PheThr: 2.693 ± 0.476
1.737PheVal: 1.737 ± 0.336
0.521PheTrp: 0.521 ± 0.176
0.521PheTyr: 0.521 ± 0.252
0.0PheXaa: 0.0 ± 0.0
Gly
6.95GlyAla: 6.95 ± 0.676
1.042GlyCys: 1.042 ± 0.327
3.736GlyAsp: 3.736 ± 0.569
5.56GlyGlu: 5.56 ± 0.528
3.909GlyPhe: 3.909 ± 0.716
5.473GlyGly: 5.473 ± 0.899
1.737GlyHis: 1.737 ± 0.409
4.691GlyIle: 4.691 ± 0.776
4.778GlyLys: 4.778 ± 0.676
6.516GlyLeu: 6.516 ± 0.711
2.78GlyMet: 2.78 ± 0.4
2.346GlyAsn: 2.346 ± 0.904
3.041GlyPro: 3.041 ± 0.522
3.214GlyGln: 3.214 ± 0.583
4.691GlyArg: 4.691 ± 0.607
4.952GlySer: 4.952 ± 0.759
4.865GlyThr: 4.865 ± 0.989
6.429GlyVal: 6.429 ± 0.594
1.39GlyTrp: 1.39 ± 0.271
1.911GlyTyr: 1.911 ± 0.549
0.0GlyXaa: 0.0 ± 0.0
His
1.998HisAla: 1.998 ± 0.425
0.174HisCys: 0.174 ± 0.126
1.042HisAsp: 1.042 ± 0.379
1.477HisGlu: 1.477 ± 0.335
0.695HisPhe: 0.695 ± 0.27
1.651HisGly: 1.651 ± 0.492
0.521HisHis: 0.521 ± 0.182
1.129HisIle: 1.129 ± 0.354
0.956HisLys: 0.956 ± 0.265
2.085HisLeu: 2.085 ± 0.451
0.608HisMet: 0.608 ± 0.232
1.216HisAsn: 1.216 ± 0.38
1.042HisPro: 1.042 ± 0.353
1.477HisGln: 1.477 ± 0.422
1.911HisArg: 1.911 ± 0.562
0.695HisSer: 0.695 ± 0.238
1.129HisThr: 1.129 ± 0.33
1.042HisVal: 1.042 ± 0.347
0.261HisTrp: 0.261 ± 0.161
0.521HisTyr: 0.521 ± 0.267
0.0HisXaa: 0.0 ± 0.0
Ile
5.299IleAla: 5.299 ± 0.679
0.521IleCys: 0.521 ± 0.216
2.606IleAsp: 2.606 ± 0.456
3.214IleGlu: 3.214 ± 0.498
0.956IlePhe: 0.956 ± 0.297
2.867IleGly: 2.867 ± 0.554
1.651IleHis: 1.651 ± 0.322
2.693IleIle: 2.693 ± 0.513
2.693IleLys: 2.693 ± 0.443
3.388IleLeu: 3.388 ± 0.482
0.869IleMet: 0.869 ± 0.23
1.824IleAsn: 1.824 ± 0.406
2.519IlePro: 2.519 ± 0.487
1.737IleGln: 1.737 ± 0.363
3.041IleArg: 3.041 ± 0.539
4.17IleSer: 4.17 ± 0.634
4.17IleThr: 4.17 ± 0.556
3.388IleVal: 3.388 ± 0.525
0.782IleTrp: 0.782 ± 0.216
0.782IleTyr: 0.782 ± 0.305
0.0IleXaa: 0.0 ± 0.0
Lys
8.948LysAla: 8.948 ± 1.058
0.695LysCys: 0.695 ± 0.271
3.041LysAsp: 3.041 ± 0.408
3.562LysGlu: 3.562 ± 0.544
1.911LysPhe: 1.911 ± 0.415
5.473LysGly: 5.473 ± 0.771
1.216LysHis: 1.216 ± 0.275
1.651LysIle: 1.651 ± 0.357
2.954LysLys: 2.954 ± 0.523
4.691LysLeu: 4.691 ± 0.671
1.737LysMet: 1.737 ± 0.363
0.869LysAsn: 0.869 ± 0.342
2.346LysPro: 2.346 ± 0.356
1.477LysGln: 1.477 ± 0.366
3.301LysArg: 3.301 ± 0.625
2.519LysSer: 2.519 ± 0.658
4.344LysThr: 4.344 ± 0.527
5.212LysVal: 5.212 ± 0.571
1.216LysTrp: 1.216 ± 0.312
1.216LysTyr: 1.216 ± 0.311
0.0LysXaa: 0.0 ± 0.0
Leu
7.732LeuAla: 7.732 ± 0.935
1.216LeuCys: 1.216 ± 0.303
5.907LeuAsp: 5.907 ± 0.903
5.647LeuGlu: 5.647 ± 0.669
1.564LeuPhe: 1.564 ± 0.406
5.907LeuGly: 5.907 ± 0.862
1.911LeuHis: 1.911 ± 0.518
4.083LeuIle: 4.083 ± 0.533
4.344LeuLys: 4.344 ± 0.769
5.299LeuLeu: 5.299 ± 0.576
3.388LeuMet: 3.388 ± 0.544
3.736LeuAsn: 3.736 ± 0.512
4.517LeuPro: 4.517 ± 0.632
2.867LeuGln: 2.867 ± 0.572
5.386LeuArg: 5.386 ± 0.593
5.821LeuSer: 5.821 ± 0.631
6.081LeuThr: 6.081 ± 0.764
4.865LeuVal: 4.865 ± 0.63
1.564LeuTrp: 1.564 ± 0.297
1.998LeuTyr: 1.998 ± 0.401
0.0LeuXaa: 0.0 ± 0.0
Met
4.604MetAla: 4.604 ± 0.63
0.261MetCys: 0.261 ± 0.144
1.824MetAsp: 1.824 ± 0.383
2.172MetGlu: 2.172 ± 0.387
1.042MetPhe: 1.042 ± 0.265
2.172MetGly: 2.172 ± 0.435
0.174MetHis: 0.174 ± 0.13
1.216MetIle: 1.216 ± 0.343
1.911MetLys: 1.911 ± 0.369
1.564MetLeu: 1.564 ± 0.372
0.521MetMet: 0.521 ± 0.195
1.216MetAsn: 1.216 ± 0.406
0.782MetPro: 0.782 ± 0.277
1.042MetGln: 1.042 ± 0.325
2.259MetArg: 2.259 ± 0.508
2.519MetSer: 2.519 ± 0.417
2.78MetThr: 2.78 ± 0.402
2.78MetVal: 2.78 ± 0.602
0.261MetTrp: 0.261 ± 0.143
0.521MetTyr: 0.521 ± 0.16
0.0MetXaa: 0.0 ± 0.0
Asn
2.693AsnAla: 2.693 ± 0.672
0.087AsnCys: 0.087 ± 0.082
1.477AsnAsp: 1.477 ± 0.414
1.651AsnGlu: 1.651 ± 0.287
1.042AsnPhe: 1.042 ± 0.291
3.475AsnGly: 3.475 ± 0.784
0.782AsnHis: 0.782 ± 0.249
1.216AsnIle: 1.216 ± 0.358
1.39AsnLys: 1.39 ± 0.342
2.606AsnLeu: 2.606 ± 0.412
0.782AsnMet: 0.782 ± 0.255
0.869AsnAsn: 0.869 ± 0.337
2.867AsnPro: 2.867 ± 0.404
1.737AsnGln: 1.737 ± 0.299
2.519AsnArg: 2.519 ± 0.44
2.085AsnSer: 2.085 ± 0.5
2.172AsnThr: 2.172 ± 0.399
2.519AsnVal: 2.519 ± 0.548
0.608AsnTrp: 0.608 ± 0.206
1.129AsnTyr: 1.129 ± 0.287
0.0AsnXaa: 0.0 ± 0.0
Pro
4.083ProAla: 4.083 ± 0.582
0.521ProCys: 0.521 ± 0.225
2.867ProAsp: 2.867 ± 0.441
4.865ProGlu: 4.865 ± 0.584
1.216ProPhe: 1.216 ± 0.295
3.127ProGly: 3.127 ± 0.482
0.869ProHis: 0.869 ± 0.23
2.432ProIle: 2.432 ± 0.423
3.301ProLys: 3.301 ± 0.501
3.214ProLeu: 3.214 ± 0.478
0.695ProMet: 0.695 ± 0.202
1.042ProAsn: 1.042 ± 0.28
1.39ProPro: 1.39 ± 0.423
1.303ProGln: 1.303 ± 0.342
1.564ProArg: 1.564 ± 0.37
3.214ProSer: 3.214 ± 0.509
2.693ProThr: 2.693 ± 0.444
4.257ProVal: 4.257 ± 0.726
0.434ProTrp: 0.434 ± 0.182
1.129ProTyr: 1.129 ± 0.289
0.0ProXaa: 0.0 ± 0.0
Gln
4.865GlnAla: 4.865 ± 0.63
0.608GlnCys: 0.608 ± 0.242
1.824GlnAsp: 1.824 ± 0.342
2.78GlnGlu: 2.78 ± 0.438
0.608GlnPhe: 0.608 ± 0.236
3.041GlnGly: 3.041 ± 0.578
0.782GlnHis: 0.782 ± 0.268
1.564GlnIle: 1.564 ± 0.298
2.954GlnLys: 2.954 ± 0.484
3.822GlnLeu: 3.822 ± 0.536
1.564GlnMet: 1.564 ± 0.363
1.39GlnAsn: 1.39 ± 0.361
0.956GlnPro: 0.956 ± 0.303
2.519GlnGln: 2.519 ± 0.593
1.737GlnArg: 1.737 ± 0.45
1.564GlnSer: 1.564 ± 0.425
2.519GlnThr: 2.519 ± 0.416
2.867GlnVal: 2.867 ± 0.524
0.695GlnTrp: 0.695 ± 0.188
0.869GlnTyr: 0.869 ± 0.297
0.0GlnXaa: 0.0 ± 0.0
Arg
6.602ArgAla: 6.602 ± 0.745
0.695ArgCys: 0.695 ± 0.258
3.649ArgAsp: 3.649 ± 0.549
2.867ArgGlu: 2.867 ± 0.579
2.519ArgPhe: 2.519 ± 0.41
2.867ArgGly: 2.867 ± 0.479
1.477ArgHis: 1.477 ± 0.384
2.954ArgIle: 2.954 ± 0.394
3.214ArgLys: 3.214 ± 0.61
6.168ArgLeu: 6.168 ± 0.846
1.564ArgMet: 1.564 ± 0.378
2.085ArgAsn: 2.085 ± 0.369
3.388ArgPro: 3.388 ± 0.637
2.519ArgGln: 2.519 ± 0.414
4.083ArgArg: 4.083 ± 0.954
4.083ArgSer: 4.083 ± 0.654
2.954ArgThr: 2.954 ± 0.374
4.344ArgVal: 4.344 ± 0.663
1.042ArgTrp: 1.042 ± 0.289
1.477ArgTyr: 1.477 ± 0.358
0.0ArgXaa: 0.0 ± 0.0
Ser
5.994SerAla: 5.994 ± 0.761
0.608SerCys: 0.608 ± 0.226
3.214SerAsp: 3.214 ± 0.534
3.736SerGlu: 3.736 ± 0.505
1.477SerPhe: 1.477 ± 0.341
5.647SerGly: 5.647 ± 0.655
1.303SerHis: 1.303 ± 0.395
2.867SerIle: 2.867 ± 0.456
3.041SerLys: 3.041 ± 0.732
5.907SerLeu: 5.907 ± 0.795
2.259SerMet: 2.259 ± 0.394
1.477SerAsn: 1.477 ± 0.239
2.954SerPro: 2.954 ± 0.529
2.085SerGln: 2.085 ± 0.406
3.562SerArg: 3.562 ± 0.579
3.822SerSer: 3.822 ± 0.54
3.736SerThr: 3.736 ± 0.548
3.041SerVal: 3.041 ± 0.558
1.129SerTrp: 1.129 ± 0.332
0.956SerTyr: 0.956 ± 0.259
0.0SerXaa: 0.0 ± 0.0
Thr
6.602ThrAla: 6.602 ± 0.926
0.521ThrCys: 0.521 ± 0.228
3.041ThrAsp: 3.041 ± 0.674
2.867ThrGlu: 2.867 ± 0.399
2.085ThrPhe: 2.085 ± 0.371
6.342ThrGly: 6.342 ± 0.809
0.956ThrHis: 0.956 ± 0.28
3.214ThrIle: 3.214 ± 0.531
3.996ThrLys: 3.996 ± 0.676
6.429ThrLeu: 6.429 ± 0.71
1.824ThrMet: 1.824 ± 0.401
1.998ThrAsn: 1.998 ± 0.444
3.388ThrPro: 3.388 ± 0.637
2.172ThrGln: 2.172 ± 0.491
3.214ThrArg: 3.214 ± 0.42
2.519ThrSer: 2.519 ± 0.474
3.909ThrThr: 3.909 ± 0.778
4.431ThrVal: 4.431 ± 0.792
0.521ThrTrp: 0.521 ± 0.233
1.911ThrTyr: 1.911 ± 0.424
0.0ThrXaa: 0.0 ± 0.0
Val
8.687ValAla: 8.687 ± 1.039
1.129ValCys: 1.129 ± 0.298
4.083ValAsp: 4.083 ± 0.513
3.909ValGlu: 3.909 ± 0.5
1.39ValPhe: 1.39 ± 0.381
5.56ValGly: 5.56 ± 0.772
1.39ValHis: 1.39 ± 0.333
3.475ValIle: 3.475 ± 0.64
4.952ValLys: 4.952 ± 0.512
3.388ValLeu: 3.388 ± 0.466
2.259ValMet: 2.259 ± 0.502
3.649ValAsn: 3.649 ± 0.933
2.606ValPro: 2.606 ± 0.461
2.78ValGln: 2.78 ± 0.423
4.083ValArg: 4.083 ± 0.629
5.039ValSer: 5.039 ± 0.635
3.649ValThr: 3.649 ± 0.483
6.342ValVal: 6.342 ± 1.015
1.39ValTrp: 1.39 ± 0.276
1.737ValTyr: 1.737 ± 0.568
0.0ValXaa: 0.0 ± 0.0
Trp
1.737TrpAla: 1.737 ± 0.336
0.174TrpCys: 0.174 ± 0.115
1.477TrpAsp: 1.477 ± 0.373
1.39TrpGlu: 1.39 ± 0.352
0.782TrpPhe: 0.782 ± 0.183
1.129TrpGly: 1.129 ± 0.314
0.347TrpHis: 0.347 ± 0.162
0.608TrpIle: 0.608 ± 0.235
0.434TrpLys: 0.434 ± 0.193
1.129TrpLeu: 1.129 ± 0.29
0.347TrpMet: 0.347 ± 0.177
0.695TrpAsn: 0.695 ± 0.257
0.261TrpPro: 0.261 ± 0.147
0.782TrpGln: 0.782 ± 0.266
1.129TrpArg: 1.129 ± 0.334
0.869TrpSer: 0.869 ± 0.385
0.608TrpThr: 0.608 ± 0.2
1.39TrpVal: 1.39 ± 0.396
0.087TrpTrp: 0.087 ± 0.077
0.434TrpTyr: 0.434 ± 0.17
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.432TyrAla: 2.432 ± 0.485
0.347TyrCys: 0.347 ± 0.156
1.303TyrAsp: 1.303 ± 0.389
1.303TyrGlu: 1.303 ± 0.318
0.869TyrPhe: 0.869 ± 0.374
1.824TyrGly: 1.824 ± 0.383
0.869TyrHis: 0.869 ± 0.265
0.956TyrIle: 0.956 ± 0.361
0.869TyrLys: 0.869 ± 0.211
2.259TyrLeu: 2.259 ± 0.42
0.434TyrMet: 0.434 ± 0.198
0.782TyrAsn: 0.782 ± 0.226
0.782TyrPro: 0.782 ± 0.246
1.129TyrGln: 1.129 ± 0.258
2.432TyrArg: 2.432 ± 0.597
1.216TyrSer: 1.216 ± 0.349
1.216TyrThr: 1.216 ± 0.426
1.303TyrVal: 1.303 ± 0.374
0.521TyrTrp: 0.521 ± 0.201
0.434TyrTyr: 0.434 ± 0.201
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (11512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski