Amino acid dipepetide frequency for Oleiphilus sp. HI0043

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.101AlaAla: 7.101 ± 0.096	1.074AlaCys: 1.074 ± 0.036	4.473AlaAsp: 4.473 ± 0.067	5.865AlaGlu: 5.865 ± 0.071	3.309AlaPhe: 3.309 ± 0.067	5.883AlaGly: 5.883 ± 0.087	1.72AlaHis: 1.72 ± 0.037	5.635AlaIle: 5.635 ± 0.083	5.06AlaLys: 5.06 ± 0.086	9.866AlaLeu: 9.866 ± 0.111	2.395AlaMet: 2.395 ± 0.054	3.25AlaAsn: 3.25 ± 0.061	2.865AlaPro: 2.865 ± 0.053	3.541AlaGln: 3.541 ± 0.06	3.614AlaArg: 3.614 ± 0.051	6.113AlaSer: 6.113 ± 0.078	3.751AlaThr: 3.751 ± 0.071	5.136AlaVal: 5.136 ± 0.075	0.945AlaTrp: 0.945 ± 0.03	2.546AlaTyr: 2.546 ± 0.049	0.003AlaXaa: 0.003 ± 0.001
Cys	0.797CysAla: 0.797 ± 0.028	0.151CysCys: 0.151 ± 0.012	0.628CysAsp: 0.628 ± 0.028	0.674CysGlu: 0.674 ± 0.023	0.474CysPhe: 0.474 ± 0.02	0.872CysGly: 0.872 ± 0.029	0.333CysHis: 0.333 ± 0.016	0.625CysIle: 0.625 ± 0.024	0.465CysLys: 0.465 ± 0.021	1.165CysLeu: 1.165 ± 0.034	0.231CysMet: 0.231 ± 0.012	0.362CysAsn: 0.362 ± 0.017	0.485CysPro: 0.485 ± 0.028	0.452CysGln: 0.452 ± 0.021	0.473CysArg: 0.473 ± 0.019	0.81CysSer: 0.81 ± 0.03	0.482CysThr: 0.482 ± 0.021	0.624CysVal: 0.624 ± 0.021	0.106CysTrp: 0.106 ± 0.008	0.319CysTyr: 0.319 ± 0.015	0.001CysXaa: 0.001 ± 0.001
Asp	4.584AspAla: 4.584 ± 0.079	0.563AspCys: 0.563 ± 0.021	3.373AspAsp: 3.373 ± 0.102	4.268AspGlu: 4.268 ± 0.069	2.471AspPhe: 2.471 ± 0.048	3.87AspGly: 3.87 ± 0.141	1.188AspHis: 1.188 ± 0.033	4.36AspIle: 4.36 ± 0.07	3.411AspLys: 3.411 ± 0.06	6.005AspLeu: 6.005 ± 0.068	1.491AspMet: 1.491 ± 0.037	2.295AspAsn: 2.295 ± 0.073	2.197AspPro: 2.197 ± 0.049	2.496AspGln: 2.496 ± 0.053	2.476AspArg: 2.476 ± 0.048	4.022AspSer: 4.022 ± 0.076	2.929AspThr: 2.929 ± 0.078	3.654AspVal: 3.654 ± 0.07	0.736AspTrp: 0.736 ± 0.027	2.111AspTyr: 2.111 ± 0.042	0.001AspXaa: 0.001 ± 0.001
Glu	6.052GluAla: 6.052 ± 0.077	0.579GluCys: 0.579 ± 0.023	3.644GluAsp: 3.644 ± 0.061	4.796GluGlu: 4.796 ± 0.081	2.571GluPhe: 2.571 ± 0.048	4.381GluGly: 4.381 ± 0.072	1.73GluHis: 1.73 ± 0.042	4.193GluIle: 4.193 ± 0.054	4.147GluLys: 4.147 ± 0.072	7.655GluLeu: 7.655 ± 0.092	1.651GluMet: 1.651 ± 0.039	2.811GluAsn: 2.811 ± 0.046	2.177GluPro: 2.177 ± 0.057	3.826GluGln: 3.826 ± 0.072	3.659GluArg: 3.659 ± 0.048	4.683GluSer: 4.683 ± 0.06	3.431GluThr: 3.431 ± 0.057	4.509GluVal: 4.509 ± 0.063	0.712GluTrp: 0.712 ± 0.025	1.854GluTyr: 1.854 ± 0.041	0.003GluXaa: 0.003 ± 0.001
Phe	3.169PheAla: 3.169 ± 0.058	0.465PheCys: 0.465 ± 0.02	2.823PheAsp: 2.823 ± 0.051	2.736PheGlu: 2.736 ± 0.044	1.8PhePhe: 1.8 ± 0.045	2.924PheGly: 2.924 ± 0.055	0.824PheHis: 0.824 ± 0.026	2.61PheIle: 2.61 ± 0.052	2.189PheLys: 2.189 ± 0.047	3.513PheLeu: 3.513 ± 0.061	0.93PheMet: 0.93 ± 0.027	1.753PheAsn: 1.753 ± 0.038	1.473PhePro: 1.473 ± 0.037	1.343PheGln: 1.343 ± 0.033	1.58PheArg: 1.58 ± 0.035	3.641PheSer: 3.641 ± 0.063	2.1PheThr: 2.1 ± 0.047	2.636PheVal: 2.636 ± 0.056	0.491PheTrp: 0.491 ± 0.022	1.22PheTyr: 1.22 ± 0.029	0.003PheXaa: 0.003 ± 0.001
Gly	5.294GlyAla: 5.294 ± 0.078	0.792GlyCys: 0.792 ± 0.024	3.834GlyAsp: 3.834 ± 0.114	4.529GlyGlu: 4.529 ± 0.071	3.1GlyPhe: 3.1 ± 0.056	4.733GlyGly: 4.733 ± 0.112	1.507GlyHis: 1.507 ± 0.034	4.625GlyIle: 4.625 ± 0.062	3.983GlyLys: 3.983 ± 0.056	7.326GlyLeu: 7.326 ± 0.109	1.942GlyMet: 1.942 ± 0.045	2.511GlyAsn: 2.511 ± 0.077	1.687GlyPro: 1.687 ± 0.038	2.662GlyGln: 2.662 ± 0.059	3.126GlyArg: 3.126 ± 0.042	4.499GlySer: 4.499 ± 0.066	3.322GlyThr: 3.322 ± 0.073	4.954GlyVal: 4.954 ± 0.075	0.831GlyTrp: 0.831 ± 0.026	2.248GlyTyr: 2.248 ± 0.045	0.004GlyXaa: 0.004 ± 0.002
His	1.634HisAla: 1.634 ± 0.037	0.34HisCys: 0.34 ± 0.016	1.159HisAsp: 1.159 ± 0.036	1.35HisGlu: 1.35 ± 0.044	1.044HisPhe: 1.044 ± 0.032	1.506HisGly: 1.506 ± 0.04	0.675HisHis: 0.675 ± 0.025	1.386HisIle: 1.386 ± 0.036	1.088HisLys: 1.088 ± 0.031	2.295HisLeu: 2.295 ± 0.045	0.52HisMet: 0.52 ± 0.022	0.856HisAsn: 0.856 ± 0.028	1.097HisPro: 1.097 ± 0.034	1.059HisGln: 1.059 ± 0.032	1.074HisArg: 1.074 ± 0.034	1.48HisSer: 1.48 ± 0.037	0.989HisThr: 0.989 ± 0.032	1.241HisVal: 1.241 ± 0.03	0.284HisTrp: 0.284 ± 0.017	0.853HisTyr: 0.853 ± 0.029	0.001HisXaa: 0.001 ± 0.001
Ile	5.925IleAla: 5.925 ± 0.083	0.714IleCys: 0.714 ± 0.025	4.555IleAsp: 4.555 ± 0.072	5.096IleGlu: 5.096 ± 0.068	2.228IlePhe: 2.228 ± 0.049	4.313IleGly: 4.313 ± 0.054	1.324IleHis: 1.324 ± 0.035	3.635IleIle: 3.635 ± 0.067	3.639IleLys: 3.639 ± 0.066	5.469IleLeu: 5.469 ± 0.073	1.187IleMet: 1.187 ± 0.033	2.949IleAsn: 2.949 ± 0.055	2.697IlePro: 2.697 ± 0.053	2.314IleGln: 2.314 ± 0.051	2.843IleArg: 2.843 ± 0.044	5.18IleSer: 5.18 ± 0.087	3.257IleThr: 3.257 ± 0.063	4.099IleVal: 4.099 ± 0.065	0.57IleTrp: 0.57 ± 0.025	1.722IleTyr: 1.722 ± 0.037	0.002IleXaa: 0.002 ± 0.001
Lys	5.298LysAla: 5.298 ± 0.081	0.336LysCys: 0.336 ± 0.018	3.048LysAsp: 3.048 ± 0.051	3.853LysGlu: 3.853 ± 0.074	1.61LysPhe: 1.61 ± 0.035	3.67LysGly: 3.67 ± 0.058	1.454LysHis: 1.454 ± 0.036	3.117LysIle: 3.117 ± 0.061	3.416LysLys: 3.416 ± 0.074	5.713LysLeu: 5.713 ± 0.091	1.341LysMet: 1.341 ± 0.037	2.248LysAsn: 2.248 ± 0.053	2.447LysPro: 2.447 ± 0.047	3.022LysGln: 3.022 ± 0.057	3.065LysArg: 3.065 ± 0.049	3.7LysSer: 3.7 ± 0.063	3.038LysThr: 3.038 ± 0.046	4.006LysVal: 4.006 ± 0.059	0.498LysTrp: 0.498 ± 0.019	1.42LysTyr: 1.42 ± 0.034	0.001LysXaa: 0.001 ± 0.001
Leu	9.53LeuAla: 9.53 ± 0.106	1.13LeuCys: 1.13 ± 0.029	6.278LeuAsp: 6.278 ± 0.082	7.231LeuGlu: 7.231 ± 0.091	4.075LeuPhe: 4.075 ± 0.077	6.856LeuGly: 6.856 ± 0.088	1.935LeuHis: 1.935 ± 0.038	6.356LeuIle: 6.356 ± 0.09	6.368LeuLys: 6.368 ± 0.074	10.504LeuLeu: 10.504 ± 0.15	2.463LeuMet: 2.463 ± 0.043	4.699LeuAsn: 4.699 ± 0.054	4.561LeuPro: 4.561 ± 0.061	3.498LeuGln: 3.498 ± 0.058	4.57LeuArg: 4.57 ± 0.069	9.64LeuSer: 9.64 ± 0.104	4.96LeuThr: 4.96 ± 0.063	6.973LeuVal: 6.973 ± 0.089	0.977LeuTrp: 0.977 ± 0.031	2.689LeuTyr: 2.689 ± 0.052	0.007LeuXaa: 0.007 ± 0.002
Met	2.151MetAla: 2.151 ± 0.05	0.23MetCys: 0.23 ± 0.013	1.294MetAsp: 1.294 ± 0.038	1.282MetGlu: 1.282 ± 0.035	0.841MetPhe: 0.841 ± 0.026	1.683MetGly: 1.683 ± 0.046	0.492MetHis: 0.492 ± 0.022	1.499MetIle: 1.499 ± 0.039	1.441MetLys: 1.441 ± 0.035	2.578MetLeu: 2.578 ± 0.05	0.66MetMet: 0.66 ± 0.026	1.169MetAsn: 1.169 ± 0.031	1.135MetPro: 1.135 ± 0.029	0.999MetGln: 0.999 ± 0.03	1.056MetArg: 1.056 ± 0.03	2.105MetSer: 2.105 ± 0.049	1.404MetThr: 1.404 ± 0.037	1.462MetVal: 1.462 ± 0.036	0.189MetTrp: 0.189 ± 0.012	0.532MetTyr: 0.532 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.393AsnAla: 3.393 ± 0.07	0.428AsnCys: 0.428 ± 0.025	2.437AsnAsp: 2.437 ± 0.081	2.769AsnGlu: 2.769 ± 0.05	1.503AsnPhe: 1.503 ± 0.036	2.609AsnGly: 2.609 ± 0.067	0.799AsnHis: 0.799 ± 0.03	2.9AsnIle: 2.9 ± 0.056	2.405AsnLys: 2.405 ± 0.048	3.925AsnLeu: 3.925 ± 0.053	0.925AsnMet: 0.925 ± 0.027	1.82AsnAsn: 1.82 ± 0.049	1.828AsnPro: 1.828 ± 0.048	1.886AsnGln: 1.886 ± 0.043	1.805AsnArg: 1.805 ± 0.042	2.678AsnSer: 2.678 ± 0.05	2.308AsnThr: 2.308 ± 0.054	2.408AsnVal: 2.408 ± 0.06	0.541AsnTrp: 0.541 ± 0.022	1.384AsnTyr: 1.384 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.89ProAla: 2.89 ± 0.052	0.31ProCys: 0.31 ± 0.018	2.496ProAsp: 2.496 ± 0.05	3.507ProGlu: 3.507 ± 0.06	1.598ProPhe: 1.598 ± 0.037	2.707ProGly: 2.707 ± 0.057	0.768ProHis: 0.768 ± 0.028	2.41ProIle: 2.41 ± 0.046	2.158ProLys: 2.158 ± 0.052	3.789ProLeu: 3.789 ± 0.054	0.906ProMet: 0.906 ± 0.027	1.544ProAsn: 1.544 ± 0.04	1.238ProPro: 1.238 ± 0.035	1.387ProGln: 1.387 ± 0.037	1.298ProArg: 1.298 ± 0.036	2.827ProSer: 2.827 ± 0.044	1.76ProThr: 1.76 ± 0.043	3.024ProVal: 3.024 ± 0.061	0.448ProTrp: 0.448 ± 0.019	1.205ProTyr: 1.205 ± 0.029	0.002ProXaa: 0.002 ± 0.001
Gln	4.322GlnAla: 4.322 ± 0.061	0.448GlnCys: 0.448 ± 0.019	2.115GlnAsp: 2.115 ± 0.043	2.656GlnGlu: 2.656 ± 0.051	1.584GlnPhe: 1.584 ± 0.033	2.965GlnGly: 2.965 ± 0.051	1.003GlnHis: 1.003 ± 0.03	2.43GlnIle: 2.43 ± 0.048	2.089GlnLys: 2.089 ± 0.045	4.601GlnLeu: 4.601 ± 0.068	0.946GlnMet: 0.946 ± 0.03	1.698GlnAsn: 1.698 ± 0.039	1.324GlnPro: 1.324 ± 0.034	2.165GlnGln: 2.165 ± 0.046	2.12GlnArg: 2.12 ± 0.04	2.963GlnSer: 2.963 ± 0.044	2.227GlnThr: 2.227 ± 0.041	2.994GlnVal: 2.994 ± 0.049	0.485GlnTrp: 0.485 ± 0.022	1.25GlnTyr: 1.25 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.497ArgAla: 3.497 ± 0.057	0.498ArgCys: 0.498 ± 0.023	2.469ArgAsp: 2.469 ± 0.047	3.115ArgGlu: 3.115 ± 0.06	2.243ArgPhe: 2.243 ± 0.042	2.405ArgGly: 2.405 ± 0.046	1.109ArgHis: 1.109 ± 0.026	3.132ArgIle: 3.132 ± 0.056	2.554ArgLys: 2.554 ± 0.05	5.078ArgLeu: 5.078 ± 0.076	1.227ArgMet: 1.227 ± 0.032	1.793ArgAsn: 1.793 ± 0.042	1.661ArgPro: 1.661 ± 0.041	2.061ArgGln: 2.061 ± 0.042	2.286ArgArg: 2.286 ± 0.05	3.044ArgSer: 3.044 ± 0.049	2.023ArgThr: 2.023 ± 0.046	3.19ArgVal: 3.19 ± 0.049	0.537ArgTrp: 0.537 ± 0.022	1.759ArgTyr: 1.759 ± 0.045	0.003ArgXaa: 0.003 ± 0.001
Ser	5.997SerAla: 5.997 ± 0.085	0.72SerCys: 0.72 ± 0.026	4.683SerAsp: 4.683 ± 0.092	5.053SerGlu: 5.053 ± 0.069	3.255SerPhe: 3.255 ± 0.056	5.441SerGly: 5.441 ± 0.061	1.661SerHis: 1.661 ± 0.037	4.748SerIle: 4.748 ± 0.07	4.006SerLys: 4.006 ± 0.059	8.202SerLeu: 8.202 ± 0.107	1.811SerMet: 1.811 ± 0.041	2.847SerAsn: 2.847 ± 0.056	2.788SerPro: 2.788 ± 0.047	3.125SerGln: 3.125 ± 0.054	3.272SerArg: 3.272 ± 0.063	5.714SerSer: 5.714 ± 0.089	3.604SerThr: 3.604 ± 0.06	4.802SerVal: 4.802 ± 0.06	0.819SerTrp: 0.819 ± 0.028	2.304SerTyr: 2.304 ± 0.05	0.001SerXaa: 0.001 ± 0.001
Thr	3.998ThrAla: 3.998 ± 0.076	0.481ThrCys: 0.481 ± 0.02	2.723ThrAsp: 2.723 ± 0.07	3.146ThrGlu: 3.146 ± 0.05	1.854ThrPhe: 1.854 ± 0.037	3.735ThrGly: 3.735 ± 0.065	1.115ThrHis: 1.115 ± 0.033	3.151ThrIle: 3.151 ± 0.057	2.371ThrLys: 2.371 ± 0.05	5.949ThrLeu: 5.949 ± 0.069	0.972ThrMet: 0.972 ± 0.031	1.886ThrAsn: 1.886 ± 0.043	2.421ThrPro: 2.421 ± 0.042	2.069ThrGln: 2.069 ± 0.043	2.211ThrArg: 2.211 ± 0.044	3.415ThrSer: 3.415 ± 0.056	2.478ThrThr: 2.478 ± 0.057	3.348ThrVal: 3.348 ± 0.075	0.541ThrTrp: 0.541 ± 0.021	1.454ThrTyr: 1.454 ± 0.045	0.001ThrXaa: 0.001 ± 0.001
Val	5.541ValAla: 5.541 ± 0.074	0.751ValCys: 0.751 ± 0.027	4.177ValAsp: 4.177 ± 0.076	4.626ValGlu: 4.626 ± 0.062	2.751ValPhe: 2.751 ± 0.046	4.259ValGly: 4.259 ± 0.076	1.258ValHis: 1.258 ± 0.032	4.606ValIle: 4.606 ± 0.066	3.549ValLys: 3.549 ± 0.059	6.815ValLeu: 6.815 ± 0.087	1.698ValMet: 1.698 ± 0.039	2.84ValAsn: 2.84 ± 0.06	2.457ValPro: 2.457 ± 0.047	2.103ValGln: 2.103 ± 0.044	2.836ValArg: 2.836 ± 0.049	5.399ValSer: 5.399 ± 0.083	3.412ValThr: 3.412 ± 0.065	4.775ValVal: 4.775 ± 0.075	0.682ValTrp: 0.682 ± 0.028	1.819ValTyr: 1.819 ± 0.04	0.003ValXaa: 0.003 ± 0.001
Trp	0.74TrpAla: 0.74 ± 0.026	0.126TrpCys: 0.126 ± 0.01	0.591TrpAsp: 0.591 ± 0.022	0.576TrpGlu: 0.576 ± 0.022	0.546TrpPhe: 0.546 ± 0.024	0.717TrpGly: 0.717 ± 0.026	0.272TrpHis: 0.272 ± 0.016	0.549TrpIle: 0.549 ± 0.023	0.493TrpLys: 0.493 ± 0.02	1.464TrpLeu: 1.464 ± 0.04	0.288TrpMet: 0.288 ± 0.015	0.407TrpAsn: 0.407 ± 0.016	0.429TrpPro: 0.429 ± 0.016	0.682TrpGln: 0.682 ± 0.025	0.624TrpArg: 0.624 ± 0.024	0.725TrpSer: 0.725 ± 0.027	0.441TrpThr: 0.441 ± 0.018	0.825TrpVal: 0.825 ± 0.026	0.145TrpTrp: 0.145 ± 0.012	0.327TrpTyr: 0.327 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.232TyrAla: 2.232 ± 0.044	0.394TyrCys: 0.394 ± 0.018	1.697TyrAsp: 1.697 ± 0.044	1.935TyrGlu: 1.935 ± 0.041	1.366TyrPhe: 1.366 ± 0.029	1.983TyrGly: 1.983 ± 0.046	0.765TyrHis: 0.765 ± 0.024	1.75TyrIle: 1.75 ± 0.033	1.462TyrLys: 1.462 ± 0.034	3.386TyrLeu: 3.386 ± 0.057	0.615TyrMet: 0.615 ± 0.024	1.005TyrAsn: 1.005 ± 0.033	1.302TyrPro: 1.302 ± 0.038	1.695TyrGln: 1.695 ± 0.037	1.693TyrArg: 1.693 ± 0.043	2.211TyrSer: 2.211 ± 0.045	1.404TyrThr: 1.404 ± 0.042	1.694TyrVal: 1.694 ± 0.034	0.43TyrTrp: 0.43 ± 0.019	0.941TyrTyr: 0.941 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.002	0.002XaaGlu: 0.002 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.003XaaIle: 0.003 ± 0.002	0.006XaaLys: 0.006 ± 0.002	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.003XaaAsn: 0.003 ± 0.002	0.0XaaPro: 0.0 ± 0.0	0.002XaaGln: 0.002 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.003XaaVal: 0.003 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 3862 proteins (1195953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---